المؤلفون: Hayashi, Keigo, McDermott, Gregory C, Juge, Pierre-Antoine, Moll, Matthew, Cho, Michael H, Wang, Xiaosong, Paudel, Misti L, Doyle, Tracy J, Kinney, Gregory L, Sansone-Poe, Danielle, Young, Kendra, Dellaripa, Paul F, Wallace, Zachary S, Regan, Elizabeth A, Hunninghake, Gary M, Silverman, Edwin K, Ash, Samuel Y, San Jose Estepar, Raul, Washko, George R, Sparks, Jeffrey A

المساهمون: National Institutes of Health, NHLBI, National Institutes of Health/National Heart, Lung, and Blood Institute, National Institute of Arthritis and Musculoskeletal and Skin Diseases, COPD Foundation

المصدر: RMD Open ; volume 10, issue 2, page e004281 ; ISSN 2056-5933

الوصف: Objective To compare longitudinal changes in spirometric measures between patients with rheumatoid arthritis (RA) and non-RA comparators. Methods We analysed longitudinal data from two prospective cohorts: the UK Biobank and COPDGene. Spirometry was conducted at baseline and a second visit after 5–7 years. RA was identified based on self-report and disease-modifying antirheumatic drug use; non-RA comparators reported neither. The primary outcomes were annual changes in the per cent-predicted forced expiratory volume in 1 s (FEV 1 %) and per cent predicted forced vital capacity (FVC%). Statistical comparisons were performed using multivariable linear regression. The analysis was stratified based on baseline smoking status and the presence of obstructive pattern (FEV 1 /FVC <0.7). Results Among participants who underwent baseline and follow-up spirometry, we identified 233 patients with RA and 37 735 non-RA comparators. Among never-smoking participants without an obstructive pattern, RA was significantly associated with more FEV 1 % decline (β=−0.49, p=0.04). However, in ever smokers with ≥10 pack-years, those with RA exhibited significantly less FEV 1 % decline than non-RA comparators (β=0.50, p=0.02). This difference was more pronounced among those with an obstructive pattern at baseline (β=1.12, p=0.01). Results were similar for FEV 1 /FVC decline. No difference was observed in the annual FVC% change in RA versus non-RA. Conclusions Smokers with RA, especially those with baseline obstructive spirometric patterns, experienced lower FEV 1 % and FEV 1 /FVC decline than non-RA comparators. Conversely, never smokers with RA had more FEV 1 % decline than non-RA comparators. Future studies should investigate potential treatments and the pathogenesis of obstructive lung diseases in smokers with RA.

الإتاحة: https://doi.org/10.1136/rmdopen-2024-004281Test

المؤلفون: McDermott, Gregory C., Monshadizeh, Armaan, Selzer, Faith, Zhao, Sizheng S., Ermann, Joerg, Katz, Jeffrey N.

المصدر: McDermott , G C , Monshadizeh , A , Selzer , F , Zhao , S S , Ermann , J & Katz , J N 2024 , ' Factors associated with diagnostic delay in axial spondyloarthritis: impact of clinical factors and social vulnerability ' , Arthritis Care & Research , vol. 76 , no. 4 , pp. 541-549 . https://doi.org/10.1002/acr.25264Test

مصطلحات موضوعية: axial spondyloarthritis, diagnostic delay, uveitis

الوصف: Objective: Axial spondyloarthritis (axSpA) patients often experience significant delay between symptom onset and diagnosis. Determinants of delay are incompletely understood. We investigated associations between demographic, medical, and socioeconomic factors and axSpA diagnostic delay. Methods: We identified axSpA patients diagnosed by rheumatologists in the Mass General Brigham health care system between December 1990 and October 2021. All patients met modified New York criteria for ankylosing spondylitis (AS) or 2009 Assessment of SpondloArthritis international Society (ASAS) criteria for axSpA. We determined the duration of diagnostic delay, defined as the duration of back pain symptoms reported at diagnosis, as well as extra-articular disease manifestations and specialty care received prior to diagnosis from the electronic health record. We obtained each patient’s social vulnerability index (SVI) by mapping their address to the US Centers for Disease Control SVI Atlas. We examined associations between disease manifestations, SVI, and diagnostic delay using ordinal logistic regression. Results: We identified 554 axSpA patients with mean diagnostic delay 6.8 (SD 8.5) years. In multivariable ordinal logistic regression analyses, peripheral arthritis (OR 0.65, 95%CI 0.45-0.93) and older age at symptom onset (OR 0.83, 95%CI 0.78-0.88 per 5 years) were associated with shorter delay. AS at diagnosis (OR 1.85, 95%CI 1.30-2.63), having a history of uveitis prior to diagnosis (OR 2.77, 95%CI 1.73-4.52), and higher social vulnerability (defined as being in the 80-99th percentile of SVI – OR 1.99, 95%CI 1.06-3.84) were associated with longer diagnostic delay. Conclusion: Older age at back pain onset and peripheral arthritis were associated with shorter delay while uveitis was associated with longer diagnostic delay. Patients with higher socioeconomic vulnerability had longer diagnostic delay independent of clinical factors.

وصف الملف: application/vnd.openxmlformats-officedocument.wordprocessingml.document

العلاقة: https://research.manchester.ac.uk/en/publications/d0a4aea8-b9f2-4f29-99de-350c9741d068Test

الإتاحة: https://doi.org/10.1002/acr.25264Test
https://research.manchester.ac.uk/en/publications/d0a4aea8-b9f2-4f29-99de-350c9741d068Test
https://pure.manchester.ac.uk/ws/files/278740331/axspa_diagnostic_delay.docxTest

المؤلفون: Robinette, Michelle L., Weeks, Lachelle D., Kramer, Ryan J., Agrawal, Mridul, Gibson, Christopher J., Yu, Zhi, Sekar, Aswin, Mehta, Arnav, Niroula, Abhishek, Brown, Jared T., McDermott, Gregory C., Reshef, Edith R., Lu, Jonathan E., Liou, Victor D., Chiou, Carolina A., Natarajan, Pradeep, Freitag, Suzanne K., Rao, Deepak A., Ebert, Benjamin L.

المساهمون: National Institute of Arthritis and Musculoskeletal and Skin Diseases, Burroughs Wellcome Fund, Deutsche Forschungsgemeinschaft, Doris Duke Charitable Foundation, Dr. Miriam and Sheldon G. Adelson Medical Research Foundation, Edward P. Evans Foundation, Howard Hughes Medical Institute, Knut och Alice Wallenbergs Stiftelse, Sarnoff Cardiovascular Research Foundation

المصدر: Arthritis & Rheumatology ; volume 76, issue 3, page 438-443 ; ISSN 2326-5191 2326-5205

الوصف: Objective Giant cell arteritis (GCA) is an age‐related vasculitis. Prior studies have identified an association between GCA and hematologic malignancies (HMs). How the presence of somatic mutations that drive the development of HMs, or clonal hematopoiesis (CH), may influence clinical outcomes in GCA is not well understood. Methods To examine an association between CH and GCA, we analyzed sequenced exomes of 470,960 UK Biobank (UKB) participants for the presence of CH and used multivariable Cox regression. To examine the clinical phenotype of GCA in patients with and without somatic mutations across the spectrum of CH to HM, we performed targeted sequencing of blood samples and electronic health record review on 114 patients with GCA seen at our institution. We then examined associations between specific clonal mutations and GCA disease manifestations. Results UKB participants with CH had a 1.48‐fold increased risk of incident GCA compared to UKB participants without CH. GCA risk was highest among individuals with cytopenia (hazard ratio [HR] 2.98, P = 0.00178) and with TET2 mutation (HR 2.02, P = 0.00116). Mutations were detected in 27.2% of our institutional GCA cohort, three of whom had HM at GCA diagnosis. TET2 mutations were associated with vision loss in patients with GCA (odds ratio 4.33, P = 0.047). Conclusions CH increases risk for development of GCA in a genotype‐specific manner, with the greatest risk being conferred by the presence of mutations in TET2 . Somatic TET2 mutations likewise increase the risk of GCA‐associated vision loss. Integration of somatic genetic testing in GCA diagnostics may be warranted in the future.

الإتاحة: https://doi.org/10.1002/art.42738Test

المؤلفون: McDermott, Gregory C, DiIorio, Michael, Kawano, Yumeko, Jeffway, Mary, MacVicar, Megan, Dahal, Kumar, Moon, Su-Jin, Seyok, Thany, Coblyn, Jonathan, Massarotti, Elena, Weinblatt, Michael E, Weisenfeld, Dana, Liao, Katherine P

المساهمون: NIAMS

المصدر: Seminars in Arthritis and Rheumatism ; volume 66, page 152421 ; ISSN 0049-0172

مصطلحات موضوعية: Anesthesiology and Pain Medicine, Rheumatology

الإتاحة: https://doi.org/10.1016/j.semarthrit.2024.152421Test
https://api.elsevier.com/content/article/PII:S0049017224000611?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S0049017224000611?httpAccept=text/plainTest

المؤلفون: Juge, Pierre-Antoine, Hayashi, Keigo, McDermott, Gregory C., Vanni, Kathleen M.M., Kowalski, Emily, Qian, Grace, Bade, Katarina, Saavedra, Alene, Dieudé, Philippe, Dellaripa, Paul F., Doyle, Tracy J., Sparks, Jeffrey A.

المساهمون: Société Française d'Hématologie, National Institutes of Health, National Heart, Lung, and Blood Institute, National Institute of Arthritis and Musculoskeletal and Skin Diseases, Rheumatology Research Foundation

المصدر: Seminars in Arthritis and Rheumatism ; volume 64, page 152312 ; ISSN 0049-0172

مصطلحات موضوعية: Anesthesiology and Pain Medicine, Rheumatology

الإتاحة: https://doi.org/10.1016/j.semarthrit.2023.152312Test
https://api.elsevier.com/content/article/PII:S0049017223001543?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S0049017223001543?httpAccept=text/plainTest

المؤلفون: Kronzer, Vanessa L., Hayashi, Keigo, Crowson, Cynthia S., Davis, John M., McDermott, Gregory C., Cui, Jing, Losina, Elena, Juge, Pierre-Antoine, Cerhan, James R., Sparks, Jeffrey A.

المساهمون: NIAMS, Rheumatology Research Foundation

المصدر: Seminars in Arthritis and Rheumatism ; volume 63, page 152254 ; ISSN 0049-0172

مصطلحات موضوعية: Anesthesiology and Pain Medicine, Rheumatology

الإتاحة: https://doi.org/10.1016/j.semarthrit.2023.152254Test
https://api.elsevier.com/content/article/PII:S0049017223000963?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S0049017223000963?httpAccept=text/plainTest

المؤلفون: Kronzer, Vanessa L, Hayashi, Keigo, Yoshida, Kazuki, Davis, John M, McDermott, Gregory C, Huang, Weixing, Dellaripa, Paul F, Cui, Jing, Feathers, Vivi, Gill, Ritu R, Hatabu, Hiroto, Nishino, Mizuki, Blaustein, Rachel, Crowson, Cynthia S, Robinson, William H, Sokolove, Jeremy, Liao, Katherine P, Weinblatt, Michael E, Shadick, Nancy A, Doyle, Tracy J, Sparks, Jeffrey A

المصدر: The Lancet Rheumatology ; volume 5, issue 2, page e77-e87 ; ISSN 2665-9913

مصطلحات موضوعية: Immunology, Immunology and Allergy, Rheumatology

الإتاحة: https://doi.org/10.1016/s2665-9913Test(22)00380-0
https://api.elsevier.com/content/article/PII:S2665991322003800?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S2665991322003800?httpAccept=text/plainTest

المؤلفون: Juge, Pierre-Antoine, Sparks, Jeffrey A, Gazal, Steven, Ebstein, Esther, Borie, Raphaël, Debray, Marie-Pierre, Kannengiesser, Caroline, McDermott, Gregory C, Cui, Jing, Hayashi, Keigo, Doyle, Tracy J, Moorsel, Coline H M van, Vis, Joanne J van der, Grutters, Jan C, Knevel, Rachel, Heckert, Sascha L, Vasarmidi, Eirini, Antoniou, Katerina M, Mil, Annette H M van der Helm van, Boileau, Catherine

المصدر: Rheumatology Advances in Practice; 2024, Vol. 8 Issue 2, p1-5, 5p

مصطلحات موضوعية: RHEUMATOID arthritis, INTERSTITIAL lung diseases, SMOKING

مستخلص: Objective Recently, a genome-wide association study identified an association between RA-associated interstitial lung disease (ILD) and RPA3-UMAD1 rs12702634 in the Japanese population, especially for patients with a usual interstitial pneumonia (UIP) pattern. We aimed to replicate this association in a European population and test for interaction with MUC5B rs35705950. Methods In this genetic case–control association study, patients with RA and ILD and controls with RA and no ILD were included from France, the USA and the Netherlands. Only cases and controls from European genetic ancestries determined by principal components analysis were included in the analyses. RA was defined by the 1987 ACR or 2010 ACR/EULAR criteria and ILD by chest high-resolution CT scan, except in the control dataset from the Netherlands, where the absence of ILD was determined by chart review. Patients were genotyped for RPA3-UMAD1 rs12702634 and MUC5B rs35705950. Associations were tested using logistic regression adjusted for sex, age at RA onset, age at ILD onset or at certified absence of ILD, tobacco smoking status and country of origin. Results Among the 883 patients included, 322 were RA-ILD cases (36.5%). MUC5B rs35705950 was strongly associated with RA-ILD in all datasets {combined adjusted odds ratio [OR] 2.9 [95% CI 2.1, 3.9], P  = 1.1 × 10⁻¹¹. No association between RPA3-UMAD1 rs12702634 and RA-ILD was observed [combined OR 1.2 (95% CI 0.8, 1.6), P  = 0.31. No interaction was found between RPA3-UMAD1 rs12702634 and MUC5B rs35705950 (P  = 0.70). Conclusion Our findings did not support a contribution of RPA3-UMAD1 rs12702634 to the overall RA-ILD susceptibility in the European population. [ABSTRACT FROM AUTHOR]

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المؤلفون: Juge, Pierre-Antoine, Sparks, Jeffrey A, Gazal, Steven, Ebstein, Esther, Borie, Raphaël, Debray, Marie-Pierre, Kannengiesser, Caroline, McDermott, Gregory C, Cui, Jing, Hayashi, Keigo, Doyle, Tracy J, van Moorsel, Coline H M, van der Vis, Joanne J, Grutters, Jan C, Knevel, Rachel, Heckert, Sascha L, Vasarmidi, Eirini, Antoniou, Katerina M, van der Helm van Mil, Annette H M, Boileau, Catherine, Crestani, Bruno, Dieudé, Philippe

المصدر: Rheumatol Adv Pract ; ISSN:2514-1775 ; Volume:8 ; Issue:2

مصطلحات موضوعية: genetic, interstitial lung disease, rheumatoid arthritis

الوصف: Recently, a genome-wide association study identified an association between RA-associated interstitial lung disease (ILD) and RPA3-UMAD1 rs12702634 in the Japanese population, especially for patients with a usual interstitial pneumonia (UIP) pattern. We aimed to replicate this association in a European population and test for interaction with MUC5B rs35705950.

العلاقة: https://doi.org/10.1093/rap/rkae059Test; https://pubmed.ncbi.nlm.nih.gov/38854416Test; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11157136Test/

الإتاحة: https://doi.org/10.1093/rap/rkae059Test
https://pubmed.ncbi.nlm.nih.gov/38854416Test
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11157136Test/

المؤلفون: Sun, Zihan, Kleine-Borgmann, Julian, Suh, Joome, McDermott, Gregory C, Vishnevetsky, Anastasia, Rist, Pamela M

المصدر: European Stroke Journal; Dec2023, Vol. 8 Issue 4, p904-914, 11p