المؤلفون: Melis Orhan, Nicole Korten, Ralph Kupka, Patricia van Oppen, Max Stek, Eduard Vieta, Sigfried Schouws, Wouter van Ballegooijen, Annemiek Dols

المصدر: International Journal of Bipolar Disorders, Vol 8, Iss 1, Pp 1-7 (2020)

مصطلحات موضوعية: Older, Bipolar disorder, Daily functioning, Instrument, Reliability, Validity, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571, Neurophysiology and neuropsychology, QP351-495

الوصف: Abstract Background Many frequently used instruments fail to assess psychosocial functioning in patients with bipolar disorder. The Functioning Assessment Short Test (FAST) was developed in order to tackle this problem and to assess the main functioning problems experienced by patients with bipolar disorder. However, the original FAST is not fully applicable in older adults due to the domain of occupational functioning. The aim of our study was to validate an adapted version for Older adults (FAST-O) in a group of older adults with bipolar disorder (OABD). Methods 88 patients aged 50 years and over diagnosed with bipolar disorder were included. We adapted the items in the area of “work-related functioning” of the FAST into items assessing “societal functioning”. Several measurements were conducted in order to analyse the psychometric qualities of the FAST-O (confirmatory factor analysis for internal structure, Cronbach’s alpha for internal consistency, Spearman’s rho for concurrent validity, Mann–Whitney U test for discriminant validity). Results Mean age in the study sample was 65.3 (SD = 7.5) and 57.3% was female. The internal structure was most similar to the internal structure of the original FAST. The internal consistency was excellent (Cronbach’s alpha = .93). The concurrent validity when correlated with the Social and Occupational Functioning Assessment Scale was low, but significant. The FAST-O was also able to distinguish between euthymic and symptomatic OABD patients. Conclusions The FAST-O has strong psychometric qualities. Based on our results, we can conclude that the FAST-O is a short, efficient solution in order to replace global rating scales or extensive test batteries in order to assess daily functioning of older psychiatric patients in a valid and reliable manner.

وصف الملف: electronic resource

العلاقة: http://link.springer.com/article/10.1186/s40345-020-00193-2Test; https://doaj.org/toc/2194-7511Test

الوصول الحر: https://doaj.org/article/9ee503e0d1ae4dfb8356458bcd78a5b6Test

المؤلفون: Peter C.R. Mulders, Alberto Llera, Christian F. Beckmann, Mathieu Vandenbulcke, Max Stek, Pascal Sienaert, Ronny Redlich, Georgios Petrides, Mardien Leoniek Oudega, Leif Oltedal, Ketil J. Oedegaard, Katherine L. Narr, Peter O. Magnusson, Ute Kessler, Anders Jorgensen, Randall Espinoza, Verena Enneking, Louise Emsell, Annemieke Dols, Udo Dannlowski, Tom G. Bolwig, Hauke Bartsch, Miklos Argyelan, Amit Anand, Christopher C. Abbott, Philip F.P. van Eijndhoven, Indira Tendolkar

المصدر: Brain Stimulation, Vol 13, Iss 3, Pp 696-704 (2020)

مصطلحات موضوعية: Electroconvulsive therapy, Depression, Major depressive disorder, MRI, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571

الوصف: Background: Electroconvulsive therapy (ECT) is the most effective treatment option for major depressive disorder, so understanding whether its clinical effect relates to structural brain changes is vital for current and future antidepressant research. Objective: To determine whether clinical response to ECT is related to structural volumetric changes in the brain as measured by structural magnetic resonance imaging (MRI) and, if so, which regions are related to this clinical effect. We also determine whether a similar model can be used to identify regions associated with electrode placement (unilateral versus bilateral ECT). Methods: Longitudinal MRI and clinical data (Hamilton Depression Rating Scale) was collected from 10 sites as part of the Global ECT-MRI research collaboration (GEMRIC). From 192 subjects, relative changes in 80 (sub)cortical areas were used as potential features for classifying treatment response. We used recursive feature elimination to extract relevant features, which were subsequently used to train a linear classifier. As a validation, the same was done for electrode placement. We report accuracy as well as the structural coefficients of regions included in the discriminative spatial patterns obtained. Results: A pattern of structural changes in cortical midline, striatal and lateral prefrontal areas discriminates responders from non-responders (75% accuracy, p

وصف الملف: electronic resource

العلاقة: http://www.sciencedirect.com/science/article/pii/S1935861X20300425Test; https://doaj.org/toc/1935-861XTest

الوصول الحر: https://doaj.org/article/3952106f9b7748f2956b82ef2ed749e1Test

المؤلفون: Melis Orhan, Sigfried Schouws, Patricia van Oppen, Max Stek, Paul Naarding, Didi Rhebergen, Annemieke Dols, Nicole Korten

المساهمون: APH - Mental Health, Neurology, Psychiatry, Amsterdam Neuroscience - Compulsivity, Impulsivity & Attention, APH - Aging & Later Life, Amsterdam Neuroscience - Mood, Anxiety, Psychosis, Stress & Sleep, Amsterdam Neuroscience - Neurodegeneration

المصدر: Orhan, M, Schouws, S, van Oppen, P, Stek, M, Naarding, P, Rhebergen, D, Dols, A & Korten, N 2023, ' Cognitive functioning in late life affective disorders : Comparing older adults with bipolar disorder, late life depression and healthy controls ', Journal of Affective Disorders, vol. 320, pp. 468-473 . https://doi.org/10.1016/j.jad.2022.09.127Test
Journal of Affective Disorders, 320, 468-473. Elsevier

مصطلحات موضوعية: Psychiatry and Mental health, Clinical Psychology, Bipolar Disorder, Cognition, Depression, Mood Disorders, Humans, Neuropsychological Tests, Cognition Disorders, Aged

الوصف: Introduction: Both older age bipolar disorder (OABD) and late life depression (LLD) have been associated with cognitive dysfunction. It is unclear how cognitive functioning differs between these disorders and what the influence of current depressive symptoms is. Methods: We compared OABD (n = 148), LLD (n = 378) and healthy controls (HC) (n = 132) on cognitive functioning. Cognitive functioning was measured by an extensive neuropsychological assessment, and divided into four domains: episodic memory, processing speed, interference inhibition and working memory. Separate linear regression analyses were conducted with OABD as reference category, controlling for age, gender, level of education and severity of depressive symptoms. Results: Our findings show that OABD and LLD patients exhibit more cognitive dysfunction than HC, with OABD showing worst cognitive functioning on all cognitive domains, except for interference inhibition. These differences remained significant, even after controlling for the effect of depressive symptoms at the time of testing. Discussion: Our findings suggest that cognitive dysfunction in OABD is more severe in magnitude albeit in the same domains as in LLD. This difference cannot be fully explained by the severity of depressive symptoms. Future research should focus on other disease characteristics and how these characteristics are associated with the complex concept of cognitive functioning in both OABD and LLD.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb4fee078a5f2290fe8a637900567c56Test
https://research.vumc.nl/en/publications/5ff7309c-a4c1-4fdb-bedd-5e18797e5adbTest

المؤلفون: Miranda Laurant, Marjolijn Heerings, Max Stek, Miranda Gh Laurant, Max L Stek, Eric Van Exel

المساهمون: The Pennsylvania State University CiteSeerX Archives

المصدر: http://www.implementationscience.com/content/pdf/s13012-014-0107-y.pdfTest.

الوصف: Implementation Science This Provisional PDF corresponds to the article as it appeared upon acceptance. Fully formatted PDF and full text (HTML) versions will be made available soon. Implementing an outreaching, preference-led stepped care intervention programme to reduce late life depressive symptoms: results of a mixed-methods study Implementation Science 2014, 9:107 doi:10.1186/s13012-014-0107-y

وصف الملف: application/pdf

العلاقة: http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.568.3965Test; http://www.implementationscience.com/content/pdf/s13012-014-0107-y.pdfTest

الإتاحة: http://www.implementationscience.com/content/pdf/s13012-014-0107-y.pdfTest

المؤلفون: Annette, Hegeman, Natasja, Schutter, Hannie, Comijs, Tjalling, Holwerda, Jack, Dekker, Max, Stek, Roos, van der Mast

المصدر: International journal of geriatric psychiatry. 33(1)

مصطلحات موضوعية: Aged, 80 and over, Male, Depressive Disorder, Cross-Sectional Studies, Logistic Models, Sex Factors, Cardiovascular Diseases, Loneliness, Humans, Female, Middle Aged, Aged, Netherlands

الوصف: Loneliness and depression have a strong reciprocal influence, and both predict adverse health outcomes at old age. Therefore, this study examines whether loneliness is associated with the presence of cardiovascular diseases taking into account the role of late-life depression.Cross-sectional data of 477 older adults in the Netherlands Study of Depressed Older Persons were used. Logistic regression analysis was performed to examine the relation between loneliness and cardiovascular disease. Depression was added to the regression model to examine whether depression is an explanatory factor in the association between loneliness and cardiovascular disease. Interaction terms between loneliness and depression and between loneliness and sex were introduced in the regression model to investigate whether depressed and non-depressed participants, and men and women differed in their association between loneliness and cardiovascular disease.Of the overall group, 61% were lonely, 28% had a history of cardiovascular disease and 74% were depressed. Loneliness and cardiovascular disease were not associated in the overall group after adjustment for confounders (continuous: odds ratio [OR] = 1.04, 95% confidence interval [CI] = 0.98-1.10), p = 0.25; dichotomous: OR = 1.27, 95% CI = 0.80-2.03, p = 0.32). For women, there was an association between loneliness and cardiovascular diseases (continuous: OR = 1.13, 95% CI = 1.06-1.21, p 0.001; dichotomous: OR = 2.64, 95% CI = 1.50-4.65, p = 0.001), but this association was not present in men (OR = 0.96, 95% CI = 0.88-1.05, p = 0.38). This association remained significant after adjustment for confounders, but it lost significance after adding depression to the model.For women only, there was an association between loneliness and cardiovascular disease. However, this association was explained by depression, indicating that loneliness in its own right seems not related with cardiovascular disease. Copyright © 2017 John WileySons, Ltd.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=pmid________::467e26936d885ada3d9c08ef6e44645fTest
https://pubmed.ncbi.nlm.nih.gov/28418079Test

المؤلفون: Arie van Loenen, Max Stek, Pierre M. Bet

المصدر: Tijdschrift voor VerpleeghuisGeneeskunde. 30:113-119

مصطلحات موضوعية: medicine.medical_specialty, Pediatrics, Risperidone, Dose, medicine.drug_class, business.industry, medicine.medical_treatment, Incidence (epidemiology), Rehabilitation, Atypical antipsychotic, medicine.disease, Typical antipsychotic, medicine, Haloperidol, Dementia, Geriatrics and Gerontology, Antipsychotic, Psychiatry, business, Gerontology, medicine.drug

الوصف: Recently new data has become available on the safety and the effectiveness of antipsychotic drugs in the treatment of neuropsychiatric symptoms in elderly patients with dementia. The effectiveness of antipsychotic drugs on behavioural disturbances in elderly patients with dementia is poor. The application of atypical antipsychotic drugs in this group of patients leads to an increased risk on cerebrovasculair accidents (CVA). First generation typical antipsychotic drugs may also increase the incidence of CVA. Haloperidol and risperidone, in dosages up till 2 mg a day, remain the preferred drugs. The effectiveness of antipsychotic therapy drugs must be evaluated periodically.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::dcb3f8391e8d8fdb401f59fb2e7f163cTest
https://doi.org/10.1007/bf03075084Test

المؤلفون: Janine van Kooten, Martin Smalbrugge, Johannes van der Wouden, Max Stek, Cees Hertogh

المصدر: Journal of the American Medical Directors Association. 17:B26

مصطلحات موضوعية: Long-term care, medicine.medical_specialty, business.industry, Health Policy, Advanced dementia, Physical therapy, medicine, General Medicine, Geriatrics and Gerontology, business, General Nursing

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::1a42f1a516a7537d9d9d24b02b552bedTest
https://doi.org/10.1016/j.jamda.2015.12.080Test

المؤلفون: Janine van Kooten, Martin Smalbrugge, Johannes van der Wouden, Max Stek, Cees Hertogh

المصدر: Journal of the American Medical Directors Association. 17:B28

مصطلحات موضوعية: medicine.medical_specialty, Nursing, business.industry, Health Policy, Family medicine, Advanced dementia, Medicine, General Medicine, Geriatrics and Gerontology, Nursing homes, business, General Nursing

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::2815cef45d44a609df83ecd56ca4b8b6Test
https://doi.org/10.1016/j.jamda.2015.12.087Test

المؤلفون: Paul D, Meesters, Sigfried, Schouws, Max, Stek, Lieuwe, de Haan, Jan, Smit, Piet, Eikelenboom, Aartjan, Beekman, Hannie, Comijs

المصدر: International journal of geriatric psychiatry. 28(1)

مصطلحات موضوعية: Aged, 80 and over, Male, Analysis of Variance, Bipolar Disorder, Schizophrenia, Humans, Female, Schizophrenic Psychology, Age of Onset, Neuropsychological Tests, Cognition Disorders, Aged

الوصف: Evidence in younger populations suggests quantitative but not categorical differences in cognitive impairments between schizophrenia and bipolar disorder. It is uncertain whether a similar distinction applies to patients in later life.We compared the cognitive abilities of older, community-living schizophrenia patients, controlling for their state of symptomatic remission, with those of older euthymic patients with bipolar I disorder. The study included 67 patients with schizophrenia (20 in symptomatic remission, 47 not in symptomatic remission; mean age 68 years) and 74 euthymic bipolar I patients (mean age 70 years), who were compared using analysis of covariance on clinical and neuropsychological variables (e.g., attention/working memory, verbal memory, executive function and verbal fluency) and contrasted with 69 healthy controls.Remitted (SR) and non-remitted (SN) schizophrenia patients and bipolar I (BP) patients were impaired relative to healthy controls, with mostly large effect sizes for verbal memory (Cohen's d: SR 1.34, SN 1.48, BP 1.09), executive function (Cohen's d: SR 0.87, SN 1.29, BP 0.71) and verbal fluency (Cohen's d: SR 1.09, SN 1.25, BP 0.88), but smaller effect sizes for the domain of attention/working memory (Cohen's d: SR 0.26, SN 0.18, BP 0.52). Differences in cognitive performance between the remitted schizophrenia patients and the bipolar I patients were not significant.In both older patients with schizophrenia and with bipolar disorder, serious and pervasive cognitive deficits can be demonstrated. Trait-related cognitive deficits in schizophrenia and bipolar disorder may share major phenotypic similarity in later life.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=pmid________::917a56fd80cc3d98859ac13e5e362293Test
https://pubmed.ncbi.nlm.nih.gov/22407730Test

المؤلفون: Arie van Loenen, Pierre M. Bet, Max Stek

المصدر: Tijdschrift voor VerpleeghuisGeneeskunde. 31:4-5

مصطلحات موضوعية: Rehabilitation, Geriatrics and Gerontology, Gerontology

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::a97e15a08a4086512a223772b7ab7769Test
https://doi.org/10.1007/bf03075125Test