المؤلفون: Jouneau, Stéphane, Ricard, Jean-Damien, Seguin-Givelet, Agathe, Bigé, Naïke, Contou, Damien, Desmettre, Thibaut, Hugenschmitt, Delphine, Kepka, Sabrina, Le Gloan, Karinne, Maitre, Bernard, Mangiapan, Gilles, Marchand-Adam, Sylvain, Mariolo, Alessio, Marx, Tania, Messika, Jonathan, Noël-Savina, Elise, Oberlin, Mathieu, Palmier, Ludovic, Perruez, Morgan, Pichereau, Claire, Roche, Nicolas, Garnier, Marc, Martinez, Mikaël

المصدر: Annals of Intensive Care ; volume 13, issue 1 ; ISSN 2110-5820

مصطلحات موضوعية: Critical Care and Intensive Care Medicine

الوصف: Introduction Primary spontaneous pneumothorax (PSP) is the presence of air in the pleural space, occurring in the absence of trauma and known lung disease. Standardized expert guidelines on PSP are needed due to the variety of diagnostic methods, therapeutic strategies and medical and surgical disciplines involved in its management. Methods Literature review, analysis of the literature according to the GRADE (Grading of Recommendation, Assessment, Development and Evaluation) methodology; proposals for guidelines rated by experts, patients and organizers to reach a consensus. Only expert opinions with strong agreement were selected. Results A large PSP is defined as presence of a visible rim along the entire axillary line between the lung margin and the chest wall and ≥ 2 cm at the hilum level on frontal chest X-ray. The therapeutic strategy depends on the clinical presentation: emergency needle aspiration for tension PSP; in the absence of signs of severity: conservative management (small PSP), needle aspiration or chest tube drainage (large PSP). Outpatient treatment is possible if a dedicated outpatient care system is previously organized. Indications, surgical procedures and perioperative analgesia are detailed. Associated measures, including smoking cessation, are described. Conclusion These guidelines are a step towards PSP treatment and follow-up strategy optimization in France.

الإتاحة: https://doi.org/10.1186/s13613-023-01181-2Test

المؤلفون: Lula Lukadi, Joseph, Mariolo, Alessio Vincenzo, Ozgur, Emrah Gokay, Gossot, Dominique, Baste, Jean-Marc, De Latour, Bertrand, Seguin-Givelet, Agathe

المصدر: Interdisciplinary CardioVascular and Thoracic Surgery ; volume 37, issue 4 ; ISSN 2753-670X

الوصف: OBJECTIVES Segmentectomy may be indicated for T1a-cN0 non-small-cell lung cancer. However, several patients are upstaged pT2a at final pathological examination due to visceral pleural invasion (VPI). As resection is usually not completed to lobectomy, this may raise issue of potential worse prognosis. The aim of this study is to compare prognosis of VPI upstaged cT1N0 patients operated on by segmentectomy or lobectomy. METHODS Data of patients from 3 centres were analysed. This was a retrospective study, of patients operated on from April 2007 to December 2019. Survival and recurrence were assessed by Kaplan–Meier method and cox regression analysis. RESULTS Lobectomy and segmentectomy were performed in 191 (75.4%) and in 62 (24.5%) patients, respectively. No difference in 5-year disease-free survival rate between lobectomy (70%) and segmentectomy (64.7%) was observed. There was no difference in loco-regional recurrence, nor in ipsilateral pleural recurrence. The distant recurrence rate was higher (P = 0.027) in the segmentectomy group. Five-year overall survival rate was similar for both lobectomy (73%) and segmentectomy (75.8%) groups. After propensity score matching, there was no difference in 5-year disease-free survival rate (P = 0.27) between lobectomy (85%) and segmentectomy (66.9%), and in 5-year overall survival rate (P = 0.42) between the 2 groups (lobectomy 76.3% vs segmentectomy 80.1%). Segmentectomy was not impacting neither recurrence, nor survival. CONCLUSIONS Detection of VPI (pT2a upstage) in patients who underwent segmentectomy for cT1a-c non-small-cell lung cancer does not seem to be an indication to extend resection to lobectomy.

الإتاحة: https://doi.org/10.1093/icvts/ivad102Test
https://academic.oup.com/icvts/article-pdf/37/4/ivad102/52147106/ivad102.pdfTest

المؤلفون: Grigoroiu, Madalina, Paul, Jean-François, Brian, Emmanuel, Aegerter, Philippe, Boddaert, Guillaume, Mariolo, Alessio, Jorrot, Pierre, Bellahoues, Mouloud, Seguin-Givelet, Agathe, Perduca, Vittorio

المصدر: Heliyon ; ISSN:2405-8440 ; Volume:10 ; Issue:11

الوصف: This pilot study evaluated the impact of using a 3D printed model of the patient's bronchovascular lung anatomy on the mental workload and fatigue of surgeons during full thoracoscopic segmentectomy.

العلاقة: https://doi.org/10.1016/j.heliyon.2024.e31842Test; https://pubmed.ncbi.nlm.nih.gov/38867971Test; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11168317Test/

الإتاحة: https://doi.org/10.1016/j.heliyon.2024.e31842Test
https://pubmed.ncbi.nlm.nih.gov/38867971Test
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11168317Test/

المؤلفون: Gossot, Dominique, Mariolo, Alessio Vincenzo, Lefevre, Marine, Boddaert, Guillaume, Brian, Emmanuel, Grigoroiu, Madalina, Girard, Nicolas, Seguin-Givelet, Agathe

المصدر: Frontiers in Surgery ; volume 8 ; ISSN 2296-875X

مصطلحات موضوعية: Surgery

الإتاحة: https://doi.org/10.3389/fsurg.2021.725005Test

المؤلفون: Lukadi, Joseph Lula, Mariolo, Alessio Vincenzo, Ozgur, Emrah Gokay, Gossot, Dominique, Baste, Jean-Marc, Latour, Bertrand De, Seguin-Givelet, Agathe

المصدر: Interdisciplinary Cardiovascular & Thoracic Surgery; Oct2023, Vol. 37 Issue 4, p1-8, 8p

المؤلفون: Tessitore, Adele, Mariolo, Alessio V., Galetta, Domenico, Sedda, Giulia, Spirito, Rosa, Spaggiari, Lorenzo

المصدر: AORTA ; volume 07, issue 06, page 169-171 ; ISSN 2325-4637

الوصف: Primitive aortic sarcomas are rare tumors characterized by resistance to medical treatment and a poor prognosis with high metastatic rates and local recurrences. Surgery remains the mainstay treatment and is based on challenging and technically demanding resections with high rate of major intraoperative and postoperative complications. We report the case of a patient with primitive intimal sarcoma of the aorta, who underwent a descending aortic resection and reconstruction with a prosthetic tube.

الإتاحة: https://doi.org/10.1055/s-0039-3401809Test

المؤلفون: Casiraghi, Monica, Sedda, Giulia, Diotti, Cristina, Mariolo, Alessio Vincenzo, Galetta, Domenico, Tessitore, Adele, Maisonneuve, Patrick, Spaggiari, Lorenzo

المصدر: Interactive CardioVascular and Thoracic Surgery ; volume 30, issue 3, page 359-365 ; ISSN 1569-9285

الوصف: OBJECTIVES The aim of this study was to assess the postoperative outcomes of robotic-assisted lobectomy in obese patients to determine the impact of the robotic approach on a high-risk population who were candidates for major pulmonary resection for non-small-cell lung cancer (NSCLC). METHODS Between January 2007 and August 2018, we retrospectively reviewed the medical records of 224 obese patients (body mass index ≥ 30) who underwent pulmonary lobectomy at our institution via robotic-assisted thoracic surgery (RATS, n = 51) or lateral muscle-sparing thoracotomy (n = 173). RESULTS Forty-two patients were individually matched with those who had the same pathological tumour stage and similar comorbidities and presurgical treatment. The median operative time was significantly longer in the RATS group compared to that in the thoracotomy group (200 vs 158 min; P = 0.003), whereas the length of stay was significantly better for the RATS group (5 vs 6 days; P = 0.047). Postoperative complications were significantly more frequent after open lobectomy than in the RATS group (42.9% vs 16.7%; P = 0.027). After a median follow-up of 4.4 years, the 5-year overall survival rate was 67.6% [95% confidence interval (CI) 45.7–82.2] for the RATS group, and 66.1% (95% CI 46.8–79.9) for the open surgery group (log-rank P = 0.54). The 5-year cumulative incidence of cancer-related deaths was 24.8% (95% CI 9.7–43.5) for the RATS group and 23.6% (95% CI 10.8–39.2) for the open surgery group (Gray’s test, P = 0.69). CONCLUSIONS RATS is feasible and safe for obese patients with NSCLC with advantages compared to open surgery in terms of early postoperative outcomes. In addition, the long-term survival rate was comparable to that of the open approach.

الإتاحة: https://doi.org/10.1093/icvts/ivz273Test
http://academic.oup.com/icvts/article-pdf/30/3/359/32651157/ivz273.pdfTest

المؤلفون: Mariolo, Alessio Vincenzo, Casiraghi, Monica, Galetta, Domenico, Spaggiari, Lorenzo

المساهمون: A.V. Mariolo, M. Casiraghi, D. Galetta, L. Spaggiari

مصطلحات موضوعية: Surgery, Pulmonary and Respiratory Medicine, Cardiology and Cardiovascular Medicine, Settore MED/21 - Chirurgia Toracica

الوصف: Several different surgical approaches to anterior Pancoast tumors have been proposed. The osteomuscular-sparing transmanubrial approach allows optimal exposure and control of apical chest wall structures, but it requires an additional thoracotomy to perform the lobectomy with radical lymph node resection. The presented technique combines the osteomuscular-sparing transmanubrial approach with robotic-assisted upper lobectomy in a severely obese patient, thereby reducing the invasiveness of the surgical approach and the postoperative complications.

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/29654726; info:eu-repo/semantics/altIdentifier/wos/WOS:000442130600003; volume:106; issue:3; firstpage:e115; lastpage:e116; numberofpages:2; journal:ANNALS OF THORACIC SURGERY; http://hdl.handle.net/2434/868520Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85051642387

الإتاحة: https://doi.org/10.1016/j.athoracsur.2018.03.013Test
http://hdl.handle.net/2434/868520Test

المؤلفون: Kappos, Elisabeth A, Sieber, Patricia K, Engels, Patricia E, Mariolo, Alessio V, D'Arpa, Salvatore, Schaefer, Dirk J, Kalbermatten, Daniel

المصدر: ISSN: 2162-3279 ; Brain and Behavior, vol. 7, no. 7 (2017) e00723.

مصطلحات موضوعية: info:eu-repo/classification/ddc/617, Automated gait analysis system, Dynamic and static gait parameters, Peripheral nerve regeneration, Rat and mouse sciatic nerve

الوصف: A range of behavioral testing paradigms have been developed for the research of central and peripheral nerve injuries with the help of small animal models. Following any nerve repair strategy, improved functional outcome may be the most important evidence of axon regeneration. A novel automated gait analysis system, the CatWalk™, can measure dynamic as well as static gait patterns of small animals. Of most interest in detecting functional recovery are in particular dynamic gait parameters, coordination measures, and the intensity of the animals paw prints. This article is designed to lead to a more efficient choice of CatWalk parameters in future studies concerning the functional evaluation of nerve regeneration and simultaneously add to better interstudy comparability.

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/28729931; https://archive-ouverte.unige.ch/unige:154929Test; unige:154929

الإتاحة: https://doi.org/10.1002/brb3.723Test
https://archive-ouverte.unige.ch/unige:154929Test

المؤلفون: Kappos, Elisabeth A., Sieber, Patricia K., Engels, Patricia E., Mariolo, Alessio V., D'Arpa, Salvatore, Schaefer, Dirk J., Kalbermatten, Daniel F.

المساهمون: Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung, Gottfried und Julia Bangerter-Rhyner-Stiftung, Universität Basel

المصدر: Brain and Behavior ; volume 7, issue 7 ; ISSN 2162-3279 2162-3279

الوصف: Introduction A range of behavioral testing paradigms have been developed for the research of central and peripheral nerve injuries with the help of small animal models. Following any nerve repair strategy, improved functional outcome may be the most important evidence of axon regeneration. A novel automated gait analysis system, the CatWalk ™ , can measure dynamic as well as static gait patterns of small animals. Of most interest in detecting functional recovery are in particular dynamic gait parameters, coordination measures, and the intensity of the animals paw prints. This article is designed to lead to a more efficient choice of CatWalk parameters in future studies concerning the functional evaluation of nerve regeneration and simultaneously add to better interstudy comparability. Methods The aims of the present paper are threefold: (1) to describe the functional method of CatWalk gait analysis, (2) to characterize different parameters acquired by CatWalk gait analysis, and to find the most frequently used parameters as well as (3) to compare their reliability and validity throughout the different studies. Results In the reviewed articles, the most frequently used parameters were Swing Duration (30), Print Size (27), Stride Length (26), and Max Contact Area (24). Swing Duration was not only frequently used but was also the most reliable and valid parameter. Therefore, we hypothesize that Swing Duration constitutes an important parameter to be chosen for future studies, as it has the highest level of reliability and validity. Conclusion In conclusion, CatWalk can be used as a complementary approach to other behavioral testing paradigms to assess clinically relevant behavioral benefits, with the main advantage that this system demonstrates both static and dynamic gait parameters at the same time. Due to limited reliability and validity of certain parameters, we recommend that only the most frequently assessed parameters should be used in the future.

الإتاحة: https://doi.org/10.1002/brb3.723Test