المؤلفون: Gómez Martín, Paz

المصدر: Quaderns de la Fundació Dr. Antoni Esteve; Nº25. El periodismo biomédico en la era 2.0; p. 39-46

مصطلحات موضوعية: periodismo, biomedicina, era 2.0, información, internet, TIC, divulgación, divulgación científica, comunicación, comunicación científica

وصف الملف: application/octet-stream

العلاقة: https://www.raco.cat/index.php/QuadernsFDAE/article/view/278649/366395Test

الوصول الحر: https://www.raco.cat/index.php/QuadernsFDAE/article/view/278649Test

المؤلفون: Rodrigo Caresani, Martín Paz

مصطلحات موضوعية: Archivo, América Latina, Archivos Latinoamericanos, Archivos institucionales, Archivos personales

الوصف: El escenario de pandemia y post-pandemia implicó una aceleración masiva y violenta de la alfabetización digital. En este contexto, las bibliotecas, los archivos, los museos y las instituciones de la memoria en general asumieron un rol de protagonismo no solo por el caudal de documentos que pusieron al alcance de un público “en cuarentena” sino como verdaderos laboratorios donde se ensayan y diseñan los métodos para tejer las comunidades del mañana. Por estos factores, ante la coyuntura reciente, las políticas de digitalización cobraron un predominio decisivo en las instituciones de guarda de acervos bibliográficos y archivísticos.

العلاقة: https://zenodo.org/record/8212442Test; https://doi.org/10.5281/zenodo.8212442Test; oai:zenodo.org:8212442

الإتاحة: https://doi.org/10.5281/zenodo.8212442Test
https://doi.org/10.5281/zenodo.8212441Test
https://zenodo.org/record/8212442Test

المؤلفون: Serrano, Dolores R., Fraguas-Sánchez, Ana Isabel, González-Burgos, Elena, Martín, Paz, Llorente, Catalina, Lalatsa, Aikaterini

مصطلحات موضوعية: ddc:650, Higher Education, Industry 4.0, Science, technology, engineering, and mathematics (STEM) education, Women entrepreneurship

الوصف: Industry 4.0 is the realization of digital transformation including enhanced productivity and flexibility due to real-time decision-making, which is possible due to the high-speed internet, the internet of things, and smart machines capable of autonomously exchanging information, triggering actions, and controlling each other independently. A high level of education and skills is increasingly more important in the job market over the next years necessitating finding a balance among behavioural, technological, analytical, and entrepreneurial skills. EU and governments worldwide should invest in closing the gender gap in science, technology, engineering, and mathematics (STEM) education as this will directly impact the economic growth. Even though there is some progress in the hiring percentage of women in large technological companies, a clear glass ceiling in leadership roles is still remains. Here, we have undertaken a pilot study at University Complutense of Madrid (UCM, Spain) aimed at empowering women in academia to transition from the "publish or perish" paradigm towards creating and protecting their intellectual property to close the gender gap in STEM fields and leadership roles as well as training to fuel the development of innovative start-ups addressing societal challenges. A total of 20 participants inclusive of UCM staff and postgraduate and postdoctoral researchers were enrolled after successfully obtaining at least a score of 5 out of 10 in custom-made Entrepreneurial competency test provided by Business and Professional Women Association (BPW, Spain) and theGrowBox Innovation Ltd. The study, approved by the UCM ethical committee, was conducted after participants engaged and completed a training programme on "Enterpreneurship in STEM-related fields in Higher Education" aimed to introduce the participants to the entrepreneurial world. This involved a structured training programme covering the (i) business canvas design; (ii) development of minimum viable product (MVP); (iii) market evaluation; (iv) ...

العلاقة: gbv-ppn:1884195695; Journal: Journal of Innovation and Entrepreneurship; Volume: 12; Year: 2023; Issue: 1; Pages: 1-18; https://hdl.handle.net/10419/290301Test

الإتاحة: https://doi.org/10.1186/s13731-023-00346-4Test
https://hdl.handle.net/10419/290301Test

المؤلفون: Pascual Izquierdo, Cristina, Mingot Castellano, María Eva, Kerguelen Fuentes, Ana E., García-Arroba Peinado, José, Cid, Joan, Moraima Jimenez, Maria, Valcarcel, David, Gómez Seguí, Inés, de la Rubia, Javier, Martin, Paz, Goterris, Rosa, Hernández, Luis, Tallón, Inmaculada, Varea, Sara, Fernández, Marta, García Muñoz, Nadia, Vara, Míriam, Fernández Zarzoso, Miguel, García Candel, Faustino, Paciello, María Liz, García García, Irene, Zalba, Saioa, Campuzano, Verónica, Gala, José María, Vidán Estévez, Julia, Moreno Jiménez, Gemma, López Lorenzo, José Luis, González Arias, Elena, Freiría, Carmen, Solé, María, Ávila Idrovo, Laura Francisca, Hernández Castellet, José Carlos, Cruz, Naylen, Lavilla, Esperanza, Pérez Montaña, Albert, Atucha, Jon Ander, Moreno Beltrán, María Esperanza, Moreno Macías, Juán Ramón, Salinas, Ramón, del Rio Garma, Julio

المصدر: Blood Advances. Vol. 6, nº 24, December 2022, pp. 6219 - 6227

مصطلحات موضوعية: caplacizumab, prednisone, rituximab

الوصف: Immune thrombotic thrombocytopenic purpura (iTTP) is a thrombotic microangiopathy caused by anti-ADAMTS13 antibodies. Caplacizumab is approved for adults with an acute episode of iTTP in conjunction with plasma exchange (PEX) and immunosuppression. The objective of this study was to analyze and compare the safety and efficacy of caplacizumab vs the standard of care and assess the effect of the concomitant use of rituximab. A retrospective study from the Spanish TTP Registry of patients treated with caplacizumab vs those who did not receive it was conducted. A total of 155 patients with iTTP (77 caplacizumab, 78 no caplacizumab) were included. Patients initially treated with caplacizumab had fewer exacerbations (4.5% vs 20.5%; P < .05) and less refractoriness (4.5% vs 14.1%; P < .05) than those who were not treated. Time to clinical response was shorter when caplacizumab was used as initial treatment vs caplacizumab used after refractoriness or exacerbation. The multivariate analysis showed that its use in the first 3 days after PEX was associated with a lower number of PEX (odds ratio, 7.5; CI, 2.3-12.7; P < .05) and days of hospitalization (odds ratio, 11.2; CI, 5.6-16.9; P < .001) compared with standard therapy. There was no difference in time to clinical remission in patients treated with caplacizumab compared with the use of rituximab. No severe adverse event was described in the caplacizumab group. In summary, caplacizumab reduced exacerbations and refractoriness compared with standard of care regimens. When administered within the first 3 days after PEX, it also provided a faster clinical response, reducing hospitalization time and the need for PEX. ; 9 páginas

وصف الملف: application/pdf

العلاقة: http://hdl.handle.net/10498/29789Test

الإتاحة: https://doi.org/10.1182/bloodadvances.2022008028Test
http://hdl.handle.net/10498/29789Test

المؤلفون: Rodrigo Caresani, Martín Paz

المصدر: Revista Chuy, Vol 10, Iss 14 (2023)

مصطلحات موضوعية: Archivos latinoamericanos, Humanidades digitales, Latin American Archives, Digital Humanities, Literature (General), PN1-6790, French literature - Italian literature - Spanish literature - Portuguese literature, PQ1-3999

الوصف: El escenario de pandemia y post-pandemia implicó una aceleración masiva y violenta de la alfabetización digital. En este contexto, las bibliotecas, los archivos, los museos y las instituciones de la memoria en general asumieron un rol de protagonismo no solo por el caudal de documentos que pusieron al alcance de un público “en cuarentena” sino como verdaderos laboratorios donde se ensayan y diseñan los métodos para tejer las comunidades del mañana. Por estos factores, ante la coyuntura reciente, las políticas de digitalización cobraron un predominio decisivo en las instituciones de guarda de acervos bibliográficos y archivísticos. En algunos casos, se trata de programas que funcionaban desde hacía años; en otros, de tareas muy incipientes. La necesidad de volver disponibles documentos para la consulta remota contribuyó a mejorar las prácticas y hacerlas más eficaces. Al mismo tiempo, estimuló la reflexión sobre la naturaleza de estos programas y su pertinencia prioritaria. Sin embargo, como hito inicial para un debate, cabría preguntarse si el supuesto potencial democratizador de la conectividad global puede trasladarse sin reparos ni retrocesos a América Latina.

العلاقة: https://revistas.untref.edu.ar/index.php/chuy/article/view/1744Test; https://doaj.org/toc/2422-5932Test; https://doaj.org/article/28a2d48165c046e688bee390e3214ac0Test

الإتاحة: https://doaj.org/article/28a2d48165c046e688bee390e3214ac0Test

المؤلفون: Prieto Martin, Paz

المساهمون: Ono, Masahiro

مصطلحات موضوعية: 616.07

الوصف: T cell development and differentiation are dependent on T cell receptor (TCR) signalling. This project investigates the events downstream of TCR-signalling in CD4+T cell development and differentiation by studying the transcriptional dynamics of two key genes in individual cells: an immediate early transcribed gene upon TCR engagement (Nr4a3) and a more lately transcribed gene following TCR signalling (Foxp3). Because there were no technologies to study those transcriptional dynamics in vivo in individual cells, a new reporter technology (a fluorescent timer protein called Timer) was used. The first part of this project establishes two new transgenic mouse strains expressing Timer fluorescent protein, Nr4a3Timer and Foxp3Timer. Several independent reporter lines were assessed by their Timer expression, and selected. The second part studies the dynamics of Timer protein expression in the selected transgenic strains. An analysis framework was established to reveal the dynamics of expression of the reported genes (Nr4a3 and Foxp3) by using the expression and colour maturation of Timer. The last part of the project was dedicated to addressing biological questions using our new fluorescent reporter strains. First, I used the Timer technology to investigate the temporal dynamics of Nr4a3, CD25 and Foxp3 expression during neonatal thymocyte development upon TCR signalling. This information placed CD25 expression as an early event downstream of TCR signalling, while Foxp3 expression appeared later on, with or without coexpression of CD25. Second, the investigation of the mechanisms downstream of TCR-signalling in peripheral CD4+ T cells in vitro showed the modulatory role of IL-6 and TGFβ on Nr4a3 expression. Finally, investigation of the role of Nr4a3 overexpression in T cell apoptosis showed that Nr4a3 proapoptotic effects are context- dependent, depending on the cytokine environment. This project constitutes the first application of a fluorescent timer reporter system to the field of T cell immunology. It also provides a better understanding of the role of Nr4a3 in TCR-mediated events in T cell differentiation and activation.

الوصول الحر: https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.806435Test

المؤلفون: García-Botella, Alejandra, Martín, Paz, Méndez, Ramiro, Ortega, Luis, Méndez, Jose, Sastre, Javier, Diez-Valladares, Luis, Torres, Antonio J.

المساهمون: Fundacion Mutua Madrilena

المصدر: HPB ; volume 26, issue 4, page 603-605 ; ISSN 1365-182X

مصطلحات موضوعية: Gastroenterology, Hepatology

الإتاحة: https://doi.org/10.1016/j.hpb.2024.01.008Test
https://api.elsevier.com/content/article/PII:S1365182X2400008X?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S1365182X2400008X?httpAccept=text/plainTest

المؤلفون: Pascual Izquierdo, Cristina, Mingot Castellano, María Eva, Kerguelen Fuentes, Ana E., García Arroba Peinado, José, Cid Vidal, Joan, Jimenez, Maria Moraima, Valcarcel, David, Gómez Seguí, Inés, Rubia, Javier de la, Martin, Paz, Goterris, Rosa, Hernández, Luis, Tallón, Inmaculada, Varea, Sara, Fernández, Marta, García Muñoz, Nadia, Vara, Míriam, Fernández Zarzoso, Miguel, García Candel, Faustino, Paciello, María Liz, García García, Irene, Zalba, Saioa, Campuzano, Verónica, Gala, José María, Vidán Estévez, Julia, Moreno Jiménez, Gemma, López Lorenzo, José Luis, González Arias, Elena, Freiría, Carmen, Solé, María, Ávila Idrovo, Laura Francisca, Hernández Castellet, José Carlos, Cruz, Naylen, Lavilla, Esperanza, Pérez Montaña, Albert, Atucha, Jon Ander, Moreno Beltrán, María Esperanza, Moreno Macías, Juán Ramón, Salinas, Ramón, Rio Garma, Julio del, Spanish Apheresis Group (GEA), Spanish Thrombotic Thrombocytopenic Purpura Registry (REPTT)

المصدر: Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))

مصطلحات موضوعية: Rituximab, Trombosi, Assaigs clínics, Thrombosis, Clinical trials

الوصف: Immune thrombotic thrombocytopenic purpura (iTTP) is a thrombotic microangiopathy caused by anti-ADAMTS13 antibodies. Caplacizumab is approved for adults with an acute episode of iTTP in conjunction with plasma exchange (PEX) and immunosuppression. The objective of this study was to analyze and compare the safety and efficacy of caplacizumab vs the standard of care and assess the effect of the concomitant use of rituximab. A retrospective study from the Spanish TTP Registry of patients treated with caplacizumab vs those who did not receive it was conducted. A total of 155 patients with iTTP (77 caplacizumab, 78 no caplacizumab) were included. Patients initially treated with caplacizumab had fewer exacerbations (4.5% vs 20.5%; P < .05) and less refractoriness (4.5% vs 14.1%; P < .05) than those who were not treated. Time to clinical response was shorter when caplacizumab was used as initial treatment vs caplacizumab used after refractoriness or exacerbation. The multivariate analysis showed that its use in the first 3 days after PEX was associated with a lower number of PEX (odds ratio, 7.5; CI, 2.3-12.7; P < .05) and days of hospitalization (odds ratio, 11.2; CI, 5.6-16.9; P < .001) compared with standard therapy. There was no difference in time to clinical remission in patients treated with caplacizumab compared with the use of rituximab. No severe adverse event was described in the caplacizumab group. In summary, caplacizumab reduced exacerbations and refractoriness compared with standard of care regimens. When administered within the first 3 days after PEX, it also provided a faster clinical response, reducing hospitalization time and the need for PEX.

وصف الملف: 9 p.; application/pdf

العلاقة: Reproducció del document publicat a: https://doi.org/10.1182/bloodadvances.2022008028Test; Blood Advances, 2022, vol. 6, num. 24, p. 6219-6227; https://doi.org/10.1182/bloodadvances.2022008028Test; http://hdl.handle.net/2445/196688Test

الإتاحة: https://doi.org/10.1182/bloodadvances.2022008028Test
http://hdl.handle.net/2445/196688Test

المؤلفون: Pascual, Cristina, Mingot-Castellano, María Eva, Kerguelen Fuentes, Ana E., García-Arroba, José, Cid, Joan, Jimenez, Moraima, Valcárcel, David, Gómez-Seguí, Inés, de la Rubia, Javier, Martin, Paz, Goterris, Rosa, Hernández, Luis, Tallón, Inmaculada, Varea, Sara, Fernández, Marta, García-Muñoz, Nadia, Vara, Míriam, Fernández-Zarzoso, Miguel, García-Candel, Faustino, Paciello, María Liz, García-García, Irene, Zalba, Saioa, Campuzano, Verónica, Gala, José María, Vidan, Julia, Moreno-Jiménez, Gemma, López Lorenzo, José Luis, González Arias, Elena, Freiría, Carmen, Solé, María, Ãvila Idrovo, Laura Francisca, Hernández Castellet, José Carlos, Cruz, Naylen, Lavilla, Esperanza, Pérez-Montaña, Albert, Atucha, Jon Ander, Moreno Beltrán, María Esperanza, Moreno Macías, Juan Ramón, Salinas, Ramón, del Rio-Garma, Julio

الوصف: Immune thrombotic thrombocytopenic purpura (iTTP) is a thrombotic microangiopathy caused by anti-ADAMTS13 antibodies. Caplacizumab is approved for adults with an acute episode of iTTP in conjunction with plasma exchange (PEX) and immunosuppression. The objective of this study was to analyze and compare the safety and efficacy of caplacizumab vs the standard of care and assess the effect of the concomitant use of rituximab. A retrospective study from the Spanish TTP Registry of patients treated with caplacizumab vs those who did not receive it was conducted. A total of 155 patients with iTTP (77 caplacizumab, 78 no caplacizumab) were included. Patients initially treated with caplacizumab had fewer exacerbations (4.5% vs 20.5%; P <.05) and less refractoriness (4.5% vs 14.1%; P <.05) than those who were not treated. Time to clinical response was shorter when caplacizumab was used as initial treatment vs caplacizumab used after refractoriness or exacerbation. The multivariate analysis showed that its use in the first 3 days after PEX was associated with a lower number of PEX (odds ratio, 7.5; CI, 2.3-12.7; P <.05) and days of hospitalization (odds ratio, 11.2; CI, 5.6-16.9; P <.001) compared with standard therapy. There was no difference in time to clinical remission in patients treated with caplacizumab compared with the use of rituximab. No severe adverse event was described in the caplacizumab group. In summary, caplacizumab reduced exacerbations and refractoriness compared with standard of care regimens. When administered within the first 3 days after PEX, it also provided a faster clinical response, reducing hospitalization time and the need for PEX.

وصف الملف: application/pdf

العلاقة: Blood advances; Vol. 6 Núm. 24 (December 2022), p. 6219-6227; https://ddd.uab.cat/record/282297Test; urn:10.1182/bloodadvances.2022008028; urn:oai:ddd.uab.cat:282297; urn:scopus_id:85141669213; urn:articleid:24739537v6n24p6219; urn:pmid:35930694; urn:pmc-uid:9792393; urn:pmcid:PMC9792393; urn:oai:pubmedcentral.nih.gov:9792393

الإتاحة: https://ddd.uab.cat/record/282297Test

المؤلفون: Castrillo Bustamante, Concepción, Martín, Paz, Arnal, María, Serrano, Araceli

مصطلحات موضوعية: Gender regimes, vulnerable households, social resilience, poverty

الوصف: This chapter focuses on the relationship between gender and resilience in households strongly affected by the economic crisis and subsequent recession of the last decade. More specifically, in the first section the aim is to analyse the ways in which different gender regimes in the households studied helped or hampered their capacity to overcome hardship during this period, while the second section explores the ways in which different coping styles and the strategies set in motion to overcome difficulties in turn influenced gender relations at the household level, shaking up existing gender orders. ; 2020-21

العلاقة: Poverty, crisis and resilience. New Horizons in Social Policy series; http://hdl.handle.net/20.500.12226/440Test

الإتاحة: https://doi.org/20.500.12226/440Test
https://hdl.handle.net/20.500.12226/440Test