المؤلفون: Marshall, Anne, Kalteniece, Alise, Ferdousi, Maryam, Azmi, Shazli, Jude, Edward B, Adamson, Clare, D’Onofrio, Luca, Dhage, Shaishav, Soran, Handrean, Campbell, Jackie, Lee-Kubli, Corinne A, Hamdy, Shaheen, Malik, Rayaz A, Calcutt, Nigel A, Marshall, Andrew G

المصدر: Brain Communications. 5(2)

مصطلحات موضوعية: Biomedical and Clinical Sciences, Neurosciences, Clinical Sciences, Neurodegenerative, Peripheral Neuropathy, Clinical Research, Chronic Pain, Mental Health, Diabetes, Pain Research, Aetiology, 2.1 Biological and endogenous factors, Neurological, diabetes, neuropathy, pain, spinal disinhibition, phenotype, Clinical sciences, Biological psychology

الوصف: The dominant sensory phenotype in patients with diabetic polyneuropathy and neuropathic pain is a loss of function. This raises questions as to which mechanisms underlie pain generation in the face of potentially reduced afferent input. One potential mechanism is spinal disinhibition, whereby a loss of spinal inhibition leads to increased ascending nociceptive drive due to amplification of, or a failure to suppress, incoming signals from the periphery. We aimed to explore whether a putative biomarker of spinal disinhibition, impaired rate-dependent depression of the Hoffmann reflex, is associated with a mechanistically appropriate and distinct pain phenotype in patients with painful diabetic neuropathy. In this cross-sectional study, 93 patients with diabetic neuropathy underwent testing of Hoffmann reflex rate-dependent depression and detailed clinical and sensory phenotyping, including quantitative sensory testing. Compared to neuropathic patients without pain, patients with painful diabetic neuropathy had impaired Hoffmann reflex rate-dependent depression at 1, 2 and 3 Hz (P ≤ 0.001). Patients with painful diabetic neuropathy exhibited an overall loss of function profile on quantitative sensory testing. However, within the painful diabetic neuropathy group, cluster analysis showed evidence of greater spinal disinhibition associated with greater mechanical pain sensitivity, relative heat hyperalgesia and higher ratings of spontaneous burning pain. These findings support spinal disinhibition as an important centrally mediated pain amplification mechanism in painful diabetic neuropathy. Furthermore, our analysis indicates an association between spinal disinhibition and a distinct phenotype, arguably akin to hyperpathia, with combined loss and relative gain of function leading to increasing nociceptive drive.

وصف الملف: application/pdf

الوصول الحر: https://escholarship.org/uc/item/3jj8m210Test

المؤلفون: Taylor, Rachel, Marshall, Andrew G., Crimp, Steven, Cary, Geoffrey J., Harris, Sarah

مصطلحات موضوعية: Australia, extreme event skill score, subseasonal prediction, forecast skill, climate drivers, fire danger

الوصف: Fire danger poses a pressing threat to ecosystems and societies worldwide. Adequate preparation and forewarning can help reduce these threats, but these rely on accurate prediction of extreme fire danger. With the knowledge that climatic conditions contribute heavily to overall fire danger, this study evaluates the skill with which episodes of extreme fire danger in Australia can be predicted from the activity of large-scale climate driver patterns. An extremal dependence index for extreme events is used to depict the historical predictive skill of the Australian Bureau of Meteorology’s subseasonal climate prediction system in replicating known relationships between the probability of top-decile fire danger and climate driver states at a lead time of 2–3 weeks. Results demonstrate that the El Niño Southern Oscillation, Southern Annular Mode, persistent modes of atmospheric blocking, Indian Ocean Dipole and Madden-Julian Oscillation are all key for contributing to predictability of fire danger forecasts in different regions during critical fire danger periods. Northwest Australia is found to be particularly predictable, with the highest mean index differences (>0.50) when certain climate drivers are active, compared with the climatological index mean. This integrated approach offers a valuable resource for decision-making in fire-prone regions, providing greater confidence to users relying on fire danger outlooks for key management decisions, such as those involved in the sectors of national park and forest estate management, agriculture, emergency services, health and energy. Furthermore, the results highlight strengths and weaknesses in both the Australian Fire Danger Rating System and the operational climate model, contributing additional information for improving and refining future iterations of these systems.

وصف الملف: application/pdf

العلاقة: https://research.usq.edu.au/download/5446cd51f8979829c5f5797461c6c628a7ada856d817166b23c754957dd19250/5165906/atmosphere-15-00203.pdfTest; https://doi.org/10.3390/atmos15020203Test; Taylor, Rachel, Marshall, Andrew G., Crimp, Steven, Cary, Geoffrey J. and Harris, Sarah. 2024. "Climate Driver Influences on Prediction of the Australian Fire Behaviour Index." Atmosphere. 15 (2). https://doi.org/10.3390/atmos15020203Test

الإتاحة: https://doi.org/10.3390/atmos15020203Test
https://research.usq.edu.au/item/z5vx4/climate-driver-influences-on-prediction-of-the-australian-fire-behaviour-indexTest
https://research.usq.edu.au/download/5446cd51f8979829c5f5797461c6c628a7ada856d817166b23c754957dd19250/5165906/atmosphere-15-00203.pdfTest

المؤلفون: Cowan, Tim, Hinds, Emily, Marshall, Andrew G., Wheeler, Matthew C., Burgh-Day, Catherine

مصطلحات موضوعية: Australian monsoon, beef cattle, Bureau of Meteorolo, monsoon retreat, El Niño–Southern Oscillation, Madden–Julian Oscillation, prediction, wet season

الوصف: According to the Australian Bureau of Meteorology, the northern Australian wet season extends through to April, which also formally marks the end of Australia’s tropical cyclone season. Mid-autumn is when the tropical dry season transition period begins, when crop farmers prepare land for annual crops or pasture–fodder harvest, or when beef cattle producers make decisions regarding stock numbers and feed rationing. Potentially knowing if the last rains of the wet season will be later or earlier than normal would be valuable information for northern sectors such as agriculture, infrastructure and tourism. The Bureau of Meteorology provides seasonal forecasts of the Northern Rainfall Onset – the date when a location has accumulated 50 mm of rain from 1 September – yet there is currently no prediction of the rainy season retreat (the Northern Rainfall Retreat, NRR). In this study, we draw on three different NRR definitions and investigate how they vary with the El Niño–Southern Oscillation and the Madden–Julian Oscillation (MJO). In general, retreats occur ~1 week later than normal across the far northern tropics following La Niña events, but little change from normal occurs for El Niño. Although most retreats occur when the MJO is weak, if the MJO is active, retreats are mostly observed in phases 6 and 7, when convection is passing through the western Pacific. Utilising the Bureau of Meteorology’s sub-seasonal to seasonal forecast system, ACCESS-S2, we show that the model has some skill in forecasting the NRR across the far northern regions at a lead time of ~2.5 months, but poor skill in the subtropics and arid locations. Verification of the 2023 NRR forecasts, highlights the challenges of predicting the timing and magnitude of daily rainfall at such a long lead time.

وصف الملف: application/pdf

العلاقة: https://research.usq.edu.au/download/9ac300d2cf0ff0d715f8dc5be3afefe6f498817961572bcde807e87e86173e6b/7328360/ES23022.pdfTest; https://doi.org/10.1071/ES23022Test; Cowan, Tim, Hinds, Emily, Marshall, Andrew G., Wheeler, Matthew C. and Burgh-Day, Catherine. 2024. "Observing and forecasting the retreat of northern Australia’s rainy season." Journal of Southern Hemisphere Earth Systems Science. 74 (1). https://doi.org/10.1071/ES23022Test

الإتاحة: https://doi.org/10.1071/ES23022Test
https://research.usq.edu.au/item/z5qvy/observing-and-forecasting-the-retreat-of-northern-australia-s-rainy-seasonTest
https://research.usq.edu.au/download/9ac300d2cf0ff0d715f8dc5be3afefe6f498817961572bcde807e87e86173e6b/7328360/ES23022.pdfTest

المؤلفون: Jiang, Xiaoxuan, Holbrook, Neil J., Marshall, Andrew G., Love, Peter T.

مصطلحات موضوعية: Australian summer rainfall

الوصف: The variability and distribution of Australia’s summer rainfall are influenced by modes of climate variability on multi-week to multi-year time scales. Here, we investigate the role of the stratospheric quasi-biennial oscillation (QBO) and demonstrate that the QBO influences rainfall variations and extremes’ responses across large regions of Australia. We find the QBO modulates convective heating to the east of the Maritime Continent and over the central South Atlantic Ocean in the austral summer. The baroclinic response and barotropic structure of the extra-tropical Rossby wave train induces anomalous circulation that affects the distribution and amount of rainfall over Australia. Our analysis and findings of QBO teleconnections with the dynamics that drive Australia’s rainfall variability and extremes represents a pathway to improve our understanding of rainfall potential predictability and scope to extend Australia’s rainfall prediction lead times. © 2024, The Author(s).

وصف الملف: application/pdf

العلاقة: https://research.usq.edu.au/download/2c3e2506597df70293ac0910996d5c98bf49369f00d83e9c8f474c8c5ef2e03d/11331578/s41612-023-00552-7.pdfTest; https://doi.org/10.1038/s41612-023-00552-7Test; Jiang, Xiaoxuan, Holbrook, Neil J., Marshall, Andrew G. and Love, Peter T. 2024. "Quasi-Biennial Oscillation influence on Australian summer rainfall." Npj Climate and Atmospheric Science. 7 (1). https://doi.org/10.1038/s41612-023-00552-7Test

الإتاحة: https://doi.org/10.1038/s41612-023-00552-7Test
https://research.usq.edu.au/item/z5v2v/quasi-biennial-oscillation-influence-on-australian-summer-rainfallTest
https://research.usq.edu.au/download/2c3e2506597df70293ac0910996d5c98bf49369f00d83e9c8f474c8c5ef2e03d/11331578/s41612-023-00552-7.pdfTest

المؤلفون: Reid, Kimberley J., Hudson, Debra, King, Andrew D., Lane, Todd P., Marshall, Andrew G.

مصطلحات موضوعية: application/context, subseasonal, atmosphere, forecasting (methods), tools and methods, rainfall, physical phenomenon, subseasonal prediction, synoptic

الوصف: Extended warning of above-average and extreme precipitation is valuable to a wide range of stakeholders. However, the sporadic nature of precipitation makes it difficult to forecast skilfully beyond one week. Subseasonal forecasting is a growing area of science that aims to predict average weather conditions multiple weeks in advance using dynamical models. Building on recent work in this area, we test the hypothesis that using large-scale horizontal moisture transport as a predictor for precipitation may increase the forecast skill of the above-median and high-precipitation weeks on subseasonal time-scales. We analysed retrospective forecast (hindcast) sets from the Australian Bureau of Meteorology's latest operational subseasonal-to-seasonal forecasting model, ACCESS-S2, to compare the forecast skill of precipitation using integrated water vapour transport (IVT) as a proxy, compared to using precipitation forecasts directly. We show that ACCESS-S2 precipitation generally produces more skilful forecasts, except over some regions where IVT could be a useful additional diagnostic for warning of heavy precipitation events.

وصف الملف: application/pdf

العلاقة: https://research.usq.edu.au/download/c46a55f47f33e8529c031524eeaf99fc54846d27289fb5b56d1e72f0cc10bbe7/23169381/Quart%20J%20Royal%20Meteoro%20Soc%20-%202023%20-%20Reid%20-%20Atmospheric%20water%20vapour%20transport%20in%20ACCESS%E2%80%90S2%20and%20the%20potential%20for%20enhancing.pdfTest; https://doi.org/10.1002/qj.4585Test; Reid, Kimberley J., Hudson, Debra, King, Andrew D., Lane, Todd P. and Marshall, Andrew G. 2024. "Atmospheric water vapour transport in ACCESS-S2 and the potential for enhancing skill of subseasonal forecasts of precipitation." Quarterly Journal of the Royal Meteorological Society. 150 (758), pp. 68-80. https://doi.org/10.1002/qj.4585Test

الإتاحة: https://doi.org/10.1002/qj.4585Test
https://research.usq.edu.au/item/z26qz/atmospheric-water-vapour-transport-in-access-s2-and-the-potential-for-enhancing-skill-of-subseasonal-forecasts-of-precipitationTest
https://research.usq.edu.au/download/c46a55f47f33e8529c031524eeaf99fc54846d27289fb5b56d1e72f0cc10bbe7/23169381/Quart%20J%20Royal%20Meteoro%20Soc%20-%202023%20-%20Reid%20-%20Atmospheric%20water%20vapour%20transport%20in%20ACCESS%E2%80%90S2%20and%20the%20potential%20for%20enhancing.pdfTest

المؤلفون: Worthington, Anne, Kalteniece, Alise, Ferdousi, Maryam, D’Onofrio, Luca, Dhage, Shaishav, Azmi, Shazli, Adamson, Clare, Hamdy, Shaheen, Malik, Rayaz A, Calcutt, Nigel A, Marshall, Andrew G

المصدر: Diagnostics. 11(7)

مصطلحات موضوعية: Biomedical and Clinical Sciences, Neurosciences, Clinical Sciences, Peripheral Neuropathy, Clinical Research, Pain Research, Diabetes, Neurodegenerative, Chronic Pain, Aetiology, 2.1 Biological and endogenous factors, Metabolic and endocrine, diabetic neuropathy, pain, spinal disinhibition, H-reflex, Clinical sciences

الوصف: Impaired rate-dependent depression of the Hoffman reflex (HRDD) is a potential biomarker of impaired spinal inhibition in patients with painful diabetic neuropathy. However, the optimum stimulus-response parameters that identify patients with spinal disinhibition are currently unknown. We systematically compared HRDD, performed using trains of 10 stimuli at five stimulation frequencies (0.3, 0.5, 1, 2 and 3 Hz), in 42 subjects with painful and 62 subjects with painless diabetic neuropathy with comparable neuropathy severity, and 34 healthy controls. HRDD was calculated using individual and mean responses compared to the initial response. At stimulation frequencies of 1, 2 and 3 Hz, HRDD was significantly impaired in patients with painful diabetic neuropathy compared to patients with painless diabetic neuropathy for all parameters and for most parameters when compared to healthy controls. HRDD was significantly enhanced in patients with painless diabetic neuropathy compared to controls for responses towards the end of the 1 Hz stimulation train. Receiver operating characteristic curve analysis in patients with and without pain showed that the area under the curve was greatest for response averages of stimuli 2-4 and 2-5 at 1 Hz, AUC = 0.84 (95%CI 0.76-0.92). Trains of 5 stimuli delivered at 1 Hz can segregate patients with painful diabetic neuropathy and spinal disinhibition, whereas longer stimulus trains are required to segregate patients with painless diabetic neuropathy and enhanced spinal inhibition.

وصف الملف: application/pdf

الوصول الحر: https://escholarship.org/uc/item/08m9d9b3Test

المؤلفون: Ali, S Hasan, Makdani, Adarsh D, Cordero, Maria I, Paltoglou, Aspasia, Marshall, Andrew G, McFarquhar, Martyn J, McGlone, Francis P, Walker, Susannah C, Trotter, Paula D

الوصف: Low-threshold mechanosensory C-fibres, C-tactile afferents (CTs), respond optimally to sensations associated with a human caress. Additionally, CT-stimulation activates brain regions associated with processing affective states. This evidence has led to the social touch hypothesis, that CTs have a key role in encoding the affective properties of social touch. Thus, to date, the affective touch literature has focussed on gentle stroking touch. However, social touch interactions involve many touch types, including static, higher force touch such as hugging and holding. This study aimed to broaden our understanding of the social touch hypothesis by investigating relative preference for static vs dynamic touch and the influence of force on these preferences. Additionally, as recent literature has highlighted individual differences in CT-touch sensitivity, this study investigated the influence of affective touch experiences and attitudes, autistic traits, depressive symptomology and perceived stress on CT-touch sensitivity. Directly experienced, robotic touch responses were obtained through a lab-based study and vicarious touch responses through an online study where participants rated affective touch videos. Individual differences were determined by self-report questionnaire measures. In general, static touch was preferred over CT-non-optimal stroking touch, however, consistent with previous reports, CT-optimal stroking (velocity 1-10 cm/s) was rated most pleasant. However, static and CT-optimal vicarious touch were rated comparably for dorsal hand touch. For all velocities, 0.4N was preferred over 0.05N and 1.5N robotic touch. Participant dynamic touch quadratic terms were calculated for robotic and vicarious touch as a proxy CT-sensitivity measure. Attitudes to intimate touch significantly predict robotic and vicarious quadratic terms, as well as vicarious static dorsal hand touch ratings. Perceived stress negatively predicted robotic static touch ratings. This study has identified individual difference predictors ...

وصف الملف: text

العلاقة: https://e-space.mmu.ac.uk/631936Test/; https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0281253Test; https://e-space.mmu.ac.uk/631936/1/journal.pone.0281253.pdfTest; Ali, S Hasan , Makdani, Adarsh D , Cordero, Maria I , Paltoglou, Aspasia , Marshall, Andrew G , McFarquhar, Martyn J , McGlone, Francis P , Walker, Susannah C and Trotter, Paula D (2023) Hold me or stroke me? Individual differences in static and dynamic affective touch. PLoS One, 18 (5). e0281253. ISSN 1932-6203

الإتاحة: https://e-space.mmu.ac.uk/631936/1/journal.pone.0281253.pdfTest

المؤلفون: Marshall, Andrew G, Worthington, Anne, Jolivalt, Corinne G

مصطلحات موضوعية: Biomedical and Clinical Sciences, Neurosciences, Clinical Sciences, Neurodegenerative, Autoimmune Disease, Diabetes, Chronic Pain, Pain Research, Physical Injury - Accidents and Adverse Effects, Peripheral Neuropathy, Spinal Cord Injury, Traumatic Head and Spine Injury, Metabolic and endocrine, Neurological

وصف الملف: application/pdf

العلاقة: qt0nc0k461; https://escholarship.org/uc/item/0nc0k461Test

الإتاحة: https://escholarship.org/uc/item/0nc0k461Test

المؤلفون: Reid, Kimberley J., Hudson, Debra, King, Andrew D., Lane, Todd P., Marshall, Andrew G.

المساهمون: Climate Extremes

المصدر: Quarterly Journal of the Royal Meteorological Society ; volume 150, issue 758, page 68-80 ; ISSN 0035-9009 1477-870X

الوصف: Extended warning of above‐average and extreme precipitation is valuable to a wide range of stakeholders. However, the sporadic nature of precipitation makes it difficult to forecast skilfully beyond one week. Subseasonal forecasting is a growing area of science that aims to predict average weather conditions multiple weeks in advance using dynamical models. Building on recent work in this area, we test the hypothesis that using large‐scale horizontal moisture transport as a predictor for precipitation may increase the forecast skill of the above‐median and high‐precipitation weeks on subseasonal time‐scales. We analysed retrospective forecast (hindcast) sets from the Australian Bureau of Meteorology's latest operational subseasonal‐to‐seasonal forecasting model, ACCESS‐S2, to compare the forecast skill of precipitation using integrated water vapour transport (IVT) as a proxy, compared to using precipitation forecasts directly. We show that ACCESS‐S2 precipitation generally produces more skilful forecasts, except over some regions where IVT could be a useful additional diagnostic for warning of heavy precipitation events.

الإتاحة: https://doi.org/10.1002/qj.4585Test

المؤلفون: Ali, S. Hasan, Makdani, Adarsh D., Cordero, Maria I., Paltoglou, Aspasia E., Marshall, Andrew G., McFarquhar, Martyn J., McGlone, Francis P., Walker, Susannah C., Trotter, Paula D.

المساهمون: Scilingo, Enzo Pasquale, Manchester Metropolitan University

المصدر: PLOS ONE ; volume 18, issue 5, page e0281253 ; ISSN 1932-6203

الوصف: Low-threshold mechanosensory C-fibres, C-tactile afferents (CTs), respond optimally to sensations associated with a human caress. Additionally, CT-stimulation activates brain regions associated with processing affective states. This evidence has led to the social touch hypothesis, that CTs have a key role in encoding the affective properties of social touch. Thus, to date, the affective touch literature has focussed on gentle stroking touch. However, social touch interactions involve many touch types, including static, higher force touch such as hugging and holding. This study aimed to broaden our understanding of the social touch hypothesis by investigating relative preference for static vs dynamic touch and the influence of force on these preferences. Additionally, as recent literature has highlighted individual differences in CT-touch sensitivity, this study investigated the influence of affective touch experiences and attitudes, autistic traits, depressive symptomology and perceived stress on CT-touch sensitivity. Directly experienced, robotic touch responses were obtained through a lab-based study and vicarious touch responses through an online study where participants rated affective touch videos. Individual differences were determined by self-report questionnaire measures. In general, static touch was preferred over CT-non-optimal stroking touch, however, consistent with previous reports, CT-optimal stroking (velocity 1–10 cm/s) was rated most pleasant. However, static and CT-optimal vicarious touch were rated comparably for dorsal hand touch. For all velocities, 0.4N was preferred over 0.05N and 1.5N robotic touch. Participant dynamic touch quadratic terms were calculated for robotic and vicarious touch as a proxy CT-sensitivity measure. Attitudes to intimate touch significantly predict robotic and vicarious quadratic terms, as well as vicarious static dorsal hand touch ratings. Perceived stress negatively predicted robotic static touch ratings. This study has identified individual difference predictors ...

الإتاحة: https://doi.org/10.1371/journal.pone.0281253Test