يعرض 1 - 10 نتائج من 108 نتيجة بحث عن '"McGuirk, Simon"', وقت الاستعلام: 1.06s تنقيح النتائج
  1. 1
    دورية أكاديمية

    المؤلفون: Li, Weihao, Doef, Hubert van der, Wildhaber, Barbara E, Marra, Paolo, Bravi, Michela, Pinelli, Domenico, Minetto, Julia, Dip, Marcelo, Sierre, Sergio, Santibañes, Martin de, Ardiles, Victoria, Uno, Jimmy Walker, Hardikar, Winita, Bates, Sue, Goh, Lynette, Aldrian, Denise, Seisenbacher, Jonathan, Vogel, Georg F, Neto, Joao Seda, Fonseca, Eduardo Antunes da, Costa, Carolina Magalhães, Ferreira, Cristina T, Nader, Luiza S, Farina, Marco A, Dajani, Khaled Z, Parente, Alessandro, Bigam, David L, Liang, Ting-Bo, Bai, Xueli, Gonsorčíková, Lucie, Froněk, Jiří, Bohuš, Šimon, Franchi-Abella, Stéphanie, Gonzales, Emmanuel, Guérin, Florent, Junge, Norman, Baumann, Ulrich, Richter, Nicolas, Hartleif, Steffen, Rajakannu, Muthukumarassamy, Palaniappan, Kumar, Rela, Mohamed, Pawaria, Arti, Rajakrishnan, Haritha, Surendran, Sudhindran, Kumar, Mukesh, Agarwal, Shaleen, Gupta, Subhash, Asthana, Sonal, Bandewar, Vaishnavi, Raichurkar, Karthik, Spada, Marco, Monti, Lidia, Alterio, Tommaso, Yanagi, Yusuke, Uchida, Hajime, Komine, Ryuji, Evans, Helen, Carr-Boyd, Peter, Duncan, David, Stefanowicz, Marek, Latka-Grot, Julita, Kolesnik, Adam, Broering, Dieter C, Raptis, Dimitri A, Marquez, Kris Ann H, Mali, Vidyadhar, Aw, Marion, Beretta, Marisa, Schyff, Francisca Van der, Quintero-Bernabeu, Jesús, Mercadal-Hally, Maria, Mauricio, Larrarte K, Andres, Ane M, Hernandez-Oliveros, Francisco, Frauca, Esteban, Casswall, Thomas, Jorns, Carl, Delle, Martin, Gupte, Girish, Sharif, Khalid, McGuirk, Simon, Superina, Riccardo, Caicedo, Juan Carlos, Jaramillo, Catalina, Bitterfeld, Leandra, Kastenberg, Zachary, Shah, Amit A, Domenick, Bryanna, Acord, Michael R, Mazariegos, George V, Soltys, Kyle, DiNorcia, Joseph, Antala, Swanti, Florman, Sander S, Buchholz, Bettina M, Herden, Uta, Fischer, Lutz, Dierckx, Rudi A J O, Hartog, Hermien, Bokkers, Reinoud P H

    المصدر: Li , W , Doef , H V D , Wildhaber , B E , Marra , P , Bravi , M , Pinelli , D , Minetto , J , Dip , M , Sierre , S , Santibañes , M D , Ardiles , V , Uno , J W , Hardikar , W , Bates , S , Goh , L , Aldrian , D , Seisenbacher , J , Vogel , G F , Neto , J S , Fonseca , E A D , Costa , C M , Ferreira , C T , ....

  2. 2
    دورية أكاديمية

    المصدر: Dammann , E , Ording-Müller , L-S , Franchi-Abella , S , Verhagen , M V , McGuirk , S P , Bokkers , R P H , Clapuyt , P R M , Deganello , A , Tandoi , F , de Ville de Goyet , J , Hebelka , H , de Lange , C , Lozach , C , Marra , P , Mirza , D , Kaliciński , P , Patsch , J M , Perucca , G , Tsiflikas , I , Renz , D M , Schweiger , B , Spada , M ....

    الوصف: BACKGROUND: Liver transplantation is the state-of-the-art curative treatment for end-stage liver disease. Imaging is a key element in the detection of postoperative complications. So far, limited data is available regarding the best radiologic approach to monitor children after liver transplantation. OBJECTIVE: To harmonize the imaging of pediatric liver transplantation, the European Society of Pediatric Radiology Abdominal Taskforce initiated a survey addressing the current status of imaging including the pre-, intra-, and postoperative phases. This paper reports the responses related to postoperative imaging. MATERIALS AND METHODS: An online survey, initiated in 2021, asked European centers performing pediatric liver transplantation 48 questions about their imaging approach. In total, 26 centers were contacted, and 22 institutions from 11 countries returned the survey. RESULTS: All sites commence ultrasound (US) monitoring within 24 h after liver transplantation. Monitoring frequency varies across sites, ranging from every 8 h to 72 h in early, and from daily to sporadic use in late postoperative phases. Predefined US protocols are used by 73% of sites. This commonly includes gray scale, color Doppler, and quantitative flow assessment. Alternative flow imaging techniques, contrast-enhanced US, and elastography are applied at 31.8%, 18.2%, and 63.6% of sites, respectively. Computed tomography is performed at 86.4% of sites when clarification is needed. Magnetic resonance imaging is used for selected cases at 36.4% of sites, mainly for assessment of biliary abnormalities or when blood tests are abnormal. CONCLUSION: Diagnostic imaging is extensively used for postoperative surveillance of children after liver transplantation. While US is generally prioritized, substantial differences were noted in US protocol, timing, and monitoring frequency. The study highlights potential areas for future optimization and standardization of imaging, essential for conducting multicenter studies.

    وصف الملف: application/pdf

  3. 3
  4. 4
    دورية أكاديمية

    المساهمون: Universitätsklinikum Hamburg-Eppendorf (UKE)

    المصدر: Pediatric Radiology ; volume 54, issue 2, page 269-275 ; ISSN 1432-1998

    الوصف: Background Liver transplantation is the state-of-the-art curative treatment for end-stage liver disease. Imaging is a key element in the detection of intraoperative and postoperative complications. So far, only limited data regarding the best radiological approach to monitor children during liver transplantation is available. Objective To harmonize the imaging of pediatric liver transplantation, the European Society of Pediatric Radiology Abdominal Taskforce initiated a survey addressing the current status of imaging including the pre-, intra- and postoperative phase. This paper reports the responses related to intraoperative imaging. Materials and methods An online survey, initiated in 2021, asked European centers performing pediatric liver transplantation 48 questions about their imaging approach. In total, 26 centers were contacted, and 22 institutions from 11 countries returned the survey. Results Intraoperative ultrasound (US) is used by all sites to assess the quality of the vascular anastomosis in order to ensure optimal perfusion of the liver transplant. Vessel depiction is commonly achieved using color Doppler (95.3%). Additional US-based techniques are employed by fewer centers (power angio mode, 28.6%; B-flow, 19%; contrast-enhanced US, 14.3%). Most centers prefer a collaborative approach, with surgeons responsible for probe handling, while radiologists operate the US machine (47.6%). Less commonly, the intraoperative US is performed by the surgeon alone (28.6%) or by the radiologist alone (23.8%). Timing of US, imaging frequency, and documentation practices vary among centers. Conclusion Intraoperative US is consistently utilized across all sites during pediatric liver transplantation. However, considerable variations were observed in terms of the US setup, technique preferences, timing of controls, and documentation practices. These differences provide valuable insights for future optimization and harmonization studies.

  5. 5

    المصدر: Pediatric radiology. 54(2):260-268

    الوصف: Liver transplantation is the state-of-the-art curative treatment in end-stage liver disease. Imaging is a key element for successful organ-transplantation to assist surgical planning. So far, only limited data regarding the best radiological approach to prepare children for liver transplantation is available.In an attempt to harmonize imaging surrounding pediatric liver transplantation, the European Society of Pediatric Radiology (ESPR) Abdominal Taskforce initiated a survey addressing the current status of imaging including the pre-, intra-, and postoperative phase. This paper reports the responses on preoperative imaging.An online survey, initiated in 2021, asked European centers performing pediatric liver transplantation 44 questions about their imaging approach. In total, 26 centers were contacted and 22 institutions from 11 countries returned the survey. From 2018 to 2020, the participating centers collectively conducted 1,524 transplantations, with a median of 20 transplantations per center per annum (range, 8-60).Most sites (64%) consider ultrasound their preferred modality to define anatomy and to plan surgery in children before liver transplantation, and additional cross-sectional imaging is only used to answer specific questions (computed tomography [CT], 90.9%; magnetic resonance imaging [MRI], 54.5%). One-third of centers (31.8%) rely primarily on CT for pre-transplant evaluation. Imaging protocols differed substantially regarding applied CT scan ranges, number of contrast phases (range 1-4 phases), and applied MRI techniques.Diagnostic imaging is generally used in the work-up of children before liver transplantation. Substantial differences were noted regarding choice of modalities and protocols. We have identified starting points for future optimization and harmonization of the imaging approach to multicenter studies.

  6. 6
    دورية أكاديمية

    المصدر: Alfares , B A , Van Der Doef , H P J , Wildhaber , B E , Casswall , T , Nowak , G , Delle , M , Aldrian , D , Berchtold , V , Vogel , G F , Kaliciński , P , Markiewicz-Kijewska , M , Kolesnik , A , Bernabeu , J Q , Hally , M M , Larrarte K , M , Marra , P , Bravi , M , Pinelli , D , Kasahara , M , Sakamoto , S , Uchida , H , Mali , V , Aw ....

    الوصف: Introduction Portal vein obstruction (PVO) consists of anastomotic stenosis and thrombosis, which occurs due to a progression of the former. The aim of this large-scale international study is to assess the prevalence, current management practices and efficacy of treatment in patients with PVO. Methods and analysis The Portal vein Obstruction Revascularisation Therapy After Liver transplantation registry will facilitate an international, retrospective, multicentre, observational study, with 25 centres around the world already actively involved. Paediatric patients (aged <18 years) with a diagnosed PVO between 1 January 2001 and 1 January 2021 after liver transplantation will be eligible for inclusion. The primary endpoints are the prevalence of PVO, primary and secondary patency after PVO intervention and current management practices. Secondary endpoints are patient and graft survival, severe complications of PVO and technical success of revascularisation techniques. Ethics and dissemination Medical Ethics Review Board of the University Medical Center Groningen has approved the study (METc 2021/072). The results of this study will be disseminated via peer-reviewed publications and scientific presentations at national and international conferences.

    وصف الملف: application/pdf

  7. 7
    دورية أكاديمية

    المساهمون: Universitätsklinikum Hamburg-Eppendorf (UKE)

    المصدر: Pediatric Radiology ; volume 54, issue 2, page 260-268 ; ISSN 1432-1998

    الوصف: Background Liver transplantation is the state-of-the-art curative treatment in end-stage liver disease. Imaging is a key element for successful organ-transplantation to assist surgical planning. So far, only limited data regarding the best radiological approach to prepare children for liver transplantation is available. Objectives In an attempt to harmonize imaging surrounding pediatric liver transplantation, the European Society of Pediatric Radiology (ESPR) Abdominal Taskforce initiated a survey addressing the current status of imaging including the pre-, intra-, and postoperative phase. This paper reports the responses on preoperative imaging. Material and methods An online survey, initiated in 2021, asked European centers performing pediatric liver transplantation 48 questions about their imaging approach. In total, 26 centers were contacted and 22 institutions from 11 countries returned the survey. From 2018 to 2020, the participating centers collectively conducted 1,524 transplantations, with a median of 20 transplantations per center per annum (range, 8–60). Results Most sites (64%) consider ultrasound their preferred modality to define anatomy and to plan surgery in children before liver transplantation, and additional cross-sectional imaging is only used to answer specific questions (computed tomography [CT], 90.9%; magnetic resonance imaging [MRI], 54.5%). One-third of centers (31.8%) rely primarily on CT for pre-transplant evaluation. Imaging protocols differed substantially regarding applied CT scan ranges, number of contrast phases (range 1–4 phases), and applied MRI techniques. Conclusion Diagnostic imaging is generally used in the work-up of children before liver transplantation. Substantial differences were noted regarding choice of modalities and protocols. We have identified starting points for future optimization and harmonization of the imaging approach to multicenter studies.

  8. 8
    دورية أكاديمية

    المساهمون: British Heart Foundation

    المصدر: Interdisciplinary CardioVascular and Thoracic Surgery ; volume 37, issue 1 ; ISSN 2753-670X

    الوصف: OBJECTIVES The aim of this study was to describe the early and late outcomes of the arterial switch for transposition. METHODS A single-centre retrospective cohort study was conducted to assess the early and late outcomes of arterial switch performed during infancy using a standardized institutional approach between 1988 and 2018, compared by morphological groups. RESULTS A total of 749 consecutive patients undergoing arterial switch during infancy were included, 464 (61.9%) with intact septum, 163 (21.8%) with isolated ventricular septal defect and 122 (16.3%) with complex transposition with associated lesions, including 67 (8.9%) with Taussig–Bing anomaly. There were 34 early deaths [4.5%, 95% confidence interval (CI) 3.1–6.1] with only 10 (2.6%) early deaths since 2000. Complex morphology (odds ratio 11.44, 95% CI 4.76–27.43) and intramural coronary artery (odds ratio 5.17, 95% CI 1.61–15.91) were identified as the most important risk factors for 90-day mortality. Overall survival was 92.7% (95% CI 90.8–94.6) at 5 years and 91.9% (95% CI 89.9–94.1) at 20 years; in hospital survivors, there were 15 (2.1%) late deaths during a median follow-up of 13.7 years. Cumulative incidence of surgical or catheter reintervention was 16.0% (95% CI 14.5–17.5) at 5 years and 22.7% (95% CI 21.0–24.0) at 20 years; early and late reinterventions were more common in the complex group, with no difference between the other groups. CONCLUSIONS Using a standardized approach, the arterial switch can be performed with low early mortality, moderate rates of reintervention and excellent long-term survival. Concomitant lesions were the most important risk factor for early death and were associated with increased risk of late reintervention.

  9. 9
    دورية أكاديمية
  10. 10
    رسالة جامعية

    المؤلفون: McGuirk, Simon Prosser

    مصطلحات موضوعية: 617, RD Surgery, RJ Pediatrics

    الوصف: This thesis reports a series of laboratory and clinical studies designed to investigate the acute effect of surgical palliation on ventricular function in children with functionally single ventricle anatomy. Ventricular volume and pressure were measured using a combined pressure-conductance catheter. Initial laboratory-based experiments were performed using a physical model of the left ventricle, which allowed examination of the measurement techniques used in the clinical studies but under controlled conditions. These experiments identified a non-linear conductance-absolute volume relationship and demonstrated for the first time that the calibration coefficient, \(\alpha_{SV}\) produced a significant, volume-dependent measurement error. These experiments also demonstrated that conductance volume measurements were adversely influenced by other electrical signals. The ventricular electrogram produced clinically important measurement error that has not previously been described. Two clinical studies were then undertaken to investigate the separate effects of the bidirectional cavo-pulmonary anastomosis (BCPA) and the completion total cavo-pulmonary connection (TCPC). These studies represent the core of the thesis. Both procedures were associated with significant changes in the pressure and volume conditions of the dominant ventricle. In addition, the BCPA was associated with a substantial and immediate improvement in ventricular systolic function but this was accompanied by an increase in diastolic chamber stiffness. By contrast, the TCPC was not associated with a significant change ventricular systolic or diastolic function in spite of the changes in ventricular load. Comparable changes were observed in patients with a dominant ventricle of either left or right ventricular morphology. These studies provide a more detailed understanding about the acute events that accompany surgical palliation in children with functionally single ventricle anatomy. These findings confirm the validity of staged surgical palliation in the management of these children.