المؤلفون: Cattalini M, Della Paolera S, Zunica F, Bracaglia C, Giangreco M, Verdoni L, Meini A, Sottile R, Caorsi R, Zuccotti G, Fabi M, Montin D, Meneghel A, Consolaro A, Dellepiane RM, Maggio MC, La Torre F, Marchesi A, Simonini G, Villani A, Cimaz R, Ravelli A, Taddio A Maria Concetta Alberelli: UOC Pediatria, Marche-Nord, Clotilde Alizzi: Department of Health Promotion Sciences Maternal and Infantile Care, Internal Medicine and Medical Specialities “G. D’Alessandro”, University of Palermo, Palermo Italy, Patrizia Barone: Unità Operativa Complessa di Broncopneumologia Pediatrica AOU “Policlinico - Vittorio Emanuele Via Santa Sofia 78 Catania, Lucia Augusta Baselli: Pediatric Intermediate Care Unit, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Milan Italy, Veronica Bennato: U. O. Pediatria, Ospedale A, Manzoni Lecco, Francesca Biscaro: UOC Pediatria, Ospedale Ca’ Foncello, Treviso, Grazia Bossi: UOC Pediatria, Fondazione IRCCS Policlinico San Matteo, Pavia Italy, Andrea Campana: Bambino Gesù Children’s Hospital, Rome Italy, Maurizio Carone: UO Malattie Infettive, Ospedale Pediatrico ‘Giovanni XXIII’, Bari Italy, Adele Civino: U. O. C. Pediatria P. O. Vito Fazzi, Lecce, Giovanni Conti: Nefrologia e Reumatologia Pediatrica con Dialisi, Azienda Ospedaliero-Universitario “G. Martino”, Eleonora Dei Rossi: University of Trieste, Trieste Italy, Emanuela Del Giudice: Department of Maternal Infantile and Urological Sciences, Sapeinza University of Rome, Polo Pontini, Alice Dell’Anna: U. O. C. Pediatria P. O. Vito Fazzi Lecce, Maia De Luca: Bambino Gesù Children’s Hospital, Piazza S. Onofrio n. 4, 00165 Rome, Italy, Enrico Felici: Pediatric and Pediatric Emergency Unit, The Children Hospital, AO SS Antonio e Biago e C. Arrigo, Alessandria Italy, Giovanni Filocamo: Fondazione IRCCS Cà Granda, Ospedale Maggiore Policlinico, Milano, Ilenia Floretta: Pediatria, Ospedale Santa Chiara, Trento Italy, Maria Loreta Foschini: SC Pediatria, PO SAN MICHELE AOBrotzu, Cagliari Italy, Marcello Lanari: Department of Pediatrics, University of Bologna, IRCCS S. Orsola-Malpighi Hospital, Bologna Italy, Bianca Lattanzi: SOD Pediatria, Ospedali Riuniti, Ancona Italy, Alessandra Lazzerotti: Clinica Pediatrica, Università Milano Bicocca, Fondazione MBBM - onlus c/o Ospedale San Gerardo, Monza Italy, Francesco Licciardi: Department of Pediatrics and Public Health, University of Turin, Turin Italy, Alessandra Manerba: Child Cardiology, ASST Spedali Civili di Brescia and University of Brescia, Brescia Italy, Savina Mannarino: Division of Cardiology, Children’s Hospital V Buzzi, ASST FBF Sacco, Achille Marino: Department of Pediatrics, Desio Hospital, ASST Monza, Desio Italy, Agostina Marolda: Pediatrics and Neonatology Dipartment, ASST Ovest Milanese, “G. Fornaroli” Hospital, Magenta Milan, Laura Martelli: Paediatric Department, Hospital Papa Giovanni XXIII, Bergamo Italy, Giorgia Martini, Department of Woman’s and Child’s Health, University of Padova, Padua Italy, Angela Mauro: Department of Paediatrics, Emergency Department, Santobono-Pausilipon Children’s Hospital, Naples, Italy. Maria Vincenza Mastrolia: Pediatric Rheumatology Unit, AOU Meyer, University of Florence, Florence, Italy. Angelo Mazza: Paediatric Department, Angela Miniaci: Clinica Pediatrica, Reumatologia, Azienda Ospedaliero-Universitaria di Bologna, Francesca Minoia: Fondazione IRCCS Cà Granda, Alma Olivieri: Dipartimento della donna, del bambino e di chirurgia generale e specialistica, Università della Campania, “L Vanvitelli, Napoli, Guido Pennoni: Dipartimento Materno-Infantile, Gubbio-Gualdo Tadino, Italy, Rossana Pignataro: UOC Pediatria e Neonatologia, ASST Lodi, Lodi, Francesca Ricci, Clinica Pediatrica, ASST Spedali Civili di Brescia e Università degli Studi di Brescia, Donato Rigante: Department of Pediatrics, Univarsità Cattolica Sacro Cuore, Matilde Rossi: UOC di Pediatrai e Neonatologia, Ospedale di Macerata, Macerata, Claudia Santagati: Dipartimento di Pediatria, Ospedale di Rovigo, Rovigo, Martina Soliani: Pediatria ASST Cremona, Italy, Silvia Sonego: University of Trieste, Domenico Sperlì: UOC di Pediatria, S. O. “Annunziata” - A. O. di Cosenza, Sara Stucchi: Maternal and Child Health, Division of Paediatrics, ASST Grande Ospedale Metropolitano Niguarda, Milano Italy, Barbara Teruzzi: Maternal and Child Health, Elpidio Tierno: UOC di Pediatria, Dipartimento della Salute della Donna e del Bambin, AORN “Sant’Anna e San Sebastiano”- Caserta, Tatiana Utytatnikova: Dipartimento Materno-Infantile, Pediatria, ASST Bergamo-EST, Seriate Bergamo, Piero Valentini, Department of Pediatrics, Gianluca Vergine, UOC Pediatria Rimini, Ospedale Infermi, ASL Romagna, Rimini Italy.

المساهمون: Cattalini, M, Della Paolera, S, Zunica, F, Bracaglia, C, Giangreco, M, Verdoni, L, Meini, A, Sottile, R, Caorsi, R, Zuccotti, G, Fabi, M, Montin, D, Meneghel, A, Consolaro, A, Dellepiane, Rm, Maggio, Mc, La Torre, F, Marchesi, A, Simonini, G, Villani, A, Cimaz, R, Ravelli, A, Taddio, A Maria Concetta Alberelli: UOC Pediatria, Marche-Nord, Clotilde Alizzi: Department of Health Promotion Sciences Maternal and Infantile, Care, Internal Medicine and Medical Specialities “G., D’Alessandro”, University of, Palermo, Palermo, Italy, Patrizia Barone: Unità Operativa Complessa di Broncopneumologia Pediatrica AOU “Policlinico, - Vittorio Emanuele Via Santa Sofia 78 Catania, Lucia Augusta Baselli: Pediatric Intermediate Care, Unit, Fondazione IRCCS Ca’ Granda Ospedale Maggiore, Policlinico, Milan, Italy, Veronica Bennato: U. O., Pediatria, Ospedale, A, Manzoni, Lecco, Francesca Biscaro: UOC, Pediatria, Ospedale Ca’, Foncello, Treviso, Grazia Bossi: UOC, Pediatria, Fondazione IRCCS Policlinico San, Matteo, Pavia, Italy, Andrea Campana: Bambino Gesù Children’s, Hospital, Rome, Italy, Maurizio Carone: UO Malattie, Infettive, Ospedale Pediatrico ‘Giovanni, Xxiii’, Bari, Italy, Adele Civino: U. O. C. Pediatria P. O. Vito Fazzi, Lecce, Giovanni Conti: Nefrologia e Reumatologia Pediatrica con Dialisi, Azienda Ospedaliero-Universitario “G. Martino”, Eleonora Dei Rossi: University of, Trieste, Trieste, Italy, Emanuela Del Giudice: Department of Maternal Infantile and Urological, Science, Sapeinza University of, Rome, Polo, Pontini, Alice Dell’Anna: U. O. C. Pediatria P. O., Vito Fazzi Lecce, Maia De Luca: Bambino Gesù Children’s, Hospital, Piazza, S. Onofrio n. 4., 00165, Rome, Italy, Enrico Felici: Pediatric and Pediatric Emergency, Unit, The Children, Hospital, AO SS Antonio e Biago e C., Arrigo, Alessandria, Italy, Giovanni Filocamo: Fondazione IRCCS Cà, Granda, Ospedale Maggiore, Policlinico, Milano, Ilenia Floretta:, Pediatria, Ospedale Santa, Chiara, Trento, Italy, Maria Loreta Foschini: SC, Pediatria, PO SAN MICHELE, Aobrotzu, Cagliari, Italy, Marcello Lanari: Department of, Pediatric, University of, Bologna, IRCCS S., Orsola-Malpighi Hospital, Bologna, Italy, Bianca Lattanzi: SOD, Pediatria, Ospedali, Riuniti, Ancona, Italy, Alessandra Lazzerotti: Clinica, Pediatrica, Università Milano, Bicocca, Fondazione MBBM, - onlus c/o Ospedale San Gerardo, Monza, Italy, Francesco Licciardi: Department of Pediatrics and Public, Health, University of, Turin, Turin, Italy, Alessandra Manerba: Child, Cardiology, ASST Spedali Civili di Brescia and University of, Brescia, Brescia, Italy, Savina Mannarino: Division of, Cardiology, Children’s Hospital, V Buzzi, ASST FBF, Sacco, Achille Marino: Department of, Pediatric, Desio, Hospital, Asst, Monza, Desio, Italy, Agostina Marolda: Pediatrics and Neonatology, Dipartment, ASST Ovest, Milanese

مصطلحات موضوعية: SARS-CoV-2, Kawasaki disease, Pediatric inflammatory multisystem syndrome-temporally associated to SARS-CoV-2 infection, Myocarditis, Hypotension, Multisystem inflammatory syndrome associated with coronavirus disease, Coronary artery abnormalities

الوصف: Background: There is mounting evidence on the existence of a Pediatric Inflammatory Multisystem Syndrome-temporally associated to SARS-CoV-2 infection (PIMS-TS), sharing similarities with Kawasaki Disease (KD). The main outcome of the study were to better characterize the clinical features and the treatment response of PIMS-TS and to explore its relationship with KD determining whether KD and PIMS are two distinct entities. Methods: The Rheumatology Study Group of the Italian Pediatric Society launched a survey to enroll patients diagnosed with KD (Kawasaki Disease Group - KDG) or KD-like (Kawacovid Group - KCG) disease between February 1st 2020, and May 31st 2020. Demographic, clinical, laboratory data, treatment information, and patients' outcome were collected in an online anonymized database (RedCAP®). Relationship between clinical presentation and SARS-CoV-2 infection was also taken into account. Moreover, clinical characteristics of KDG during SARS-CoV-2 epidemic (KDG-CoV2) were compared to Kawasaki Disease patients (KDG-Historical) seen in three different Italian tertiary pediatric hospitals (Institute for Maternal and Child Health, IRCCS "Burlo Garofolo", Trieste; AOU Meyer, Florence; IRCCS Istituto Giannina Gaslini, Genoa) from January 1st 2000 to December 31st 2019. Chi square test or exact Fisher test and non-parametric Wilcoxon Mann-Whitney test were used to study differences between two groups. Results: One-hundred-forty-nine cases were enrolled, (96 KDG and 53 KCG). KCG children were significantly older and presented more frequently from gastrointestinal and respiratory involvement. Cardiac involvement was more common in KCG, with 60,4% of patients with myocarditis. 37,8% of patients among KCG presented hypotension/non-cardiogenic shock. Coronary artery abnormalities (CAA) were more common in the KDG. The risk of ICU admission were higher in KCG. Lymphopenia, higher CRP levels, elevated ferritin and troponin-T characterized KCG. KDG received more frequently immunoglobulins (IVIG) and ...

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/33726806; volume:16; issue:19; journal:PEDIATRIC RHEUMATOLOGY ONLINE JOURNAL; http://hdl.handle.net/11591/449901Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85102710196; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7962084Test/

الإتاحة: https://doi.org/10.1186/s12969-021-00511-7Test
http://hdl.handle.net/11591/449901Test
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7962084Test/

المؤلفون: Cattalini M, Della Paolera S, Zunica F, Bracaglia C, Giangreco M, Verdoni L, Meini A, Sottile R, Caorsi R, Zuccotti G, Fabi M, Montin D, Meneghel A, Consolaro A, Dellepiane RM, Maggio MC, La Torre F, Marchesi A, Simonini G, Villani A, Cimaz R, Ravelli A, Taddio A Maria Concetta Alberelli: UOC Pediatria, Marche-Nord, Clotilde Alizzi: Department of Health Promotion Sciences Maternal and Infantile Care, Internal Medicine and Medical Specialities 'G. D’Alessandro', University of Palermo, Palermo Italy, Patrizia Barone: Unità Operativa Complessa di Broncopneumologia Pediatrica AOU 'Policlinico - Vittorio Emanuele Via Santa Sofia 78 Catania, Lucia Augusta Baselli: Pediatric Intermediate Care Unit, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Milan Italy, Veronica Bennato: U. O. Pediatria, Ospedale A, Manzoni Lecco, Francesca Biscaro: UOC Pediatria, Ospedale Ca’ Foncello, Treviso, Grazia Bossi: UOC Pediatria, Fondazione IRCCS Policlinico San Matteo, Pavia Italy, Andrea Campana: Bambino Gesù Children’s Hospital, Rome Italy, Maurizio Carone: UO Malattie Infettive, Ospedale Pediatrico ‘Giovanni XXIII’, Bari Italy, Adele Civino: U. O. C. Pediatria P. O. Vito Fazzi, Lecce, Giovanni Conti: Nefrologia e Reumatologia Pediatrica con Dialisi, Azienda Ospedaliero-Universitario 'G. Martino', Eleonora Dei Rossi: University of Trieste, Trieste Italy, Emanuela Del Giudice: Department of Maternal Infantile and Urological Sciences, Sapeinza University of Rome, Polo Pontini, Alice Dell’Anna: U. O. C. Pediatria P. O. Vito Fazzi Lecce, Maia De Luca: Bambino Gesù Children’s Hospital, Piazza S. Onofrio n. 4, 00165 Rome, Italy, Enrico Felici: Pediatric and Pediatric Emergency Unit, The Children Hospital, AO SS Antonio e Biago e C. Arrigo, Alessandria Italy, Giovanni Filocamo: Fondazione IRCCS Cà Granda, Ospedale Maggiore Policlinico, Milano, Ilenia Floretta: Pediatria, Ospedale Santa Chiara, Trento Italy, Maria Loreta Foschini: SC Pediatria, PO SAN MICHELE AOBrotzu, Cagliari Italy, Marcello Lanari: Department of Pediatrics, University of Bologna, IRCCS S. Orsola-Malpighi Hospital, Bologna Italy, Bianca Lattanzi: SOD Pediatria, Ospedali Riuniti, Ancona Italy, Alessandra Lazzerotti: Clinica Pediatrica, Università Milano Bicocca, Fondazione MBBM - onlus c/o Ospedale San Gerardo, Monza Italy, Francesco Licciardi: Department of Pediatrics and Public Health, University of Turin, Turin Italy, Alessandra Manerba: Child Cardiology, ASST Spedali Civili di Brescia and University of Brescia, Brescia Italy, Savina Mannarino: Division of Cardiology, Children’s Hospital V Buzzi, ASST FBF Sacco, Achille Marino: Department of Pediatrics, Desio Hospital, ASST Monza, Desio Italy, Agostina Marolda: Pediatrics and Neonatology Dipartment, ASST Ovest Milanese, 'G. Fornaroli' Hospital, Magenta Milan, Laura Martelli: Paediatric Department, Hospital Papa Giovanni XXIII, Bergamo Italy, Giorgia Martini, Department of Woman’s and Child’s Health, University of Padova, Padua Italy, Angela Mauro: Department of Paediatrics, Emergency Department, Santobono-Pausilipon Children’s Hospital, Naples, Italy. Maria Vincenza Mastrolia: Pediatric Rheumatology Unit, AOU Meyer, University of Florence, Florence, Italy. Angelo Mazza: Paediatric Department, Angela Miniaci: Clinica Pediatrica, Reumatologia, Azienda Ospedaliero-Universitaria di Bologna, Francesca Minoia: Fondazione IRCCS Cà Granda, Alma Olivieri: Dipartimento della donna, del bambino e di chirurgia generale e specialistica, Università della Campania, 'L Vanvitelli, Napoli, Guido Pennoni: Dipartimento Materno-Infantile, Gubbio-Gualdo Tadino, Italy, Rossana Pignataro: UOC Pediatria e Neonatologia, ASST Lodi, Lodi, Francesca Ricci, Clinica Pediatrica, ASST Spedali Civili di Brescia e Università degli Studi di Brescia, Donato Rigante: Department of Pediatrics, Univarsità Cattolica Sacro Cuore, Matilde Rossi: UOC di Pediatrai e Neonatologia, Ospedale di Macerata, Macerata, Claudia Santagati: Dipartimento di Pediatria, Ospedale di Rovigo, Rovigo, Martina Soliani: Pediatria ASST Cremona, Italy, Silvia Sonego: University of Trieste, Domenico Sperlì: UOC di Pediatria, S. O. 'Annunziata' - A. O. di Cosenza, Sara Stucchi: Maternal and Child Health, Division of Paediatrics, ASST Grande Ospedale Metropolitano Niguarda, Milano Italy, Barbara Teruzzi: Maternal and Child Health, Elpidio Tierno: UOC di Pediatria, Dipartimento della Salute della Donna e del Bambin, AORN 'Sant’Anna e San Sebastiano'- Caserta, Tatiana Utytatnikova: Dipartimento Materno-Infantile, Pediatria, ASST Bergamo-EST, Seriate Bergamo, Piero Valentini, Department of Pediatrics, Gianluca Vergine, UOC Pediatria Rimini, Ospedale Infermi, ASL Romagna, Rimini Italy.

المساهمون: Cattalini, Marco, Della Paolera, Sara, Zunica, Fiammetta, Bracaglia, Claudia, Giangreco, Manuela, Verdoni, Lucio, Meini, Antonella, Sottile, Rita, Caorsi, Roberta, Zuccotti, Gianvincenzo, Fabi, Marianna, Montin, Davide, Meneghel, Alessandra, Consolaro, Alessandro, Dellepiane, Rosa Maria, Maggio, Maria Cristina, La Torre, Francesco, Marchesi, Alessandra, Simonini, Gabriele, Villani, Alberto, Cimaz, Rolando, Ravelli, Angelo, Taddio, Andrea, Cattalini, M, Della Paolera, S, Zunica, F, Bracaglia, C, Giangreco, M, Verdoni, L, Meini, A, Sottile, R, Caorsi, R, Zuccotti, G, Fabi, M, Montin, D, Meneghel, A, Consolaro, A, Dellepiane, Rm, Maggio, Mc, La Torre, F, Marchesi, A, Simonini, G, Villani, A, Cimaz, R, Ravelli, A, Taddio, A Maria Concetta Alberelli: UOC Pediatria, Marche-Nord, Clotilde Alizzi: Department of Health Promotion Sciences Maternal and Infantile, Care, Internal Medicine and Medical Specialities 'G., D’Alessandro', University of, Palermo, Palermo, Italy, Patrizia Barone: Unità Operativa Complessa di Broncopneumologia Pediatrica AOU 'Policlinico, - Vittorio Emanuele Via Santa Sofia 78 Catania, Lucia Augusta Baselli: Pediatric Intermediate Care, Unit, Fondazione IRCCS Ca’ Granda Ospedale Maggiore, Policlinico, Milan, Italy, Veronica Bennato: U. O., Pediatria, Ospedale, A, Manzoni, Lecco, Francesca Biscaro: UOC, Pediatria, Ospedale Ca’, Foncello, Treviso, Grazia Bossi: UOC, Pediatria, Fondazione IRCCS Policlinico San, Matteo, Pavia, Italy, Andrea Campana: Bambino Gesù Children’s, Hospital, Rome, Italy, Maurizio Carone: UO Malattie, Infettive, Ospedale Pediatrico ‘Giovanni, Xxiii’, Bari, Italy, Adele Civino: U. O. C. Pediatria P. O. Vito Fazzi, Lecce, Giovanni Conti: Nefrologia e Reumatologia Pediatrica con Dialisi, Azienda Ospedaliero-Universitario 'G. Martino', Eleonora Dei Rossi: University of, Trieste, Trieste, Italy, Emanuela Del Giudice: Department of Maternal Infantile and Urological, Science, Sapeinza University of, Rome, Polo, Pontini, Alice Dell’Anna: U. O. C. Pediatria P. O., Vito Fazzi Lecce, Maia De Luca: Bambino Gesù Children’s, Hospital, Piazza, S. Onofrio n. 4., 00165, Rome, Italy, Enrico Felici: Pediatric and Pediatric Emergency, Unit, The Children, Hospital, AO SS Antonio e Biago e C., Arrigo, Alessandria, Italy, Giovanni Filocamo: Fondazione IRCCS Cà, Granda, Ospedale Maggiore, Policlinico, Milano, Ilenia Floretta:, Pediatria, Ospedale Santa, Chiara, Trento, Italy, Maria Loreta Foschini: SC, Pediatria, PO SAN MICHELE, Aobrotzu, Cagliari, Italy, Marcello Lanari: Department of, Pediatric, University of, Bologna, IRCCS S., Orsola-Malpighi Hospital, Bologna, Italy, Bianca Lattanzi: SOD, Pediatria, Ospedali, Riuniti, Ancona, Italy, Alessandra Lazzerotti: Clinica, Pediatrica, Università Milano, Bicocca, Fondazione MBBM, - onlus c/o Ospedale San Gerardo, Monza, Italy, Francesco Licciardi: Department of Pediatrics and Public, Health, University of, Turin, Turin, Italy, Alessandra Manerba: Child, Cardiology, ASST Spedali Civili di Brescia and University of, Brescia, Brescia, Italy, Savina Mannarino: Division of, Cardiology, Children’s Hospital, V Buzzi, ASST FBF, Sacco, Achille Marino: Department of, Pediatric, Desio, Hospital, Asst, Monza, Desio, Italy, Agostina Marolda: Pediatrics and Neonatology, Dipartment, ASST Ovest, Milanese, 'G., Fornaroli' Hospital, Magenta, Milan, Laura Martelli: Paediatric, Department, Hospital Papa Giovanni, Xxiii, Bergamo, Italy, Giorgia, Martini, Department of Woman’s and Child’s, Health, University of, Padova, Padua, Italy, Angela Mauro: Department of, Paediatric, Emergency, Department, Santobono-Pausilipon Children’s, Hospital, Naples, Italy., Maria Vincenza Mastrolia: Pediatric Rheumatology Unit, Aou, Meyer, University of, Florence, Florence, Italy., Angelo Mazza: Paediatric Department, Angela Miniaci: Clinica, Pediatrica, Reumatologia, Azienda Ospedaliero-Universitaria di, Bologna, Francesca Minoia: Fondazione IRCCS Cà, Granda, Alma Olivieri: Dipartimento della, Donna, del bambino e di chirurgia generale, e specialistica, Università della, Campania, 'L, Vanvitelli, Napoli, Claudio, Guido Pennoni: Dipartimento, Materno-Infantile, Gubbio-Gualdo Tadino, Italy, Rossana Pignataro: UOC Pediatria, e Neonatologia, Asst, Lodi, Lodi, Francesca, Ricci, Clinica, Pediatrica, ASST Spedali Civili di Brescia, e Università degli Studi di Brescia, Donato Rigante: Department of, Pediatric, Univarsità Cattolica Sacro, Cuore, Matilde Rossi: UOC di Pediatrai, e Neonatologia, Ospedale di, Macerata, Macerata, Claudia Santagati: Dipartimento di, Pediatria, Ospedale di, Rovigo, Rovigo, Martina Soliani: Pediatria ASST Cremona, Italy, Silvia Sonego: University of, Trieste, Domenico Sperlì: UOC di Pediatria, S. O. 'Annunziata' - A. O. di Cosenza, Sara Stucchi: Maternal and Child, Health, Division of, Paediatric, ASST Grande Ospedale Metropolitano, Niguarda, Milano, Italy, Barbara Teruzzi: Maternal and Child, Health, Elpidio Tierno: UOC di, Pediatria, Dipartimento della Salute della Donna, e del Bambin, AORN 'Sant’Anna, e San Sebastiano'- Caserta, Tatiana Utytatnikova: Dipartimento, Materno-Infantile, Pediatria, Asst, Bergamo-EST, Seriate, Bergamo, Piero, Valentini, Department of, Pediatric, Gianluca, Vergine, UOC Pediatria, Rimini, Ospedale, Infermi, Asl, Romagna, Rimini, Italy., Cattalini M., Della Paolera S., Zunica F., Bracaglia C., Giangreco M., Verdoni L., Meini A., Sottile R., Caorsi R., Zuccotti G., Fabi M., Montin D., Meneghel A., Consolaro A., Dellepiane R.M., Maggio M.C., La Torre F., Marchesi A., Simonini G., Villani A., Cimaz R., Ravelli A., Taddio A., Adamoli P., Alberelli M.C., Alizzi C., Barone P., Bennato V., Biscaro F., Bossi G., Campana A., Carone M., Civino A., Conti G., Rossi E.D., Del Giudice E., Dell'Anna A., De Luca M., Felici E., Filocamo G., Floretta I., Foschini M.L., Lanari M., Lattanzi B., Lazzerotti A., Licciardi F., Manerba A., Mannarino S., Marino A., Marolda A., Martelli L., Martini G., Mauro A., Mastrolia M.V., Mazza A., Miniaci A., Minoia F., Olivieri A., Pennoni G., Pignataro R., Ricci F., Rigante D., Rossi M., Santagati C., Soliani M., Sonego S., Sperli D., Stucchi S., Teruzzi B., Tierno E., Utytatnikova T., Valentini P., Vergine G.

المصدر: Pediatric Rheumatology Online Journal
Pediatric Rheumatology Online Journal, Vol 19, Iss 1, Pp 1-11 (2021)

مصطلحات موضوعية: Coronary artery abnormalities, Hypotension, Kawasaki disease, Multisystem inflammatory syndrome associated with coronavirus disease, Myocarditis, Pediatric inflammatory multisystem syndrome-temporally associated to SARS-CoV-2 infection, SARS-CoV-2, Age Distribution, Antirheumatic Agents, Aspirin, C-Reactive Protein, COVID-19, Child, Child, Preschool, Coronary Artery Disease, Cough, Diarrhea, Dyspnea, Female, Glucocorticoids, Heart Failure, Humans, Hyperferritinemia, Immunoglobulins, Intravenous, Immunologic Factors, Infant, Intensive Care Units, Pediatric, Interleukin 1 Receptor Antagonist Protein, Italy, Lymphopenia, Male, Mucocutaneous Lymph Node Syndrome, Platelet Aggregation Inhibitors, Shock, Systemic Inflammatory Response Syndrome, Tachypnea, Troponin T, Vomiting, lcsh:Diseases of the musculoskeletal system, coronary artery abnormalities, hypotension, kawasaki disease, multisystem inflammatory syndrome associated with coronavirus disease, myocarditis, pediatric inflammatory multisystem syndrome-temporally associated to SARS-CoV-2 infection, age distribution, antirheumatic agents, aspirin, C-reactive protein, child, preschool, coronary artery disease, cough, diarrhea, yspnea, female, glucocorticoids, heart failure, humans, hyperferritinemia, immunoglobulins, intravenous, immunologic factors, infant, intensive care units, pediatric, interleukin 1 receptor antagonist protein, italy, lymphopenia, male, mucocutaneous lymph node syndrome, platelet aggregation inhibitors, shock, systemic inflammatory response syndrome, tachypnea, troponin T, vomiting, Myocarditi, 030204 cardiovascular system & hematology, SARS-CoV-2, Kawasaki disease, Pediatric inflammatory multisystem syndrome-temporally associated to SARS-CoV-2 infection, Myocarditis, Hypotension, Multisystem inflammatory syndrome associated with coronavirus disease, Coronary artery abnormalities, Coronary artery disease, Settore MED/38 - Pediatria Generale E Specialistica, 0302 clinical medicine, Glucocorticoid, Immunologic Factor, Immunology and Allergy, Coronary artery abnormalitie, Fisher's exact test, Pediatric, biology, lcsh:RJ1-570, Antirheumatic Agent, Settore MED/38, Intensive Care Units, Cohort, symbols, Platelet aggregation inhibitor, Intravenous, Human, Research Article, medicine.medical_specialty, Immunoglobulins, 03 medical and health sciences, symbols.namesake, Rheumatology, Internal medicine, medicine, Preschool, 030203 arthritis & rheumatology, business.industry, Platelet Aggregation Inhibitor, lcsh:Pediatrics, medicine.disease, Systemic inflammatory response syndrome, Immunoglobulins, Intravenou, Pediatrics, Perinatology and Child Health, biology.protein, lcsh:RC925-935, business

الوصف: Background There is mounting evidence on the existence of a Pediatric Inflammatory Multisystem Syndrome-temporally associated to SARS-CoV-2 infection (PIMS-TS), sharing similarities with Kawasaki Disease (KD). The main outcome of the study were to better characterize the clinical features and the treatment response of PIMS-TS and to explore its relationship with KD determining whether KD and PIMS are two distinct entities. Methods The Rheumatology Study Group of the Italian Pediatric Society launched a survey to enroll patients diagnosed with KD (Kawasaki Disease Group – KDG) or KD-like (Kawacovid Group - KCG) disease between February 1st 2020, and May 31st 2020. Demographic, clinical, laboratory data, treatment information, and patients’ outcome were collected in an online anonymized database (RedCAP®). Relationship between clinical presentation and SARS-CoV-2 infection was also taken into account. Moreover, clinical characteristics of KDG during SARS-CoV-2 epidemic (KDG-CoV2) were compared to Kawasaki Disease patients (KDG-Historical) seen in three different Italian tertiary pediatric hospitals (Institute for Maternal and Child Health, IRCCS “Burlo Garofolo”, Trieste; AOU Meyer, Florence; IRCCS Istituto Giannina Gaslini, Genoa) from January 1st 2000 to December 31st 2019. Chi square test or exact Fisher test and non-parametric Wilcoxon Mann-Whitney test were used to study differences between two groups. Results One-hundred-forty-nine cases were enrolled, (96 KDG and 53 KCG). KCG children were significantly older and presented more frequently from gastrointestinal and respiratory involvement. Cardiac involvement was more common in KCG, with 60,4% of patients with myocarditis. 37,8% of patients among KCG presented hypotension/non-cardiogenic shock. Coronary artery abnormalities (CAA) were more common in the KDG. The risk of ICU admission were higher in KCG. Lymphopenia, higher CRP levels, elevated ferritin and troponin-T characterized KCG. KDG received more frequently immunoglobulins (IVIG) and acetylsalicylic acid (ASA) (81,3% vs 66%; p = 0.04 and 71,9% vs 43,4%; p = 0.001 respectively) as KCG more often received glucocorticoids (56,6% vs 14,6%; p Conclusion Our study suggests that SARS-CoV-2 infection might determine two distinct inflammatory diseases in children: KD and PIMS-TS. Older age at onset and clinical peculiarities like the occurrence of myocarditis characterize this multi-inflammatory syndrome. Our patients had an optimal response to treatments and a good outcome, with few complications and no deaths.

وصف الملف: ELETTRONICO

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1edde4e3ad084013d31cd2737af2d82Test
https://pubmed.ncbi.nlm.nih.gov/33726806Test

المؤلفون: David Rossi, Azienda Ospedaliera, Marche Nord, Vincenzo Catalano, Paolo Alessandroni, Paolo Giordani, See Profile

المساهمون: The Pennsylvania State University CiteSeerX Archives

المصدر: https://www.researchgate.net/profile/David_Rossi4/publication/47301157_Activity_and_safety_of_erlotinib_as_second-_and_third-line_treatment_in_elderly_patients_with_advanced_non-small_cell_lung_cancer_a_phase_II_trial/links/0fcfd505c557c6017c000000.pdfTest.

الوصف: Activity and safety of erlotinib as second- And third-line treatment in elderly patients with advanced non-small cell lung cancer: A phase II trial

وصف الملف: application/pdf

العلاقة: http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.1025.9616Test

المؤلفون: Ospedale San Paolo, Ospedali Riuniti Marche Nord pesaro

المساهمون: Pierpaolo Sileri, Professor

المصدر: Gaskl CE, Klg CE, Varghese TK Jr, Veenstra DL, Thlby RC, Flum DR, Alfonso-Crtancho R. Fancl benef of a smokg cessatn program prr to electe colorectal surgery. J Surg Res. 2017 Jul;215:183-189. do 10.1016/j.jss.2017.03.067. Epub 2017 Apr 7.
Gronkjaer M, Elsen M, Skov-Ettrup LS, Tolstrup JS, Chrtnsen AH, Mkelsen SS, Becker U, Flensborg-Madsen T. Preoperate smokg status and postoperate complatns: a systemat revw and meta-analys. Ann Surg. 2014 Jan;259(1):52-71. do 10.1097/SLA.0b013e3182911913.
Balla A, Saraceno F, Rullo M, Morales-Conde S, Targarona Soler EM, DSaver S, GuerrrM, Lepne P, DLorenzo N, Adama M, Alarcon Arezzo A, Bollo Rodruez J, BonL, Bndo S, Carrano FM, Chand M, Jenks JT, Davs J, Delgado Rla S, Delr P, Elmore U, Esp-Basany E, Fhera A, Flor Lorente B, Franc N, Gomez Ru M, Hahnloser D, Lard E, Martez C, OrtenzM, Pan Y, Pastor oate C, PaganAM, Pera M, PerottR, Popowh DA, Rockall T, RosatR, SartorA, Scogl D, Shalaby M, So Fernandez V, Smart NJ, SpellA, Sylla P, Tan PJ, Valdes-Hernandez J, Wexner SD, SerP. Protecte eostomy creatn after anterr resectn of the rectum: Shared decn-makg or stl subjecte? Colorectal D. 2023 Apr;25(4):647-659. do 10.1111/cod16454. Epub 2022 Dec 28.
TsaKY, Huang SH, You JF, Tang R, Chng JM, Yeh CY, Hsh PS, TsaWS, Chng SF, LaCC. Smokg cessatn for less than 10 years remas a rk factor of anastomot leakage m-to-low rectal cancer patnts undergog sphcter-preservg surgery. Langenbecks Arch Surg. 2022 May;407(3):1131-1138. do 10.1007/s00423-021-02381-9. Epub 2022 Jan 26.
Sverste P. Smokg and wound healg. Am J Med. 1992 Jul 15;93(1A):22S-24S. do 10.1016/0002-9343(92)90623-j.
Guer V, Atlan M, CrtofarS. Pathophyslogy of note, place of note substutes and electron carettes plast surgery: A revw of the lerature. Ann Ch Plast Esthet. 2022 Jun;67(3):119-124. do 10.1016/j.anplas.2022.05.001. Epub 2022 Jun 4.
Turan A, Mascha EJ, Roberman D, Turner PL, You J, Kurz A, Sessler D Saager L. Smokg and perperate outcomes. Anestheslogy. 2011 Apr;114(4):837-46. do 10.1097/ALN.0b013e318210f560.
ShY, Warner DO. Surgery as a teachable moment for smokg cessatn. Anestheslogy. 2010 Jan;112(1):102-7. do 10.1097/ALN.0b013e3181c61cf9.
Parthasarathy M, Greensmh M, Bowers D, Groot-Wassk T. Rk factors for anastomot leakage after colorectal resectn: a retrospecte analys of 17 518 patnts. Colorectal D. 2017 Mar;19(3):288-298. do 10.1111/cod13476.
Zhang W, Lou Z, L Q, Meng R, Gong H, Hao L, L P, Sun G, Ma J, Zhang W. Multenter analys of rk factors for anastomot leakage after mdle and low rectal cancer resectn whout dertg stoma: a retrospecte study of 319 consecute patnts. t J Colorectal D. 2017 Oct;32(10):1431-1437. do 10.1007/s00384-017-2875-8. Epub 2017 Aug 2.
Shahab L, Gonwz ML, Blount BC, Brown J, McNel A, Alw KU, Feng J, Wang L, West R. Note, Carcogen, and Tox Exposure Long-Term E-Carette and Note Replacement Therapy Users: A Cross-sectnal Study. Ann tern Med. 2017 Mar 21;166(6):390-400. do 10.7326/M16-1107. Epub 2017 Feb 7.
Sun R, Mendez D, Warner KE. Trends Note Product Use Among US Adolescents, 1999-2020. JAMA Netw Open. 2021 Aug 2;4(8):e2118788. do 10.1001/jamanetworkopen.2021.18788.
von Elm E, Altman DG, Egger M, Pocock SJ, Gotzsche PC, Vandenbroucke JP; STROBE te. The Strengtheng the Reportg of Observatnal Studs Epemlogy (STROBE) statement: gueles for reportg observatnal studs. J Cl Epeml. 2008 Apr;61(4):344-9. do 10.1016/j.jclep2007.11.008.
Choe S Fley C. Confrontg the Negate pact of Carette Smokg on Cancer Surgery. Curr Oncol. 2022 Aug 18;29(8):5869-5874. do 10.3390/curroncol29080463.
Charlson ME, PompeP, Ales KL, MacKenz CR. A new method of classyg prognost comorby longudal studs: development and valatn. J Chron D. 1987;40(5):373-83. do 10.1016/0021-9681(87)90171-8.
Clavn PA, Barkun J, de Olea ML, Vauthey JN, Ddo D, Schulk RD, de Santanes E, Pekolj J, Slankamenac K, BassC, Graf R, Vonlanthen R, Padbury R, Cameron JL, MakuuchM. The Clavn-Ddo classatn of surgal complatns: fe-year expernce. Ann Surg. 2009 Aug;250(2):187-96. do 10.1097/SLA.0b013e3181b13ca2.
RahbarNN, Wez J, Hohenberger W, Heald RJ, Moran B, Ulrh A, Holm T, Wong WD, Tet E, Mora Y, Laurberg S, den Dulk M, van de Velde C, Buchler MW. Defn and gradg of anastomot leakage followg anterr resectn of the rectum: a proposal by the ternatnal Study Group of Rectal Cancer. Surgery. 2010 Mar;147(3):339-51. do 10.1016/j.surg.2009.10.012. Epub 2009 Dec 11.
Complicanze Post-operatorie e Abitudine Tabagica in Chirurgia Colorettale (Studio PASSAGE). Uno Studio Multicentrico Osservazionale Prospettico e Retrospettivo in Italia

الوصول الحر: https://clinicaltrials.gov/ct2/show/NCT06339671Test

Other URLs: https://nap.nationalacademies.org/catalog/24952/public-health-consequences-of-e-cigarettesTest

المؤلفون: Azienda Ospedaliera Ospedali Riuniti Marche Nord, Italy, Federico II University, Humanitas Hospital, Italy, San Giovanni Addolorata Hospital, Policlinico Universitario, Catania, Azienda Ospedaliero-Universitaria Careggi, Azienda Ospedaliero Universitaria di Sassari, Azienda Ospedaliera Universitaria Policlinico Paolo Giaccone Palermo, Ospedale Universitario di Genova, Italy, Istituto per la Sicurezza Sociale (ISS) della Repubblica di San Marino, Ospedale Bufalini di Cesena, Italy

المساهمون: Arianna Di Stadio, Adjunct Professor

المصدر: RallM, DStad A, Greco A, de Vcents M, PolenA. Defg the burden of olfactory dysfunctn COV-19 patnts. Eur Rev Med Pharmacol Sc 2020 Apr;24(7):3440-3441. do 10.26355/eurrev_202004_20797. No abstract avaable.
Mehardt J, Radke J, Dtmayer C, Franz J, Thomas C, Mothes R, Laue M, Schneer J, Brunk S, Greuel S, Lehmann M, Hassan O, Aschman T, Schumann E, Chua RL, Conrad C, Es R, Stenzel W, Wdgassen M, Rossler L, Goebel HH, Gelderblom HR, Mart H, Nsche A, Schulz-Schaeffer WJ, Hakroush S, Wkler MS, Tampe B, Schee F, Kortvelyessy P, Rehold D, Sgmund B, Kuhl AA, Elezkurtaj S, Horst D, Oesterhelweg L, Tsokos M, gold-Heppner B, Stadelmann C, Drosten C, Corman VM, Radbruch H, Heppner FL. Olfactory transmucosal SARS-CoV-2 vasn as a port of central nervous system entry duals wh COV-19. Nat Neurosc 2021 Feb;24(2):168-175. do 10.1038/s41593-020-00758-5. Epub 2020 Nov 30.
Levy JM. Treatment Recommendatns for Perstent Smell and Taste Dysfunctn Followg COV-19-The Comg Deluge. JAMA Otolaryngol Head Neck Surg. 2020 Aug 1;146(8):733. do 10.1001/jamaoto.2020.1378. No abstract avaable.
D'Ascan L, PandolfM, CgolanC, LatG, GradonP, Capalbo M, FrausG, Maranzano M, Brenner MJ, DStad A. Olfactory Dysfunctn COV-19 Patnts: Prevalence and Prognos for Recoverg Sense of Smell. Otolaryngol Head Neck Surg. 2021 Jan;164(1):82-86. do 10.1177/0194599820943530. Epub 2020 Jul 14.
Ch A, Fchbe N, Wtermark M, Zaharchuk G, Yun PT, Zeeh M. COV-19-duced anosm assocted wh olfactory bulb atrophy. Neuroradlogy. 2021 Jan;63(1):147-148. do 10.1007/s00234-020-02554-1. Epub 2020 Sep 15.
Laurendon T, Radulesco T, Mugnr J, Gerault M, Chagnaud C, El AhmadAA, Varoquaux A. Bateral transnt olfactory bulb edema durg COV-19-related anosm. Neurology. 2020 Aug 4;95(5):224-225. do 10.1212/WNL.0000000000009850. Epub 2020 May 22. No abstract avaable.
Lee MH, Perl DP, Na G, LW, Mar D, Murray H, Dodd SJ, Koretsky AP, Watts JA, Cheung V, Maslh E, Horkayne-Szakaly Jones R, Stram MN, Moncur J, HeftM, Folkerth RD, Nath A. Mrovascular jury the Bras of Patnts wh Cov-19. N Engl J Med. 2021 Feb 4;384(5):481-483. do 10.1056/NEJMc2033369. Epub 2020 Dec 30. No abstract avaable.
Stoyanov GS, Petkova L, Dzhenkov DL, Sapundzhv NR, Todorov Gross and Htopathology of COV-19 Wh Fst Htology Report of Olfactory Bulb Changes. Cureus. 2020 Dec 4;12(12):e11912. do 10.7759/cureus.11912.
Skaper SD, FaccL, GstP. Gl and mast cells as targets for palmoylethanolame, an antflammatory and neuroprotecte l medtor. Mol Neurobl. 2013 Oct;48(2):340-52. do 10.1007/s12035-013-8487-6. Epub 2013 Jun 28.
Pan-MondolfA, Bryce C, Gres Z, Gordon RE, Rey J, Lednky J, Sordlo EM, Fowkes M. Central nervous system volvement by severe acute respatory syndrome coronavus-2 (SARS-CoV-2). J Med Vol. 2020 Jul;92(7):699-702. do 10.1002/jmv.25915.
Gua F, Luongo L, Boccella S, Grdano ME, Romano R, BellG, Manzo Furno A, Rzo A, peratore R, nnottFA, D'Anllo E, PcellF, Sca RossF, Crto L, DMarzo V, de Novell V, Mane S. Palmoylethanolame duces mrogl changes assocted wh creased mratn and phagocyt acty: volvement of the CB2 receptor. ScRep. 2017 Mar 23;7(1):375. do 10.1038/s41598-017-00342-1.
Tan D, Yu X, Chen M, Chen J, Xu J. Lute protects agast severe traumat bra jury through antflammatn and antxate effects v AM-1/Nrf-2. Mol Med Rep. 2017 Oct;16(4):4235-4240. do 10.3892/mmr.2017.7040. Epub 2017 Jul 20.
Olfactory Disfunction After COVID-19: Conventional Therapy Versus Intervention Treatment With Co-ultraPEALut

الوصول الحر: https://clinicaltrials.gov/ct2/show/NCT04853836Test

المؤلفون: Azienda Ospedaliera Ospedali Riuniti Marche Nord, Ospedale Civile Santo Spirito, Pescara, Università Magna Grecia, Catanzaro, ASST Papa Giovanni XXIII, Bergamo, Azienda Ospedaliero Universitaria Policlinico Umberto I, Roma, ASST Cremona, Cremona, Fondazione IRCCS Cà Granda, Ospedale Maggiore Policlinico, Milano, Ospedale di Circolo e Fondazione Macchi, Varese

المساهمون: Armando Gabrielli, Full Professor Internal Medicine

المصدر: TOFAcitinib Plus Hydroxycloroquine vs Hydroxycloroquine in Patients With Early Onset SARS-CoV2 (COVID-19) Interstitial Pneumonia:a Multicenter Randomized Controlled Open Label Trial

الوصول الحر: https://clinicaltrials.gov/ct2/show/NCT04390061Test

المؤلفون: Azienda Ospedaliera Ospedali Riuniti Marche Nord

المساهمون: Armando Gabrielli, Full Professor Internal Medicine

المصدر: Tn S, Hu W, N L, L H, Xu H, Xo SY. Pulmonary Pathology of Early-Phase 2019 Novel Coronavus (COV-19) Pneumon Two Patnts Wh Lung Cancer. J Thorac Oncol. 2020 May;15(5):700-704. do 10.1016/j.jtho.2020.02.010. Epub 2020 Feb 28.
Ashour HM, Elkhat WF, Rahman MM, Elshabrawy HA. shts to the Recent 2019 Novel Coronavus (SARS-CoV-2) Lht of Past Human Coronavus Outbreaks. Pathogens. 2020 Mar 4;9(3):186. do 10.3390/pathogens9030186.
Channappanavar R, Perlman S. Pathogen human coronavus fectns: causes and consequences of cytoke storm and munopathology. Sem munopathol. 2017 Jul;39(5):529-539. do 10.1007/s00281-017-0629-x. Epub 2017 May 2.
Zumla A, polo G, NtoumF, Seyfert-Margols V, Nagu TJ, Clo D, Chakaya JM, Mara B, Maeurer M. Host-dected theraps and holt care for tuberculos. Lancet Resp Med. 2020 Apr;8(4):337-340. do 10.1016/S2213-2600(20)30078-3. Epub 2020 Feb 27. No abstract avaable.
Tocilizumab (RoActemra) as Early Treatment of Patients Affected by SARS-CoV2 (COVID-19) Infection With Severe Multifocal Interstitial Pneumonia

الوصول الحر: https://clinicaltrials.gov/ct2/show/NCT04315480Test

المؤلفون: Ospedali Riuniti Marche Nord, Pesaro, Italy, NOCSAE Hospital, Modena, Italy, University of Siena, Italy, Papa Giovanni XXIII Hospital

المساهمون: MASSIMO CONIO, MD, Director of Gastroenterology Department, General Hospital Sanremo, Italy

المصدر: Warshaw AL, Fernandez-del Castlo C. Pancreat carcoma. N Engl J Med. 1992 Feb 13;326(7):455-65. do 10.1056/NEJM199202133260706. No abstract avaable.
Cublla J, Castells A, Fondeva C, Sans M, Sabater L, Navarro S, Fernandez-Cruz L. Prognost factors nonresectable pancreat adenocarcoma: a ratnale to desn therapeut trls. Am J Gastroenterol. 1999 May;94(5):1271-8. do 10.1111/j.1572-0241.1999.01018.x.
Dumonceau JM, Cremer M, Auroux J, Delhaye M, Devre J. A comparon of Ultraflex Dmond stents and Wallstents for palltn of dtal malnant bry strtures. Am J Gastroenterol. 2000 Mar;95(3):670-6. do 10.1111/j.1572-0241.2000.01844.x.
Ferlsch A, Oesterreher C, Dumonceau JM, Devre J, Leban T, Born P, Rosch T, Suter W, Bek J, Meyenberger C, Mullner M, Schneer B, Schofl R. Dmond stents for palltn of malnant be duct obstructn: a prospecte multenter evaluatn. Endoscopy. 2001 Aug;33(8):645-50. do 10.1055/s-2001-16214.
Ahmad J, Suea E, Mart J, Slka A. Effecteness of the Ultraflex Dmond stent for the palltn of malnant bry obstructn. Endoscopy. 2002 Oct;34(10):793-6. do 10.1055/s-2002-34269.
Shah RJ, Howell DA, Desets DJ, Sheth SG, Parsons WG, Okolo P 3rd, Lehman GA, Sherman S, Bal J, Branch MS, Pleskow D, ChuttanR, Bosco JJ. Multenter randomed trl of the spal Z-stent compared wh the Wallstent for malnant bry obstructn. Gastrotest Endosc. 2003 Jun;57(7):830-6. do 10.1016/s0016-5107(03)70016-9.
Kaass M, Boyer J, Dumas R, Ponchon T, Coumaros D, Delcenser R, Canard JM, Frsch J, Rey JF, Burt P. Plast or metal stents for malnant strture of the common be duct? Results of a randomed prospecte study. Gastrotest Endosc. 2003 Feb;57(2):178-82. do 10.1067/mge.2003.66.
Knyr K, Wagner HJ, Pausch J, Vak N. A prospecte, randomed, controlled trl of metal stents for malnant obstructn of the common be duct. Endoscopy. 1993 Mar;25(3):207-12. do 10.1055/s-2007-1010294.
Sao H, SakuraY, Takamura A, Hor K. [Bry endoprosthes usg Gore-Tex covered expandable metall stents: prelary clal evaluatn]. Non aku Hoshasen GakkaZassh 1994 Feb 25;54(2):180-2. Japanese.
ayama H, Komatsu Y, Tsujo T, Sasaha N, Hano K, Toda N, NakaY, Yamamoto N, Tada M, Yosha H, ShatorY, Kawabe T, Omata M. A prospecte randomed study of "covered" versus "uncovered" dmond stents for the management of dtal malnant bry obstructn. Gut. 2004 May;53(5):729-34. do 10.1136/gut.2003.018945.
Park DH, K MH, ChoJS, Lee SS, Seo DW, K JH, Han J, K JC, ChoEK, Lee SK. Covered versus uncovered wallstent for malnant extrahepat bry obstructn: a cohort comparate analys. Cl Gastroenterol Hepatol. 2006 Jun;4(6):790-6. do 10.1016/j.cgh.2006.03.032. Epub 2006 May 22.
Yoon WJ, Lee JK, Lee KH, Lee WJ, Ryu JK, K YT, Yoon YB. A comparon of covered and uncovered Wallstents for the management of dtal malnant bry obstructn. Gastrotest Endosc. 2006 Jun;63(7):996-1000. do 10.1016/j.g.2005.11.054.
ayama H, Kawabe T, NakaY, Tsujo T, Sasaha N, Yamamoto N, ArumT, Togawa O, Matsubara S, o Y, SasakT, Hano K, Toda N, Komatsu Y, Tada M, Yosha H, Omata M. Cholecyst after metall stent placement patnts wh malnant dtal bry obstructn. Cl Gastroenterol Hepatol. 2006 Sep;4(9):1148-53. do 10.1016/j.cgh.2006.06.004. Epub 2006 Aug 14.
Davs PH, Groen AK, Rauws EA, Tytgat GN, Huregtse K. Randomed trl of self-expandg metal stents versus polyethylene stents for dtal malnant bry obstructn. Lancet. 1992 Dec 19-26;340(8834-8835):1488-92. do 10.1016/0140-6736(92)92752-2.
Prat F, Chapat O, Ducot B, Ponchon T, Pelletr G, Frsch J, Choury AD, Buffet C. A randomed trl of endoscop draage methods for operable malnant strtures of the common be duct. Gastrotest Endosc. 1998 Jan;47(1):1-7. do 10.1016/s0016-5107(98)70291-3.
Covered Versus Uncovered Self-conformable Metal Stent for Palliation of Primary Malignant Extra-hepatic Biliary Strictures: a Randomized Multicenter Study

الوصول الحر: https://clinicaltrials.gov/ct2/show/NCT02930252Test

المؤلفون: Leonardi, Sergio, Frigoli, Enrico, Rothenbühler, Martina, Navarese, Eliano, Calabró, Paolo, Bellotti, Paolo, Briguori, Carlo, Ferlini, Marco, Cortese, Bernardo, Lupi, Alessandro, Lerna, Salvatore, Zavallonito-Parenti, Dennis, Esposito, Giovanni, Tresoldi, Simone, Zingarelli, Antonio, Rigattieri, Stefano, Palmieri, Cataldo, Liso, Armando, Abate, Fabio, Zimarino, Marco, Comeglio, Marco, Gabrielli, Gabriele, Chieffo, Alaide, Brugaletta, Salvatore, Mauro, Ciro, Van Mieghem, Nicolas M, Heg, Dik, Jüni, Peter, Windecker, Stephan, Valgimigli, Marco, Maria Salomone, Enrico Frigoli, Pierpaolo Occhilupo, Veronica Lodolini, Monia Monti, Maria Grazia Mazzone, Erika Delos, Maria Teresa Caruso, Maggie Testa, Nestor Ciociano, Maurizio Lazzero, Davide Gazzotti, Lorenzo Cagliari, Leila Shahmohammadi, Martina Caiazza, Vittorio Virga, Elena Guerra, Eva Michalska, Sara Castellini, Vincenzo Serino, Gabriella Visconti, Gianluca Pendenza, Monica Portolan, Marco Anzini, Elisa Silvetti, Tiziana Coco, Francesco Costa, Sara Ariotti, Linda Valli, Marianna Adamo, Marcello Marino, Pascal Vranckx, Sergio Leonardi, Pierluigi Tricoci, Peter Jüni, Martina Rothenbühler, Dik Heg, Marco Valgimigli, Andrea Gagnor, Paolo Calabrò, Paolo Rubartelli, Stefano Garducci, Giuseppe Andò, Andrea Santarelli, Mario Galli, Roberto Garbo, Ezio Bramucci, Salvatore Ierna, Carlo Briguori, Bernardo Cortese, Ugo Limbruno, Roberto Violini, Patrizia Presbitero, Nicoletta de Cesare, Paolo Sganzerla, Arturo Ausiello, Paolo Tosi, Gennaro Sardella, Manel Sabate', Salvatore Brugaletta, Giovanni Saccone, Pietro Vandoni, Antonio Zingarelli, Armando Liso, Stefano Rigattieri, Sandro Pertini, Emilio Di Lorenzo, Carlo Vigna, Cataldo Palmieri, Camillo Falcone, Raffaele De Caterina, Marcello Caputo, Annunziata Chieti, Giovanni Esposito, Alessandro Lupi, Pietro Mazzarotto, Fernando Varbella, Tiziana Zaro, Marco Nazzaro, Sunil V Rao, Arnoud W J van't Hof, Elmir Omerovic, Gianluca Campo, Lucia Uguccioni, Marche Nord, Corrado Tamburino, Dennis Zavalloni-Parenti, Fabio Ferrari, Roberto Ceravolo, Fabio Tarantino, Giampaolo Pasquetto, Gavino Casu, Stefano Mameli, Maria Letizia Stochino, Alberto Cremonesi, Francesco Saia, Fabio Abate, Andrea Picchi, Salvatore Colangelo, Giacomo Boccuzzi, Vincenzo Guiducci, Ferdinando Varbella, Stefano Tresoldi, Marco Contarini, Antonio Dellavalle, Salvatore Curello, Fabio Mangiacapra, Rosario Evola, Francesco Liistro, Manuela Creaco, Antonio Colombo, Alaide Chieffo, Andrea Perkan, Stefano De Servi, Dionigi Fischetti, Alessandro Sciahbasi, Edoardo Pucci, Enrico Romagnoli, Claudio Moretti, Luciano Moretti, Marco Zimmarino, Maurizio Ferrario, Maurizio Turturo, Roberto Bonmassari, Carlo Penzo, Bruno Loi, Ciro Mauro, Anna Sonia Petronio, Gabriele Gabrielli, Antonio Micari, Flavia Belloni, Francesco Amico, Marco Comeglio, Claudio Fresco, Nicolas Van Mieghem, Roberto Diletti, Evelyn Regar, Manel Sabaté, Joan Antoni Gómez, José Francisco Díaz Fernández, Juan Ramón Jiménez, Vicente Mainar, Jose Maria de la Torre Hernandez

المساهمون: Leonardi, Sergio, Frigoli, Enrico, Rothenbühler, Martina, Navarese, Eliano, Calabró, Paolo, Bellotti, Paolo, Briguori, Carlo, Ferlini, Marco, Cortese, Bernardo, Lupi, Alessandro, Lerna, Salvatore, Zavallonito-Parenti, Denni, Esposito, Giovanni, Tresoldi, Simone, Zingarelli, Antonio, Rigattieri, Stefano, Palmieri, Cataldo, Liso, Armando, Abate, Fabio, Zimarino, Marco, Comeglio, Marco, Gabrielli, Gabriele, Chieffo, Alaide, Brugaletta, Salvatore, Mauro, Ciro, Van Mieghem, Nicolas M, Heg, Dik, Jüni, Peter, Windecker, Stephan, Valgimigli, Marco, Salomone, Maria, Occhilupo, Pierpaolo, Lodolini, Veronica, Monti, Monia, Maria Grazia Mazzone, Delos, Erika, Maria Teresa Caruso, Testa, Maggie, Ciociano, Nestor, Lazzero, Maurizio, Gazzotti, Davide, Cagliari, Lorenzo, Shahmohammadi, Leila, Caiazza, Martina, Virga, Vittorio, Guerra, Elena, Michalska, Eva, Castellini, Sara, Serino, Vincenzo, Visconti, Gabriella, Pendenza, Gianluca, Portolan, Monica, Anzini, Marco, Silvetti, Elisa, Coco, Tiziana, Costa, Francesco, Ariotti, Sara, Valli, Linda, Adamo, Marianna, Marino, Marcello, Vranckx, Pascal, Tricoci, Pierluigi, Gagnor, Andrea, Calabrò, Paolo, Rubartelli, Paolo, Garducci, Stefano, Andò, Giuseppe, Santarelli, Andrea, Galli, Mario, Garbo, Roberto, Bramucci, Ezio, Ierna, Salvatore, Limbruno, Ugo, Violini, Roberto, Presbitero, Patrizia, Nicoletta de Cesare, Sganzerla, Paolo, Ausiello, Arturo, Tosi, Paolo, Sardella, Gennaro, Sabate', Manel, Saccone, Giovanni, Vandoni, Pietro, Pertini, Sandro, Emilio Di Lorenzo, Vigna, Carlo, Falcone, Camillo

الوصف: Objective: To test the optimal antithrombotic regimen in patients with acute coronary syndrome. Design: Randomised controlled trial. Setting: Patients with acute coronary syndrome with and without ST segment elevation in 78 centres in Italy, the Netherlands, Spain, and Sweden. Participants: 7213 patients with acute coronary syndrome and planned percutaneous coronary intervention: 4010 with ST segment elevation and 3203 without ST segment elevation. The primary study results in the overall population have been reported previously. Interventions: Patients were randomly assigned, in an open label fashion, to one of two regimens: bivalirudin with glycoprotein IIb/IIIa inhibitors restricted to procedural complications or heparin with or without glycoprotein IIb/IIIa inhibitors. Main outcome measures: Primary endpoints were the occurrence of major adverse cardiovascular events, defined as death, myocardial infarction or stroke; and net adverse clinical events, defined as major bleeding or major adverse cardiovascular events, both assessed at 30 days. Analyses were performed by the principle of intention to treat. Results: Use of a glycoprotein IIb/IIIa inhibitor in patients assigned to heparin was planned at baseline in 30.7% of patients with ST segment elevation, in 10.9% without ST segment elevation, and in no patients assigned to bivalirudin. In patients with ST segment elevation, major adverse cardiovascular events occurred in 118 (5.9%) assigned to bivalirudin and 129 (6.5%) assigned to heparin (rate ratio 0.90, 95% confidence interval 0.70 to 1.16; P=0.43), whereas net adverse clinical events occurred in 139 (7.0%) patients assigned to bivalirudin and 163 (8.2%) assigned to heparin (0.84, 0.67 to 1.05; P=0.13). In patients without ST segment elevation, major adverse cardiovascular events occurred in 253 (15.9%) assigned to bivalirudin and 262 (16.4%) assigned to heparin (0.97, 0.80 to 1.17; P=0.74), whereas net adverse clinical events occurred in 262 (16.5%) patients assigned to bivalirudin and 281 (17.6%) ...

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/27677503; info:eu-repo/semantics/altIdentifier/wos/WOS:000385855100001; volume:354; firstpage:1; lastpage:11; numberofpages:11; journal:BMJ; https://hdl.handle.net/11570/3284420Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-84995747091; https://www.bmj.com/content/354/bmj.i4935.longTest

الإتاحة: https://doi.org/10.1136/bmj.i4935Test
https://hdl.handle.net/11570/3284420Test
https://www.bmj.com/content/354/bmj.i4935.longTest

المؤلفون: Mooijaart, Simon P, Nickel, Christian H, Conroy, Simon P, Lucke, Jacinta A, van Tol, Lisa S, Olthof, Mareline, Blomaard, Laura C, Buurman, Bianca M, Dundar, Zerrin D, de Groot, Bas, Gasperini, Beatrice, Heeren, Pieter, Karamercan, Mehmet A, McNamara, Rosa, Mitchell, Aine, van Oppen, James D, Martin Sanchez, F Javier, Schoon, Yvonne, Singler, Katrin, Spode, Renan, Skúldóttir, Sigrun, Thorrsteindottir, Thordis, van der Velde, Marije, Wallace, James

المساهمون: 1Department of Gerontology and Geriatrics, Leiden University Medical Centre, PO Box 9600, 2300 RC, Leiden, The Netherlands. S.P.Mooijaart@lumc.nl. 2Institute for Evidence-Based Medicine for Older People (IEMO), Leiden, The Netherlands. S.P.Mooijaart@lumc.nl. 3Department of Emergency Medicine, University Hospital Basel, University of Basel, Basel, Switzerland. 4Department of Health Sciences, University of Leicester, Leicester, UK. 5Department of Gerontology and Geriatrics, Leiden University Medical Centre, PO Box 9600, 2300 RC, Leiden, The Netherlands. 6Department of Emergency Medicine, Spaarne Gasthuis, Haarlem, The Netherlands. 7Section of Geriatric Medicine, Department of Internal Medicine, Amsterdam Public Health Research Institute, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands. 8Department of Emergency Medicine, Necmettin Erbakan University Meram Faculty of Medicine, Konya, Turkey. 9Department of Emergency Medicine, Leiden University Medical Centre, Leiden, The Netherlands. 10Department of Geriatrics and Rehabilitation, Santa Croce Hospital, Azienda Ospedaliera Ospedali Riuniti Marche Nord, Fano, Italy. 11Department of Public Health and Primary Care, KU Leuven, Leuven, Belgium. 12Department of Geriatric Medicine, University Hospitals Leuven, Leuven, Belgium. 13Research Foundation-Flanders (FWO), Brussels, Belgium. 14Department of Emergency Medicine, Gazi University School of Medicine, Ankara, Turkey. 15Department of Emergency Medicine, St. Vincent University Hospital, Dublin, Ireland. 16Department of Emergency Medicine, Sligo University Hospital, Sligo, Ireland. 17Emergency Department, University Hospitals of Leicester NHS Trust, Leicester, UK. 18Emergency Department, Hospital Clínico San Carlos, Instituto de Investigación Sanitaria Hospital Clínico San Carlos (IdISSC), Universidad Complutense de Madrid, Madrid, Spain. 19Department of Emergency Medicine and Department of Geriatrics, Radboud Institute for Health Sciences, Radboud University Medical Center, Nijmegen, The Netherlands. 20Department of Geriatrics, Klinikum Nürnberg, Paracelsus Private, Medical University, Nuremberg, Germany. 21Department of Emergency Medicine, Charité University Hospital, Berlin, Germany. 22Research Institute in Emergency Care, Landspitali National University Hospital of Iceland, Reykjavík, Iceland. 23The Icelandic Gerontological Research Institute, Reykjavík, Iceland. 24Department of Geriatrics, Amphia Hospital, Breda, The Netherlands. 25Emergency Department, Warrington and Halton Hospitals NHS Teaching Trust, Warrington, England, UK.

المصدر: European geriatric medicine ; Switzerland

مصطلحات موضوعية: Geriatric Emergency Medicine, Research prioritisation, Öldrunarlækningar, Bráðalækningar, Aldraðir, Emergency Medicine, Geriatrics

الوصف: To access publisher's full text version of this article, please click on the hyperlink in Additional Links field or click on the hyperlink at the top of the page marked Download ; Purpose: Geriatric Emergency Medicine (GEM) focuses on delivering optimal care to (sub)acutely ill older people. This involves a multidisciplinary approach throughout the whole healthcare chain. However, the underpinning evidence base is weak and it is unclear which research questions have the highest priority. The aim of this study was to provide an inventory and prioritisation of research questions among GEM professionals throughout Europe. Methods: A two-stage modified Delphi approach was used. In stage 1, an online survey was administered to various professionals working in GEM both in the Emergency Department (ED) and other healthcare settings throughout Europe to make an inventory of potential research questions. In the processing phase, research questions were screened, categorised, and validated by an expert panel. Subsequently, in stage 2, remaining research questions were ranked based on relevance using a second online survey administered to the same target population, to identify the top 10 prioritised research questions. Results: In response to the first survey, 145 respondents submitted 233 potential research questions. A total of 61 research questions were included in the second stage, which was completed by 176 respondents. The question with the highest priority was: Is implementation of elements of CGA (comprehensive geriatric assessment), such as screening for frailty and geriatric interventions, effective in improving outcomes for older patients in the ED? Conclusion: This study presents a top 10 of high-priority research questions for a European Research Agenda for Geriatric Emergency Medicine. The list of research questions may serve as guidance for researchers, policymakers and funding bodies in prioritising future research projects. Keywords: Geriatric Emergency Medicine; Research prioritisation. ; Dutch Ministry ...

العلاقة: https://link.springer.com/article/10.1007/s41999-020-00426-8Test; Mooijaart SP, Nickel CH, Conroy SP, Lucke JA, van Tol LS, Olthof M, et al. A European Research Agenda for Geriatric Emergency Medicine: a modified Delphi study. European geriatric medicine. 2020.doi:10.1007/s41999-020-00426-8.; http://hdl.handle.net/2336/621615Test; European geriatric medicine

الإتاحة: https://doi.org/10.1007/s41999-020-00426-8Test
http://hdl.handle.net/2336/621615Test