المؤلفون: Yu Shionoya, Megumi Katsumata, Hajime Kasai, Kohei Shikano, Aoi Hino, Masaki Suzuki, Mitsuhiro Abe, Takuji Suzuki

المصدر: Radiology Case Reports, Vol 19, Iss 2, Pp 567-571 (2024)

مصطلحات موضوعية: Lung cancer, Radiation-induced organizing pneumonia, Carbon-ion radiotherapy, Corticosteroids, Medical physics. Medical radiology. Nuclear medicine, R895-920

الوصف: Radiation-induced organizing pneumonia is a rare complication of radiation therapy for thoracic cancer. Carbon-ion radiotherapy, an emerging treatment modality for early-stage lung cancer treatment, can also cause lung injuries. However, as cases of radiation-induced organizing pneumonia caused by carbon-ion radiotherapy for lung cancer have not been reported, its clinical features remain unclear. A 69-year-old woman was referred to our hospital 11 months after being diagnosed with early lung cancer due to refractory pneumonitis induced by carbon-ion radiotherapy. She had developed fever and dyspnea 4 months after undergoing carbon-ion radiotherapy and was subsequently diagnosed with radiation pneumonitis. The administration of oral prednisolone resulted in improvement. However, she relapsed each time the dose of prednisolone was tapered. She was diagnosed with radiation-induced organizing pneumonia caused by carbon-ion radiotherapy for lung cancer based on the clinical course and the results of the examination performed at our hospital. An improvement was observed after administering methylprednisolone (1000 mg/d) for 3 days. The dose of oral prednisolone was slowly tapered over a period of ≥6 months with no relapse. Organizing pneumonia caused by carbon-ion radiotherapy for lung cancer is treatable with corticosteroids; however, tapering the dose of corticosteroids may lead to relapse.

وصف الملف: electronic resource

العلاقة: http://www.sciencedirect.com/science/article/pii/S1930043323008373Test; https://doaj.org/toc/1930-0433Test

الوصول الحر: https://doaj.org/article/75b2df47dfdb4925be73a45120c2980dTest

المؤلفون: Masaki Suzuki, Yohei Iida, Yohei Tsukui, Hazumu Kusama, Ryosuke Kinoshita, Eiji Kusui, Yuta Sunohara, Rintaro Minegishi, Yuna Sugiyama, Yuko Nishimura, Chihiro Sekine, Ohmi Fuchiwaki

المصدر: Advanced Intelligent Systems, Vol 6, Iss 4, Pp n/a-n/a (2024)

مصطلحات موضوعية: automatic micromanipulations, holonomic mobile robots, machine learning, piezoelectric actuators, visual servo, Computer engineering. Computer hardware, TK7885-7895, Control engineering systems. Automatic machinery (General), TJ212-225

الوصف: Holonomic mobile micromanipulators driven by piezoelectric actuators offer precision and compact design. However, attaining both high speed and positioning repeatability with sufficient load capacity poses challenges, given that lightweight robots are susceptible to nonuniform driving surfaces and external forces. A holonomic beetle (HB) is proposed to realize a wide range, compact size, precise holonomic motion, automatic micromanipulation, and high‐speed movement simultaneously. Inspired by the biological makeup of a Rhinoceros Beetle, a length, weight, and load capacity of 8 cm, 74 g, and of 2000 g, respectively, are used. The HB is a two‐legged robot with a pseudoalternating tripod gait locomotion principle, with five piezoelectric actuators for XYθ displacement and switching of the contact leg. It achieves maximum walking velocities of 11.6 mm s−1 for translational motion and 19.3 deg s−1 for rotation, with a displacement resolution of 12 nm. Notably, under open‐loop control, the HB demonstrates high repeatability with a coefficient of variation of 0.3%. It exhibits the capability to climb 30°‐inclined surfaces, traverse flat surfaces with 0.1 mm bumps, and navigate 30 mm pits. Furthermore, the HB showcases practical automatic micromanipulation through visual servo control and machine learning, presenting potential applications in biomedical and microassembly fields.

وصف الملف: electronic resource

العلاقة: https://doaj.org/toc/2640-4567Test

الوصول الحر: https://doaj.org/article/35904b1261b242558a8341e204bf2f63Test

المؤلفون: Nobuyuki Yoshiyasu, Rei Matsuki, Masaaki Sato, Hirokazu Urushiyama, Etsuko Toda, Yasuhiro Terasaki, Masaki Suzuki, Aya Shinozaki-Ushiku, Yuya Terashima, Jun Nakajima

المصدر: Transplant International, Vol 37 (2024)

مصطلحات موضوعية: lung transplantation, acute lung rejection, macrophage, disulfiram, rodent study, Specialties of internal medicine, RC581-951

الوصف: Macrophages contribute to post-transplant lung rejection. Disulfiram (DSF), an anti-alcoholic drug, has an anti-inflammatory effect and regulates macrophage chemotactic activity. Here, we investigated DSF efficacy in suppressing acute rejection post-lung transplantation. Male Lewis rats (280–300 g) received orthotopic left lung transplants from Fisher 344 rats (minor histocompatibility antigen-mismatched transplantation). DSF (0.75 mg/h) monotherapy or co-solvent only (50% hydroxypropyl-β-cyclodextrin) as control was subcutaneously administered for 7 days (n = 10/group). No post-transplant immunosuppressant was administered. Grades of acute rejection, infiltration of immune cells positive for CD68, CD3, or CD79a, and gene expression of monocyte chemoattractant protein and pro-inflammatory cytokines in the grafts were assessed 7 days post-transplantation. The DSF-treated group had significantly milder lymphocytic bronchiolitis than the control group. The infiltration levels of CD68+ or CD3+ cells to the peribronchial area were significantly lower in the DSF than in the control groups. The normalized expression of chemokine ligand 2 and interleukin-6 mRNA in allografts was lower in the DSF than in the control groups. Validation assay revealed interleukin-6 expression to be significantly lower in the DSF than in the control groups. DSF can alleviate acute rejection post-lung transplantation by reducing macrophage accumulation around peripheral bronchi and suppressing pro-inflammatory cytokine expression.

وصف الملف: electronic resource

العلاقة: https://www.frontierspartnerships.org/articles/10.3389/ti.2024.12556/fullTest; https://doaj.org/toc/1432-2277Test

الوصول الحر: https://doaj.org/article/e599124be47545639922fef2bb35d661Test

المؤلفون: Wataru Ogawa, Masaaki Yamamoto, Naoki Yamamoto, Hironori Bando, Shin Urai, Yuma Motomura, Yuriko Sasaki, Yuka Ohmachi, Masaki Kobatake, Yasutaka Tsujimoto, Yuka Oi-Yo, Masaki Suzuki, Michiko Takahashi, Hidenori Fukuoka, Genzo Iguchi

المصدر: Journal for ImmunoTherapy of Cancer, Vol 12, Iss 2 (2024)

مصطلحات موضوعية: Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

الوصف: Immune checkpoint inhibitor (ICI)-related hypophysitis (RH) is a common immune-related adverse event. The early detection of ICI-RH prevents life-threatening adrenal insufficiency. However, good predictors of secondary adrenal insufficiency in ICI-RH have not yet been reported. We hypothesized that fluctuations in plasma adrenocorticotropic hormone (ACTH) and cortisol levels occur similarly to those in thyroid-stimulating hormone and thyroid hormone (thyroxine and triiodothyronine) levels in ICI-related thyroiditis. Here, we sought to test this hypothesis. Patients who used ICI and had a history of measurement of plasma ACTH and serum cortisol concentrations were retrieved from electronic medical records, and those with a history of glucocorticoid use were excluded from the analysis. We evaluated fluctuations in plasma ACTH and serum cortisol concentrations and the development of ICI-RH. For patients with ICI-RH, data at three points (before ICI administration (pre), maximum ACTH concentration (peak), and onset of ICI-RH) were analyzed to evaluate hormone fluctuations. A total of 202 patients were retrieved from the medical record. Forty-three patients were diagnosed with ICI-RH. Twenty-six out of 43 patients had sufficient data to evaluate fluctuations in plasma ACTH and serum cortisol concentrations and no history of glucocorticoid use. ACTH concentrations changed from 37.4 (29.9–48.3) (pre) to 64.4 (46.5–106.2) (peak) pg/mL (1.72–fold increase, p=0.0026) in the patients with ICI-RH before the onset. There were no differences in cortisol concentrations between the pre and peak values in patients with ICI-RH. We also evaluated the fluctuations in plasma ACTH and serum cortisol levels in patients who did not receive ICI-RH (62 cases). However, elevation of plasma ACTH levels was not observed in patients without ICI-RH, suggesting that transient elevation of plasma ACTH levels is a unique phenomenon in patients with ICI-RH. In conclusion, plasma ACTH levels were transiently elevated in some patients with ICI-RH before the onset of secondary adrenal insufficiency. Monitoring the ACTH levels and their fluctuations may help predict the onset of ICI-RH.

وصف الملف: electronic resource

العلاقة: https://jitc.bmj.com/content/12/2/e008634.fullTest; https://doaj.org/toc/2051-1426Test

الوصول الحر: https://doaj.org/article/ba14ad9298c541548ab6e516b79879dfTest

المؤلفون: Ayumi Okizaki, Kozo Tada, Kuniko Shinohara, Masaki Suzuki, Nobuyasu Sugimoto, Tomoya Kudo, Yoshiko Tominaga, 多田 耕三, 富永 佳子, 工藤 知也, 杉本 修康, 沖﨑 歩, 篠原 久仁子, 鈴木 雅基

المصدر: 医薬品情報学 / Japanese Journal of Drug Informatics. 2023, 25(3):143

المؤلفون: Atsushi TAGAMI, Chikara SASAKI, Masaki SUZUKI, Takuya MIYASAKA

المصدر: IEICE Transactions on Communications. 2023, E106.B(12):1267

المؤلفون: Ichiro Yoshino, Jun Ikari, Kohei Shikano, Koichiro Tatsumi, Masaki Suzuki, Mitsuhiro Abe, Takahiro Nakajima, Takeshi Kawasaki, Terunaga Inage, Yuki Ito, Yuki Sata

المصدر: Respiratory Endoscopy. 2023, 1(1):13

المؤلفون: Akira Uchiyama, Akihito Hiromori, Ryota Akikawa, Hirozumi Yamaguchi, Teruo Higashino, Masaki Suzuki, Yasuhiko Hiehata, Takeshi Kitahara

المصدر: IEEE Open Journal of Intelligent Transportation Systems, Vol 4, Pp 846-857 (2023)

مصطلحات موضوعية: Risky traffic situation, smartphone, traffic safety, Transportation engineering, TA1001-1280, Transportation and communications, HE1-9990

الوصف: Behind many traffic accidents, there are more frequent minor incidents (risky traffic situations) that may lead to severe accidents. Analyzing such minor incidents effectively reduces accidents, but the challenge is to design a method to collect and analyze such incident information. In this paper, we propose a novel platform that aggregates behavioral data from pedestrians and drivers using their smartphones and recognizes risky traffic situations from the aggregated data. We design a two-stage approach where the smartphones of pedestrians and vehicles act as local anomaly detectors for triggering the event detector and classifier in the post-stage at the cloud server to suppress the processing and communication overhead. We also introduce an unsupervised learning system to cope with unseen risky situations enabled by joint utilization of the autoencoder-based anomaly detector and the risky situation classifier. The evaluation is conducted through both simulation and real experiments. The simulation result shows the risky situation detector achieves an F-measure of 0.89. We also collected real data at a car driving course to evaluate the risky situation classifier. From the results, we have confirmed that the proposed method succeeded in classifying three risky traffic situations involving pedestrians and/or vehicles with an accuracy of 89.3%.

وصف الملف: electronic resource

العلاقة: https://ieeexplore.ieee.org/document/10318156Test/; https://doaj.org/toc/2687-7813Test

الوصول الحر: https://doaj.org/article/3f1122e539d7408883527a9757388cf1Test

المؤلفون: Masaki Suzuki, Shin Urai, Hidenori Fukuoka, Yushi Hirota, Masaaki Yamamoto, Yuko Okada, Naoki Yamamoto, Hiroki Shichi, Yasunori Fujita, Keitaro Kanie, Genzo Iguchi, Yutaka Takahashi, Wataru Ogawa

المصدر: Journal of Diabetes Investigation, Vol 13, Iss 9, Pp 1585-1595 (2022)

مصطلحات موضوعية: Bone mineral density, Subtypes, Type 1 diabetes mellitus, Diseases of the endocrine glands. Clinical endocrinology, RC648-665

الوصف: Abstract Aims/Introduction The bone mineral density in patients with type 1 diabetes mellitus is reduced due to impaired insulin secretion. However, it is unclear whether the rate of bone mineral density reduction is affected by the type 1 diabetes mellitus subtype. This study aimed to clarify the difference in bone mineral density across type 1 diabetes mellitus subtypes: slowly progressive (SP), acute‐onset (AO), and fulminant (F). Methods This was a retrospective, single‐center, cross‐sectional study conducted on 98 adult type 1 diabetes mellitus patients. The main outcome included the bone mineral density Z‐score (BMD‐Z) measured at the lumbar spine and femoral neck. Results The lumbar spine BMD‐Z was lower in the acute‐onset than in the slowly progressive subtype (P = 0.03). No differences were observed when compared with the fulminant subtype. The femoral neck BMD‐Z tended to be higher in the slowly progressive than in the acute‐onset and fulminant subtypes. Multiple regression analyses showed that the lumbar spine BMD‐Z was associated with subtypes (AO vs SP) (P = 0.01), but not subtypes (F vs SP), adjusted for sex, duration, retinopathy, and C‐peptide immunoreactivity (CPR). When the patients were divided into disease duration tertiles, in the first and second tertiles, the CPR levels were lower in the acute‐onset or fulminant than in the slowly progressive subtype. In contrast, the lumbar spine and femoral neck BMD‐Z differed between the acute‐onset and slowly progressive only in the second tertiles (both P

وصف الملف: electronic resource

العلاقة: https://doaj.org/toc/2040-1116Test; https://doaj.org/toc/2040-1124Test

الوصول الحر: https://doaj.org/article/3e3b932e5d6f4a7c810966a1c79b1628Test

المؤلفون: Yuiko Inaba, Masaaki Yamamoto, Shin Urai, Masaki Suzuki, Seiji Nishikage, Maki Kanzawa, Yayoi Aoyama, Tomonori Kanda, Katsumi Shigemura, Hironori Bando, Genzo Iguchi, Yasuhiro Nakamura, Masato Fujisawa, Akihisa Imagawa, Hidenori Fukuoka, Wataru Ogawa

المصدر: Scientific Reports, Vol 12, Iss 1, Pp 1-9 (2022)

مصطلحات موضوعية: Medicine, Science

الوصف: Abstract Cases in which bilateral adrenal 123I-Metaiodobenzylguanidine (123I-MIBG) scintigraphy accumulation is sometimes shown, with mildly elevated catecholamine (CA) or metanephrine (MN) levels (within 3 times the upper reference limit) are diagnostic dilemmas. We experienced 3 cases of adrenal incidentalomas with this dilemma in the differential diagnosis. The clinical diagnosis was subclinical Cushing's syndrome in 2 cases, and primary aldosteronism in 1. Despite suspected CA excess in clinical symptoms and imaging findings, the pathological findings of all these tumors were revealed to be cytochrome P450 family 11 subfamily B member 1 (CYP11B1) positive adrenocortical adenomas. Interestingly, adrenal medullary hyperplasia (AMH) was detected in the adrenal parenchyma of all those backgrounds. To clarify the clinical features of such cases, a cross-sectional study was conducted at the Kobe University Hospital from 2014 to 2020. One-hundred sixty-four patients who had undergone 123I-MIBG scintigraphy were recruited. Among them, 10 patients (6.1%) met the above criteria, including the presented 3 cases. Plasma adrenaline, noradrenaline, urinary metanephrine, and normetanephrine had values of 0.05 ± 0.05 ng/mL, 0.63 ± 0.32 ng/mL, 0.22 ± 0.05 mg/day, and 0.35 ± 0.16 mg/day, respectively. Nine cases were complicated with hypertension, and symptoms related to CA excess were observed. Half of them (5 cases) including presented 3 cases had unilateral adrenal tumors. These suggest that in cases of bilateral adrenal uptake on 123I-MIBG, AMH needs to be considered. Adrenocortical adenomas may be associated with AMH and further larger investigation is needed for this pathology.

وصف الملف: electronic resource

العلاقة: https://doaj.org/toc/2045-2322Test

الوصول الحر: https://doaj.org/article/c19ae7a9322245fe9683e47fdcc38d9bTest