المؤلفون: Banga, Ajay, Sanchez, Roberto, Kaushal, Ritesh, Mehta, Sonal, Sampath, Raghuram S.

المصدر: 33rd Annual Meeting North American Skull Base Society ; Journal of Neurological Surgery Part B: Skull Base ; ISSN 2193-634X

الإتاحة: https://doi.org/10.1055/s-0044-1780389Test

المؤلفون: Savas, Mesut, Mehta, Sonal, Agrawal, Nidhi, van Rossum, Elisabeth F. C., Feelders, Richard A.

المصدر: Savas , M , Mehta , S , Agrawal , N , van Rossum , E F C & Feelders , R A 2022 , ' Approach to the Patient : Diagnosis of Cushing Syndrome ' , Journal of Clinical Endocrinology and Metabolism , vol. 107 , no. 11 , pp. 3162-3174 . https://doi.org/10.1210/clinem/dgac492Test

مصطلحات موضوعية: /dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being, name=SDG 3 - Good Health and Well-being

الوصف: Cushing syndrome results from supraphysiological exposure to glucocorticoids and is associated with significant morbidity and mortality. The pathogenesis includes administration of corticosteroids (exogenous Cushing syndrome) or autonomous cortisol overproduction, whether or not ACTH-dependent (endogenous Cushing syndrome). An early diagnosis of Cushing syndrome is warranted; however, in clinical practice, it is very challenging partly because of resemblance with other common conditions (ie, pseudo-Cushing syndrome). Initial workup should start with excluding local and systemic corticosteroid use. First-line screening tests including the 1-mg dexamethasone suppression test, 24-hour urinary free cortisol excretion, and late-night salivary cortisol measurement should be performed to screen for endogenous Cushing syndrome. Scalp-hair cortisol/cortisone analysis helps in the assessment of long-term glucocorticoid exposure as well as in detection of transient periods of hypercortisolism as observed in cyclical Cushing syndrome. Interpretation of results can be difficult because of individual patient characteristics and hence requires awareness of test limitations. Once endogenous Cushing syndrome is established, measurement of plasma ACTH concentrations differentiates between ACTH-dependent (80%-85%) or ACTH-independent (15%-20%) causes. Further assessment with different imaging modalities and dynamic biochemical testing including bilateral inferior petrosal sinus sampling helps further pinpoint the cause of Cushing's syndrome. In this issue of "Approach to the patient," the diagnostic workup of Cushing syndrome is discussed with answering the questions when to screen, how to screen, and how to differentiate the different causes. In this respect, the latest developments in biochemical and imaging techniques are discussed as well.

وصف الملف: application/pdf

العلاقة: https://pure.eur.nl/en/publications/d9eb3b18-71c0-4f76-8dc1-34d5ca108ed7Test

الإتاحة: https://doi.org/10.1210/clinem/dgac492Test
https://pure.eur.nl/en/publications/d9eb3b18-71c0-4f76-8dc1-34d5ca108ed7Test
https://pure.eur.nl/ws/files/67713448/dgac492.pdfTest
http://www.scopus.com/inward/record.url?scp=85142918543&partnerID=8YFLogxKTest

المؤلفون: Sharma, Vivek, Dave, Vishal, Mehta, Sonal, Shah, Ankita

المساهمون: Intas Pharmaceuticals Limited

المصدر: International Journal of Reproduction, Contraception, Obstetrics and Gynecology; Vol 11, No 11 (2022): November 2022; 2967-2973 ; 2320-1789 ; 2320-1770

مصطلحات موضوعية: COS, rFSH, In vitro-fertilization, Controlled ovarian stimulation

الوصف: Background: The objective of the study was to evaluate the practice patterns of controlled ovarian stimulation (COS) in patients who underwent in vitro-fertilization and embryo transfer (IVF-ET) or intracytoplasmic sperm injection (ICSI).Methods: In REAL-COS (REAL-world observational study to capture practice pattern of COS in IVF-ET/ ICSI cycle) study, data was collected by 138 clinicians across India between April 2021 and March 2022 in a retrospective manner.Results: Data of 1651 subfertility female patients were evaluated. The mean (SD) age was 31.8 (3.9) years and majority (77.8%) of the patients were aged <35 years. Obese patients constituted 28.1% of the total population. The majority (79.5%) of the patients had primary subfertility and the polycystic ovarian syndrome (PCOS) was the most (27.8%) common cause of subfertility. Nearly equal percent of patients were treated with frozen or fresh embryo transfer. Most (~96%) of the patients received GnRH antagonist protocol wherein cetrorelix acetate was the most common drug (98.7%) while ~4% patients received GnRH agonist protocol wherein luprorelin was the most common one (83%). The most commonly used gonadotropin was recombinant follicle stimulating hormone alone therapy (rFSH, 49.2%). Majority (51.8%) of the patients were initiated at 225 IU dose of gonadotropin for COS. For ovulation trigger, human chorionic gonadotropin (hCG) was used in majority (59%) of the cases. Treatment with rFSH alone therapy resulted in max mean no. of oocytes and mean metaphase-II oocytes as compared with other treatments.Conclusions: This real-world observational study reports primary subfertility as the major reason for IVF-ET/ICSI in the study population. The GnRH antagonist protocol was followed by most of the clinicians participating in this study. rFSH was the most commonly used gonadotropin. rFSH alone therapy yielded the greatest number of oocytes and metaphase II oocytes versus other treatments.

وصف الملف: application/pdf

العلاقة: https://www.ijrcog.org/index.php/ijrcog/article/view/12299/7623Test; https://www.ijrcog.org/index.php/ijrcog/article/downloadSuppFile/12299/11716Test; https://www.ijrcog.org/index.php/ijrcog/article/view/12299Test

الإتاحة: https://doi.org/10.18203/2320-1770.ijrcog20222641Test
https://www.ijrcog.org/index.php/ijrcog/article/view/12299Test

المؤلفون: Gordon, Alex J., Dastagirzada, Yosef, Schlacter, Jamie, Mehta, Sonal, Agrawal, Nidhi, Golfinos, John G., Lebowitz, Richard, Pacione, Donato, Lieberman, Seth

المصدر: Journal of Neurological Surgery. Part B. Skull Base; Dec2023, Vol. 84 Issue 6, p560-566, 7p

مصطلحات موضوعية: HEALTH equity, PUBLIC hospitals, PITUITARY tumors, TUMOR surgery, SOCIOECONOMIC disparities in health

مستخلص: Objectives Few studies have assessed the role of socioeconomic health care disparities in skull base pathologies. We compared the clinical history and outcomes of pituitary tumors at private and public hospitals to delineate whether health care disparities exist in pituitary tumor surgery. Methods We reviewed the records of patients who underwent transsphenoidal pituitary tumor resection at NYU Langone Health and Bellevue Hospital. Seventy-two consecutive patients were identified from each hospital. The primary outcome was time-to-surgery from initial recommendation. Secondary outcomes included postoperative diabetes insipidus, cerebrospinal fluid (CSF) leak, and gross total resection. Results Of 144 patients, 23 (32%) public hospital patients and 24 (33%) private hospital patients had functional adenomas (p = 0.29). Mean ages for public and private hospital patients were 46.5 and 51.1 years, respectively (p = 0.06). Private hospital patients more often identified as white (p < 0.001), spoke English (p < 0.001), and had private insurance (p < 0.001). The average time-to-surgery for public and private hospital patients were 46.2 and 34.8 days, respectively (p = 0.39). No statistically significant differences were found in symptom duration, tumor size, reoperation, CSF leak, or postoperative length of stay; however, public hospital patients more frequently required emergency surgery (p = 0.03), developed transient diabetes insipidus (p = 0.02), and underwent subtotal resection (p = 0.04). Conclusion Significant socioeconomic differences exist among patients undergoing pituitary surgery at our institution's hospitals. Public hospital patients more often required emergency surgery, developed diabetes insipidus, and underwent subtotal tumor resection. Identifying these differences is an imperative initial step in improving the care of our patients. [ABSTRACT FROM AUTHOR]

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المؤلفون: Mehta, Sonal¹, Sodhi, Manmeet Kaur², Vipul³, Kaur, Navjot³, kaur, Kirandeep¹

المصدر: Journal of Cardiovascular Disease Research (Journal of Cardiovascular Disease Research). 2023, Vol. 14 Issue 7, p1530-1536. 7p.

مصطلحات موضوعية: *ASPHYXIA neonatorum, *KIDNEY diseases, *NEWBORN infants, *ACUTE kidney failure, *GLOMERULAR filtration rate, *NEONATAL mortality

مصطلحات جغرافية: AMRITSAR (India)

مستخلص: Background: Perinatal asphyxia is a common neonatal problem that contributes significantly to neonatal morbidity and mortality. Perinatal asphyxia is perceived to be the primary cause of transient renal dysfunction or acute renal failure. Adenosine plays an important role in tubuloglomerular feedback. Aminophylline is an adenosine receptor inhibitor, thus promotes renal perfusion and decreases solute load. Objectives: To study the role of aminophylline in preventing renal dysfunction in neonates with perinatal asphyxia. Methods: It is a prospective study with randomized control trials with cases and control group conducted over a period of one year in Department of Paediatrics, Govt. Medical College, Amritsar in collaboration with Department of Biochemistry. Renal functions were assessed on the basis of urine output, GFR and S. creatinine values on day1, 4 and 7. Results:Two comparable groups of cases and controls showed that there was a significant difference in urine output between the two groups on day 1(p=0.0003) and day4(p=0.000007). However, no such difference was found on day 7. Statically, no significant difference was found in values of glomerular filtration rate and S. creatinine values. Conclusion: Prophylactic use of aminophylline in neonates with perinatal asphyxia does not have significant impact in preventing AKI as there was no significant difference in S. creatinine values and GFR. There was no reduction in mortality rates in aminophylline treated group as compared to control group. [ABSTRACT FROM AUTHOR]

المؤلفون: Mehta, Sonal R.¹ drsonalrmehta@gmail.com, Mehta, Rajkumar N.², Mehta, Varun R.³

المصدر: Journal of Cardiovascular Disease Research (Journal of Cardiovascular Disease Research). 2023, Vol. 14 Issue 6, p1472-1478. 7p.

مصطلحات موضوعية: *SOFT tissue tumors, *ROTATOR cuff, *SHOULDER disorders, *ULTRASONIC imaging, *SHOULDER, *SHOULDER pain

مستخلص: Background: Painful soft tissue lesions in the adult shoulder, specifically associated with rotator cuff syndrome, pose diagnostic challenges for clinicians. Ultrasonography has emerged as a promising imaging modality for diagnosing and characterizing these lesions. This study aimed to evaluate the correlation between ultrasonography findings and painful soft tissue lesions in adult shoulders, with a specific focus on rotator cuff syndrome. Methods: A retrospective analysis was conducted on a cohort of adult patients presenting with shoulder pain and suspected rotator cuff syndrome. The study included 100 patients who underwent ultrasonography examination followed by clinical evaluation. The ultrasonography findings were subsequently compared with the final diagnosis determined through clinical assessment. Results: The results of the study indicate a robust association between ultrasonography findings and the presence of painful soft tissue lesions in the shoulder. The sensitivity of ultrasonography in detecting these lesions was determined to be 85%, meaning that it correctly identified the majority of true positive cases. Additionally, the specificity of ultrasonography was found to be 92%, indicating its ability to accurately exclude the presence of lesions in true negative cases. These findings underscore the diagnostic accuracy and reliability of ultrasonography in the identification and characterization of painful soft tissue lesions associated with rotator cuff syndrome. Conclusion: Ultrasonography is a valuable imaging modality for diagnosing and assessing painful soft tissue lesions in adult shoulders, particularly in cases of suspected rotator cuff syndrome. Its high diagnostic accuracy, non-invasiveness, and cost-effectiveness make it a practical tool for clinicians in the initial evaluation and management of shoulder pain. The results of this study contribute to improving diagnostic precision and guiding appropriate treatment strategies for patients with rotator cuff syndrome. Further research is warranted to validate these findings and explore the potential of ultrasonography in longitudinal monitoring and follow-up of these lesions. [ABSTRACT FROM AUTHOR]

المؤلفون: Chakrapani, Venkatesan, Shaikh, Simran, Arumugam, Visvanathan, Chawla, Umesh, Mehta, Sonal

المصدر: Transgender Health ; volume 6, issue 2, page 64-73 ; ISSN 2688-4887 2380-193X

الإتاحة: https://doi.org/10.1089/trgh.2019.0076Test

المؤلفون: Shroff, Beheroze, Mehta, Sonal

المصدر: Narrating Africa in South Asia ; page 57-70 ; ISBN 9781003402640

الإتاحة: https://doi.org/10.4324/9781003402640-5Test

المؤلفون: Gupta, Deeksha, Lokwani, BhavnaVasudev, Agrawal, ReemaSarvesh, Mehta, Sonal, Nirmal, NarendraJ

المصدر: The Journal of Indian Prosthodontic Society ; volume 20, issue 1, page 3 ; ISSN 0972-4052

الإتاحة: https://doi.org/10.4103/jips.jips_375_19Test

المؤلفون: Sanders, Barton J., Bakar, Melissa, Mehta, Sonal, Reid, M. Carrington, Siegler, Eugenia L., Abrams, Robert C., Adelman, Ronald D., Lachs, Mark S.

المصدر: Journal of Pain and Symptom Management ; volume 60, issue 2, page e31-e32 ; ISSN 0885-3924

مصطلحات موضوعية: Anesthesiology and Pain Medicine, Neurology (clinical), General Nursing

الإتاحة: https://doi.org/10.1016/j.jpainsymman.2020.05.013Test
https://api.elsevier.com/content/article/PII:S0885392420303894?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S0885392420303894?httpAccept=text/plainTest