المؤلفون: Escrichs, Anira, Sanz Perl, Yonatan, Martínez-Molina, Noelia, Biarnés, Carles, Garre Olmo, Josep, Fernández Real, José Manuel, Ramos, Rafel, Martí, Ruth, Pamplona Gras, Reinald, Brugada, Ramon, Serena, Joaquín, Ramió Torrentà, Lluís, Coll-De-Tuero, Gabriel, Gallart, Luís, Barretina Ginesta, Jordi, Vilanova, Joan Carles, Mayneris Perxachs, Jordi, Saba, Luca, Pedraza, Salvador, Kringelbach, Morten L., Puig, Josep, Deco, Gustavo

مصطلحات موضوعية: Aging, Computational modeling, Resting-state fMRI, Brain states, In silico perturbations

الوصف: Understanding the brain changes occurring during aging can provide new insights for developing treatments that alleviate or reverse cognitive decline. Neurostimulation techniques have emerged as potential treatments for brain disorders and to improve cognitive functions. Nevertheless, given the ethical restrictions of neurostimulation approaches, in silico perturbation protocols based on causal whole-brain models are fundamental to gaining a mechanistic understanding of brain dynamics. Furthermore, this strategy could serve to identify neurophysiological biomarkers differentiating between age groups through an exhaustive exploration of the global effect of all possible local perturbations. Here, we used a resting-state fMRI dataset divided into middle-aged (N =310, <65 years) and older adults (N =310, ≥ 65) to characterize brain states in each group as a probabilistic metastable substate (PMS) space. We showed that the older group exhibited a reduced capability to access a metastable substate that overlaps with the rich club. Then, we fitted the PMS to a whole-brain model and applied in silico stimulations in each node to force transitions from the brain states of the older- to the middle-aged group. We found that the precuneus was the best stimulation target. Overall, these findings could have important implications for designing neurostimulation interventions for reversing the effects of aging on whole-brain dynamics. ; AE, YS and GD were supported by the HBP SGA3 Human Brain Project Specific Grant Agreement 3 (grant agreement no. 945539), funded by the EU H2020 FET Flagship.

العلاقة: Versió preprint del document publicat a https://doi.org/10.1093/cercor/bhac064Test; Cerebral Cortex, 2023, vol. 33, núm. 1, p. 235-245; info:eu-repo/grantAgreement/EC/H2020/945539/EU/HBP SGA3; https://doi.org/10.1093/cercor/bhac064Test; https://repositori.udl.cat/handle/10459.1/464515Test

الإتاحة: https://doi.org/10.1093/cercor/bhac064Test
https://repositori.udl.cat/handle/10459.1/464515Test

المؤلفون: Gómez-Sánchez, Leticia, Rodríguez-Sánchez, Emiliano, Ramos, Rafel, Marti, Ruth, Gómez-Sánchez, Marta, Lugones-Sánchez, Cristina, Tamayo-Morales, Olaya, Sánchez, Susana Gonzalez, Rigo, Fernando, García-Ortiz, Luis, Gómez-Marcos, Manuel A., Martí, Ruth, Parramon, Dídac, Ponjoan, Anna, Quesada, Miquel, Garcia-Gil, Maria, Sidera, Martina, Camós, Lourdes, Montesinos, Fernando, Montoya, Ignacio, López, Carlos, Agell, Anna, Pagès, Núria, Gil, Irina, Maria-Castro, Anna, Frontera, Guillermo, Rotger, Antònia, Feuerbach, Natalia, Pons, Susana, Garcia, Natividad, Guillaumet, John, Llull, Micaela, Gutierrez, Mercedes, Agudo-Conde, Cristina, Gómez-Sanchez, Leticia, Castaño-Sanchez, Carmen, Rodriguez-Martín, Carmela, Sanchez-Salgado, Benigna, de Cabo-Laso, Angela, Rodriguez-Sanchez, Emiliano, MaderueloFernandez, Jose Angel, Ramos-Delgado, Emilio, Patino-Alonso, Carmen, Recio-Rod-riguez, Jose I., Gomez-Marcos, Manuel A., Garcia-Ortiz, Luis

المساهمون: Instituto de Salud Carlos III, Junta de Castilla y León

المصدر: Biology of Sex Differences ; volume 13, issue 1 ; ISSN 2042-6410

مصطلحات موضوعية: Endocrinology, Gender Studies

الوصف: Background The aim of this study was to analyze the association of physical activity and its intensity with arterial stiffness and vascular aging and differences by sex in a Spanish population with intermediate cardiovascular risk. Methods Cross-sectional study. A total of 2475 individuals aged 35–75 years participated in the study. Brachial–ankle pulse wave velocity (baPWV) was measured using a VaSera VS-1500 ® device. Based on the age and sex percentile presented by the participants, the latter were classified as follows: those with a percentile above 90 and presenting established cardiovascular disease were classified as early vascular aging (EVA); those with a percentile between 10 and 90 were classified as normal vascular aging (NVA) and those with a percentile below 10 were classified as healthy vascular aging (HVA). Physical activity was analyzed through the short version of the Minnesota Leisure Time Physical Activity Questionnaire (MLTPAQ). Results The mean age of the participants was 61.34 ± 7.70 years, with 61.60% men. Of the total sample, 86% were sedentary (83% men vs 90% women). The total physical activity showed a negative association with baPWV ( β = − 0.045; 95% CI − 0.080 to − 0.009). Intense physical activity showed a negative relationship with baPWV ( β = − 0.084; 95% CI − 0.136 to − 0.032). The OR of the total physical activity and the intense physical activity carried out by the subjects classified as NVA with respect to those classified as HVA was OR = 0.946; (95% CI 0.898 to 0.997) and OR = 0.903; (95% CI 0.840 to 0.971), and of those classified as EVA it was OR = 0.916; (95% CI 0.852 to 0.986) and OR = 0.905; (95% CI 0.818 to 1.000). No association was found with moderate- or low-intensity physical activity. Conclusions The results of this study suggest that, when intense physical activity is performed, the probability of presenting vascular aging is lower. In the analysis by sex, this association is only observed in men.

الإتاحة: https://doi.org/10.1186/s13293-022-00456-wTest

المؤلفون: Escrichs, Anira, Sanz Perl, Yonatan, Martínez-Molina, Noelia, Biarnés, Carles, Garre Olmo, Josep, Fernández Real, José Manuel, Ramos, Rafel, Martí, Ruth, Pamplona Gras, Reinald, Brugada, Ramon, Serena, Joaquín, Ramió Torrentà, Lluís, Coll-De-Tuero, Gabriel, Gallart, Luís, Barretina Ginesta, Jordi, Vilanova, Joan Carles, Mayneris Perxachs, Jordi, Saba, Luca, Pedraza, Salvador, Kringelbach, Morten, Puig, Josep, Deco, Gustavo

مصطلحات موضوعية: Aging, Computational modeling, Resting-state fMRI, Brain states, In silico perturbations

الوصف: Understanding the brain changes occurring during aging can provide new insights for developing treatments that alleviate or reverse cognitive decline. Neurostimulation techniques have emerged as potential treatments for brain disorders and to improve cognitive functions. Nevertheless, given the ethical restrictions of neurostimulation approaches, in silico perturbation protocols based on causal whole-brain models are fundamental to gaining a mechanistic understanding of brain dynamics. Furthermore, this strategy could serve to identify neurophysiological biomarkers differentiating between age groups through an exhaustive exploration of the global effect of all possible local perturbations. Here, we used a resting-state fMRI dataset divided into middle-aged (N =310, <65 years) and older adults (N =310, ≥65) to characterize brain states in each group as a probabilistic metastable substate (PMS) space. We showed that the older group exhibited a reduced capability to access a metastable substate that overlaps with the rich club. Then, we fitted the PMS to a whole-brain model and applied in silico stimulations in each node to force transitions from the brain states of the older- to the middle-aged group. We found that the precuneus was the best stimulation target. Overall, these findings could have important implications for designing neurostimulation interventions for reversing the effects of aging on whole-brain dynamics.

العلاقة: Reproducció del document publicat a https://doi.org/10.1093/cercor/bhac064Test; Cerebral Cortex, 2022, vol. 33, núm. 1, p. 235-245.; http://hdl.handle.net/10459.1/84870Test; https://doi.org/10.1093/cercor/bhac064Test

الإتاحة: https://doi.org/10.1093/cercor/bhac064Test
http://hdl.handle.net/10459.1/84870Test

المؤلفون: Gomez-Marcos, Manuel A., Gomez-Sanchez, Leticia, Patino-Alonso, Maria C., Recio-Rodriguez, Jose I., Gomez-Sanchez, Marta, Rigo, Fernando, Marti, Ruth, Agudo-Conde, Cristina, Maderuelo-Fernandez, Jose A., Ramos, Rafel, Garcia-Ortiz, Luis, Rodriguez-Sanchez, Emiliano

المساهمون: Feng, Ying-Mei, Spanish Ministry of Science and Innovation, the Carlos III Health Institute/European Regional Development Fund, Regional Health Management of Castile and León

المصدر: PLOS ONE ; volume 14, issue 1, page e0209992 ; ISSN 1932-6203

الإتاحة: https://doi.org/10.1371/journal.pone.0209992Test

المؤلفون: Garcia-Gil, Maria, Comas-Cufí, Marc, Blanch, Jordi, Martí, Ruth, Ponjoan, Anna, Alves-Cabratosa, Lia, Petersen, Irene, Marrugat, Jaume, Elosua, Roberto, Grau, María, Ramos, Rafel

المصدر: Garcia-Gil , M , Comas-Cufí , M , Blanch , J , Martí , R , Ponjoan , A , Alves-Cabratosa , L , Petersen , I , Marrugat , J , Elosua , R , Grau , M & Ramos , R 2018 , ' Effectiveness of Statins as Primary Prevention in People With Different Cardiovascular Risk: A Population-Based Cohort Study ' , Clinical Pharmacology and Therapeutics , vol. 104 , no. 4 , pp. 719-732 . https://doi.org/10.1002/cpt.954Test

الوصف: The purpose was to analyze statin effectiveness in a general population with differing levels of coronary heart disease (CHD) risk. Patients (35-74 years) without previous cardiovascular disease were included and stratified according to 10-year CHD risk (<5%, 5-7.4%, 7.5-9.9%, and 10-19.9%). New users were categorized according to their medical possession ratio (MPR). The main outcome was atherosclerotic cardiovascular disease (ASCVD) (myocardial infarction and ischemic stroke). In adherent patients (MPR 70%), statin treatment decreased ASCVD risk across the range of coronary risk (from 16-30%). The 5-year number needed to treat (NNT) was 470 and 204 in the risk categories <5% and 5-7.4%, respectively, and 75 and 62 in the 7.5-9.9% category than in the 10-19.9% category, respectively. Statin therapy should remain a priority in patients at high 10-year CHD risk (10-19.9%). Most patients with intermediate risk could benefit from statin treatment, but the treatment decision should focus on the net benefit, safety, and patient preference, given the higher NNT.

وصف الملف: application/pdf

الإتاحة: https://doi.org/10.1002/cpt.954Test
https://pure.au.dk/portal/da/publications/effectiveness-of-statins-as-primary-prevention-in-people-with-different-cardiovascular-risk-a-populationbased-cohort-studyTest(84d7e6d2-5974-4c4b-9c78-4596bec4d925).html
https://pure.au.dk/ws/files/169179396/cpt.954.pdfTest

المؤلفون: Gomez-Marcos, Manuel A., Gomez-Sanchez, Leticia, Patino-Alonso, Maria Carmen, Recio-Rodriguez, Jose I., Gomez-Sanchez, Marta, Rigo, Fernando, Marti, Ruth, Agudo-Conde, Cristina, Ramos, Rafel, Rodriguez-Sanchez, Emiliano, Maderuelo-Fernandez, Jose A., Garcia-Ortiz, Luis

المصدر: Medicine ; volume 97, issue 47, page e13299 ; ISSN 0025-7974 1536-5964

الوصف: A body shape index (ABSI) has been introduced as a marker of the relationship between body composition and all-cause mortality. However, until now, the relationships between ABSI and vascular structure and function have not been evaluated. The aim of this study was to investigate the association of ABSI with vascular structure and function in Spanish adults with intermediate cardiovascular risk. This cross-sectional study analyzed the data of 2354 subjects [age, 35–74 years (median, 62.0 years [range, 56.0–67.0 years]), 61.9% men] enrolled into the MediAte Risk management (MARK) study. ABSI was calculated by using the following formula: ABSI = waist circumference (m)/[body mass index 2/3 × height (m) 1/2 )]. Vascular function was assessed by measuring cardio-ankle vascular index (CAVI) with the VaSera device and brachial ankle pulse wave velocity (baPWV) by using a validated equation. Vascular structure was assessed by measuring carotid intima-media thickness (IMT) by ultrasonography. Median value of ABSI was 0.083 (range, 0.081–0.090), mean CAVI was (8.5 ± 1.2), and median IMT was 0.727 (range, 0.672–0.799). The values of ABSI and CAVI were higher in men. After adjusting for confounders, ABSI was positively associated with CAVI, baPWV, and average mean IMT. Thus, for each unit increase in ABSI, CAVI increased by 0.16 units, baPWV by 0.25 m/s, and IMT by 0.033 mm. In the logistic regression analysis, the odds ratio of ABSI was > 1 for high CAVI ≥ 9, baPWV ≥ 15 m/s, and IMT ≥ 0.90 mm in the overall subject group, and in the sex- and age-specific (> 62 years, ≤ 62 years) subgroups, after adjusting for confounders. The area under the receiver-operating characteristic curve of the ABSI was 0.631 (95% confidence interval [CI], 0.608–0.654) for CAVI ≥ 9, and 0.617 (95% CI, 0.593–0.641) for high baPWV ≥ 15 m/s. ABSI showed a positive association with vascular structure and function, independent of other confounders that might influence weight and fat mass distribution in Spanish subjects at intermediate ...

الإتاحة: https://doi.org/10.1097/md.0000000000013299Test
https://journals.lww.com/00005792-201811210-00042Test

المؤلفون: Gómez Sánchez, Leticia, García Ortiz, Luis, Patino Alonso, María Carmen, Recio Rodríguez, José Ignacio, Feuerbach, Natalia, Marti, Ruth, Agudo Conde, Cristina, Rodríguez Sánchez, Emiliano, Maderuelo Fernández, José A., Ramos, Rafael, Gómez Marcos, Manuel Ángel

مصطلحات موضوعية: Diabetology, Diabetes, Cardiovascular diseases, Biomakers, Vascular Stiffness

الوصف: [EN]BACKGROUND: Effect of prediabetes and normal glucose on arterial stiffness remains controversial. The primary aim of this study was to investigate the relationship of fasting plasma glucose (FPG), postprandial glucose (PG) and glycosylated haemoglobin (HbA1c) with brachial-ankle pulse wave velocity (baPWV) and cardio-ankle vascular index (CAVI) in Caucasian adults. The secondary aim was to analyse this relationship by glycaemic status. METHODS: Cross-sectional study. Setting: Primary care. Participants: 2,233 subjects, 35-74 years. Measures: FPG (mg/dL) and HbA1c (%) of all subjects were measured using standard automated enzymatic methods. PG (mg/dL) was self-measured at home two hours after meals (breakfast, lunch and dinner) for one day using an Accu-chek ® glucometer. CAVI was measured using a VaSera VS-1500® device (Fukuda Denshi), and baPWV was calculated using a validated equation. RESULTS: CAVI and baPWV values were significantly higher in subjects with diabetes mellitus than in glucose normal and prediabetes groups (p<0.001). FPG, PG and HbA1c were positively associated with CAVI and baPWV. The β regression coefficient for: HbA1c was 0.112 (CI 95% 0.068 to 0.155) with CAVI, 0.266 (CI 95% 0.172 to 0.359) with baPWV; for PG was 0.006 (CI 95% 0.004 to 0.009 and for FPG was 0.005 (CI 95% 0.002 to 0.008) with baPWV; and for PG was 0.002 (CI 95% 0.001 to 0.003) and 0.003 (CI 95% 0.002 to 0.004) with CAVI (p<0.01 in all cases). When analysing by hyperglycaemic status, FPG, PG and HbA1c were positively associated with CAVI and baPWV in subjects with type 2 diabetes mellitus. CONCLUSION: FPG, PG and HbA1c show a positive association with CAVI and baPWV, in Caucasian adults with intermediate cardiovascular risk factors. When analysing by hyperglycaemic status, the association is only maintained in subjects with type 2 diabetes mellitus.

العلاقة: https://doi.org/10.1371/journal.pone.0175982Test; Gómez-Sánchez, L. García-Ortiz, L. Patino-Alonso, M.C. Recio-Rodríguez, J.I. Feuerbach, N. Marti, R. et al. (2017). Glycemic markers and relation with arterial stiffness in Caucasian subjects of the MARK study. PLoS ONE 12(4): e0175982. https://doi.org/10.1371/journal.pone.0175982Test; http://hdl.handle.net/10366/135884Test

الإتاحة: https://doi.org/10.1371/journal.pone.0175982Test
http://hdl.handle.net/10366/135884Test

المؤلفون: Recio-Rodriguez, Jose I., Garcia-Yu, Irene A., Alonso-Dominguez, Rosario, Maderuelo-Fernandez, José A., Patino-Alonso, Maria C., Agudo-Conde, Cristina, Sanchez-Aguadero, Natalia, Ramos, Rafel, Marti, Ruth, Rodriguez-Sanchez, Emiliano, Gómez-Marcos, Manuel A., Garcia-Ortiz, Luis

المساهمون: Instituto de Salud Carlos III, Regional Health Management of the Castilla and León

المصدر: Nutrition Journal ; volume 16, issue 1 ; ISSN 1475-2891

مصطلحات موضوعية: Nutrition and Dietetics, Medicine (miscellaneous)

الإتاحة: https://doi.org/10.1186/s12937-017-0266-1Test

المؤلفون: Gomez-Sanchez, Leticia, Garcia-Ortiz, Luis, Patino-Alonso, Maria C., Recio-Rodriguez, Jose I., Feuerbach, Natalia, Marti, Ruth, Agudo-Conde, Cristina, Rodriguez-Sanchez, Emiliano, Maderuelo-Fernandez, Jose A., Ramos, Rafel, Gomez-Marcos, Manuel A.

المساهمون: Hribal, Marta Letizia, Spanish Ministry of Science and Innovation (MICINN), Carlos III Health Institute/European Regional Development Fund, Regional Health Management of Castile and León

المصدر: PLOS ONE ; volume 12, issue 4, page e0175982 ; ISSN 1932-6203

الإتاحة: https://doi.org/10.1371/journal.pone.0175982Test

المؤلفون: Gomez-Sanchez, Leticia, Garcia-Ortiz, Luis, Patino-Alonso, Maria C, Recio-Rodriguez, Jose I, Rigo, Fernando, Martí, Ruth, Agudo-Conde, Cristina, Rodriguez-Sanchez, Emiliano, Maderuelo-Fernandez, Jose A, Ramos, Rafel, Gomez-Marcos, Manuel A

المساهمون: Spanish Ministry of Science and Innovation (MICINN), the Carlos III Health Institute/European Regional Development Fund (ERDF), the Regional Health Management of Castile and León

المصدر: BMJ Open ; volume 7, issue 9, page e016422 ; ISSN 2044-6055 2044-6055

مصطلحات موضوعية: General Medicine

الوصف: Background The cardiovascular risk of obesity is potentially increased by arterial stiffness. Objective To assess the relationship of adiposity measures with arterial stiffness in Caucasian adults with intermediate cardiovascular risk. Setting Six Spanish health centres. Participants We enrolled 2354 adults (age range, 35–74 years; mean age, 61.4±7.7 years, 61.9% male). Methods This is a cross-sectional study that analyses data from the baseline visit of the improving interMediAte RisK management (MARK) study. The main outcome variables were body mass index (BMI), waist-to-height ratio (WHtR), Clínica Universidad de Navarra-body adiposity estimation (CUN-BAE) body fat percentage and body roundness index (BRI). Vascular function was assessed by the cardio-ankle vascular index (CAVI) with the VaSera device; brachial-ankle pulse wave velocity (baPWV) was determined using a validated equation. Results The mean adiposity measures were a BMI of 29.2±4.4, WHtR of 0.61±0.07, CUN-BAE of 35.7±1.7 and BRI of 5.8±1.7. The mean stiffness measures were a CAVI of 8.8±1.2 and baPWV of 14.9±2.5. In multiple linear regression analyses, all adiposity measures were negatively associated with CAVI and baPWV (p<0.01 for all) after adjustment for possible factors of confusion. The proportion of CAVI variability via the adiposity measures were 5.5% for BMI, 5.8% for CUN-BAE, 3.8% for WHtR and 3.7% for BRI. These were higher among diabetic, obese, younger (≤62 years) and non-hypertensive subjects who had similar activity and sedentary profiles. Conclusions Adiposity measures are negatively associated with arterial stiffness measures. The percentage of variation in CAVI explained by its relation to the different measures of adiposity ranges from 5.8% (CUN-BAE) to 3.7% (BRI). In the case of baPWV, it oscillates between 0.7% (CUN-BAE and BMI) and 0.1% (WHtR). Trial registration number NCT01428934.

الإتاحة: https://doi.org/10.1136/bmjopen-2017-016422Test