المؤلفون: Ivan Krečak, Josipa Antonija Bačić, Nevena Šimunić, Vesna Bušac, Ljerka Pivac, Eva Čubrić, Marko Skelin, Marko Lucijanić

المصدر: Heliyon, Vol 10, Iss 12, Pp e32827- (2024)

مصطلحات موضوعية: Steatotic liver disease, Myeloproliferative neoplasms, Thrombosis, Survival, Science (General), Q1-390, Social sciences (General), H1-99

الوصف: The presence of steatotic liver disease (SLD) is associated with an increased cardiovascular risk in the general population. Chronic myeloproliferative neoplasms (MPNs), essential thrombocythemia (ET) and polycythemia vera (PV), are characterized by clonal myeloproliferation, chronic inflammatory state, and increased cardiovascular morbidity and mortality. The aim of this single-center study was to analyze clinical associations and the potential prognostic impact of SLD in ET and PV patients. We retrospectively included 108 patients (64 ET and 44 PV); median age was 70.5 years (range 21–92), 68 (63 %) were females, and the median follow-up time was 69 months. Baseline SLD presence was defined ultrasonographically and was detected in 25 (23.1 %) patients. There were no associations of SLD with any of the clinical and laboratory patient characterictics. Also, baseline ultrasonographic presence of SLD did not have an impact on future thrombotic, bleeding and disease transformation risk, nor patient survival. None of the patients experienced signs of liver failure during the follow-up. In conclusion, the presence of SLD in ET and PV patients does not seem to have major clinical implications. Therefore, patients may be advised about the generally harmless nature of SLD when occurring in the MPN context.

وصف الملف: electronic resource

العلاقة: http://www.sciencedirect.com/science/article/pii/S2405844024088583Test; https://doaj.org/toc/2405-8440Test

الوصول الحر: https://doaj.org/article/9e831ce998004f139572cabd7289c77cTest

المؤلفون: Ivan Krecak, Ljerka Pivac, Hrvoje Holik, Bozena Coha, Ivan Zekanovic, Martina Morić Perić, Marko Skelin

المصدر: HemaSphere, Vol 7, p e8253025 (2023)

مصطلحات موضوعية: Diseases of the blood and blood-forming organs, RC633-647.5

وصف الملف: electronic resource

العلاقة: http://journals.lww.com/10.1097/01.HS9.0000975504.82530.25Test; https://doaj.org/toc/2572-9241Test

الوصول الحر: https://doaj.org/article/7c5a4a6ae9454930b8b012ac92fe3345Test

المؤلفون: Ivan Krecak, Ljerka Pivac, Eva Cubric, Marko Lucijanic, Marko Skelin

المصدر: HemaSphere, Vol 7, p e07810a6 (2023)

مصطلحات موضوعية: Diseases of the blood and blood-forming organs, RC633-647.5

وصف الملف: electronic resource

العلاقة: http://journals.lww.com/10.1097/01.HS9.0000975620.07810.a6Test; https://doaj.org/toc/2572-9241Test

الوصول الحر: https://doaj.org/article/b8128bb62aa9468190cc2de33894dfe7Test

المؤلفون: Ivan Krečak, Ljerka Pivac, Marko Lucijanić, Marko Skelin

المصدر: Biomedicines, Vol 11, Iss 5, p 1301 (2023)

مصطلحات موضوعية: myeloproliferative neoplasms, polypharmacy, drug interactions, survival, thrombosis, Biology (General), QH301-705.5

الوصف: Polypharmacy, potentially inappropriate medications (PIMs), and drug-to-drug interactions (DDIs) are highly prevalent in the elderly and may have adverse effects on health-related outcomes. Their occurrence and clinical and prognostic associations in patients with chronic myeloproliferative neoplasms (MPN) are unknown. We retrospectively evaluated polypharmacy, PIMs, and DDIs in a cohort of 124 MPN patients (essential thrombocythemia, ET = 63, polycythemia vera, PV = 44, myelofibrosis = 9, MPN unclassifiable = 8) from a single community hematology practice. There were 761 drug prescriptions with a median of five prescribed medications per patient. Polypharmacy, at least one PIM (calculated for persons >60 years of age, n = 101), and at least one DDI were recorded in 76 (61.3%), 46 (45.5%), and 77 (62.1%) of patients, respectively. Seventy-four (59.6%) and twenty-one (16.9%) patients had at least one C or at least one D interaction, respectively. Among other associations, polypharmacy and DDIs were associated with older age, management of disease-related symptoms, osteoarthritis/osteoporosis, and different CV disorders. In multivariate analyses adjusted for clinically meaningful parameters, both polypharmacy and DDIs were significantly associated with inferior overall survival (OS) and time to thrombosis (TTT), whereas PIMs had no significant associations with neither OS nor TTT. There were no associations with bleeding or transformation risks. Polypharmacy, DDIs, and PIMs are very frequent among MPN patients and may have important clinical associations.

وصف الملف: electronic resource

العلاقة: https://www.mdpi.com/2227-9059/11/5/1301Test; https://doaj.org/toc/2227-9059Test

الوصول الحر: https://doaj.org/article/c2bbd5e16d664d72bbe450b55907d207Test

المؤلفون: Laura Biganzoli, Fatima Cardoso, Marc Beishon, David Cameron, Luigi Cataliotti, Charlotte E. Coles, Roberto C. Delgado Bolton, Maria Die Trill, Sema Erdem, Maria Fjell, Romain Geiss, Mathijs Goossens, Christiane Kuhl, Lorenza Marotti, Peter Naredi, Simon Oberst, Jean Palussière, Antonio Ponti, Marco Rosselli Del Turco, Isabel T. Rubio, Anna Sapino, Elzbieta Senkus-Konefka, Marko Skelin, Berta Sousa, Tiina Saarto, Alberto Costa, Philip Poortmans

المصدر: Breast, Vol 51, Iss , Pp 65-84 (2020)

مصطلحات موضوعية: Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

الوصف: This article is an update of the requirements of a specialist breast centre, produced by EUSOMA and endorsed by ECCO as part of Essential Requirements for Quality Cancer Care (ERQCC) programme, and ESMO.To meet aspirations for comprehensive cancer control, healthcare organisations must consider the requirements in this article, paying particular attention to multidisciplinarity and patient-centred pathways from diagnosis, to treatment, to survivorship. • The centrepiece of this article is the requirements section, comprising definitions; multidisciplinary structure; minimum case, procedure and staffing volumes; and detailed descriptions of the skills of, and resources needed by, members and specialisms in the multidisciplinary team in a breast centre. • These requirements are positioned within narrative on European breast cancer epidemiology, the standard of care, challenges to delivering this standard, and supporting evidence, to enable a broad audience to appreciate the importance of establishing these requirements in specialist breast centres.

وصف الملف: electronic resource

العلاقة: http://www.sciencedirect.com/science/article/pii/S0960977620300606Test; https://doaj.org/toc/1532-3080Test

الوصول الحر: https://doaj.org/article/346f4fe7c3d74392b8181195fb68cef7Test

المؤلفون: Marko Skelin, Josip Katić, David Šarčević, Dario Rahelić, Marko Lucijanić, Arnes Rešić, Mislav Puljević, Eugen Javor

المصدر: Reviews in Cardiovascular Medicine, Vol 23, Iss 1, p 031 (2022)

مصطلحات موضوعية: altmetric, cardiovascular randomized clinical trial, positive trial, negative trial, Diseases of the circulatory (Cardiovascular) system, RC666-701

الوصف: Background: Citations are used to assess the importance of authors, articles and journals in the scientific community, but do not examine how they affect general public journal readership. The Altmetric Attention Score (AAS) is a new metric for measuring media attention of the published paper. Methods: We examined cardiovascular (CV) randomized clinical trials (RCTs), published in the 3 highest Web of Science Impact Factor journals (Journal Citation Reports 2019: category “Medicine, General & Internal”) and in the 3 highest Web of Science Impact Factor CV journals (Journal Citation Reports 2019: category “Cardiac & Cardiovascular Systems”), through the calendar year of 2017, 2018 and 2019. The primary outcomes were the assessment of the difference between number of citations and AAS among positive and negative CV RCTs. Results: Among the included 262 RCTs, more positive CV RCTs were published (p = 0.002). There was no significant statistical difference between the positive and negative trials, considering the number of citations (p = 0.61). Interestingly, positive trials had a tendency towards a higher AAS (p = 0.058). The correlation between the AAS and the number of citations was moderate positively correlated (ρ = 0.47, p < 0.001). Conclusion: We did not find any differences between CV RCTs with positive vs CV RCTs with negative results considering the number of their citations. A tendency towards a higher AAS among positive CV RCTs could indicate higher activity on social media regarding CV trials with positive results. A higher number of published positive CV RCTs among all published CV RCTs could indicate the presence of publication bias but further investigation of unpublished RCTs in trial registries (e.g., clinicaltrials.gov) is needed.

وصف الملف: electronic resource

العلاقة: https://article.imrpress.com/journal/RCM/23/1/10.31083/j.rcm2301031/2153-8174-23-1-031.pdfTest; https://doaj.org/toc/1530-6550Test

الوصول الحر: https://doaj.org/article/3990cdfc1d4749868a7a625ad6c0f550Test

المؤلفون: Ivan Krecak, Marko Skelin, Srdan Verstovsek

المصدر: Expert Review of Hematology. 16:305-316

مصطلحات موضوعية: Hematology

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::81889b7438cbb8ab75f664ce379c8462Test
https://doi.org/10.1080/17474086.2023.2199151Test

المؤلفون: Ivan Krečak, Monika Čeko, Karla Nižetić, Eva Čubrić, Mediana Županović, Marko Skelin, Marko Lucijanić

المصدر: Scandinavian Journal of Clinical and Laboratory Investigation
Volume 83
Issue 3

مصطلحات موضوعية: BIOMEDICINA I ZDRAVSTVO. Kliničke medicinske znanosti. Interna medicina, pulmonary embolism, blood plasma, prognosis, Clinical Biochemistry, General Medicine, BIOMEDICINE AND HEALTHCARE. Clinical Medical Sciences. Internal Medicine

الوصف: Hematocrit to hemoglobin ratio (HHR) may improve prognostication in patients with pulmonary embolism.

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b76a25086a5049e71ec725239752f5f5Test
https://doi.org/10.1080/00365513.2023.2191334Test

المؤلفون: Marko Skelin, David Šarčević, Dina Lešin Gaćina, Iva Mucalo, Ivo Dilber, Eugen Javor

مصطلحات موضوعية: Pharmacology, Infectious Diseases, animal structures, Oncology, endocrine system diseases, PARP inhibitors, Homologous recombination deficiency, BRCA genes, Ovarian cancer, Pharmacology (medical), skin and connective tissue diseases, female genital diseases and pregnancy complications

الوصف: BRCA1/2 mutations and homologous recombination deficiency (HRD) predispose to increased sensitivity to poly(ADP-ribose)polymerase (PARP) inhibitor treatment. Our aim was to evaluate the PARP inhibitors effect on progression free survival (PFS) in a subpopulation with homologous recombination proficient status (HRD-BRCA-). A systematic literature search was performed for all studies reporting on the effect of PARP inhibitors regarding PFS in the HRD-BRCA- subpopulation, in patients with epithelial ovarian, tubal or primary peritoneal cancers (EOC). Five studies were included, enrolling a population of 3413 patients, with 1070 of them being HRD-BRCA-. PARP inhibitors were effective in the treatment of EOC, regardless of HRD and BRCA status or line of therapy. The estimated pooled effect hazard ratio (HR), assessing PFS for PARP inhibitors compared with control, was 0.76 (95% CI: 0.65–0.88, I2 = 46%) in the HRD-BRCA- subpopulation. Comparing both subpopulations with HRD positive status (HRD+ BRCA+, HRD+ BRCA-) versus the HRD-BRCA- subpopulation, we have found statistically significant differences in the effect on PFS (P < 0.05 for every interaction test) favouring HRD positive subpopulations (HRD+ BRCA+, HRD+ BRCA-). In the HRD-BRCA- subpopulation of patients, PARP inhibitors used as the second- or later-line of therapy showed more pronounced effect then when given as first line treatment (P = 0.04). Treatment of EOC with PARP inhibitors showed a significant effect regarding PFS in the HRD-BRCA- subpopulation, although a much higher benefit was evident for patients with HRD+ status (HRD+ BRCA+ and HRD+ BRCA-). In the HRD- subpopulation second line PARP inhibitor treatment showed greater benefit compared to first line PARP inhibitor treatment.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7ce5f1ff0c633fbeffce00a65f61366Test
https://www.bib.irb.hr/1196083Test

المؤلفون: Ivan, Krečak, Gordan, Babić, Marko, Skelin

المصدر: Acta dermatovenerologica Croatica : ADC. 30(1)

مصطلحات موضوعية: Male, Contracture, Colistin, Linezolid, Anticoagulants, Fibrinogen, Anemia, Ascorbic Acid, Vitamins, Middle Aged, Thromboplastin, C-Reactive Protein, Vancomycin, Ascorbic Acid Deficiency, Humans, Prothrombin, Renal Insufficiency, Scurvy, Fatigue, Serum Albumin

الوصف: Dear Editor, Scurvy is a nutritional disorder which can develop after prolonged (1-3 months) severe vitamin C deficiency. Vitamin C is a cofactor in several enzyme reactions involved in collagen synthesis. The defect in collagen causes blood vessel fragility, poor wound healing, mucocutaneous bleedings, hair abnormalities, bone pains, and joint contractures due to periosteal and intraarticular bleeding (1,2). Risk factors for scurvy development are undernutrition, low socioeconomic status, older age, male sex, alcoholism, tobacco smoking, and severe psychiatric illnesses (1-3). The required daily intake for vitamin C is ~60 mg, and this amount of vitamin C can be found in only one medium-sized orange. For this reason, the disease is rarely encountered in developed countries and is often underrecognized by healthcare personnel. Herein, we present an illustrative case of scurvy in order to raise the awareness of this disorder. A 61-year-old Caucasian man was admitted to hospital due to fatigue, hypotension (80/50 mmHg), severe normocytic anemia (hemoglobin 76 g/L), kidney failure (estimated glomerular filtration rate of 6 mL/min/1.73m2) and mild elevation in C-reactive protein (30.9 mg/L). Prior medical history included radical cystoprostatectomy with an ileal conduit performed eight years ago due to a bladder tumor and moderate chronic kidney disease with recurrent urinary tract infections. The patient was also an alcoholic and tobacco smoker, with a very low-income and a poor diet. He did not use any medications. Heteroanamnestically, the current clinical state had developed slowly over several weeks. At admission, the patient was afebrile, lethargic, malnourished, and immobile due to generalized weakness, bone pains, and hip and knee contractures. He had generalized edema, mostly related to kidney failure, as well as severe hypoalbuminemia (serum albumin 19 g/L). There were multiple ecchymoses (Figure 1, a) and perifollicular bleedings (Figure 1, b) in the skin. The teeth were defective, and the patient's facial hair had a "corkscrew" appearance (Figure 1, c). The platelet count was normal, as was the serum fibrinogen level and the prothrombin- and activated partial thromboplastin times. Vancomycin-resistant Enterococcus faecium and multi-drug-resistant Acinetobacter baumanii were isolated from the urine. Therefore, hemodialysis, linezolid, and colistin were started. However, the patient continued to be lethargic, immobile, and with prominent skin bleeding. Medical workup excluded the possibility of an underlying malignancy or an autoimmune disorder. Finally, scurvy was suspected and 500 mg daily of oral vitamin C was introduced into therapy. In the following two weeks, the general condition of the patient significantly improved and he was discharged from the hospital in good condition - mobile and with complete resolution of skin lesions (Figure 1, d and e). Three months later, the patient was still under maintenance hemodialysis and had mild anemia (hemoglobin 123 g/L). Interestingly, scurvy was the first disease in the history of medicine for which a randomized trial found a cure (4). The differential diagnosis of scurvy includes skin infections, hematologic disorders, collagen vascular disorders, and anticoagulant/antiplatelet side-effects (1). Pathognomonic skin findings which may help raise suspicion of scurvy are perifollicular bleedings and "corkscrew" hair. Notably, laboratory testing for vitamin C concentration is not necessary to confirm scurvy as it tends to reflect recent dietary intake of vitamin C (2). Nevertheless, it may be useful to identify less typical cases (2). In our case, rapid clinical improvement with the resolution of skin lesions and joint contractures after the introduction of vitamin C confirmed the clinical diagnosis of scurvy. Additionally, vitamin C deficiency could be, at least partly (besides kidney failure and acute infection), responsible for severe anemia at disease presentation (5). This case serves to remind clinicians not to forget scurvy when treating patients at risk for vitamin C deficiency who present with fatigue, anemia, bone pains, and unexplained mucocutaneous bleedings. In suspected cases, vitamin C should be administered without hesitation.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=pmid________::58945ea447a89ebbb39f6729519795f1Test
https://pubmed.ncbi.nlm.nih.gov/36153722Test