-
1دورية أكاديمية
المؤلفون: Manuela Pastore-Wapp, Brigitte C. Kaufmann, Thomas Nyffeler, Simona Wapp, Stephan Bohlhalter, Tim Vanbellingen
المصدر: Journal of NeuroEngineering and Rehabilitation, Vol 20, Iss 1, Pp 1-6 (2023)
مصطلحات موضوعية: Parkinson’s disease, Dexterity, Video game-based training, Intermittent theta-burst stimulation, Feasibility, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571
الوصف: Abstract Background Persons with Parkinson’s disease (PD) often exhibit difficulties with dexterity during the performance of activities of daily living (ADL), inter alia due to dysfunctional supplementary motor area (SMA). Combined intermittent theta-burst stimulation (iTBS) over the SMA followed by video game-based training (VBT) may therefore improve dexterity related ADL. The VBT may induce high flow levels related to high performance during the training. The aim of this study is to evaluate the feasibility of a combined iTBS-VBT intervention in persons with PD. Methods A total of nine persons with PD (mean age 63.3 ± 8.76 years) with self-reported difficulties with dexterity related ADL were included in this pilot iTBS-VBT study. All participants received either iTBS or sham stimulation over the SMA followed by a 45-min VBT, three times a week for a total of three weeks. Feasibility was measured by means of the adherence rate and the system usability (System Usability Scale). Moreover, flow was measured after the last VBT session. Results Adherence rate was excellent with 100%. High system usability scores (i.e., mean 80%, range 55–97.5) and a significant Spearman’s correlation with the Flow State Scale (r = .762, p = .017) further point to the high feasibility of the VBT. Neither demographic variables nor difficulties in dexterity related ADL affected the usability of the VBT. Conclusion This study demonstrates the high feasibility of a combined iTBS-VBT intervention. Moreover, the level of self-reported usability was related to flow experience. Whether this kind of combined iTBS-VBT intervention improves dexterity will be evaluated in a randomized controlled trial. Trial registration clincaltrials.gov NCT04699149, date of registration 1. June 2021
وصف الملف: electronic resource
العلاقة: https://doaj.org/toc/1743-0003Test
-
2دورية أكاديمية
المؤلفون: Christian Weisstanner, Manuela Pastore-Wapp, Martin Schmitt, Pascal Zehnder, Roland Wiest, George N. Thalmann, Frédéric D. Birkhäuser
المصدر: European Urology Open Science, Vol 42, Iss , Pp 10-16 (2022)
مصطلحات موضوعية: Arousal, Brain activity, Functional magnetic resonance imaging, Libido, Seminal vesicles, Sexual activity, Diseases of the genitourinary system. Urology, RC870-923, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
الوصف: Background: Whether seminal vesicles play a role in sexual activity in men is unknown. No study so far has compared the neural processing of visual sexual stimuli in men depending on the filling state of the seminal vesicles. Objective: To evaluate potential specific cortical activation by visual sexual stimuli with distended and empty seminal vesicles. Design, setting, and participants: A prospective case-control trial was conducted. Six male individuals underwent two visits on 2 consecutive days for hormone analyses; Derogatis Interview for Sexual Functioning (DISF) questionnaire; functional magnetic resonance imaging (fMRI) with passively viewing sexual, neutral, positive, and negative emotional pictures; and structural pelvic MRI. After the first visit, the participants had to empty seminal vesicles by masturbation. During fMRI, every participant viewed alternating blocks of sexual, neutral, positive, and negative emotional pictures. Outcome measurements and statistical analysis: Comparisons between days 1 and 2 were evaluated using paired t tests. Results and limitations: No significant differences were observed regarding hormone analyses, DISF questionnaire score, and arousal scoring between days 1 and 2. Seminal vesicle volume was significantly lower on day 2 (p = 0.003). Significantly higher activation was observed in the right precentral gyrus, middle frontal gyrus, and right superior temporal sulcus when contrasted for sexual over neutral (p
وصف الملف: electronic resource
العلاقة: http://www.sciencedirect.com/science/article/pii/S266616832200619XTest; https://doaj.org/toc/2666-1683Test
-
3دورية أكاديمية
المؤلفون: Manuela Pastore-Wapp, Dávid M. Gyurkó, Tim Vanbellingen, Dirk Lehnick, Dario Cazzoli, Tobias Pflugshaupt, Stefanie Pflugi, Thomas Nyffeler, Sebastian Walther, Stephan Bohlhalter
المصدر: Frontiers in Neuroscience, Vol 16 (2022)
مصطلحات موضوعية: apraxia, gesturing, left hemispheric stroke, non-invasive brain stimulation, transcranial continuous theta burst stimulation, transcallosal connectivity, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571
الوصف: ObjectivesApraxia is a common syndrome of left hemispheric stroke. A parieto-premotor-prefrontal network has been associated with apraxia, in which the left inferior parietal lobe (IPL-L) plays a major role. We hypothesized that transcranial continuous theta burst stimulation (cTBS) over the right inferior parietal lobe (IPL-R) improves gesturing by reducing its inhibition on the contralateral IPL in left hemispheric stroke patients. It was assumed that this effect is independent of lesion volume and that transcallosal connectivity is predictive for gestural effect after stimulation.Materials and methodsNineteen stroke patients were recruited. Lesion volume and fractional anisotropy of the corpus callosum were acquired with structural magnetic resonance imaging (MRI) and diffusion tensor imaging (DTI). Each patient had pseudorandomised sessions with sham or with stimulation over the IPL-R or over the right inferior frontal gyrus IFG-R. Gesturing was assessed in a double-blinded manner before and after each session. We tested the effects of stimulation on gesture performance using a linear mixed-effects model.ResultsPairwise treatment contrasts showed, that, compared to sham, the behavioral effect was higher after stimulation over IPL-R (12.08, 95% CI 6.04 – 18.13, p < 0.001). This treatment effect was approximately twice as high as the contrasts for IFG-R vs. sham (6.25, 95% CI –0.20 – 12.70, p = 0.058) and IPL-R vs. IFG-R vs. sham (5.83, 95% CI –0.49 – 12.15, p = 0.071). Furthermore, higher fractional anisotropy in the splenium (connecting the left and right IPL) were associated with higher behavioral effect. Relative lesion volume did not affect the changes after sham or stimulation over IPL-R or IFG-R.ConclusionOne single session of cTBS over the IPL-R improved gesturing after left hemispheric stroke. Denser microstructure in the corpus callosum correlated with favorable gestural response. We therefore propose the indirect transcallosal modulation of the IPL-L as a promising model of restoring interhemispheric balance, which may be useful in rehabilitation of apraxia.
وصف الملف: electronic resource
العلاقة: https://www.frontiersin.org/articles/10.3389/fnins.2022.998729/fullTest; https://doaj.org/toc/1662-453XTest
-
4دورية أكاديمية
المؤلفون: Myla van Wegen, Just L. Herder, Rolf Adelsberger, Manuela Pastore-Wapp, Erwin E. H. van Wegen, Stephan Bohlhalter, Tobias Nef, Paul Krack, Tim Vanbellingen
المصدر: Sensors, Vol 23, Iss 3, p 1563 (2023)
مصطلحات موضوعية: object exploration, object interaction, virtual reality, haptics, wearable, VR system, Chemical technology, TP1-1185
الوصف: We often interact with our environment through manual handling of objects and exploration of their properties. Object properties (OP), such as texture, stiffness, size, shape, temperature, weight, and orientation provide necessary information to successfully perform interactions. The human haptic perception system plays a key role in this. As virtual reality (VR) has been a growing field of interest with many applications, adding haptic feedback to virtual experiences is another step towards more realistic virtual interactions. However, integrating haptics in a realistic manner, requires complex technological solutions and actual user-testing in virtual environments (VEs) for verification. This review provides a comprehensive overview of recent wearable haptic devices (HDs) categorized by the OP exploration for which they have been verified in a VE. We found 13 studies which specifically addressed user-testing of wearable HDs in healthy subjects. We map and discuss the different technological solutions for different OP exploration which are useful for the design of future haptic object interactions in VR, and provide future recommendations.
وصف الملف: electronic resource
-
5دورية أكاديمية
المؤلفون: Werner Krammer, John H. Missimer, Simon Habegger, Manuela Pastore-Wapp, Roland Wiest, Bruno J. Weder
المصدر: Journal of NeuroEngineering and Rehabilitation, Vol 17, Iss 1, Pp 1-17 (2020)
مصطلحات موضوعية: Object in-hand manipulation, Precise handling, Finger gaiting, Finger synchrony, Time series, Principal component analysis, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571
الوصف: Abstract Background Motor hand skill and associated dexterity is important for meeting the challenges of daily activity and an important resource post-stroke. In this context, the present study investigated the finger movements of right-handed subjects during tactile manipulation of a cuboid, a prototypical task underlying tactile exploration. During one motor act, the thumb and fingers of one hand surround the cuboid in a continuous and regular manner. While the object is moved by the guiding thumb, the opposed supporting fingers are replaced once they reach their joint limits by free fingers, a mechanism termed finger gaiting. Methods For both hands of 22 subjects, we acquired the time series of consecutive manipulations of a cuboid at a frequency of 1 Hz, using a digital data glove consisting of 29 sensors. Using principle component analysis, we decomposed the short action into motor patterns related to successive manipulations of the cuboid. The components purport to represent changing grasp configurations involving the stabilizing fingers and guiding thumb. The temporal features of the components permits testing whether the distinct configurations occur at the frequency of 1 Hz, i.e. within the time window of 1 s, and, thus, taxonomic classification of the manipulation as finger gaiting. Results The fraction of variance described by the principal components indicated that three components described the salient features of the single motor acts for each hand. Striking in the finger patterns was the prominent and varying roles of the MCP and PIP joints of the fingers, and the CMC joint of the thumb. An important aspect of the three components was their representation of distinct finger configurations within the same motor act. Principal component and graph theory analysis confirmed modular, functionally synchronous action of the involved joints. The computation of finger trajectories in one subject illustrated the workspace of the task, which differed for the right and left hands. Conclusion In this task one complex motor act of 1 s duration could be described by three elementary and hierarchically ordered grasp configurations occurring at the prescribed frequency of 1 Hz. Therefore, these configurations represent finger gaiting, described until now only in artificial systems, as the principal mechanism underlying this prototypical task. Trial registration clinicaltrials.gov, NCT02865642 , registered 12 August 2016.
وصف الملف: electronic resource
العلاقة: http://link.springer.com/article/10.1186/s12984-020-00755-6Test; https://doaj.org/toc/1743-0003Test
-
6دورية أكاديمية
المصدر: NeuroImage: Clinical, Vol 36, Iss , Pp 103193- (2022)
مصطلحات موضوعية: Ischemic stroke, Tactile agnosia, Principal component analysis, MRI lesions maps, White matter disconnection, Computer applications to medicine. Medical informatics, R858-859.7, Neurology. Diseases of the nervous system, RC346-429
الوصف: From a cohort of 36 patients presenting apperceptive tactile agnosia after first cortical ischemic stroke, 14 showed temporary impairment at admission. A previous multi-voxel analysis of the cortical lesions, using as explanatory variable the course of tactile object recognition performance over the recovery period of 9 months, partitioned the cohort into three subgroups. Of the 14 patients constituting two of the subgroups, 7 recovered from their impairment whereas 7 did not. These two subgroups could not be distinguished at admission. The primary aim of the present study is to present two assessments that can do so.The first assessment comprises a pattern of behavioral measures, determined via principal component analysis, encoded in three tests: picking small objects, macrogeometrical discrimination and tactile object recognition. The receiver operating characteristic curve derived from permutation of the behavioral test scores yielded an 80% probability of correct identification of the patient subgroup and an 8% probability for false identification. As done with the permuted scores, the pattern could predict the persistence of affliction of new stroke patients with tactile agnosia.The second predictive assessment extends our previous evaluation of cortical MRI lesion maps to include subcortical regions. Confirming our previous study, the lesions of the persistently impaired subgroup disrupted significantly the anterior arcuatus fasciculus and associated superior longitudinal fasciculus III in the ipsilesional hemisphere, impeding reciprocal information transfer between supramarginal gyrus and both the ventral premotor cortex and Brodmann area 44. Due to the importance of interhemispheric information transfer in tactile agnosia, we performed a supplementary analysis of tactile object recognition scores. It showed that haptic information transfer from the non-affected to the affected hands in the persistent cases partly restored function during the nine months, possibly following restoration of functional interhemispheric haptic information transfer at the border of posterior corpus callosum and splenium.In conclusion, the combined findings of the cortical lesion at subarea PFt of the inferior parietal lobule and the associated subcortical tract lesions permit almost perfect prediction of persistent impairment of tactile object recognition. The study substantiates the need for combined analysis of both cortical lesions and white matter tract disconnections.
وصف الملف: electronic resource
العلاقة: http://www.sciencedirect.com/science/article/pii/S2213158222002583Test; https://doaj.org/toc/2213-1582Test
-
7دورية أكاديمية
المصدر: Frontiers in Rehabilitation Sciences, Vol 2 (2021)
مصطلحات موضوعية: Parkinson's disease, transcranial magnetic stimulation, dexterity, video game-based training, RCT - randomized controlled trial, Other systems of medicine, RZ201-999, Medical technology, R855-855.5
الوصف: Introduction: Patients with Parkinson's disease (PD) often exhibit difficulties with dexterity during the performance of activities of daily living (ADL) due to dysfunctional supplementary motor area (SMA). The aim of this clinical trial protocol work is to describe how the effectiveness of a combined repetitive transcranial magnetic stimulation (rTMS) over SMA and video-game-based skill training (VBT) in PD will be evaluated. The short and long-term benefits are assessed.Methods and analysis: A single-blind (patients) stratified (based on Hoehn & Yahr) parallel randomized sham-controlled rTMS-VBT study with a baseline and two follow-up measurements (3 and 12 weeks) is being conducted. These measurements include the dexterity questionnaire 24 (DextQ-24) as a primary outcome, and nine hole peg test and coin rotation task as main secondary dexterity outcomes. Further secondary outcomes will be the subscale II of the movement disorders society unified PD rating scale (MDS-UPDRS) to assess improvements on overall ADL and the Parkinson's Disease Questionnaire-39 to assess quality of life. Thirty-six outpatients (from one neurorehabilitation center) with PD (diagnosis based on brain bank criteria) will be recruited who report difficulties with dexterity in performing ADL. All PD patients will receive a 45-min VBT three times a week for 3 weeks. The PD patients randomized in the experimental group will receive VBT preceded by real rTMS, being intermittent theta burst (iTBS) stimulation sessions. The PD patients randomized to the control group receive a VBT with sham rTMS.Discussion: The study will provide evidence to determine whether a combined iTBS and VBT skill intervention is more effective than a VBT intervention alone to improve dexterity in PD.Ethics and dissemination: The study was approved by the Ethics Committee for Northwest and Central Switzerland (EKNZ), Switzerland 2019–00433. The study will be conducted in accordance with the Helsinki Declaration and the Guidelines of Good Clinical Practice. Informed consent will be signed prior to subject enrolment. Dissemination will include submission to international peer-reviewed professional journals and presentation at international congresses.The study protocol has been registered in the clinicaltrials.gov registry with the identification code: NCT04699149.
وصف الملف: electronic resource
العلاقة: https://www.frontiersin.org/articles/10.3389/fresc.2021.777981/fullTest; https://doaj.org/toc/2673-6861Test
-
8دورية أكاديمية
المؤلفون: Tim Vanbellingen, Manuela Pastore-Wapp, Stefanie Kübel, Thomas Nyffeler, Anne-Catherine Schüpfer, Claus Kiefer, Leopold Zizlsperger, Kai Lutz, Andreas R. Luft, Sebastian Walther, Stephan Bohlhalter
المصدر: Brain Stimulation, Vol 13, Iss 2, Pp 457-463 (2020)
مصطلحات موضوعية: Continuous theta burst stimulation, Gestures, Imitation, Diffusion tensor imaging, Proof of concept, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571
الوصف: Background: Imaging studies point to a posture (finger vs. hand) and domain-specific neural basis of gestures. Furthermore, modulation of gestures by theta burst stimulation (TBS) may depend on interhemispheric disinhibition. Objective/Hypothesis: In this randomized sham-controlled study, we hypothesized that dual site continuous TBS over left inferior frontal gyrus (IFG-L) and right inferior parietal gyrus (IPL-R) predominantly affects pantomime of finger postures. Furthermore, we predicted that dual cTBS improves imitation of hand gestures if the effect correlates with measures of callosal connectivity. Methods: Forty-six healthy subjects participated in this study and were targeted with one train of TBS in different experimental sessions: baseline, sham, single site IFG-L, dual IFG-L/IPL-R, single site IPL-R. Gestures were evaluated by blinded raters using the Test for Upper Limb Apraxia (TULIA) and Postural Imitation Test (PIT). Callosal connectivity was analyzed by diffusion tensor imaging (DTI). Results: Dual cTBS significantly improved TULIAtotal (F [3, 28] = 4.118, p = .009), but did not affect TULIApantomime. The beneficial effect was driven by the cTBS over IPL-R, which improved TULIAimitation (p = .038). Furthermore, TULIAimitation significantly correlated with the microstructure (fractional anisotropy) of the splenium (r = 0.420, p = .026), corrected for age and whole brain volume. Conclusions: The study suggests that inhibition of IPL-R largely accounted for improved gesturing, possibly through transcallosal facilitation of IPL-L. Therefore, the findings may be relevant for the treatment of apraxic stroke patients. Gesture pantomime and postural gestures escaped the modulation by dual cTBS, suggesting a more widespread and/or variable neural representation.
وصف الملف: electronic resource
العلاقة: http://www.sciencedirect.com/science/article/pii/S1935861X1930484XTest; https://doaj.org/toc/1935-861XTest
-
9دورية أكاديمية
المؤلفون: Lea Saric, Samuel E. J. Knobel, Manuela Pastore-Wapp, Tobias Nef, Fred W. Mast, Tim Vanbellingen
المصدر: Sensors, Vol 22, Iss 16, p 6278 (2022)
مصطلحات موضوعية: exergaming, sensor, dexterity, Parkinson’s Disease, flow, usability, Chemical technology, TP1-1185
الوصف: This pilot cross-sectional study aimed to evaluate the usability of two new interactive game sensor-based hand devices (GripAble and Smart Sensor Egg) in both healthy adults as well as in persons with Parkinson’s Disease (PD). Eight healthy adults and eight persons with PD participated in this study. Besides a standardised usability measure, the state of flow after one training session and the effect of cognitive abilities on flow were evaluated. High system usability scores (SUS) were obtained both in healthy participants (72.5, IQR = 64.375–90, GripAble) as well as persons with PD (77.5, IQR = 70–80.625, GripAble; 77.5, IQR = 75–82.5, Smart Sensor Egg). Similarly, high FSSOT scores were achieved after one training session (42.5, IQR = 39.75–50, GripAble; 50, IQR = 47–50, Smart Sensor Egg; maximum score 55). Across both groups, FSSOT scores correlated significantly with SUS scores (r = 0.52, p = 0.039). Finally, MoCA did not correlate significantly with FSSOT scores (r = 0.02, p = 0.9). The present study shows high usability for both interactive game sensor-based hand training devices, for persons with PD and healthy participants.
وصف الملف: electronic resource
-
10دورية أكاديمية
المؤلفون: Janine S. Spitzhüttl, Martin Kronbichler, Lisa Kronbichler, Valentin Benzing, Valerie Siegwart, Manuela Pastore‐Wapp, Claus Kiefer, Nedelina Slavova, Michael Grotzer, Claudia M. Roebers, Maja Steinlin, Kurt Leibundgut, Regula Everts
المصدر: Brain and Behavior, Vol 11, Iss 1, Pp n/a-n/a (2021)
مصطلحات موضوعية: childhood cancer survivors, cognitive late‐effects, non‐CNS childhood cancers, resting‐state networks, rs‐fMRI analysis, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571
الوصف: Abstract Introduction Non‐central nervous system cancer in childhood (non‐CNS CC) and its treatments pose a major threat to brain development, with implications for functional networks. Structural and functional alterations might underlie the cognitive late‐effects identified in survivors of non‐CNS CC. The present study evaluated resting‐state functional networks and their associations with cognition in a mixed sample of non‐CNS CC survivors (i.e., leukemia, lymphoma, and other non‐CNS solid tumors). Methods Forty‐three patients (off‐therapy for at least 1 year and aged 7–16 years) were compared with 43 healthy controls matched for age and sex. High‐resolution T1‐weighted structural magnetic resonance and resting‐state functional magnetic resonance imaging were acquired. Executive functions, attention, processing speed, and memory were assessed outside the scanner. Results Cognitive performance was within the normal range for both groups; however, patients after CNS‐directed therapy showed lower executive functions than controls. Seed‐based connectivity analyses revealed that patients exhibited stronger functional connectivity between fronto‐ and temporo‐parietal pathways and weaker connectivity between parietal‐cerebellar and temporal‐occipital pathways in the right hemisphere than controls. Functional hyperconnectivity was related to weaker memory performance in the patients' group. Conclusion These data suggest that even in the absence of brain tumors, non‐CNS CC and its treatment can lead to persistent cerebral alterations in resting‐state network connectivity.
وصف الملف: electronic resource
العلاقة: https://doaj.org/toc/2162-3279Test
النص الكامل