المؤلفون: Norton C., Emmanuel A., Stevens N., Scott S. M., Grossi U., Bannister S., Eldridge S., Mason J. M., Knowles C. H.

المساهمون: Norton, C., Emmanuel, A., Stevens, N., Scott, S. M., Grossi, U., Bannister, S., Eldridge, S., Mason, J. M., Knowles, C. H.

مصطلحات موضوعية: Anorectal testing, Behavioural intervention, Biofeedback, Constipation, Randomised controlled trial

الوصف: Background: Constipation affects up to 20% of adults. Chronic constipation (CC) affects 1-2% of adults. Patient dissatisfaction is high; nearly 80% feel that laxative therapy is unsatisfactory and symptoms have significant impact on quality of life. There is uncertainty about the value of specialist investigations and whether equipment-intensive therapies using biofeedback confer additional benefit when compared with specialist conservative advice. Methods/design: A three-arm, parallel-group, multicentre randomised controlled trial. Objectives: to determine whether standardised specialist-led habit training plus pelvic floor retraining using computerised biofeedback is more clinically effective than standardised specialist-led habit training alone; to determine whether outcomes are improved by stratification based on prior investigation of anorectal and colonic pathophysiology. Primary outcome measure is response to treatment, defined as a 0.4-point (10% of scale) or greater reduction in Patient Assessment of Constipation-Quality of Life (PAC-QOL) score 6 months after the end of treatment. Other outcomes up to 12 months include symptoms, quality of life, health economics, psychological health and qualitative experience. Hypotheses: (1) habit training (HT) with computer-assisted direct visual biofeedback (HTBF) results in an average reduction in PAC-QOL score of 0.4 points at 6 months compared to HT alone in unselected adults with CC, (2) stratification to either HT or HTBF informed by pathophysiological investigation (INVEST) results in an average 0.4-point reduction in PAC-QOL score at 6 months compared with treatment not directed by investigations (No-INVEST). Inclusion: chronic constipation in adults (aged 18-70 years) defined by self-reported symptom duration of more than 6 months; failure of previous laxatives or prokinetics and diet and lifestyle modifications. Consenting participants (n = 394) will be randomised to one of three arms in an allocation ratio of 3:3:2: [1] habit training, [2] habit training ...

وصف الملف: ELETTRONICO

العلاقة: info:eu-repo/semantics/altIdentifier/wos/WOS:000397466200001; volume:18; issue:1; journal:TRIALS; http://hdl.handle.net/11577/3414609Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85016153960

الإتاحة: https://doi.org/10.1186/s13063-017-1880-0Test
http://hdl.handle.net/11577/3414609Test

المؤلفون: Sirunyan, A. M., Tumasyan, A., Adam, W., Ambrogi, F., Bergauer, T., Dragicevic, M., Ero, J., Del, Valle, Escalante, A., Flechl, M., Fruhwirth, R., Jeitler, M., Krammer, N., Kratschmer, I, Liko, D., Madlener, T., Mikulec, I, Rad, N., Schieck, J., Schofbeck, R., Spanring, M., Waltenberger, W., Wulz, C-E, Zarucki, M., Drugakov, V, Mossolov, V, Gonzalez, Suarez, J., Darwish, M. R., Wolf, De, E. A., Croce, Di, Janssen, D., Kello, X., Lelek, T., Pieters, A., Sfar, M., Rejeb, H., Van, Haevermaet, Van, Mechelen, Van, Putte, Van, Remortel, Blekman, N., Bols, F., Chhibra, E. S., D'Hondt, S. S., Clercq, De, Lontkovskyi, J., Lowette, D., Marchesini, S., Moortgat, I, Python, S., Tavernier, Q., Van, Doninck, Van, Mulders, Beghin, P., Bilin, D., Clerbaux, B., Lentdecker, De, Delannoy, G., Dorney, H., Favart, B., Grebenyuk, L., Kalsi, A., Moureaux, A. K., Popov, L., Postiau, A., Starling, N., Thomas, E., L. V., Velde, Er, Vanlaer, C., Vannerom, P., Cornelis, D., Dobur, T., Khvastunov, D., Niedziela, I, Roskas, M., Skovpen, C., Tytgat, K., Verbeke, M., Vermassen, W., Vit, B., Bruno, M., Caputo, G., David, C., Delaere, P., Delcourt, C., Giammanco, M., Lemaitre, A., Prisci, V, Aro, J., Saggio, A., Vischia, P., Zobec, J., Alves, G. A., Silva, Correia, G., Hensel, C., Moraes, A., Batista Das Chagas, Belchior, E., Carvalho, W., Chinellato, J., Coelho, E., Costa, Da, E. M., Silveira, Da, Damiao, G. G., De Jesus, D., Martins, De Oliveira, C., Souza, De, Fonseca, S., Malbouisson, H., Martins, J., Figueiredo, Matos, D., Jaime, Medina, M., Almeida, De, Melo, M., Herrera, Mora, C., Mundim, L., Nogima, H., Prado Da Silva, Teles, W. L., Rebello, P., Rosas, Sanchez, L. J., Santoro, A., Sznajder, A., Thiel, M., Tonelli, Manganote, E. J., Da Silva De Araujo, Torres, F., Pereira, Vilela, A., Bernardes, C. A., Calligaris, L., Fern, ez Perez Tomei, Gregores, T. R., Lemos, E. M., Mercadante, D. 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المصدر: PHYSICAL REVIEW LETTERS

مصطلحات موضوعية: MODEL, Physics and Astronomy, High Energy Physics::Experiment, QUARK-GLUON PLASMA, Nuclear Experiment

الوصف: The first evidence for X(3872) production in relativistic heavy ion collisions is reported. The X(3872) production is studied in lead-lead (Pb-Pb) collisions at a center-of-mass energy of root s(NN) = 5.02 TeV per nucleon pair, using the decay chain X(3872) -> J/psi pi(+)pi(-) -> mu(+) mu(-) pi(+)pi(-). The data were recorded with the CMS detector in 2018 and correspond to an integrated luminosity of 1.7 nb(-1). The measurement is performed in the rapidity and transverse momentum ranges vertical bar y vertical bar < 1.6 and 15 < p(T) < 50 GeV/c. The significance of the inclusive X(3872) signal is 4.2 standard deviations. The prompt X(3872) to psi 2S yield ratio is found to be rho(Pb-Pb) = 1.08 +/- 0.49(stat) +/- 0.52(syst), to be compared with typical values of 0.1 for pp collisions. This result provides a unique experimental input to theoretical models of the X(3872) production mechanism, and of the nature of this exotic state.

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::19e2a059a5c8fec8a4cf5ff5f110a969Test
https://hdl.handle.net/11577/3467380Test

المؤلفون: Jameson, S. S., Mason, J. M., Baker, P., Gregg, P. J., Porter, M., Deehan, D. J., Reed, M. R.

المصدر: Acta orthopaedica, 2015, Vol.86(1), pp.7-17 [Peer Reviewed Journal]

الوصف: Background and purpose — The optimal hip replacement for young patients remains unknown. We compared patient-reported outcome measures (PROMs), revision risk, and implant costs over a range of hip replacements. Methods — We included hip replacements for osteoarthritis in patients under 60 years of age performed between 2003 and 2010 using the commonest brand of cemented, cementless, hybrid, or resurfacing prosthesis (11,622 women and 13,087 men). The reference implant comprised a cemented stem with a conventional polyethylene cemented cup and a standard-sized head (28- or 32-mm). Differences in implant survival were assessed using competing-risks models, adjusted for known prognostic influences. Analysis of covariance was used to assess improvement in PROMs (Oxford hip score (OHS) and EQ5D index) in 2014 linked procedures. Results — In males, PROMs and implant survival were similar across all types of implants. In females, revision was statistically significantly higher in hard-bearing and/or small-stem cementless implants (hazard ratio (HR) = 4) and resurfacings (small head sizes (< 48 mm): HR = 6; large head sizes (≥ 48 mm): HR = 5) when compared to the reference cemented implant. In component combinations with equivalent survival, women reported significantly greater improvements in OHS with hybrid implants (22, p = 0.006) and cementless implants (21, p = 0.03) (reference, 18), but similar EQ5D index. For men and women, National Health Service (NHS) costs were lowest with the reference implant and highest with a hard-bearing cementless replacement. Interpretation — In young women, hybrids offer a balance of good early functional improvement and low revision risk. Fully cementless and resurfacing components are more costly and do not provide any additional benefit for younger patients.

وصف الملف: application/pdf

العلاقة: dro:13631; http://dro.dur.ac.uk/13631Test/; http://dx.doi.org/10.3109/17453674.2014.972256Test; http://dro.dur.ac.uk/13631/1/13631.pdfTest

الإتاحة: https://doi.org/10.3109/17453674.2014.972256Test
http://dro.dur.ac.uk/13631Test/
http://dro.dur.ac.uk/13631/1/13631.pdfTest

المؤلفون: Jameson, S. S., Mason, J. M., Baker, P. N., Gregg, P. J., Deehan, D. J., Reed, M. R.

المصدر: Acta orthopaedica, 2015, Vol.86(1), pp.32-40 [Peer Reviewed Journal]

الوصف: Background and purpose — There has been a recent trend towards the use of greater femoral head sizes in an attempt to improve function and enhance stability after primary hip replacement. This has been associated with the use of alternative bearings, theoretically to reduce wear and improve implant longevity. Methods — We examined the influence of these variables on patient-reported outcome measures (PROMs) for a consecutive series of primary hip replacements using National Joint Registry (NJR) and PROMs-linked data. To minimize the confounding influence of implant design factors, the single most commonly used brand in England and Wales (DePuy Corail Pinnacle) was examined. Improvement in patient hip-specific outcomes (Oxford hip score, OHS), general health outcomes (Euroqol, EQ-5D), and rates of self-reported complications (bleeding, wound problems, re-admission, and reoperation) were compared for different head sizes (28-mm, 32-mm, and 36-mm) and bearings (metal-on-polyethylene (MoP), ceramic-on-polyethylene (CoP), and ceramic-on-ceramic (CoC)), adjusting for differences in case mix. Results — At a mean follow-up of 7 months, improvements in OHS and EQ5D index were similar for 28-mm and 36-mm heads. A 32-mm head was associated with poorer function (OHS: 20, 99% CI: 19–21, p = 0.002; EQ5D index: 0.39, 99% CI: 0.36–0.42, p = 0.004), although these small differences may not be of clinical importance. There were no statistically significant benefits of either CoP or CoC bearings compared to a MoP bearing. Complication rates were similar within comparisons of head sizes or bearings. Interpretation — In this short-term study, we did not find any functional benefits of larger head sizes or alternative bearings, after adjusting for other influences. We question their use in routine primary hip replacement given the lack of evidence of improved long-term survival in the literature.

وصف الملف: application/pdf

العلاقة: dro:13630; http://dro.dur.ac.uk/13630Test/; http://dx.doi.org/10.3109/17453674.2014.972259Test; http://dro.dur.ac.uk/13630/1/13630.pdfTest

الإتاحة: https://doi.org/10.3109/17453674.2014.972259Test
http://dro.dur.ac.uk/13630Test/
http://dro.dur.ac.uk/13630/1/13630.pdfTest

المؤلفون: Ormerod, A. D., Thomas, K. S., Craig, F. E., Mitchell, E., Greenlaw, N., Norrie, J., Mason, J. M., Walton, S., Johnston, G. A., Williams, H. C.

المصدر: BMJ ; volume 350, issue jun12 3, page h2958-h2958 ; ISSN 1756-1833

الإتاحة: https://doi.org/10.1136/bmj.h2958Test

المؤلفون: Dhar, A., Close, H., Hancock, H., Maier, R., Wilson, D., Mason, J. M., Vishwanath, Y. K. S., Rees, C., Dwarakanath, D.

المصدر: World journal of gastroenterology, 2014, Vol.20(48), pp.18199-18206 [Peer Reviewed Journal]

مصطلحات موضوعية: Benign oesophageal stricture, Biodegradable stent, Endoscopic balloon dilatation, Pilot study, Randomised controlled trial, Dysphagia

الوصف: AIM: To undertake a randomised pilot study comparing biodegradable stents and endoscopic dilatation in patients with strictures. METHODS: This British multi-site study recruited seventeen symptomatic adult patients with refractory strictures. Patients were randomised using a multicentre, blinded assessor design, comparing a biodegradable stent (BS) with endoscopic dilatation (ED). The primary endpoint was the average dysphagia score during the first 6 mo. Secondary endpoints included repeat endoscopic procedures, quality of life, and adverse events. Secondary analysis included follow-up to 12 mo. Sensitivity analyses explored alternative estimation methods for dysphagia and multiple imputation of missing values. Nonparametric tests were used. RESULTS: Although both groups improved, the average dysphagia scores for patients receiving stents were higher after 6 mo: BS-ED 1.17 (95%CI: 0.63-1.78) P = 0.029. The finding was robust under different estimation methods. Use of additional endoscopic procedures and quality of life (QALY) estimates were similar for BS and ED patients at 6 and 12 mo. Concomitant use of gastrointestinal prescribed medication was greater in the stent group (BS 5.1, ED 2.0 prescriptions; P < 0.001), as were related adverse events (BS 1.4, ED 0.0 events; P = 0.024). Groups were comparable at baseline and findings were statistically significant but numbers were small due to under-recruitment. The oesophageal tract has somatic sensitivity and the process of the stent dissolving, possibly unevenly, might promote discomfort or reflux. CONCLUSION: Stenting was associated with greater dysphagia, co-medication and adverse events. Rigorously conducted and adequately powered trials are needed before widespread adoption of this technology.

وصف الملف: application/pdf

العلاقة: dro:17236; http://dro.dur.ac.uk/17236Test/; http://dx.doi.org/10.3748/wjg.v20.i48.18199Test; http://dro.dur.ac.uk/17236/1/17236.pdfTest

الإتاحة: https://doi.org/10.3748/wjg.v20.i48.18199Test
http://dro.dur.ac.uk/17236Test/
http://dro.dur.ac.uk/17236/1/17236.pdfTest

المؤلفون: Lapin, V, Shirdel, E A, Wei, X, Mason, J M, Jurisica, I, Mak, T W

المصدر: Oncogenesis ; volume 3, issue 12, page e133-e133 ; ISSN 2157-9024

مصطلحات موضوعية: Cancer Research, Molecular Biology

الإتاحة: https://doi.org/10.1038/oncsis.2014.45Test
https://www.nature.com/articles/oncsis201445.pdfTest
https://www.nature.com/articles/oncsis201445Test

المؤلفون: Shelby, M. D., Bishop, J. B., Mason, J. M., Tindall, K. R.

المصدر: Environmental Health Perspectives, 1993 Apr 01. 100, 283-291.

الوصول الحر: https://www.jstor.org/stable/3431534Test

المؤلفون: Moroney, J. R., Mason, J. M.

المصدر: Journal of Money, Credit and Banking, 1971 Nov 01. 3(4), 793-814.

الوصول الحر: https://www.jstor.org/stable/1991417Test

المؤلفون: Mason, J. M., Hinkelmann, K.

المصدر: Biometrics, 1971 Jun 01. 27(2), 430-435.

الوصول الحر: https://www.jstor.org/stable/2529008Test