المؤلفون: Bhavana Seelam, Ria Sandhu, Mariam Alam, Akhila Kethireddy, Isain Zapata

المصدر: Clinics and Practice, Vol 14, Iss 1, Pp 337-343 (2024)

مصطلحات موضوعية: cancer screening, South Indian, colorectal, lung, mammography, pap smear, Medicine (General), R5-920

الوصف: Background: Studies have shown lower rates of cancer screening and high mortality rates among all Asian Americans than among non-Hispanic White populations. However, most of these studies often confound diverse Asian American subgroups with limited data on cancer screening for Indian Americans, with this group being particularly interesting because of their counterintuitive socioeconomic status. For this reason, the objective of this study is to evaluate knowledge of the United States Preventive Services Task Force (USPSTF) cancer screening guidelines and compliance among South Indian Americans residing in Southern California. Methods: This was a cross-sectional study gathering community responses through an electronic survey. The survey reports knowledge of USPSTF screening guidelines and participant compliance rates. Rates were further compared to non-Hispanic White populations from official sources. Results: South Indian Americans residing in California had lower rates of compliance for colorectal, lung, and breast cancer screening when compared to that of non-Hispanic White populations in the same region, with the exception of cervical cancer screening rates. Conclusion: Understanding the cultural characteristics of special populations, such as Indian Americans, can help communities adhere to more effective screening practices that can improve outcomes.

وصف الملف: electronic resource

العلاقة: https://www.mdpi.com/2039-7283/14/1/26Test; https://doaj.org/toc/2039-7283Test

الوصول الحر: https://doaj.org/article/eb30c669f0224dd4be4ca544a9094c10Test

المؤلفون: Mariam Alam, MD, Victoria Fang, MD, PhD, Misha Rosenbach, MD

المصدر: JAAD Case Reports, Vol 9, Iss , Pp 1-3 (2021)

مصطلحات موضوعية: cutaneous sarcoidosis, JAK inhibitor, JAK-STAT, oleocanthal, olive oil, tofacitinib, Dermatology, RL1-803

وصف الملف: electronic resource

العلاقة: http://www.sciencedirect.com/science/article/pii/S2352512620308778Test; https://doaj.org/toc/2352-5126Test

الوصول الحر: https://doaj.org/article/5894895dbfcf47c48037f93561f1e4a4Test

المؤلفون: Mustafa Alam, Baha Abdelrahim, Mariam Alam, Mohamed Hosam Horani

المصدر: Journal of the Endocrine Society. 6:A768-A769

مصطلحات موضوعية: Endocrinology, Diabetes and Metabolism

الوصف: Presentation: A 25-year-old man presented to the ED with intentional multi-drug overdose onset 9PM on the night prior to admission. PMHx is significant for seizures, hypothyroidism, resting tremors, and smoking. The patient expressed frustration over his persistent hand tremors with depressed mood and took 25 tablets of 500mg Keppra, 30-40 tablets of 150 mcg Levothyroxine, and 25 tablets of 10mg propranolol. The patient denied any chest pain, SOB, nausea, vomiting, lightheadedness, fever, focal weakness, numbness or tingling, prior SI, rash, dysuria, or bleeding. Hospital Course: Vitals were T: 37 Celsius, HR: 92 BPM, 135/87 BP, RR: 18, and SpO2: 93%. Initial EKG showed sinus rhythm with 80 heart rate. The physical exam was significant for profuse diaphoresis and generalized tremors. There were no ST or T wave abnormalities indicating ischemia. The patient had a lab workup that was significant for a TSH of 0. 006, FT4 of >5, FT3 of 7. 09, and T4 of 22.77, after which he was placed on plasmapheresis. The FT4 trended downward to 2.56 after plasmapheresis. The patient experienced transient elevations in creatine kinase and bilirubin, but lab workup was otherwise unremarkable. The patient met admission criteria for inpatient psychiatry and discharged to a psych facility. Discussion Given the 7-day half-life of Levothyroxine, plasmapheresis was considered the best option to prevent fatal thyroid storm. This case also demonstrates the importance of how a multi-drug overdose can present more benign presentation with stable vitals. In this case, the effects of propranolol masked the initial symptoms of hyperthyroidism and decreased FT3 levels, indicating the importance to conduct a thorough history to manage polypharmacy drug overdoses. This case highlights plasmapheresis as an effective treatment modality for thyroid storm. Presentation: No date and time listed

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::87efa943bf63ccab4b6949ff9a7922e8Test
https://doi.org/10.1210/jendso/bvac150.1587Test

المؤلفون: Kim M. O’Connor, Natalie Moriarty, Andrea Kalus, Mariam Alam

المصدر: The American Journal of Medicine. 132:1401-1409

مصطلحات موضوعية: Male, Health Knowledge, Attitudes, Practice, medicine.medical_specialty, Disease, 030204 cardiovascular system & hematology, medicine.disease_cause, Risk Assessment, 03 medical and health sciences, 0302 clinical medicine, Infestation, Prevalence, medicine, Humans, Morgellons Disease, 030212 general & internal medicine, Psychiatry, business.industry, General Medicine, Psychodermatology, Prognosis, Psychological evaluation, Etiology, Female, Antipsychotic Medications, Comprehension, business, Delusional Parasitosis, Antipsychotic Agents

الوصف: Delusional infestation is a psychiatric condition defined by a fixed belief of infestation despite contrary evidence. Diagnosis includes exclusion of organic etiologies. Treatment with antipsychotics is effective and safe in the majority of patients. Patients are characteristically reluctant to pursue psychiatric evaluation and may resist discussing their disease in psychiatric terms. Strategies to strengthen the provider-patient therapeutic alliance facilitate communication around appropriate treatment. Without antipsychotic medications, patients can become heavy utilizers of care and practice self-destructive behaviors in attempts to clear their perceived infestation.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50d16b320d0619ac8d5230705e9eb672Test
https://doi.org/10.1016/j.amjmed.2019.06.017Test

المؤلفون: Mariam Alam, Misha Rosenbach, Joanna Harp, William Lewis, Robert G. Micheletti, Katherine Steele

المصدر: Cutis.

مصطلحات موضوعية: Male, medicine.medical_specialty, Urticaria, Coronavirus disease 2019 (COVID-19), Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), Dermatology, Disease, Severity of Illness Index, Skin Diseases, Pathogenesis, 030207 dermatology & venereal diseases, 03 medical and health sciences, COVID-19 Testing, 0302 clinical medicine, Pandemic, Humans, Medicine, 030212 general & internal medicine, Purpura, Skin, business.industry, COVID-19, Exanthema, Morbilliform, Pathophysiology, body regions, Skin Diseases, Viral, Female, medicine.symptom, business

الوصف: Cutaneous manifestations of COVID-19-SARS-CoV-2-are common and varied. Morbilliform, vesicular, and urticarial eruptions may be nonspecific initial features of the disease. Chilblainlike lesions on the fingers or toes typically occur as part of a resolution phase, signifying a milder course, whereas livedoid lesions and retiform purpura are associated with coaguloapthy and more severe disease. Additionally, a severe Kawasaki-like multisystem inflammatory syndrome rarely is seen in children. This diverse range of cutaneous manifestations in COVID-19 reflects a spectrum of host immunologic responses to SARS-CoV-2 and may inform disease pathophysiology.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8412bb6f6476f05bdc3d4c6224cab0acTest
https://doi.org/10.12788/cutis.0230Test

المؤلفون: Bryan Kestenbaum, Matthias Kretzler, Crystal A. Gadegbeku, Zeenat Bhat, Courtney Tuegel, Nisha Bansal, Susan Steigerwalt, Jonathan Himmelfarb, Jennifer Hawkins, Frank C. Brosius, Ian H. de Boer, Ronit Katz, Debbie S. Gipson, Mariam Alam, Keith Bellovich, Cassianne Robinson-Cohen

المصدر: Kidney International Reports, Vol 4, Iss 1, Pp 103-111 (2019)
Kidney International Reports

مصطلحات موضوعية: Oncology, medicine.medical_specialty, 030232 urology & nephrology, Renal function, 030204 cardiovascular system & hematology, urologic and male genital diseases, lcsh:RC870-923, 03 medical and health sciences, 0302 clinical medicine, Clinical Research, Interquartile range, Diabetes mellitus, Internal medicine, CKD, Medicine, galectin-2, sST2, business.industry, lcsh:Diseases of the genitourinary system. Urology, medicine.disease, Comorbidity, 3. Good health, Nephrology, Heart failure, Cohort, Biomarker (medicine), business, Kidney disease

الوصف: Introduction: Cardiac biomarkers soluble ST2 (sST2) and galectin-3 may reflect cardiac inflammation and fibrosis. It is plausible that these mechanisms may also contribute to the progression of kidney disease. We examined associations of sST2 and galectin-3 with kidney function decline in participants with chronic kidney disease (CKD). Methods: This was a pooled analysis of 2 longitudinal cohorts of participants with CKD: the Clinical Phenotyping and Resource Biobank (C-PROBE) study and the Seattle Kidney Study (SKS). We measured circulating concentrations of sST2 and galectin-3 at baseline. Our primary outcome was progression to estimated glomerular filtration rate (eGFR)

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::026c32e75064aaf708f3c7db90bb425cTest
https://doi.org/10.1016/j.ekir.2018.09.013Test

المؤلفون: Bryan Kestenbaum, Crystal A. Gadegbeku, Keith Bellovich, Jonathan Himmelfarb, Zeenat Bhat, Jennifer Hawkins, Ian H. de Boer, Ronit Katz, Debbie S. Gipson, Frank C. Brosius, Wenjun Ju, Mariam Alam, Courtney Tuegel, Nisha Bansal, Susan Steigerwalt, Matthias Kretzler, Cassianne Robinson-Cohen

المصدر: American Journal of Kidney Diseases. 72:519-528

مصطلحات موضوعية: Adult, Male, medicine.medical_specialty, Growth Differentiation Factor 15, Galectin 3, Galectins, 030232 urology & nephrology, Renal function, Comorbidity, Kaplan-Meier Estimate, 030204 cardiovascular system & hematology, Risk Assessment, Severity of Illness Index, Article, Cohort Studies, 03 medical and health sciences, Sex Factors, 0302 clinical medicine, Cause of Death, Internal medicine, Risk of mortality, Humans, Medicine, Myocardial infarction, Renal Insufficiency, Chronic, Aged, Proportional Hazards Models, Retrospective Studies, business.industry, Proportional hazards model, Age Factors, Blood Proteins, Middle Aged, Prognosis, medicine.disease, Interleukin-1 Receptor-Like 1 Protein, Survival Analysis, Cardiovascular Diseases, Nephrology, Heart failure, Female, GDF15, business, Biomarkers, Kidney disease, Cohort study

الوصف: Rationale & Objective Inflammation, cardiac remodeling, and fibrosis may explain in part the excess risk for cardiovascular disease (CVD) in patients with chronic kidney disease (CKD). Growth differentiation factor 15 (GDF-15), galectin 3 (Gal-3), and soluble ST2 (sST2) are possible biomarkers of these pathways in patients with CKD. Study Design Observational cohort study. Setting & Participants Individuals with CKD enrolled in either of 2 multicenter CKD cohort studies: the Seattle Kidney Study or C-PROBE (Clinical Phenotyping and Resource Biobank Study). Exposures Circulating GDF-15, Gal-3, and sST2 measured at baseline. Outcomes Primary outcome was all-cause mortality. Secondary outcomes included hospitalization for physician-adjudicated heart failure and the atherosclerotic CVD events of myocardial infarction and cerebrovascular accident. Analytic Approach Cox proportional hazards models used to test the association of each biomarker with each outcome, adjusting for demographics, CVD risk factors, and kidney function. Results Among 883 participants, mean estimated glomerular filtration rate was 49±19mL/min/1.73m2. Higher GDF-15 (adjusted HR [aHR] per 1-SD higher, 1.87; 95% CI, 1.53-2.29), Gal-3 (aHR per 1-SD higher, 1.51; 95% CI, 1.36-1.78), and sST2 (aHR per 1-SD higher, 1.36; 95% CI, 1.17-1.58) concentrations were significantly associated with mortality. Only GDF-15 level was also associated with heart failure events (HR per 1-SD higher, 1.56; 95% CI, 1.12-2.16). There were no detectable associations between GDF-15, Gal-3, or sST2 concentrations and atherosclerotic CVD events. Limitations Event rates for heart failure and atherosclerotic CVD were low. Conclusions Adults with CKD and higher circulating GDF-15, Gal-3, and sST2 concentrations experienced greater mortality. Elevated GDF-15 concentration was also associated with an increased rate of heart failure. Further work is needed to elucidate the mechanisms linking these circulating biomarkers with CVD in patients with CKD.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2315bca579d20224bbb027db7b3f0071Test
https://doi.org/10.1053/j.ajkd.2018.03.025Test

المؤلفون: Kevin R. Patel, Meei-Li Huang, Christina M. Lockwood, Hong Xie, Rex G. Cheng, Negar Makhsous, Kevin S Ikuta, Amanda Shepherd, Amy Morris, Eric Daniel LaMotte, Ajit P. Limaye, Mariam Alam, Alexander L. Greninger, Christopher L. McClurkan, Lei Yu, Pavitra Roychoudhury, David M. Koelle, Renuka Bhattacharya, Başak Ҫoruh, Robert M. Rakita, Yodit N. Beru, Magdalena Walkiewicz, Roland B. Walter, Steven M. Holland

المصدر: Open Forum Infectious Diseases

مصطلحات موضوعية: 0301 basic medicine, Simplexvirus, food.ingredient, viruses, Viremia, medicine.disease_cause, 03 medical and health sciences, viral evolution, 0302 clinical medicine, food, HSV hepatitis, medicine, host response, hepatitis, Hepatitis, business.industry, Brief Report, Neurotoxicity, medicine.disease, herpes simplex virus, Virology, HSV-1, 030104 developmental biology, Infectious Diseases, Herpes simplex virus, Oncology, 030220 oncology & carcinogenesis, Viral evolution, Immunocompetence, business, Myopericarditis

الوصف: We describe a case of acute liver failure and myopericarditis due to herpes simplex virus–1 (HSV-1) in an immunocompetent adult. We estimate that, at the height of viremia, the patient contained a quantity of HSV-1 virions approaching that of human cells. The patient recovered with acyclovir that was dose-adjusted for neurotoxicity and developed a vigorous anti-HSV-1 T-cell response.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6e79b297994c86c3be73558b7a36225Test
http://europepmc.org/articles/PMC6868424Test

المؤلفون: David Reilly, Mariam Alam, Keesandra Agenor, Bart J. Van der Schueren, Gary Wang, Blandine Laferrère, Peter Homel

المصدر: Diabetes Care

مصطلحات موضوعية: Blood Glucose, Male, HOMEOSTASIS, Endocrinology, Diabetes and Metabolism, medicine.medical_treatment, Type 2 diabetes, medicine.disease_cause, GLUCOSE, 0302 clinical medicine, Glucagon-Like Peptide 1, 030212 general & internal medicine, Original Research, Glucose tolerance test, medicine.diagnostic_test, digestive, oral, and skin physiology, Clinical Care/Education/Nutrition/Psychosocial Research, Area under the curve, Middle Aged, Glucagon-like peptide-1, Area Under Curve, Female, Life Sciences & Biomedicine, hormones, hormone substitutes, and hormone antagonists, endocrine system, medicine.medical_specialty, Gastric Bypass, WEIGHT-LOSS, 030209 endocrinology & metabolism, Incretins, Endocrinology & Metabolism, 03 medical and health sciences, Internal medicine, Diabetes mellitus, Internal Medicine, medicine, Humans, Obesity, Advanced and Specialized Nursing, Science & Technology, Gastric bypass surgery, business.industry, Insulin, Glucose Tolerance Test, medicine.disease, INCRETIN LEVELS, Endocrinology, Diabetes Mellitus, Type 2, business, Follow-Up Studies

الوصف: OBJECTIVE To characterize the magnitude and variance of the change of glucose and glucagon-like peptide-1 (GLP-1) concentrations, and to identify determinants of glucose control up to 2 years after gastric bypass (GBP). RESEARCH DESIGN AND METHODS Glucose and GLP-1 concentrations were measured during an oral glucose challenge before and 1, 12, and 24 months after GBP in 15 severely obese patients with type 2 diabetes. RESULTS Glucose area under the curve from 0 to 180 min (AUC0–180) started decreasing in magnitude (P < 0.05) 1 month after surgery. GLP-1 AUC0–180 increased in magnitude 1 month after GBP (P < 0.05), with increased variance only after 1 year (Pσ2 ≤ 0.001). GLP-1 AUC0–180 was positively associated with insulin AUC0–180 (P = 0.025). CONCLUSIONS The increase in variance of GLP-1 at 1 and 2 years after GBP suggests mechanisms other than proximal gut bypass to explain the enhancement of GLP-1 secretion. The association between GLP-1 and insulin concentrations supports the idea that the incretins are involved in glucose control after GBP.

وصف الملف: Print-Electronic

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26771ff9f061db93c9e3c014f81b0b75Test
https://doi.org/10.2337/dc11-1472Test

المؤلفون: HAIDER, MARIAM ALAM

المصدر: Toastmaster; Jan2018, Vol. 84 Issue 1, p16-19, 4p

مصطلحات موضوعية: SYRIA-United States relations, HOMELESSNESS, IMMIGRATION status, SOCIAL conditions of immigrants, IMMIGRANTS, POVERTY

مصطلحات جغرافية: UNITED States