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1دورية أكاديمية
المؤلفون: Mar Sempere-Bigorra, Iván Julián-Rochina, Pilar Pérez-Ros, Emmanuel Navarro-Flores, Francisco Miguel Martínez-Arnau, Omar Cauli
المصدر: Life, Vol 13, Iss 9, p 1790 (2023)
مصطلحات موضوعية: somatosensory functions, deep sensory pathway, superficial sensory pathway, cognitive impairment, the symptoms of depression, aging, Science
الوصف: Aging is an inevitable process that impacts the peripheral and central nervous systems and is considered one of the strongest risk factors for neurodegenerative diseases. In addition, when it also presents with diabetes mellitus, the risk of neurological damage may be further increased. This current study aimed to explore the relationships between peripheral sensory system decline and cognitive functions, the symptoms of depression, and quality of life (QoL) as metrics of central nervous system impairment in institutionalized older adults. A total of 95 individuals participated in this case-control study, which included diabetics and non-diabetics. The superficial sensory pathway was assessed in terms of thermal sensation, nociception, and non-discriminative touch, and the deep sensory pathway was evaluated by assessing vibration and light touch-pressure sensations. To assess function at the intellectual level, the Mini-Mental State Examination (MMSE) and Trail Making Test (TMT) cognitive functional tests were used, while the symptoms of depression and QoL were explored by employing the Yesavage Geriatric Depression Scale and EuroQol 5D questionnaire (EQ-5D), respectively. In the overall population analyses, altered thermal sensation was significantly associated with cognitive impairment (CI; p < 0.05). In turn, bivariate analyses and a binary logistic regression showed that the symptoms of depression and QoL were significantly related to altered vibratory sensation when assessed using a medical tuning fork (p < 0.05). In the group of diabetic patients, those with CI also had significantly lower thermal sensation (p < 0.05) and non-discriminative touch sensation, although this was only a trend (p = 0.055). Diabetics with depression had a significantly worse non-discriminative touch (p < 0.05) and vibratory sensation when tested with a tuning fork (p < 0.05). In addition, poorer QoL was associated with reduced sensitivity to heat (p < 0.05), light touch pressure (p < 0.05), and vibrations when assessed either with a tuning fork (p < 0.05) or a biothesiometer (p < 0.05). In contrast, no relationships were found between sensory functions and cognitive assessments in non-diabetic patients. These findings indicate that superficial sensitivity damage was related to CI, while deep sensation alterations were related to depression and poor QoL, with diabetes apparently further strengthening these relationships.
وصف الملف: electronic resource
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2دورية أكاديمية
المؤلفون: Mar Sempere-Bigorra, Iván Julián-Rochina, Omar Cauli
المصدر: Current Oncology, Vol 28, Iss 4, Pp 3124-3138 (2021)
مصطلحات موضوعية: toxicity, side effects, cold sensitivity, autonomic dysfunction, regimens, cytostatic drugs, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
الوصف: Although cancer and diabetes are common diseases, the relationship between diabetes, neuropathy and the risk of developing peripheral sensory neuropathy while or after receiving chemotherapy is uncertain. In this review, we highlight the effects of chemotherapy on the onset or progression of neuropathy in diabetic patients. We searched the literature in Medline and Scopus, covering all entries until 31 January 2021. The inclusion and exclusion criteria were: (1) original article (2) full text published in English or Spanish; (3) neuropathy was specifically assessed (4) the authors separately analyzed the outcomes in diabetic patients. A total of 259 papers were retrieved. Finally, eight articles fulfilled the criteria, and four more articles were retrieved from the references of the selected articles. The analysis of the studies covered the information about neuropathy recorded in 768 cancer patients with diabetes and 5247 control cases (non-diabetic patients). The drugs investigated are chemotherapy drugs with high potential to induce neuropathy, such as platinum derivatives and taxanes, which are currently the mainstay of treatment of various cancers. The predisposing effect of co-morbid diabetes on chemotherapy-induced peripheral neuropathy depends on the type of symptoms and drug used, but manifest at any drug regimen dosage, although greater neuropathic signs are also observed at higher dosages in diabetic patients. The deleterious effects of chemotherapy on diabetic patients seem to last longer, since peripheral neuropathy persisted in a higher proportion of diabetic patients than non-diabetic patients for up to two years after treatment. Future studies investigating the risk of developing peripheral neuropathy in cancer patients with comorbid diabetes need to consider the duration of diabetes, cancer-induced neuropathic effects per se (prior chemotherapy administration), and the effects of previous cancer management strategies such as radiotherapy and surgery.
وصف الملف: electronic resource
العلاقة: https://www.mdpi.com/1718-7729/28/4/273Test; https://doaj.org/toc/1198-0052Test; https://doaj.org/toc/1718-7729Test
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3دورية أكاديمية
المؤلفون: Mar Sempere-Bigorra, Iván Julián-Rochina, Omar Cauli
المصدر: Journal of Personalized Medicine, Vol 11, Iss 3, p 230 (2021)
مصطلحات موضوعية: cytokines, vibratory sensitivity, thermal sensitivity, muscle, biomarkers, insulin, Medicine
الوصف: Background: Diabetic neuropathy is defined as the dysfunction of the peripheral nervous system in diabetic patients. It is considered a microvascular complication of diabetes mellitus. Its presence is associated with increased morbidity and mortality. Although several studies have found alterations at somatic motor, sensory levels and at the level of autonomic nervous system in diabetic patients, there is not a systematic approach regarding the differences in neuropathy between the major variants of diabetes, e.g., type 1 and 2 diabetes at both neurological and molecular level. Data sources: we systematically (Medline, Scopus, and Cochrane databases) evaluated the literature related to the difference of neuropathy in type 1 and 2 diabetes, differences in molecular biomarkers. Study characteristics: seventeen articles were selected based on pre-defined eligibility criteria. Conclusions: both superficial sensitivity (primarily thermal sensitivity to cold) and deep sensitivity (such as vibratory sensitivity), have been reported mainly in type 2 diabetes. Cardiac autonomic neuropathy is one of the diabetic complications with the greatest impact at a clinical level but is nevertheless one of the most underdiagnosed. While for type 1 diabetes patients most neuropathy alterations have been reported for the Valsalva maneuver and for the lying-to-standing test, for type 2 diabetes patients, alterations have been reported for deep-breathing test and the Valsalva test. In addition, there is a greater sympathetic than parasympathetic impairment, as indicated by the screening tests for autonomic cardiac neuropathy. Regarding subclinical inflammation markers, patients with type 2 diabetes showed higher blood levels of inflammatory markers such as high-sensitivity C-reactive protein, proinflammatory cytokines IL-6, IL-18, soluble cell adhesion molecules and E-selectin and ICAM-1, than in type 1 diabetes patients. By contrast, the blood levels of adiponectin, an adipocyte-derived protein with multiple paracrine and endocrine activities (anti-inflammatory, insulin-sensitizing and proangiogenic effects) are higher in type 1 than in type 2 diabetic patients. This review provides new insights into the clinical differences in type 1 and 2 diabetes and provide future directions in this research field.
وصف الملف: electronic resource
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المساهمون: Sempere-Bigorra, Mar, Brognara, Lorenzo, Julian-Rochina, Iván, Mazzotti, Antonio, Cauli, Omar
المصدر: Sempere-Bigorra, Mar Brognara, Lorenzo Julián Rochina, Iván Mazzotti, Antonio Cauli, Omar 2023 Relationship between deep and superficial sensitivity assessments and gait analysis in diabetic foot patients International Wound Journal n/a n/a
مصطلحات موضوعية: Neurologia, Diabetis, peripheral diabetic neuropathy, superficial sensory pathway, Surgery, gait parameter, Dermatology, deep sensory pathway
الوصف: Peripheral neuropathy is a prevalent complication of diabetes that can lead to gait impairment and its adverse consequences. This study explored the potential utility of different parameters of gait analysis using a single sensor unit as a simple tool to detect peripheral neuropathy in 85 diabetic patients (DP) with diabetic foot in whom different somato-sensitivity tests in the feet were performed. Gait spatiotemporal parameters were examined by sensor inertial measurement placed in the lumbar area, while the superficial sensitivity pathway was assessed by nociception tests and deep sensitivity was examined by light touch-pressure and vibration sensitivity tests. Correlations between each sensory test and gait parameters were analysed in a logistic regression model in order to assess if gait parameters are associated with two different sensory pathways. Impaired deep sensory pathways were significantly (P
وصف الملف: ELETTRONICO
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f55bf90e79ba538d37dd5a50da11a76Test
https://hdl.handle.net/11585/924002Test -
5
المؤلفون: Iván Julián-Rochina, Mar Sempere-Bigorra, Omar Cauli
المصدر: Current Oncology, Vol 28, Iss 273, Pp 3124-3138 (2021)
Current Oncologyمصطلحات موضوعية: Drug, medicine.medical_specialty, medicine.medical_treatment, media_common.quotation_subject, autonomic dysfunction, MEDLINE, Antineoplastic Agents, Review, Diabetes mellitus, Internal medicine, Neoplasms, cold sensitivity, medicine, Diabetes Mellitus, Humans, RC254-282, media_common, Chemotherapy, business.industry, cytostatic drugs, Cancer, Peripheral Nervous System Diseases, toxicity, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, medicine.disease, Radiation therapy, side effects, regimens, Peripheral neuropathy, Inclusion and exclusion criteria, business
الوصف: Although cancer and diabetes are common diseases, the relationship between diabetes, neuropathy and the risk of developing peripheral sensory neuropathy while or after receiving chemotherapy is uncertain. In this review, we highlight the effects of chemotherapy on the onset or progression of neuropathy in diabetic patients. We searched the literature in Medline and Scopus, covering all entries until 31 January 2021. The inclusion and exclusion criteria were: (1) original article (2) full text published in English or Spanish; (3) neuropathy was specifically assessed (4) the authors separately analyzed the outcomes in diabetic patients. A total of 259 papers were retrieved. Finally, eight articles fulfilled the criteria, and four more articles were retrieved from the references of the selected articles. The analysis of the studies covered the information about neuropathy recorded in 768 cancer patients with diabetes and 5247 control cases (non-diabetic patients). The drugs investigated are chemotherapy drugs with high potential to induce neuropathy, such as platinum derivatives and taxanes, which are currently the mainstay of treatment of various cancers. The predisposing effect of co-morbid diabetes on chemotherapy-induced peripheral neuropathy depends on the type of symptoms and drug used, but manifest at any drug regimen dosage, although greater neuropathic signs are also observed at higher dosages in diabetic patients. The deleterious effects of chemotherapy on diabetic patients seem to last longer, since peripheral neuropathy persisted in a higher proportion of diabetic patients than non-diabetic patients for up to two years after treatment. Future studies investigating the risk of developing peripheral neuropathy in cancer patients with comorbid diabetes need to consider the duration of diabetes, cancer-induced neuropathic effects per se (prior chemotherapy administration), and the effects of previous cancer management strategies such as radiotherapy and surgery.
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::665d5ef6b5916058904d5e13c8114e20Test
https://www.mdpi.com/1718-7729/28/4/273Test -
6
المؤلفون: Omar Cauli, Mar Sempere-Bigorra, Iván Julián-Rochina
المصدر: Journal of Personalized Medicine, Vol 11, Iss 230, p 230 (2021)
Sempere-Bigorra, Mar Julián Rochina, Iván Cauli, Omar 2021 Differences and Similarities in Neuropathy in Type 1 and 2 Diabetes: A Systematic Review Journal Of Personalized Medicine 11 3
RODERIC: Repositorio Institucional de la Universitat de Valéncia
instname
Journal of Personalized Medicine
RODERIC. Repositorio Institucional de la Universitat de Valénciaمصطلحات موضوعية: insulin, medicine.medical_specialty, Diabetic neuropathy, muscle, medicine.medical_treatment, lcsh:Medicine, Medicine (miscellaneous), 030209 endocrinology & metabolism, Review, Type 2 diabetes, thermal sensitivity, vibratory sensitivity, 03 medical and health sciences, 0302 clinical medicine, Infermeria, Internal medicine, Diabetes mellitus, Valsalva maneuver, Medicine, 030212 general & internal medicine, Type 1 diabetes, Adiponectin, business.industry, Insulin, lcsh:R, biomarkers, medicine.disease, cytokines, Autonomic nervous system, business
الوصف: Background: Diabetic neuropathy is defined as the dysfunction of the peripheral nervous system in diabetic patients. It is considered a microvascular complication of diabetes mellitus. Its presence is associated with increased morbidity and mortality. Although several studies have found alterations at somatic motor, sensory levels and at the level of autonomic nervous system in diabetic patients, there is not a systematic approach regarding the differences in neuropathy between the major variants of diabetes, e.g., type 1 and 2 diabetes at both neurological and molecular level. Data sources: we systematically (Medline, Scopus, and Cochrane databases) evaluated the literature related to the difference of neuropathy in type 1 and 2 diabetes, differences in molecular biomarkers. Study characteristics: seventeen articles were selected based on pre-defined eligibility criteria. Conclusions: both superficial sensitivity (primarily thermal sensitivity to cold) and deep sensitivity (such as vibratory sensitivity), have been reported mainly in type 2 diabetes. Cardiac autonomic neuropathy is one of the diabetic complications with the greatest impact at a clinical level but is nevertheless one of the most underdiagnosed. While for type 1 diabetes patients most neuropathy alterations have been reported for the Valsalva maneuver and for the lying-to-standing test, for type 2 diabetes patients, alterations have been reported for deep-breathing test and the Valsalva test. In addition, there is a greater sympathetic than parasympathetic impairment, as indicated by the screening tests for autonomic cardiac neuropathy. Regarding subclinical inflammation markers, patients with type 2 diabetes showed higher blood levels of inflammatory markers such as high-sensitivity C-reactive protein, proinflammatory cytokines IL-6, IL-18, soluble cell adhesion molecules and E-selectin and ICAM-1, than in type 1 diabetes patients. By contrast, the blood levels of adiponectin, an adipocyte-derived protein with multiple paracrine and endocrine activities (anti-inflammatory, insulin-sensitizing and proangiogenic effects) are higher in type 1 than in type 2 diabetic patients. This review provides new insights into the clinical differences in type 1 and 2 diabetes and provide future directions in this research field.
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df6c4c1d042f0065f4aa73e6060cd609Test
https://doi.org/10.3390/jpm11030230Test
النص الكامل