المؤلفون: Haydar Frangoul, Franco Locatelli, Monica Bhatia, Markus Y. Mapara, Lyndsay Molinari, Akshay Sharma, Stephan Lobitz, Mariane de Montalembert, Damiano Rondelli, Martin Steinberg, Mark C. Walters, Suzan Imren, Lanju Zhang, Anjali Sharma, Yang Song, Christopher Simard, William Hobbs, Stephen Grupp

المصدر: Blood. 140:29-31

مصطلحات موضوعية: Immunology, Cell Biology, Hematology, Biochemistry

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::e87ae89b8099103da3267d5ee5ca6710Test
https://doi.org/10.1182/blood-2022-162353Test

المؤلفون: Paola Sebastiani, Martin Steinberg

المصدر: American Journal of Hematology. 98

مصطلحات موضوعية: Hematology

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7518c373a65895230e3e87e9a0ef6eaaTest
https://doi.org/10.1002/ajh.26791Test

المؤلفون: Martin Steinberg

المصدر: American journal of hematologyREFERENCES. 97(6)

مصطلحات موضوعية: Hemoglobinopathies, Humans, Hematology, beta-Globins, Fetal Hemoglobin

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aafca44e550c481223d9a1aaac95c1e5Test
https://pubmed.ncbi.nlm.nih.gov/35253929Test

المؤلفون: Martin Steinberg

المصدر: Blood

مصطلحات موضوعية: 0301 basic medicine, congenital, hereditary, and neonatal diseases and abnormalities, Genetic Vectors, Quantitative Trait Loci, Immunology, Receptors, Cell Surface, Review Article, Anemia, Sickle Cell, beta-Globins, Polymorphism, Single Nucleotide, Biochemistry, Proto-Oncogene Proteins c-myb, 03 medical and health sciences, 0302 clinical medicine, hemic and lymphatic diseases, Humans, Hydroxyurea, gamma-Globins, RNA, Small Interfering, Fetal Hemoglobin, Gene Editing, Lentivirus, Microfilament Proteins, Genetic Therapy, Cell Biology, Hematology, Repressor Proteins, Stroke, 030104 developmental biology, Gene Expression Regulation, Haplotypes, Gene Knockdown Techniques, RNA Interference, 030215 immunology

الوصف: Fetal hemoglobin (HbF) can blunt the pathophysiology, temper the clinical course, and offer prospects for curative therapy of sickle cell disease. This review focuses on (1) HbF quantitative trait loci and the geography of β-globin gene haplotypes, especially those found in the Middle East; (2) how HbF might differentially impact the pathophysiology and many subphenotypes of sickle cell disease; (3) clinical implications of person-to-person variation in the distribution of HbF among HbF-containing erythrocytes; and (4) reactivation of HbF gene expression using both pharmacologic and cell-based therapeutic approaches. A confluence of detailed understanding of the molecular basis of HbF gene expression, coupled with the ability to precisely target by genomic editing most areas of the genome, is producing important preliminary therapeutic results that could provide new options for cell-based therapeutics with curative intent.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::732e8267047d0bc939797dd4d6e25068Test
https://doi.org/10.1182/blood.2020007645Test

المؤلفون: Kanwal Awan, Martin Steinberg

مصطلحات موضوعية: fungi, food and beverages

الوصف: Ruling out medical conditions that can cause depression or cognitive impairment is essential in effectively caring for elderly patients. Case examples illustrate how these may present. Diabetes can cause confusion due to either hyper- or hypoglycemia. Congestive heart failure and chronic obstructive lung disease can cause hypoxia and resulting confusion. Sleep apnea can present with amnesia, apathy, and depression. Physiological changes make elderly patients especially susceptible to adverse drug effects, including hyponatremia and anticholinergic symptoms. Depression and cognitive changes have been associated with both hyper- and hypothyroidism, as well as with hyperparathyroidism. Elderly patients are at risk for developing subdural hematomas which can present with cognitive deficits and blunting of mood, and some patients may not have taken notice of the traumatic incident. Vitamin B12 deficiency can present with neurological symptoms including dementia, and cancer may present with fatigue and weight loss, which may be interpreted as depression.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::60838f1245135a68036bd2185b4bcaa7Test
https://doi.org/10.1093/med/9780199959549.003.0005Test

المؤلفون: Martin Steinberg, Antonio N. Puente, Cynthia A. Munro

مصطلحات موضوعية: mental disorders, behavioral disciplines and activities

الوصف: Changes in mood and/or cognition are common complaints in the elderly population. This chapter uses case studies to illustrate insights to make clinical assessment more efficient. These include assessing for cognitive impairment when depression is present and vice versa, being mindful of assuming that patients reporting cognitive difficulties are “worried well,” avoiding overreaction to very mild symptoms, assessing the four key cortical cognitive domains (amnesia, aphasia, apraxia, agnosia), assessing for subcortical dysfunction, assessing Activities of Daily Living (ADLs) and Instrumental Activities of Daily Living (IADLs), and understanding that depression in the elderly often presents with atypical symptoms. Brief cognitive instruments which can improve assessment include the Mini Mental State Exam (MMSE), Montreal Cognitive Assessment (MoCA), Patient Health Questionnaire (PHQ), Clock Drawing Test (CDT), and the Mini Cog. Brief depression instruments include the Geriatric Depression Scale (GDSS), and Cornell Scale for Depression in Dementia (CSDD).

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::e36f947629c0cb0db411f77378939dd2Test
https://doi.org/10.1093/med/9780199959549.003.0004Test

المؤلفون: Martin Steinberg, Paul B. Rosenberg

المصدر: Oxford Medicine Online ISBN: 9780199959549

مصطلحات موضوعية: mental disorders

الوصف: Depression, mild cognitive impairment (MCI) and dementia in the elderly can present with similar features such as cognitive complaints, loss of initiative, and difficulties with psychosocial functioning. These can be difficult to distinguish in the office setting, especially when mild in severity. The relationships between the three syndromes remains incompletely understood. Patients with MCI are at high risk for conversion to dementia. Depression may be either a risk factor for or early manifestation of MCI. Depression in late life is associated with Alzheimer’s disease (AD) and other dementias, but the causal relationship remains controversial. Depression may also increase the risk of conversion from MCI to dementia and be more strongly associated with conversion to Vascular dementia (VaD) than to AD. This book will provide guidance to clinicians in the diagnosis and management of these complex conditions in the office setting.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::7bdb2f8201d7e0baf102a4428387eca4Test
https://doi.org/10.1093/med/9780199959549.001.0001Test

المؤلفون: Martin Steinberg, Paul B. Rosenberg

مصطلحات موضوعية: mental disorders, behavioral disciplines and activities

الوصف: Changes in mood and/or cognition are common complaints in the elderly population. This chapter uses case studies to illustrate insights to make clinical assessment more efficient. These include assessing for cognitive impairment when depression is present and vice versa, being mindful of assuming that patients reporting cognitive difficulties are “worried well,” avoiding overreaction to very mild symptoms, assessing the four key cortical cognitive domains (amnesia, aphasia, apraxia, agnosia), assessing for subcortical dysfunction, assessing Activities of Daily Living (ADLs) and Instrumental Activities of Daily Living (IADLs), and understanding that depression in the elderly often presents with atypical symptoms. Brief cognitive instruments which can improve assessment include the Mini Mental State Exam (MMSE), Montreal Cognitive Assessment (MoCA), Patient Health Questionnaire (PHQ), Clock Drawing Test (CDT), and the Mini Cog. Brief depression instruments include the Geriatric Depression Scale (GDSS), and Cornell Scale for Depression in Dementia (CSDD).

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::ee53d9007087a6af3d0730288977baf5Test
https://doi.org/10.1093/med/9780199959549.003.0002Test

المؤلفون: Martin Steinberg, Paul B. Rosenberg

مصطلحات موضوعية: mental disorders

الوصف: Depression, mild cognitive impairment (MCI) and dementia in the elderly can present with similar features such as cognitive complaints, loss of initiative, and difficulties with psychosocial functioning. These can be difficult to distinguish in the office setting, especially when mild in severity. The relationships between the three syndromes remains incompletely understood. Patients with MCI are at high risk for conversion to dementia. Depression may be either a risk factor for or early manifestation of MCI. Depression in late life is associated with Alzheimer’s disease (AD) and other dementias, but the causal relationship remains controversial. Depression may also increase the risk of conversion from MCI to dementia and be more strongly associated with conversion to Vascular dementia (VaD) than to AD. This book will provide guidance to clinicians in the diagnosis and management of these complex conditions in the office setting.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::3c224181dbe400f15b26c9196b9afa39Test
https://doi.org/10.1093/med/9780199959549.003.0001Test

المؤلفون: Peter V. Rabins, Maria C. Norton, Constantine G. Lyketsos, Jeannie Marie S. Leoutsakos, Sarah Forrester, Chris Corcoran, Martin Steinberg, JoAnn T. Tschanz

المصدر: International Journal of Geriatric Psychiatry. 30:824-832

مصطلحات موضوعية: education.field_of_study, Univariate analysis, Multivariate statistics, Receiver operating characteristic, Clinical Dementia Rating, Population, medicine.disease, Psychiatry and Mental health, Covariate, Statistics, medicine, Dementia, Geriatrics and Gerontology, education, Psychology, Demography, Multinomial logistic regression

الوصف: Objective Several longitudinal studies of Alzheimer's disease (AD) report heterogeneity in progression. We sought to identify groups (classes) of progression trajectories in the population-based Cache County Dementia Progression Study (N = 328) and to identify baseline predictors of membership for each group. Methods We used parallel-process growth mixture models to identify latent classes of trajectories on the basis of Mini-Mental State Exam (MMSE) and Clinical Dementia Rating sum of boxes scores over time. We then used bias-corrected multinomial logistic regression to model baseline predictors of latent class membership. We constructed receiver operating characteristic curves to demonstrate relative predictive utility of successive sets of predictors. Results We fit four latent classes; class 1 was the largest (72%) and had the slowest progression. Classes 2 (8%), 3 (11%), and 4 (8%) had more rapid worsening. In univariate analyses, longer dementia duration, presence of psychosis, and worse baseline MMSE and Clinical Dementia Rating sum of boxes were associated with membership in class 2, relative to class 1. Lower education was associated with membership in class 3. In the multivariate model, only MMSE remained a statistically significant predictor of class membership. Receiver operating characteristic areas under the curve were 0.98, 0.88, and 0.67, for classes 2, 3, and 4 relative to class 1. Conclusions Heterogeneity in AD course can be usefully characterized using growth mixture models. The majority belonged to a class characterized by slower decline than is typically reported in clinical samples. Class membership could be predicted using baseline covariates. Further study may advance our prediction of AD course at the population level and in turn shed light on the pathophysiology of progression. Copyright © 2014 John Wiley & Sons, Ltd.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::e740a673a5fafcb51b589957767aa429Test
https://doi.org/10.1002/gps.4221Test