المؤلفون: Franziska C. Trudzinski, Rudolf A. Jörres, Peter Alter, Julia Walter, Henrik Watz, Andrea Koch, Matthias John, Marek Lommatzsch, Claus F. Vogelmeier, Hans-Ulrich Kauczor, Tobias Welte, Jürgen Behr, Amanda Tufman, Robert Bals, Felix J. F. Herth, Kathrin Kahnert, The COSYCONET Study Group

المصدر: Scientific Reports, Vol 12, Iss 1, Pp 1-10 (2022)

مصطلحات موضوعية: Medicine, Science

الوصف: Abstract In patients with COPD, it has not been comprehensively assessed whether the predictive value of comorbidities for mortality differs between men and women. We therefore aimed to examine sex differences of COPD comorbidities in regard with prognosis by classifying comorbidities into a comorbidome related to extrapulmonary disorders and a pulmorbidome, referring to pulmonary disorders. The study population comprised 1044 women and 1531 men with the diagnosis of COPD from COSYCONET, among them 2175 of GOLD grades 1–4 and 400 at risk. Associations of comorbidities with mortality were studied using Cox regression analysis for men and women separately. During the follow-up (median 3.7 years) 59 women and 159 men died. In men, obesity, hypertension, coronary artery disease, liver cirrhosis, osteoporosis, kidney disease, anaemia and increased heart rate (HR) predict mortality, in women heart failure, hyperuricemia, mental disorders, kidney disease and increased HR (p

وصف الملف: electronic resource

العلاقة: https://doaj.org/toc/2045-2322Test

الوصول الحر: https://doaj.org/article/51c621bd8e324fefa23aea0da7193a99Test

المؤلفون: Zeeshan Ahmed, Matthias John, Patrick Mcevoy, Max J. Ammann

المصدر: IEEE Access, Vol 8, Pp 189003-189012 (2020)

مصطلحات موضوعية: Periodic structures, planar arrays, leaky wave antennas, Electrical engineering. Electronics. Nuclear engineering, TK1-9971

الوصف: A printed edge-fed counterpart of wire Bruce array antenna, with open-stopband mitigation at broadside, is presented. The proposed antenna comprises of 11 meandered unit-cells periodically modulated in congruence with wire Bruce array antenna's theory. To mitigate the effects of open-stopband, the horizontal and vertical lengths of unit-cell are adjusted along with the addition of an inward bent element allowing seamless scanning from backward to forward endfire region. The antenna has two distinct frequency scanning ranges between 18.0 GHz and to 37.20 GHz with Sidelobe level ≤ -10 dB. A dual Bruce array, using two-way Klopfenstein tapered feedline power divider, is then proposed to increase the peak realized gain to 18.61 dBi followed by a two-port solution to widen the scanning range of the antenna.

وصف الملف: electronic resource

العلاقة: https://ieeexplore.ieee.org/document/9224630Test/; https://doaj.org/toc/2169-3536Test

الوصول الحر: https://doaj.org/article/7c2f08a87a6f4027b94c90f4d2b9cabfTest

المؤلفون: Mahsa Keshavarz Hedayati, Abdolali Abdipour, Reza Sarraf Shirazi, Max J. Ammann, Matthias John, Cagri Cetintepe, Robert Bogdan Staszewski

المصدر: IEEE Access, Vol 7, Pp 43190-43204 (2019)

مصطلحات موضوعية: 5G, mm-wave, nanometer-scale CMOS, 28 nm CMOS, active integrated antenna (AIA), antenna-on-chip (AoC), Electrical engineering. Electronics. Nuclear engineering, TK1-9971

الوصف: This paper investigates design considerations and challenges of integrating on-chip antennas in nanoscale CMOS technology at millimeter-wave (mm-wave) to achieve a compact front-end receiver for 5G communication systems. Solutions to overcome these challenges are offered and realized in digital 28-nm CMOS. A monolithic on-chip antenna is designed and optimized in the presence of rigorous metal density rules and other back-end-of-the-line (BEoL) challenges of the nanoscale technology. The proposed antenna structure further exploits ground metallization on a PCB board acting as a reflector to increase its radiation efficiency and power gain by 37.3% and 9.8 dB, respectively, while decreasing the silicon area up to 30% compared to the previous works. The antenna is directly matched to a two-stage low noise amplifier (LNA) in a synergetic way as to give rise to an active integrated antenna (AIA) in order to avoid additional matching or interconnect losses. The LNA is followed by a double-balanced folded Gilbert cell mixer, which produces a lower intermediate frequency (IF) such that no probing is required for measurements. The measured total gain of the AIA is 14 dBi. Its total core area is 0.83 mm2 while the total chip area, including the pad frame, is 1.55 × 0.85 mm2.

وصف الملف: electronic resource

العلاقة: https://ieeexplore.ieee.org/document/8668762Test/; https://doaj.org/toc/2169-3536Test

الوصول الحر: https://doaj.org/article/d53052c09bf548918cf2a3d7f4a46915Test

المؤلفون: Ha Hoang, Matthias John, Patrick McEvoy, Max J. Ammann

المصدر: Sensors, Vol 21, Iss 2, p 514 (2021)

مصطلحات موضوعية: near-field antenna effect, radar calibration, MIMO radar, turntable radar, UWB radar, radar system, Chemical technology, TP1-1185

الوصف: A calibration method for a high-resolution hybrid MIMO turntable radar imaging system is presented. A line of small metal spheres is employed as a test pattern in the calibration process to measure the position shift caused by undesired antenna effects. The unwanted effects in the antenna near-field responses are analysed, modelled and significantly mitigated based on the symmetry and differences in the responses of the MIMO configuration.

وصف الملف: electronic resource

العلاقة: https://www.mdpi.com/1424-8220/21/2/514Test; https://doaj.org/toc/1424-8220Test

الوصول الحر: https://doaj.org/article/07a0a270fded43639eaa57a04ec22504Test

المؤلفون: Britta Schneider, Michael Grote, Matthias John, Alexander Haas, Birgit Bramlage, Ludger M lckenstein, Kerstin Jahn-Hofmann, Frieder Bauss, Weijun Cheng, Rebecca Croasdale, Karin Daub, Simone Dill, Eike Hoffmann, Wilma Lau, Helmut Burtscher, James L Ludtke, Silke Metz, Olaf Mundigl, Zane C Neal, Werner Scheuer, Jan Stracke, Hans Herweijer, Ulrjch Brinkmann

المصدر: Molecular Therapy: Nucleic Acids, Vol 1, Iss C (2012)

مصطلحات موضوعية: bispecific antibody, dynamic polyconjugate, hapten, lipid nanoparticle, RNA interference, siRNA delivery, Therapeutics. Pharmacology, RM1-950

الوصف: Bispecific antibodies (bsAbs) that bind to cell surface antigens and to digoxigenin (Dig) were used for targeted small interfering RNA (siRNA) delivery. They are derivatives of immunoglobulins G (IgGs) that bind tumor antigens, such as Her2, IGF1-R, CD22, and LeY, with stabilized Dig-binding variable domains fused to the C-terminal ends of the heavy chains. siRNA that was digoxigeninylated at its 3′end was bound in a 2:1 ratio to the bsAbs. These bsAb–siRNA complexes delivered siRNAs specifically to cells that express the corresponding antigen as demonstrated by flow cytometry and confocal microscopy. The complexes internalized into endosomes and Dig-siRNAs separated from bsAbs, but Dig-siRNA was not released into the cytoplasm; bsAb-targeting alone was thus not sufficient for effective mRNA knockdown. This limitation was overcome by formulating the Dig-siRNA into nanoparticles consisting of dynamic polyconjugates (DPCs) or into lipid-based nanoparticles (LNPs). The resulting complexes enabled bsAb-targeted siRNA-specific messenger RNA (mRNA) knockdown with IC50 siRNA values in the low nanomolar range for a variety of bsAbs, siRNAs, and target cells. Furthermore, pilot studies in mice bearing tumor xenografts indicated mRNA knockdown in endothelial cells following systemic co-administration of bsAbs and siRNA formulated in LNPs that were targeted to the tumor vasculature.

وصف الملف: electronic resource

العلاقة: http://www.sciencedirect.com/science/article/pii/S2162253116301032Test; https://doaj.org/toc/2162-2531Test

الوصول الحر: https://doaj.org/article/6bec11c8644d43c8bfff095546e986f7Test

المؤلفون: Matthias, John

الوصف: Since its founding in 1995, Notre Dame Review has become one of America's leading literary magazines. Dana Gioia, chairman of the National Endowment for the Arts, has written, "It really has become one of the most interesting journals in the country." This anthology consists of representative poetry and fiction from its first ten years of publication. Like the magazine itself, the collection includes work by well known authors—Seamus Heaney, Paul Muldoon, and Czeslaw Milosz among the poets; Marilyn Krysl, Arturo Vivante, Frances Sherwood, R. D. Skillings, and Richard Elman, among the fiction writers—while also making room for exciting work by new and emerging writers, some of whom are former Notre Dame MFA students. The anthology also includes poetry and prose by several winners of the Ernest Sandeen Prize in Poetry and the Richard Sullivan Prize in Short Fiction, works that have set standards of excellence for writers and readers around the country.Contributors to this anthology represent a wide range of ...

العلاقة: https://dx.doi.org/10.7274/25852174Test

الإتاحة: https://doi.org/10.7274/25852174.v110.7274/25852174Test
https://curate.nd.edu/articles/book/_i_Notre_Dame_Review_i_/25852174/1Test

المؤلفون: Maranan, Diego S., Grant, Jane, Matthias, John, Phillips, Mike, Denham, Susan L.

الوصف: Inspired by somatic methodologies and neurophysiology, Haplos is a low-cost, wearable technology that applies vibrotactile patterns to the skin, can be incorporated in existing clothing and implements, and can be programmed and activated remotely. We review existing vibrotactile technologies and known uses of vibrotactile stimuli; describe the hardware, textile, and software components of Haplos; describe results from a quasi-experimental workshop to evaluate Haplos; and discuss future research and development directions. To view the conference paper on which this poster is based, please see 10.1145/3374920.3374984. To view the PhD thesis on which this research is based, please see http://hdl.handle.net/10026.1/10170Test

العلاقة: info:eu-repo/grantAgreement/EC/FP7/604764/; https://zenodo.org/record/3894795Test; https://doi.org/10.5281/zenodo.3894795Test; oai:zenodo.org:3894795

الإتاحة: https://doi.org/10.5281/zenodo.3894795Test
https://doi.org/10.1145/3374920.3374984Test
https://doi.org/10.5281/zenodo.3894794Test
https://zenodo.org/record/3894795Test

المؤلفون: Perkins, Matthias John

مصطلحات موضوعية: 737.496

الوصف: The stone towns of the Swahili Coast are a visible reminder of once prosperous kingdoms who had built their wealth on the Indian Ocean trade. From the 19th century onward the coins found numerously at some of these towns intrigued European travellers and scholars alike. Initially, it was believed that they were remnants, like the stone towns, of a colonial Arab or Persian culture. At first only copper coins were known, with the majority coming from stray . finds from the beaches of the eroding settlements. These copper coins had Arabic writing on them spelling out a rhyming legend which continued from one side to the other. They were ascribed to the Sultans of Kilwa, while similar coins were believed to originate in ;Zanzibar. Little though was understood regarding their origin and they were primarily seen as a means to better understand the chronology of Kilwa. It is now clear that these copper coins were preceded by minute silver coins, similar in their designs and legends to the copper coins. 'Although it is clear that the silver and copper coins are an interrelated coinage, many issues remain regarding their chronology and development. There is no detailed study that has looked at this East African coinage as whole. It is here that this thesis finds its place. In the light of new archaeological material and with the results of XRF analysis carried out on the copper coins, it investigates the issues surrounding the origin, chronology and purpose of this coinage. It tries to understand the coinage not only from the perspective of the Indian Ocean, but also in its much neglected African context.

الوصول الحر: https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.652039Test

المؤلفون: Matthias, John Robert

مصطلحات موضوعية: 530.1, Superfluidity, Quantum fluids, Bose liquids

الوصول الحر: http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.390167Test

المؤلفون: Max J. Ammann, Patrick McEvoy, Matthias John, Ha Hoang

المساهمون: Science Foundation Ireland (SFI), European Regional Development Fund

المصدر: Articles

مصطلحات موضوعية: Clustering algorithms, Computer science, Acoustics, Near and far field, 02 engineering and technology, 01 natural sciences, Directivity, law.invention, Time-domain analysis, law, Systems and Communications, 0202 electrical engineering, electronic engineering, information engineering, Electrical and Electronic Engineering, Impulse response, Multiple signal classification, Classification algorithms, Computer Sciences, 010401 analytical chemistry, Process (computing), Pattern classification, 020206 networking & telecommunications, Condensed Matter Physics, 0104 chemical sciences, Time–frequency analysis, Time-frequency analysis, Vivaldi antennas, Antenna (radio), Vivaldi antenna, Energy (signal processing)

الوصف: Refined optimization of complex curve–linear-shaped radiators, such as traveling-wave Vivaldi antennas, can be achieved by considering simulated near fields to interpret in detail the structural influences of a design. The relationships between the space and time distributions of electromagnetic (EM) energy clusters and the geometric features are revealed with appropriate use of impulse response analysis combined with the multiple signal classification (MUSIC) algorithm. This article reports a deeper approach when applied to the adjustment of the geometric features of a traveling-wave antenna based on an analysis of near-field propagation features.

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb4cec2c18fc3d88bd23fe86e9f4aa54Test
https://doi.org/10.1109/map.2020.3003217Test