المؤلفون: Sojli, E, Tham, WW, Bryant, R, McAleer, M

الوصف: Social distancing, self-isolation, quarantining, and lockdowns arising from the COVID-19 pandemic have been common restrictions as governments have attempted to limit the rapid virus transmission. In this study, we identified drivers of adverse mental and behavioral health during the COVID-19 pandemic and whether factors such as social isolation and various restrictions serve as additional stressors for different age groups. Univariate and multivariate regression analyses were conducted on a unique dataset based on a national probability-based survey dedicated to understanding the impact of COVID-19 in the U.S., which includes 19 questions on the individual impact of restrictions, bans, and closures. The analysis used a moderate distress scale built on five questions related to mental health for 3,646 respondents. The mental health of young adults (18-34 years old) was the most affected by restrictions, while that of older adults (>55 years old) was less affected. In addition, demographic and health characteristics associated with differences in mental health varied by age group. The findings in this analysis highlight the differential mental health needs of different age groups and point to the marked necessity for differentiated and targeted responses to the mental health effects of COVID-19 by age group.

العلاقة: pii: 10.1038/s41398-021-01537-x; Sojli, E., Tham, W. W., Bryant, R. & McAleer, M. (2021). COVID-19 restrictions and age-specific mental health-US probability-based panel evidence. TRANSLATIONAL PSYCHIATRY, 11 (1), https://doi.org/10.1038/s41398-021-01537-xTest.; http://hdl.handle.net/11343/307344Test

الإتاحة: https://doi.org/10.1038/s41398-021-01537-xTest
http://hdl.handle.net/11343/307344Test

المؤلفون: Tham, WW, Sojli, E, Bryant, R, McAleer, M

المساهمون: Böckerman, P

الوصف: Mental health disorders represent an enormous cost to society, are related to economic outcomes, and have increased markedly since the COVID-19 outbreak. Economic activity contracted dramatically on a global scale in 2020, representing the worst crisis since the Great Depression. This study used the COVID Impact Survey to provide insights on the interactions of mental illness and economic uncertainty during COVID-19. We used a probability-based panel survey, COVID Impact Survey, conducted in the U.S. over three waves in the period April-June 2020. The survey covered individual information on employment, economic and financial uncertainty, mental and physical health, as well as other demographic information. The prevalence of moderate mental distress was measured using a Psychological Distress Scale, a 5-item scale that is scored on a 4-point scale (total range: 0-15). The mental distress effect of employment, economic, and financial uncertainty, was assessed in a logit regression analysis conditioning for demographic and health information. It is found that employment, health coverage, social security, and food provision uncertainty are additional stressors for mental health. These economic factors work in addition to demographic effects, where groups who display increased risk for psychological distress include: women, Hispanics, and those in poor physical health. A decrease in employment and increases in economic uncertainty are associated with a doubling of common mental disorders. The population-representative survey evidence presented strongly suggests that economic policies which support employment (e.g., job keeping, job search support, stimulus spending) provide not only economic security but also constitute a major health intervention. Moving forward, the economic uncertainty effect ought to be reflected in community level intervention and prevention efforts, which should include strengthening economic support to reduce financial and economic strain.

العلاقة: pii: PONE-D-21-23636; Tham, W. W., Sojli, E., Bryant, R. & McAleer, M. (2021). Common Mental Disorders and Economic Uncertainty: Evidence from the COVID-19 Pandemic in the U.S. PLoS One, 16 (12), pp.e0260726-. https://doi.org/10.1371/journal.pone.0260726Test.; http://hdl.handle.net/11343/307466Test

الإتاحة: https://doi.org/10.1371/journal.pone.0260726Test
http://hdl.handle.net/11343/307466Test

المؤلفون: McAleer, M. A., Jakasa, I., Stefanovic, N., McLean, W. H. I., Kezic, S., Irvine, A. D.

المساهمون: Wellcome

المصدر: British Journal of Dermatology ; volume 185, issue 1, page 153-163 ; ISSN 0007-0963 1365-2133

الإتاحة: https://doi.org/10.1111/bjd.19703Test

المؤلفون: Onoufriadis, A., Cabezas, A., Ng, J. C.F., Canales, J., Costas, M. J., Ribeiro, J. M., Rodrigues, J. R., McAleer, M. A., Castelo-Soccio, L., Simpson, M. A., Fraternali, F., Irvine, A. D., Cameselle, J. C., McGrath, J. A.

المصدر: Onoufriadis , A , Cabezas , A , Ng , J C F , Canales , J , Costas , M J , Ribeiro , J M , Rodrigues , J R , McAleer , M A , Castelo-Soccio , L , Simpson , M A , Fraternali , F , Irvine , A D , Cameselle , J C & McGrath , J A 2020 , ' Autosomal recessive hypotrichosis with loose anagen hairs associated with TKFC mutations ' , British Journal of Dermatology . https://doi.org/10.1111/bjd.19481Test

الوصف: Background: Loose anagen hair is a rare form of impaired hair anchorage in which anagen hairs that lack inner and outer root sheaths can be gently and painlessly plucked from the scalp. This condition usually occurs in children and is often self-limiting. A genetic basis for the disorder has been suggested but not proven. A better understanding the aetiology of loose anagen hair may improve prevention and treatment strategies. Objectives: To identify a possible genetic basis of loose anagen hair using next-generation DNA sequencing and functional analysis of variants identified. Methods: In this case study, whole-exome sequencing analysis of a pedigree with one affected individual with features of loose anagen hair was performed. Results: The patient was found to be compound heterozygous for two single-nucleotide substitutions in TKFC resulting in the following missense mutations: c.574G> C (p.Gly192Arg) and c.682C> T (p.Arg228Trp). Structural analysis of human TKFC showed that both mutations are located near the active site cavity. Kinetic assays of recombinant proteins bearing either of these amino acid substitutions showed almost no dihydroxyacetone kinase or D-glyceraldehyde kinase activity, and FMN cyclase activity reduced to just 10% of wildtype catalytic activity. Conclusions: TKFC missense mutations may predispose to the development of loose anagen hairs. Identification of this new biochemical pathobiology expands the metabolic and genetic basis of hypotrichosis.

الإتاحة: https://doi.org/10.1111/bjd.19481Test
https://kclpure.kcl.ac.uk/portal/en/publications/3164d956-5b18-481f-84e6-3378183b0e66Test
http://www.scopus.com/inward/record.url?scp=85096640955&partnerID=8YFLogxKTest

المؤلفون: Ghia, A., Guha-Thakurta, N., Li, J., Settle, S., McAleer, M., Briere, T., Tatsui, C., Brown, P., Beckham, T., Wang, C., Yeboa, D., Chang, E., Rhines, L.

المصدر: Radiotherapy and Oncology ; volume 182, page S341-S342 ; ISSN 0167-8140

مصطلحات موضوعية: Radiology, Nuclear Medicine and imaging, Oncology, Hematology

الإتاحة: https://doi.org/10.1016/s0167-8140Test(23)08612-7
https://api.elsevier.com/content/article/PII:S0167814023086127?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S0167814023086127?httpAccept=text/plainTest

المؤلفون: Harkins, C. P., McAleer, M. A., Bennett, D., McHugh, M., Fleury, O. M., Pettigrew, K. A., Oravcová, K., Parkhill, J., Proby, C. M., Dawe, R. S., Geoghegan, J. A., Irvine, A. D., Holden, M. T. G.

المصدر: Harkins , C P , McAleer , M A , Bennett , D , McHugh , M , Fleury , O M , Pettigrew , K A , Oravcová , K , Parkhill , J , Proby , C M , Dawe , R S , Geoghegan , J A , Irvine , A D & Holden , M T G 2018 , ' The widespread use of topical antimicrobials enriches for resistance in Staphylococcus aureus isolated from Atopic Dermatitis patients ' , British Journal of Dermatology , vol. 179 , no. 4 , pp. 951-958 . https://doi.org/10.1111/bjd.16722Test

الوصف: Background Carriage rates of Staphylococcus aureus on affected skin in atopic dermatitis (AD) are approximately 70%. Increasing disease severity during flares and overall disease severity correlate with increased burden of S. aureus . Treatment in AD therefore often targets S. aureus with topical and systemic antimicrobials. Objectives To determine whether antimicrobial sensitivities and genetic determinants of resistance differed in S. aureus isolates from the skin of children with AD and healthy child nasal carriers. Methods In this case–control study, we compared S. aureus isolates from children with AD ( n = 50) attending a hospital dermatology department against nasal carriage isolates from children without skin disease ( n = 49) attending a hospital emergency department for noninfective conditions. Using whole genome sequencing we generated a phylogenetic framework for the isolates based on variation in the core genome, then compared antimicrobial resistance phenotypes and genotypes between disease groups. Results Staphylococcus aureus from cases and controls had on average similar numbers of phenotypic resistances per isolate. Case isolates differed in their resistance patterns, with fusidic acid resistance (Fus R ) being significantly more frequent in AD ( P = 0·009). The genetic basis of Fus R also differentiated the populations, with chromosomal mutations in fusA predominating in AD ( P = 0·049). Analysis revealed that Fus R evolved multiple times and via multiple mechanism in the population. Carriage of plasmid‐derived qac genes, which have been associated with reduced susceptibility to antiseptics, was eight times more frequent in AD ( P = 0·016). Conclusions The results suggest that strong selective pressure drives the emergence and maintenance of specific resistances in AD.

وصف الملف: application/pdf

العلاقة: https://research-portal.st-andrews.ac.uk/en/researchoutput/the-widespread-use-of-topical-antimicrobials-enriches-for-resistance-instaphylococcus-aureus-isolated-from-atopic-dermatitis-patientsTest(a8dfb9a2-0f2f-4c41-9658-bda7556c3100).html

الإتاحة: https://doi.org/10.1111/bjd.16722Test
https://research-portal.st-andrews.ac.uk/en/researchoutput/the-widespread-use-of-topical-antimicrobials-enriches-for-resistance-instaphylococcus-aureus-isolated-from-atopic-dermatitis-patientsTest(a8dfb9a2-0f2f-4c41-9658-bda7556c3100).html
https://research-repository.st-andrews.ac.uk/bitstream/10023/15721/1/Harkins_et_al_2018_British_Journal_of_Dermatology.pdfTest

المؤلفون: Harkins, C P, McAleer, M A, Bennett, D, McHugh, M, Fleury, O M, Pettigrew, K A, Oravcová, K., Parkhill, J, Proby, C M, Dawe, R S, Geoghegan, J A, Irvine, A D, Holden, M T G

الوصف: Background: Carriage rates of Staphylococcus aureus on affected skin in atopic dermatitis (AD) are approximately 70%. Increasing disease severity during flares and overall disease severity correlate with increased burden of S. aureus. Treatment in AD therefore often targets S. aureus, with topical and systemic antimicrobials. Objectives: To determine if antimicrobial sensitivities and genetic determinants of resistance differed in S. aureus isolates from the skin of children with AD compared with healthy child nasal carriers. Methods: In this case‐control study, we compared S. aureus isolates from children with AD (n=50) attending a hospital dermatology department to nasal carriage isolates from children without skin disease (n=49) attending a hospital emergency department for non‐infective conditions. Using whole genome sequencing we generated a phylogenetic framework for the isolates based on variation in the core genome, then compared antimicrobial resistance phenotype and genotypes between disease groups. Results and conclusions: S. aureus from cases and controls had on average similar numbers of phenotypic resistances per isolate. Case isolates differed in their resistance patterns, with Fusidic acid resistance (FusR) being significantly more frequent in AD (p=0.009). The genetic basis of FusR also differentiated the populations, with chromosomal mutations in fusA predominating in AD (p=0.049). Analysis revealed that FusR evolved multiple times and via multiple mechanism in the population. Carriage of plasmid derived qac genes, which have been associated with reduced susceptibility to antiseptics, was 8 times more frequent in AD (p=0.016). The results suggest strong selective pressure drives the emergence and maintenance of specific resistances in AD.

وصف الملف: text

العلاقة: https://eprints.gla.ac.uk/161990/1/161990.pdfTest; Harkins, C. P. et al. (2018) The widespread use of topical antimicrobials enriches for resistance in Staphylococcus aureus isolated from atopic dermatitis patients. British Journal of Dermatology , 179(4), pp. 951-958. (doi:10.1111/bjd.16722 ) (PMID:29729180) (PMCID:PMC6221151)

الإتاحة: https://doi.org/10.1111/bjd.16722Test
https://eprints.gla.ac.uk/161990Test/
https://eprints.gla.ac.uk/161990/1/161990.pdfTest

المؤلفون: Nousbeck, J., McAleer, M., Kenny, E., Harte, K., Irvine, A.

المصدر: Journal of Investigative Dermatology ; volume 138, issue 5, page S129 ; ISSN 0022-202X

مصطلحات موضوعية: Cell Biology, Dermatology, Molecular Biology, Biochemistry

الإتاحة: https://doi.org/10.1016/j.jid.2018.03.767Test
https://api.elsevier.com/content/article/PII:S0022202X1830993X?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S0022202X1830993X?httpAccept=text/plainTest

المؤلفون: Chung, C., Brown, P., Liu, D., Grosshans, D., Dibaj, S., Guha-Thakurta, N., Li, J., McGovern, S., McAleer, M., Ghia, A., Paulino, A., Sulman, E., Penas-Prado, M., De Groot, J., Heimberger, A., Wang, J., Armstrong, T., Gilbert, M., Mahajan, A., Wefel, J.

المصدر: Radiotherapy and Oncology ; volume 127, page S686 ; ISSN 0167-8140

مصطلحات موضوعية: Radiology, Nuclear Medicine and imaging, Oncology, Hematology

الإتاحة: https://doi.org/10.1016/s0167-8140Test(18)31549-4
https://api.elsevier.com/content/article/PII:S0167814018315494?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S0167814018315494?httpAccept=text/plainTest

المؤلفون: McAleer, M.¹ (AUTHOR)

المصدر: Heart, Lung & Circulation. 2024 Supplement 2, Vol. 33, pS90-S91. 2p.

مصطلحات موضوعية: *RADIAL artery, *CORONARY angiography, *PERCUTANEOUS coronary intervention, *ARTERIES