المؤلفون: Lindfors, Katri, Lin, Jake, Lee, Hye-Seung, Hyöty, Heikki, Nykter, Matti, Kurppa, Kalle, Liu, Edwin, Koletzko, Sibylle, Rewers, Marian, Hagopian, William, Toppari, Jorma, Ziegler, Annette-Gabriele, Akolkar, Beena, Krischer, Jeffrey P, Petrosino, Joseph F, Lloyd, Richard E, Agardh, Daniel, the TEDDY Study Group, Barbour, Aaron, Bautista, Kimberly, Baxter, Judith, Felipe-Morales, Daniel, Driscoll, Kimberly, Frohnert, Brigitte I., Stahl, Marisa, Gesualdo, Patricia, Hoffman, Michelle, Karban, Rachel, Norris, Jill, Peacock, Stesha, Shorrosh, Hanan, Steck, Andrea, Stern, Megan, Villegas, Erica, Waugh, Kathleen, Simell, Olli G., Adamsson, Annika, Ahonen, Suvi, Akerlund, Mari, Hakola, Leena, Hekkala, Anne, Holappa, Henna, Ikonen, Anni, Ilonen, Jorma, Jäminki, Sinikka, Jokipuu, Sanna, Karlsson, Leena, Kero, Jukka, Kähönen, Miia, Knip, Mikael, Koivikko, Minna-Liisa, Koskinen, Merja, Koreasalo, Mirva, Kytölä, Jarita, Latva-aho, Tiina, Lönnrot, Maria, Mäntymäki, Elina, Mattila, Markus, Miettinen, Maija, Multasuo, Katja, Mykkänen, Teija, Niininen, Tiina, Niinistö, Sari, Nyblom, Mia, Oikarinen, Sami, Ollikainen, Paula, Othmani, Zhian, Pohjola, Sirpa, Rajala, Petra, Rautanen, Jenna, Riikonen, Anne, Riski, Eija, Pekkola, Miia, Romo, Minna, Ruohonen, Satu, Simell, Satu, Sjöberg, Maija, Stenius, Aino, Tossavainen, Päivi, Vähä-Mäkilä, Mari, Vainionpää, Sini, Varjonen, Eeva, Veijola, Riitta, Viinikangas, Irene, Virtanen, Suvi M., She, Jin-Xiong, Schatz, Desmond, Hopkins, Diane, Steed, Leigh, Bryant, Jennifer, Silvis, Katherine, Haller, Michael, Gardiner, Melissa, McIndoe, Richard, Sharma, Ashok, Anderson, Stephen W., Jacobsen, Laura, Marks, John, Bonifacio, Ezio, Gavrisan, Anita, Gezginci, Cigdem, Heublein, Anja, Hoffmann, Verena, Hummel, Sandra, Keimer, Andrea, Knopff, Annette, Koch, Charlotte, Ramminger, Claudia, Roth, Roswith, Scholz, Marlon, Stock, Joanna, Warncke, Katharina, Wendel, Lorena, Winkler, Christiane, Lernmark, Ake, Aronsson, Carin Andrén, Ask, Maria, Bennet, Rasmus, Cilio, Corrado, Engqvist, Helene, Ericson-Hallström, Emelie, Fors, Annika, Fransson, Lina, Gard, Thomas, Hansen, Monika, Jisser, Hanna, Johansen, Fredrik, Jonsdottir, Berglind, Jovic, Silvija, Larsson, Helena Elding, Lindström, Marielle, Lundgren, Markus, Maziarz, Marlena, Mansson-Martinez, Maria, Markan, Maria, Melin, Jessica, Mestan, Zeliha, Nilsson, Caroline, Ottosson, Karin, Rahmati, Kobra, Ramelius, Anita, Salami, Falastin, Sjöberg, Anette, Sjöberg, Birgitta, Svensson, Malin, Törn, Carina, Wallin, Anne, Wimar, Asa, Aberg, Sofie, Killian, Michael, Crouch, Claire Cowen, Skidmore, Jennifer, Chavoshi, Masumeh, Hervey, Rachel, Lyons, Rachel, Meyer, Arlene, Mulenga, Denise, Radtke, Jared, Romancik, Matei, Schmitt, Davey, Zink, Sarah, Becker, Dorothy, Franciscus, Margaret, Smith, MaryEllen Dalmagro-Elias, Daftary, Ashi, Klein, Mary Beth, Yates, Chrystal, Austin-Gonzalez, Sarah, Avendano, Maryouri, Baethke, Sandra, Brown, Rasheedah, Burkhardt, Brant, Butterworth, Martha, Clasen, Joanna, Cuthbertson, David, Dankyi, Stephen, Eberhard, Christopher, Fiske, Steven, Garmeson, Jennifer, Gowda, Veena, Heyman, Kathleen, Hsiao, Belinda, Karges, Christina, Laras, Francisco Perez, Li, Qian, Liu, Shu, Liu, Xiang, Lynch, Kristian, Maguire, Colleen, Malloy, Jamie, McCarthy, Cristina, Merrell, Aubrie, Parikh, Hemang, Quigley, Ryan, Remedios, Cassandra, Shaffer, Chris, Smith, Laura, Smith, Susan, Sulman, Noah, Tamura, Roy, Tewey, Dena, Toth, Michael, Uusitalo, Ulla, Vehik, Kendra, Vijayakandipan, Ponni, Wood, Keith, Yang, Jimin, Abbondondolo, Michael, Ballard, Lori, Hadley, David, McLeod, Wendy, Meulemans, Steven, Yu, Liping, Miao, Dongmei, Bingley, Polly, Williams, Alistair, Chandler, Kyla, Ball, Olivia, Kelland, Ilana, Grace, Sian, Ajami, Nadim J., Ross, Matthew C., O’Brien, Jacqueline L., Hutchinson, Diane S., Smith, Daniel P., Wong, Matthew C., Tian, Xianjun, Ayvaz, Tulin, Tamegnon, Auriole, Truong, Nguyen, Moreno, Hannah, Riley, Lauren, Moreno, Eduardo, Bauch, Tonya, Kusic, Lenka, Metcalf, Ginger, Muzny, Donna, Doddapaneni, HarshaVArdhan, Gibbs, Richard, Ke, Sandra, Mulholland, Niveen, Bourcier, Kasia, Briese, Thomas, Johnson, Suzanne Bennett, Triplett, Eric

مصطلحات موضوعية: Coeliac disease

الوصف: Objective Higher gluten intake, frequent gastrointestinal infections and adenovirus, enterovirus, rotavirus and reovirus have been proposed as environmental triggers for coeliac disease. However, it is not known whether an interaction exists between the ingested gluten amount and viral exposures in the development of coeliac disease. This study investigated whether distinct viral exposures alone or together with gluten increase the risk of coeliac disease autoimmunity (CDA) in genetically predisposed children. Design The Environmental Determinants of Diabetes in the Young study prospectively followed children carrying the HLA risk haplotypes DQ2 and/or DQ8 and constructed a nested case–control design. From this design, 83 CDA case–control pairs were identified. Median age of CDA was 31 months. Stool samples collected monthly up to the age of 2 years were analysed for virome composition by Illumina next-generation sequencing followed by comprehensive computational virus profiling. Results The cumulative number of stool enteroviral exposures between 1 and 2 years of age was associated with an increased risk for CDA. In addition, there was a significant interaction between cumulative stool enteroviral exposures and gluten consumption. The risk conferred by stool enteroviruses was increased in cases reporting higher gluten intake. Conclusions Frequent exposure to enterovirus between 1 and 2 years of age was associated with increased risk of CDA. The increased risk conferred by the interaction between enteroviruses and higher gluten intake indicate a cumulative effect of these factors in the development of CDA.

وصف الملف: text/html

العلاقة: http://gut.bmj.com/cgi/content/short/69/8/1416Test; http://dx.doi.org/10.1136/gutjnl-2019-319809Test

الإتاحة: https://doi.org/10.1136/gutjnl-2019-319809Test
http://gut.bmj.com/cgi/content/short/69/8/1416Test

المؤلفون: Johnson, Randi K., Lernmark, Åke, Andrén Aronsson, Carin, Ask, Maria, Bremer, Jenny, Cilio, Corrado, Ericson-Hallström, Emelie, Björne Fors, Annika, Fransson, Lina, Gard, Thomas, Bennet, Rasmus, Hansen, Monica, Hyberg-Karlsson, Suzanne, Jisser, Hanna, Johansen, Fredrik, Jónsdóttir, Berglind, JOVIC, SILVIJA, Elding Larsson, Helena, Lindström, Marielle, Lundgren, Markus, Månsson Martinez, Maria, Markan, Maria, Melin, Marie Jessica, Mestan, Zeliha, Nilsson, Caroline N, Ottosson, Karin, Rahmati, Kobra, Ramelius, Anita, Salami, Falastin, Sjöberg, Anette, Sjöberg, Birgitta, Törn, Carina, Wallin, Anne, Wimar, Åsa, Åberg, Sofie, Norris, Jill M, TEDDY Study Group

المصدر: Scientific Reports; 9(1), no 14819 (2019) ; ISSN: 2045-2322

مصطلحات موضوعية: Endocrinology and Diabetes, Nutrition and Dietetics

الوصف: The role of diet in type 1 diabetes development is poorly understood. Metabolites, which reflect dietary response, may help elucidate this role. We explored metabolomics and lipidomics differences between 352 cases of islet autoimmunity (IA) and controls in the TEDDY (The Environmental Determinants of Diabetes in the Young) study. We created dietary patterns reflecting pre-IA metabolite differences between groups and examined their association with IA. Secondary outcomes included IA cases positive for multiple autoantibodies (mAb+). The association of 853 plasma metabolites with outcomes was tested at seroconversion to IA, just prior to seroconversion, and during infancy. Key compounds in enriched metabolite sets were used to create dietary patterns reflecting metabolite composition, which were then tested for association with outcomes in the nested case-control subset and the full TEDDY cohort. Unsaturated phosphatidylcholines, sphingomyelins, phosphatidylethanolamines, glucosylceramides, and phospholipid ethers in infancy were inversely associated with mAb+ risk, while dicarboxylic acids were associated with an increased risk. An infancy dietary pattern representing higher levels of unsaturated phosphatidylcholines and phospholipid ethers, and lower sphingomyelins was protective for mAb+ in the nested case-control study only. Characterization of this high-risk infant metabolomics profile may help shape the future of early diagnosis or prevention efforts. © 2019, The Author(s).

العلاقة: https://lup.lub.lu.se/record/4093762d-1d72-4627-ab46-e0e9a6d8f362Test; http://dx.doi.org/10.1038/s41598-019-51251-4Test; scopus:85073451757; pmid:31616039

الإتاحة: https://doi.org/10.1038/s41598-019-51251-4Test
https://lup.lub.lu.se/record/4093762d-1d72-4627-ab46-e0e9a6d8f362Test

المؤلفون: Roth, Roswith, Lynch, Kristian, Hyoty, Heikki, Lonnrot, Maria, Driscoll, Kimberly A., Johnson, Suzanne Bennett, Rewers, Marian, Bautista, Kimberly, Baxter, Judith, Bedoy, Ruth, Felipe-Morales, Daniel, Driscoll, Kimberly, Frohnert, Brigitte I., Gesualdo, Patricia, Hoffman, Michelle, Karban, Rachel, Liu, Edwin, Norris, Jill, Samper-Imaz, Adela, Steck, Andrea, Waugh, Kathleen, Wright, Hali, Toppari, Jorma, Simell, Olli G., Adamsson, Annika, Ahonen, Suvi, Ilonen, Jorma, Jokipuu, Sanna, Kallio, Tiina, Karlsson, Leena, Kahonen, Miia, Knip, Mikael, Kovanen, Lea, Koreasalo, Mirva, Kurppa, Kalle, Latva-aho, Tiina, Mantymaki, Elina, Multasuo, Katja, Mykkanen, Juha, Niininen, Tiina, Niinisto, Sari, Nyblom, Mia, Rajala, Petra, Rautanen, Jenna, Riikonen, Anne, Riikonen, Mika, Rouhiainen, Jenni, Romo, Minna, Simell, Tuula, Simell, Ville, Sjoberg, Maija, Stenius, Aino, Leppanen, Maria, Vainionpaa, Sini, Varjonen, Eeva, Veijola, Riitta, Virtanen, Suvi M., Vaha-Makila, Mari, Akerlund, Mari, Lindfors, Katri, She, Jin-Xiong, Schatz, Desmond, Hopkins, Diane, Steed, Leigh, Thomas, Jamie, Adams, Janey, Silvis, Katherine, Haller, Michael, Gardiner, Melissa, McIndoe, Richard, Sharma, Ashok, Williams, Joshua, Young, Gabriela, Anderson, Stephen W., Jacobsen, Laura, Ziegler, Anette G., Beyerlein, Andreas, Bonifacio, Ezio, Hummel, Michael, Hummel, Sandra, Foterek, Kristina, Janz, Nicole, Kersting, Mathilde, Knopff, Annette, Koletzko, Sibylle, Peplow, Claudia, Scholz, Marlon, Stock, Joanna, Warncke, Katharina, Wendel, Lorena, Winkler, Christiane, Lernmark, Ake, Agardh, Daniel, Aronsson, Carin Andren, Ask, Maria, Bremer, Jenny, Carlsson, Ulla-Marie, Cilio, Corrado, Ericson-Hallstrom, Emelie, Fransson, Lina, Gard, Thomas, Gerardsson, Joanna, Bennet, Rasmus, Hansen, Monica, Hansson, Gertie, Hyberg, Susanne, Johansen, Fredrik, Jonsdottir, Berglind, Larsson, Helena Elding, Lindstrom, Marielle, Lundgren, Markus, Mansson-Martinez, Maria, Markan, Maria, Melin, Jessica, Mestan, Zeliha, Ottosson, Karin, Rahmati, Kobra, Ramelius, Anita, Salami, Falastin, Sibthorpe, Sara, Sjoberg, Birgitta, Swartling, Ulrica, Amboh, Evelyn Tekum, Torn, Carina, Wallin, Anne, Wimar, Asa, Aberg, Sofie, Hagopian, William A., Killian, Michael, Crouch, Claire Cowen, Skidmore, Jennifer, Carson, Josephine, Dalzell, Maria, Dunson, Kayleen, Hervey, Rachel, Johnson, Corbin, Lyons, Rachel, Meyer, Arlene, Mulenga, Denise, Tarr, Alexander, Uland, Morgan, Willis, John, Becker, Dorothy, Franciscus, Margaret, Smith, MaryEllen Dalmagro-Elias, Daftary, Ashi, Klein, Mary Beth, Yates, Chrystal, Krischer, Jeffrey P., Abbondondolo, Michael, Austin-Gonzalez, Sarah, Avendano, Maryouri, Baethke, Sandra, Brown, Rasheedah, Burkhardt, Brant, Butterworth, Martha, Clasen, Joanna, Cuthbertson, David, Eberhard, Christopher, Fiske, Steven, Garcia, Dena, Garmeson, Jennifer, Gowda, Veena, Heyman, Kathleen, Laras, Francisco Perez, Lee, Hye-Seung, Liu, Shu, Liu, Xiang, Malloy, Jamie, McCarthy, Cristina, Meulemans, Steven, Parikh, Hemang, Shaffer, Chris, Smith, Laura, Smith, Susan, Sulman, Noah, Tamura, Roy, Uusitalo, Ulla, Vehik, Kendra, Vijayakandipan, Ponni, Wood, Keith, Yang, Jimin, Akolkar, Beena, Bourcier, Kasia, Briese, Thomas, Triplett, Eric

المساهمون: Klinik und Poliklinik für Kinderheilkunde und Jugendmedizin

مصطلحات موضوعية: info:eu-repo/classification/ddc

الوصف: The aim of this study was to conduct a prospective analysis of the association between negative life events (NLEs) and respiratory infections in children genetically at risk for islet autoimmunity (IA) and type 1 diabetes (T1D). Long- and short-term temporal associations between NLEs and rate of respiratory infection episodes (RIEs) in 5,618 children in The Environmental Determinants of Diabetes in the Young study for at least 1 up to 4 years were analysed. All models were adjusted for demographic, day care, season of infection, and psychosocial factors associated with the rate of child RIEs between study visits. The rate of child RIEs was 26% higher in Europe (Sweden, Finland, Germany) than in the United States (rate ratio [RR] = 1.26, p < 0.001). However, the percentage of child NLEs (odds ratio [OR] = 1.18, p < 0.001) and mother NLEs (OR = 1.83, p < 0.001) was higher in the United States compared with Europe. In both continents (Europe, RR = 1.12, p < 0.001; United States, RR = 1.07, p = 0.006), high child cumulative NLEs (>1 NLE per year since study inception) was significantly associated with an increased rate of child RIEs. This large-scale prospective study confirms observations that stress may increase the susceptibility for infections in paediatric populations and suggests at least one mechanism by which stress could increase risk for IA and T1D in genetically at risk children.

العلاقة: https://mediatum.ub.tum.de/1588319Test

الإتاحة: https://doi.org/10.1002/smi.2861Test
https://mediatum.ub.tum.de/1588319Test

المؤلفون: Koskenniemi, Jaakko J., Maziarz, Marlena, Månsson Martinez, Maria, Spiliopoulos, Lampros, Salami, Falastin, Toppari, Jorma, Kero, Jukka, Veijola, Riitta, Tossavainen, Päivi, Palmu, Sauli, Andrén Aronsson, Carin, Lundgren, Markus, Borg, Henrik, Katsarou, Anastasia, Larsson, Helena Elding, Knip, Mikael, Lou, Olivia, Dunne, Jessica L., Törn, Carina, Lernmark, Ake, Group, TEDDY Family (TEFA) Study

الإتاحة: https://doi.org/10.2139/ssrn.4649515Test

المؤلفون: Norris, Jill M, Lee, Hye-Seung, Frederiksen, Brittni, Erlund, Iris, Uusitalo, Ulla, Yang, Jimin, Lernmark, Åke, Simell, Olli, Toppari, Jorma, Rewers, Marian, Ziegler, Anette-G, She, Jin-Xiong, Onengut-Gumuscu, Suna, Chen, Wei-Min, Rich, Stephen S, Sundvall, Jouko, Akolkar, Beena, Krischer, Jeffrey, Virtanen, Suvi M, Hagopian, William, TEDDY Study Group, Bautista, Kimberly, Baxter, Judith, Bedoy, Ruth, Felipe-Morales, Daniel, Driscoll, Kimberly, Frohnert, Brigitte I, Gesualdo, Patricia, Hoffman, Michelle, Karban, Rachel, Liu, Edwin, Norris, Jill, Samper-Imaz, Adela, Steck, Andrea, Waugh, Kathleen, Wright, Hali, Simell, Olli G, Adamsson, Annika, Ahonen, Suvi, Hyöty, Heikki, Ilonen, Jorma, Jokipuu, Sanna, Kallio, Tiina, Karlsson, Leena, Kähönen, Miia, Knip, Mikael, Kovanen, Lea, Koreasalo, Mirva, Kurppa, Kalle, Latva-Aho, Tiina, Lönnrot, Maria, Mäntymäki, Elina, Multasuo, Katja, Mykkänen, Juha, Niininen, Tiina, Niinistö, Sari, Nyblom, Mia, Rajala, Petra, Rautanen, Jenna, Riikonen, Anne, Riikonen, Mika, Rouhiainen, Jenni, Romo, Minna, Simell, Tuula, Simell, Ville, Sjöberg, Maija, Stenius, Aino, Leppänen, Maria, Vainionpää, Sini, Varjonen, Eeva, Veijola, Riitta, Vähä-Mäkilä, Mari, Åkerlund, Mari, Lindfors, Katri, Schatz, Desmond, Hopkins, Diane, Steed, Leigh, Thomas, Jamie, Adams, Janey, Silvis, Katherine, Haller, Michael, Gardiner, Melissa, McIndoe, Richard, Sharma, Ashok, Williams, Joshua, Young, Gabriela, Anderson, Stephen W, Jacobsen, Laura, Ziegler, Anette G, Beyerlein, Andreas, Bonifacio, Ezio, Hummel, Michael, Hummel, Sandra, Foterek, Kristina, Janz, Nicole, Kersting, Mathilde, Knopff, Annette, Koletzko, Sibylle, Peplow, Claudia, Roth, Roswith, Scholz, Marlon, Stock, Joanna, Warncke, Katharina, Wendel, Lorena, Winkler, Christiane, Agardh, Daniel, Aronsson, Carin Andrén, Ask, Maria, Bremer, Jenny, Carlsson, Ulla-Marie, Cilio, Corrado, Ericson-Hallström, Emelie, Fransson, Lina, Gard, Thomas, Gerardsson, Joanna, Bennet, Rasmus, Hansen, Monica, Hansson, Gertie, Hyberg, Susanne, Johansen, Fredrik, Jonsdottir, Berglind, Larsson, Helena Elding, Lindström, Marielle, Lundgren, Markus, Månsson-Martinez, Maria, Markan, Maria, Melin, Jessica, Mestan, Zeliha, Ottosson, Karin, Rahmati, Kobra, Ramelius, Anita, Salami, Falastin, Sibthorpe, Sara, Sjöberg, Birgitta, Swartling, Ulrica, Amboh, Evelyn Tekum, Törn, Carina, Wallin, Anne, Wimar, Åsa, Åberg, Sofie, Hagopian, William A, Killian, Michael, Crouch, Claire Cowen, Skidmore, Jennifer, Carson, Josephine, Dalzell, Maria, Dunson, Kayleen, Hervey, Rachel, Johnson, Corbin, Lyons, Rachel, Meyer, Arlene, Mulenga, Denise, Tarr, Alexander, Uland, Morgan, Willis, John, Becker, Dorothy, Franciscus, Margaret, Dalmagro-Elias Smith, MaryEllen, Daftary, Ashi, Klein, Mary Beth, Yates, Chrystal, Krischer, Jeffrey P, Abbondondolo, Michael, Austin-Gonzalez, Sarah, Avendano, Maryouri, Baethke, Sandra, Brown, Rasheedah, Burkhardt, Brant, Butterworth, Martha, Clasen, Joanna, Cuthbertson, David, Eberhard, Christopher, Fiske, Steven, Garcia, Dena, Garmeson, Jennifer, Gowda, Veena, Heyman, Kathleen, Laras, Francisco Perez, Liu, Shu, Liu, Xiang, Lynch, Kristian, Malloy, Jamie, McCarthy, Cristina, Meulemans, Steven, Parikh, Hemang, Shaffer, Chris, Smith, Laura, Smith, Susan, Sulman, Noah, Tamura, Roy, Vehik, Kendra, Vijayakandipan, Ponni, Wood, Keith, Bourcier, Kasia, Briese, Thomas, Johnson, Suzanne Bennett, Triplett, Eric, Yu, Liping, Miao, Dongmei, Bingley, Polly, Williams, Alistair, Chandler, Kyla, Rokni, Saba, Williams, Claire, Wyatt, Rebecca, George, Gifty, Grace, Sian, Salminen, Irma, Leiviskä, Jaana, Kangas, Nina, Arohonka, Petra, Erlich, Henry, Mack, Steven J, Fear, Anna Lisa, Ke, Sandra, Mulholland, Niveen, Farber, Emily, Pickin, Rebecca Roche, Davis, Jordan, Gallo, Dan, Bonnie, Jessica, Campolieto, Paul

المساهمون: Klinik und Poliklinik für Kinder- und Jugendmedizin

مصطلحات موضوعية: info:eu-repo/classification/ddc

الوصف: We examined the association between plasma 25-hydroxyvitamin D [25(OH)D] concentration and islet autoimmunity (IA) and whether vitamin D gene polymorphisms modify the effect of 25(OH)D on IA risk. We followed 8,676 children at increased genetic risk of type 1 diabetes at six sites in the U.S. and Europe. We defined IA as positivity for at least one autoantibody (GADA, IAA, or IA-2A) on two or more visits. We conducted a risk set sampled nested case-control study of 376 IA case subjects and up to 3 control subjects per case subject. 25(OH)D concentration was measured on all samples prior to, and including, the first IA positive visit. Nine polymorphisms in , and were analyzed as effect modifiers of 25(OH)D. Adjusting for HLA-DR-DQ and ancestry, higher childhood 25(OH)D was associated with lower IA risk (odds ratio = 0.93 for a 5 nmol/L difference; 95% CI 0.89, 0.97). Moreover, this association was modified by rs7975232 (interaction = 0.0072), where increased childhood 25(OH)D was associated with a decreasing IA risk based upon number of minor alleles: 0 (1.00; 0.93, 1.07), 1 (0.92; 0.89, 0.96), and 2 (0.86; 0.80, 0.92). Vitamin D and may have a combined role in IA development in children at increased genetic risk for type 1 diabetes.

العلاقة: https://mediatum.ub.tum.de/1453079Test

الإتاحة: https://doi.org/10.2337/db17-0802Test
https://mediatum.ub.tum.de/1453079Test

المؤلفون: Köhler, Meike, Beyerlein, Andreas, Vehik, Kendra, Greven, Sonja, Umlauf, Nikolaus, Lernmark, Åke, Hagopian, William A, Rewers, Marian, She, Jin-Xiong, Toppari, Jorma, Akolkar, Beena, Krischer, Jeffrey P, Bonifacio, Ezio, Ziegler, Anette-G, TEDDY study group, Bautista, Kimberly, Baxter, Judith, Bedoy, Ruth, Felipe-Morales, Daniel, Driscoll, Kimberly, Frohnert, Brigitte I, Gesualdo, Patricia, Hoffman, Michelle, Karban, Rachel, Liu, Edwin, Norris, Jill, Samper-Imaz, Adela, Steck, Andrea, Waugh, Kathleen, Wright, Hali, Simell, Olli G, Adamsson, Annika, Ahonen, Suvi, Hyöty, Heikki, Ilonen, Jorma, Jokipuu, Sanna, Kallio, Tiina, Karlsson, Leena, Kähönen, Miia, Knip, Mikael, Kovanen, Lea, Koreasalo, Mirva, Kurppa, Kalle, Latva-Aho, Tiina, Lönnrot, Maria, Mäntymäki, Elina, Multasuo, Katja, Mykkänen, Juha, Niininen, Tiina, Niinistö, Sari, Nyblom, Mia, Rajala, Petra, Rautanen, Jenna, Riikonen, Anne, Riikonen, Mika, Rouhiainen, Jenni, Romo, Minna, Simell, Tuula, Simell, Ville, Sjöberg, Maija, Stenius, Aino, Leppänen, Maria, Vainionpää, Sini, Varjonen, Eeva, Veijola, Riitta, Virtanen, Suvi M, Vähä-Mäkilä, Mari, Åkerlund, Mari, Lindfors, Katri, Schatz, Desmond, Hopkins, Diane, Steed, Leigh, Thomas, Jamie, Adams, Janey, Silvis, Katherine, Haller, Michael, Gardiner, Melissa, McIndoe, Richard, Sharma, Ashok, Williams, Joshua, Young, Gabriela, Anderson, Stephen W, Jacobsen, Laura, Hummel, Michael, Hummel, Sandra, Foterek, Kristina, Janz, Nicole, Kersting, Mathilde, Knopff, Annette, Koletzko, Sibylle, Peplow, Claudia, Roth, Roswith, Scholz, Marlon, Stock, Joanna, Warncke, Katharina, Wendel, Lorena, Winkler, Christiane, Agardh, Daniel, Aronsson, Carin Andrén, Ask, Maria, Bremer, Jenny, Carlsson, Ulla-Marie, Cilio, Corrado, Ericson-Hallström, Emelie, Fransson, Lina, Gard, Thomas, Gerardsson, Joanna, Bennet, Rasmus, Hansen, Monica, Hansson, Gertie, Hyberg, Susanne, Johansen, Fredrik, Jonsdottir, Berglind, Larsson, Helena Elding, Lindström, Marielle, Lundgren, Markus, Månsson-Martinez, Maria, Markan, Maria, Melin, Jessica, Mestan, Zeliha, Ottosson, Karin, Rahmati, Kobra, Ramelius, Anita, Salami, Falastin, Sibthorpe, Sara, Sjöberg, Birgitta, Swartling, Ulrica, Amboh, Evelyn Tekum, Törn, Carina, Wallin, Anne, Wimar, Åsa, Åberg, Sofie, Killian, Michael, Crouch, Claire Cowen, Skidmore, Jennifer, Carson, Josephine, Dalzell, Maria, Dunson, Kayleen, Hervey, Rachel, Johnson, Corbin, Lyons, Rachel, Meyer, Arlene, Mulenga, Denise, Tarr, Alexander, Uland, Morgan, Willis, John, Becker, Dorothy, Franciscus, Margaret, Smith, MaryEllen Dalmagro-Elias, Daftary, Ashi, Klein, Mary Beth, Yates, Chrystal, Abbondondolo, Michael, Austin-Gonzalez, Sarah, Avendano, Maryouri, Baethke, Sandra, Brown, Rasheedah, Burkhardt, Brant, Butterworth, Martha, Clasen, Joanna, Cuthbertson, David, Eberhard, Christopher, Fiske, Steven, Garcia, Dena, Garmeson, Jennifer, Gowda, Veena, Heyman, Kathleen, PerezLaras, Francisco, Lee, Hye-Seung, Liu, Shu, Liu, Xiang, Lynch, Kristian, Malloy, Jamie, McCarthy, Cristina, Meulemans, Steven, Parikh, Hemang, Shaffer, Chris, Smith, Laura, Smith, Susan, Sulman, Noah, Tamura, Roy, Uusitalo, Ulla, Vijayakandipan, Ponni, Wood, Keith, Yang, Jimin, Ballard, Lori, Hadley, David, McLeod, Wendy, Yu, Liping, Miao, Dongmei, Bingley, Polly, Williams, Alistair, Chandler, Kyla, Rokni, Saba, Williams, Claire, Wyatt, Rebecca, George, Gifty, Grace, Sian, Erlich, Henry, Mack, Steven J, Ke, Sandra, Mulholland, Niveen, Bourcier, Kasia, Briese, Thomas, Johnson, Suzanne Bennett, Triplett, Eric

مصطلحات موضوعية: info:eu-repo/classification/ddc, stat, demo

الوصف: The onset of clinical type 1 diabetes (T1D) is preceded by the occurrence of disease-specific autoantibodies. The level of autoantibody titers is known to be associated with progression time from the first emergence of autoantibodies to the onset of clinical symptoms, but detailed analyses of this complex relationship are lacking. We aimed to fill this gap by applying advanced statistical models.We investigated data of 613 children from the prospective TEDDY study who were persistent positive for IAA, GADA and/or IA2A autoantibodies. We used a novel approach of Bayesian joint modeling of longitudinal and survival data to assess the potentially time- and covariate-dependent association between the longitudinal autoantibody titers and progression time to T1D.For all autoantibodies we observed a positive association between the titers and the T1D progression risk. This association was estimated as time-constant for IA2A, but decreased over time for IAA and GADA. For example the hazard ratio [95% credibility interval] for IAA (per transformed unit) was 3.38 [2.66, 4.38] at 6 months after seroconversion, and 2.02 [1.55, 2.68] at 36 months after seroconversion.These findings indicate that T1D progression risk stratification based on autoantibody titers should focus on time points early after seroconversion. Joint modeling techniques allow for new insights into these associations.

العلاقة: http://mediatum.ub.tum.de/node?id=1453062Test

الإتاحة: http://mediatum.ub.tum.de/node?id=1453062Test

المؤلفون: Smith, Laura B., Lynch, Kristian, Kurppa, Kalle, Koletzko, Sibylle, Krischer, Jeffrey, Liu, Edwin, Johnson, Suzanne Bennett, Agardh, Daniel, Rewers, Marian, Bautista, Kimberly, Baxter, Judith, Lernmark, Åke, Aronsson, Carin Andrén, Ask, Maria, Bremer, Jenny, Carlsson, Ulla Marie, Cilio, Corrado, Ericson-Hallström, Emelie, Fransson, Lina, Gard, Thomas, Gerardsson, Joanna, Bennet, Rasmus, Hansen, Monica, Hansson, Gertie, Harmby, Cecilia, Hyberg-Karlsson, Suzanne, Johansen, Fredrik, Jonsdottir, Berglind, Larsson, Helena Elding, Forss, Sigrid Lenrick, Lundgren, Markus, Månsson-Martinez, Maria, Markan, Maria, Melin, Marie Jessica, Mestan, Zeliha, Rahmati, Kobra, Ramelius, Anita, Rosenquist, Anna, Salami, Falastin, Sibthorpe, Sara, Sjöberg, Birgitta, Swartling, Ulrica, Amboh, Evelyn Tekum, Törn, Carina, Wallin, Anne, Wimar, Åsa, Åberg, Sofie, Parikh, Hemang, Vehik, Kendra, TEDDY Study Group

المصدر: Pediatrics; 139(3), no e20162848 (2017) ; ISSN: 0031-4005

مصطلحات موضوعية: Pediatrics, celiac disease, yong children, psychological

الوصف: BACKGROUND AND OBJECTIVES: Psychological symptoms can be associated with celiac disease; abstract however, this association has not been studied prospectively in a pediatric cohort. We examined mother report of psychological functioning in children persistently positive for tissue transglutaminase autoantibodies (tTGA), defined as celiac disease autoimmunity (CDA), compared with children without CDA in a screening population of genetically at-risk children. We also investigated differences in psychological symptoms based on mothers' awareness of their child's CDA status. METHODS: The Environmental Determinants of Diabetes in the Young study followed 8676 children to identify triggers of type 1 diabetes and celiac disease. Children were tested for tTGA beginning at 2 years of age. The Achenbach Child Behavior Checklist assessed child psychological functioning at 3.5 and 4.5 years of age. RESULTS: At 3.5 years, 66 mothers unaware their child had CDA reported more child anxiety and depression, aggressive behavior, and sleep problems than 3651 mothers of children without CDA (all Ps ≤ .03). Unaware-CDA mothers also reported more child anxiety and depression, withdrawn behavior, aggressive behavior, and sleep problems than 440 mothers aware of their child's CDA status (all Ps ≤.04). At 4.5 years, there were no differences. CONCLUSIONS: In 3.5-year-old children, CDA is associated with increased reports of child depression and anxiety, aggressive behavior, and sleep problems when mothers are unaware of their child's CDA status. Mothers' knowledge of their child's CDA status is associated with fewer reports of psychological symptoms, suggesting that awareness of the child's tTGA test results affects reporting of symptoms.

العلاقة: https://lup.lub.lu.se/record/7c9044fb-7705-4481-9add-55b0b3b08d48Test; http://dx.doi.org/10.1542/peds.2016-2848Test; pmid:28219962; scopus:85016036285

الإتاحة: https://doi.org/10.1542/peds.2016-2848Test
https://lup.lub.lu.se/record/7c9044fb-7705-4481-9add-55b0b3b08d48Test

المؤلفون: Lundgren, Markus, Steed, Leigh Johnson, Tamura, Roy N., Jonsdottir, Berglind, Gesualdo, Patricia, Crouch, Claire Cowen, Sjöberg, Maija, Hansson, Gertie, Hagopian, William A., Ziegler, Anette-G, Rewers, Marian J., Lernmark, Åke, Toppari, Jorma, She, Jin-Xiong, Akolkar, Beena, Krischer, Jeffrey P., Haller, Michael J., Elding Larsson, Helena, Bautista, Kimberly, Baxter, Judith, Bedoy, Ruth, Felipe-Morales, Daniel, Driscoll, Kimberly, Frohnert, Brigitte I., Hoffman, Michelle, Karban, Rachel, Liu, Edwin, Norris, Jill, Samper-Imaz, Adela, Steck, Andrea K, Waugh, Kathleen, Wright, Hali, Simell, Olli G., Adamsson, Annika, Ahonen, Suvi, Hyöty, Heikki, Ilonen, Jorma, Jokipuu, Sanna, Kallio, Tiina, Karlsson, Leena, Kähönen, Miia, Knip, Mikael, Kovanen, Lea, Koreasalo, Mirva, Kurppa, Kalle, Latvaaho, Tiina, Lönnrot, Maria, Mäntymäki, Elina, Multasuo, Katja, Mykkänen, Juha, Niininen, Tiina, Niinistö, Sari, Nyblom, Mia, Rajala, Petra, Rautanen, Jenna, Riikonen, Anne, Riikonen, Mika, Rouhiainen, Jenni, Romo, Minna, Simell, Tuula, Simell, Ville, Stenius, Aino, Leppänen, Maria, Vainionpää, Sini, Varjonen, Eeva, Veijola, Riitta, Virtanen, Suvi M, Vähä-Mäkilä, Mari, Åkerlund, Mari, Lindfors, Katri, Schatz, Desmond, Hopkins, Diane, Thomas, Jamie, Adams, Janey, Silvis, Katherine, Gardiner, Melissa, McIndoe, Richard, Sharma, Ashok, Williams, Joshua W, Young, Gabriela, Anderson, Stephen W., Jacobsen, Laura Mary, Beyerlein, Andreas, Bonifacio, Ezio, Hummel, Michael, Hummel, Sandra, Foterek, Kristina, Janz, Nicole, Kersting, Mathilde, Knopff, Annette, Koletzko, Sibylle, Peplow, Claudia, Roth, Roswith, Scholz, Marlon, Stock, Joanna, Warncke, Katharina, Wendel, Lorena, Winkler, Christiane, Agardh, Daniel, Aronsson, Carin Andrén, Ask, Maria, Bremer, Jenny, Carlsson, Ulla Marie, Cilio, Corrado, Ericson-Hallström, Emelie, Fransson, Lina, Gard, Thomas, Gerardsson, Joanna, Bennet, Rasmus, Hansen, Monica, Hyberg, Susanne, Johansen, Fredrik, Lindström, Marielle, Månsson-Martinez, Maria, Markan, Maria, Melin, Jessica, Mestan, Zeliha, Ottosson, Karin, Rahmati, Kobra, Ramelius, Anita, Salami, Falastin, Sibthorpe, Sara, Sjöberg, Birgitta, Swartling, Ulrica, Amboh, Evelyn Tekum, Törn, Carina, Wallin, Anne, Wimar, Åsa, Åberg, Sofie, Michael Killian, Killian, Skidmore, Jennifer, Carson, Josephine, Dalzell, Maria, Dunson, Kayleen, Hervey, Rachel, Johnson, Corbin, Lyons, Rachel, Meyer, Arlene, Mulenga, Denise, Tarr, Alexander, Uland, Morgan, Willis, John, Becker, Dorothy, Franciscus, Margaret, Ellen, Mary, Smith, Mary Ellen Dalmagro Elias, Daftary, Ashi, Klein, Mary Beth, Yates, Chrystal, Abbondondolo, Michael, Austin-Gonzalez, Sarah, Avendano, Maryouri, Baethke, Sandra, Brown, Rasheedah, Burkhardt, Brant R., Butterworth, Martha, Clasen, Joanna, Cuthbertson, David, Christopher Eberhard, Eberhard, Fiske, Steven W., Garcia, Dena, Garmeson, Jennifer, Gowda, Veena, Heyman, Kathleen, Laras, Francisco Perez, Lee, Hye-Seung, Liu, Shu, Liu, Xiang, Lynch, Kristian, Malloy, Jamie, McCarthy, Cristina, Meulemans, Steven, Parikh, Hemang, Shaffer, Chris, Smith, Laura, Smith, Susan, Sulman, Noah, Uusitalo, Ulla, Vehik, Kendra, Vijayakandipan, Ponni, Wood, Keith, Yang, Jimin, Lori Ballard, R. D., Hadley, David, Mcleod, Wendy, Yu, Liping, Miao, Dongmei, Bingley, Polly J, Williams, Alistair, Chandler, Kyla, Rokni, Saba, Williams, Claire L., Wyatt, Rebecca, George, Gifty, Grace, Sian, Erlich, Henry, Mack, Steven J., Fear, Anna Lisa, Ke, Sandra, Mulholland, Niveen, Rich, Stephen, Chen, Wei-Min, Onengut-Gumuscu, Suna, Farber, Emily, Pickin, Rebecca Roche, Davis, Jordan, Gallo, Dan, Bonnie, Jessica, Campolieto, Paul, Bourcier, Kasia, Briese, Thomas, Johnson, Suzanne Bennett, Triplett, Eric W

المصدر: BMC Pediatrics; 17(1), no 127 (2017) ; ISSN: 1471-2431

مصطلحات موضوعية: Endocrinology and Diabetes, Analgesics, Islet autoimmunity, Prospective studies, Type 1 diabetes

الوصف: Background: The use of analgesic antipyretics (ANAP) in children have long been a matter of controversy. Data on their practical use on an individual level has, however, been scarce. There are indications of possible effects on glucose homeostasis and immune function related to the use of ANAP. The aim of this study was to analyze patterns of analgesic antipyretic use across the clinical centers of The Environmental Determinants of Diabetes in the Young (TEDDY) prospective cohort study and test if ANAP use was a risk factor for islet autoimmunity. Methods: Data were collected for 8542 children in the first 2.5 years of life. Incidence was analyzed using logistic regression with country and first child status as independent variables. Holm's procedure was used to adjust for multiplicity of intercountry comparisons. Time to autoantibody seroconversion was analyzed using a Cox proportional hazards model with cumulative analgesic use as primary time dependent covariate of interest. For each categorization, a generalized estimating equation (GEE) approach was used. Results: Higher prevalence of ANAP use was found in the U.S. (95.7%) and Sweden (94.8%) compared to Finland (78.1%) and Germany (80.2%). First-born children were more commonly given acetaminophen (OR 1.26; 95% CI 1.07, 1.49; p = 0.007) but less commonly Non-Steroidal Anti-inflammatory Drugs (NSAID) (OR 0.86; 95% CI 0.78, 0.95; p = 0.002). Acetaminophen and NSAID use in the absence of fever and infection was more prevalent in the U.S. (40.4%; 26.3% of doses) compared to Sweden, Finland and Germany (p < 0.001). Acetaminophen or NSAID use before age 2.5 years did not predict development of islet autoimmunity by age 6 years (HR 1.02, 95% CI 0.99-1.09; p = 0.27). In a sub-analysis, acetaminophen use in children with fever weakly predicted development of islet autoimmunity by age 3 years (HR 1.05; 95% CI 1.01-1.09; p = 0.024). Conclusions: ANAP use in young children is not a risk factor for seroconversion by age 6 years. Use of ANAP is widespread in young ...

العلاقة: https://lup.lub.lu.se/record/6a59c413-936c-4908-8bed-26b4774b1f84Test; http://dx.doi.org/10.1186/s12887-017-0884-yTest; scopus:85019465441; pmid:28511706; wos:000401666800002

الإتاحة: https://doi.org/10.1186/s12887-017-0884-yTest
https://lup.lub.lu.se/record/6a59c413-936c-4908-8bed-26b4774b1f84Test

المؤلفون: Haghighi, Mona, Johnson, Suzanne Bennett, Qian, Xiaoning, Lynch, Kristian F, Vehik, Kendra, Huang, Shuai, TEDDY Study Group, Rewers, Marian, Bautista, Kimberly, Baxter, Judith, Bedoy, Ruth, Felipe-Morales, Daniel, Driscoll, Kimberly, Frohnert, Brigitte I, Gesualdo, Patricia, Hoffman, Michelle, Karban, Rachel, Liu, Edwin, Norris, Jill, Samper-Imaz, Adela, Steck, Andrea, Waugh, Kathleen, Wright, Hali, Sharma, Ashok, Hopkins, Diane, Young, Gabriela, She, Jin-Xiong, Williams, Joshua, Silvis, Katherine, Steed, Leigh, Gardiner, Melissa, McIndoe, Richard, Schatz, Desmond, Thomas, Jamie, Adams, Janey, Jacobsen, Laura, Haller, Michael, Triplett, Eric, Anderson, Stephen W, Mykkänen, Juha, Lindfors, Katri, Adamsson, Annika, Jokipuu, Sanna, Kallio, Tiina, Karlsson, Leena, Mäntymäki, Elina, Rajala, Petra, Riikonen, Mika, Rouhiainen, Jenni, Romo, Minna, Leppänen, Maria, Vainionpää, Sini, Vähä-Mäkilä, Mari, Stenius, Aino, Toppari, Jorma, Simell, Olli G, Simell, Tuula, Sjöberg, Maija, Varjonen, Eeva, Hyöty, Heikki, Knip, Mikael, Kurppa, Kalle, Lönnrot, Maria, Niininen, Tiina, Nyblom, Mia, Ahonen, Suvi, Kovanen, Lea, Koreasalo, Mirva, Riikonen, Anne, Virtanen, Suvi M, Åkerlund, Mari, Ilonen, Jorma, Kähönen, Miia, Latva-Aho, Tiina, Multasuo, Katja, Veijola, Riitta, Niinistö, Sari, Rautanen, Jenna, Ziegler, Anette G, Hummel, Michael, Hummel, Sandra, Janz, Nicole, Knopff, Annette, Peplow, Claudia, Roth, Roswith, Scholz, Marlon, Stock, Joanna, Warncke, Katharina, Wendel, Lorena, Winkler, Christiane, Beyerlein, Andreas, Bonifacio, Ezio, Koletzko, Sibylle, Foterek, Kristina, Kersting, Mathilde, Lernmark, Åke, Agardh, Daniel, Andrén Aronsson, Carin, Ask, Maria, Bremer, Jenny, Carlsson, Ulla-Marie, Cilio, Corrado, Ericson-Hallström, Emelie, Fransson, Lina, Gard, Thomas, Gerardsson, Joanna, Bennet, Rasmus, Hansen, Monica, Hansson, Gertie, Hyberg, Susanne, Johansen, Fredrik, Jonsdottir, Berglind, Elding Larsson, Helena, Lindström, Marielle, Lundgren, Markus, Månsson-Martinez, Maria, Markan, Maria, Melin, Jessica, Mestan, Zeliha, Ottosson, Karin, Rahmati, Kobra, Ramelius, Anita, Salami, Falastin, Sibthorpe, Sara, Sjöberg, Birgitta, Swartling, Ulrica, Tekum Amboh, Evelyn, Törn, Carina, Wallin, Anne, Wimar, Åsa, Åberg, Sofie, Hagopian, William A, Killian, Michael, Cowen Crouch, Claire, Skidmore, Jennifer, Carson, Josephine, Dalzell, Maria, Dunson, Kayleen, Hervey, Rachel, Johnson, Corbin, Lyons, Rachel, Meyer, Arlene, Mulenga, Denise, Tarr, Alexander, Uland, Morgan, Willis, John, Becker, Dorothy, Franciscus, Margaret, Smith, MaryEllen Dalmagro-Elias, Daftary, Ashi, Beth Klein, Mary, Yates, Chrystal, Krischer, Jeffrey P, Abbondondolo, Michael, Austin-Gonzalez, Sarah, Avendano, Maryouri, Baethke, Sandra, Brown, Rasheedah, Burkhardt, Brant, Butterworth, Martha, Clasen, Joanna, Cuthbertson, David, Eberhard, Christopher, Fiske, Steven, Garcia, Dena, Garmeson, Jennifer, Gowda, Veena, Heyman, Kathleen, Perez Laras, Francisco, Lee, Hye-Seung, Liu, Shu, Liu, Xiang, Malloy, Jamie, McCarthy, Cristina, Meulemans, Steven, Parikh, Hemang, Shaffer, Chris, Smith, Laura, Smith, Susan, Sulman, Noah, Tamura, Roy, Uusitalo, Ulla, Vijayakandipan, Ponni, Wood, Keith, Yang, Jimin, Akolkar, Beena, Bourcier, Kasia, Briese, Thomas

المساهمون: Klinik und Poliklinik für Kinder- und Jugendmedizin

مصطلحات موضوعية: info:eu-repo/classification/ddc

العلاقة: https://mediatum.ub.tum.de/1453064Test

الإتاحة: https://doi.org/10.1038/srep39723Test
https://mediatum.ub.tum.de/1453064Test

المؤلفون: Lundgren, Markus, Steed, Leigh Johnson, Tamura, Roy, Jonsdottir, Berglind, Gesualdo, Patricia, Crouch, Claire, Sjöberg, Maija, Hansson, Gertie, Hagopian, William A, Ziegler, Anette G, Rewers, Marian J, Lernmark, Åke, Toppari, Jorma, She, Jin-Xiong, Akolkar, Beena, Krischer, Jeffrey P, Haller, Michael J, Elding Larsson, Helena, TEDDY Study Group, Rewers, Marian, Bautista, Kimberly, Baxter, Judith, Bedoy, Ruth, Felipe-Morales, Daniel, Driscoll, Kimberly, Frohnert, Brigitte I, Hoffman, Michelle, Karban, Rachel, Liu, Edwin, Norris, Jill, Samper-Imaz, Adela, Steck, Andrea, Waugh, Kathleen, Wright, Hali, Simell, Olli G, Adamsson, Annika, Ahonen, Suvi, Ilonen, Jorma, Jokipuu, Sanna, Kallio, Tiina, Karlsson, Leena, Kähönen, Miia, Knip, Mikael, Kovanen, Lea, Koreasalo, Mirva, Kurppa, Kalle, Latva-Aho, Tiina, Lönnrot, Maria, Mäntymäki, Elina, Multasuo, Katja, Mykkänen, Juha, Niininen, Tiina, Niinistö, Sari, Nyblom, Mia, Rajala, Petra, Rautanen, Jenna, Riikonen, Anne, Riikonen, Mika, Rouhiainen, Jenni, Romo, Minna, Simell, Tuula, Simell, Ville, Stenius, Aino, Leppänen, Maria, Vainionpää, Sini, Varjonen, Eeva, Veijola, Riitta, Virtanen, Suvi M, Vähä-Mäkilä, Mari, Lindfors, Mari ÅkerlundKatri, Schatz, Desmond, Hopkins, Diane, Steed, Leigh, Thomas, Jamie, Adams, Janey, Silvis, Katherine, Haller, Michael, Gardiner, Melissa, McIndoe, Richard, Sharma, Ashok, Williams, Joshua, Young, Gabriela, Anderson, Stephen W, Jacobsen, Laura, Beyerlein, Andreas, Bonifacio, Ezio, Hummel, Michael, Hummel, Sandra, Foterek, Kristina, Janz, Nicole, Kersting, Mathilde, Knopff, Annette, Koletzko, Sibylle, Peplow, Claudia, Roth, Roswith, Scholz, Marlon, Stock, Joanna, Warncke, Katharina, Wendel, Lorena, Winkler, Christiane, Agardh, Daniel, Aronsson, Carin Andrén, Ask, Maria, Bremer, Jenny, Carlsson, Ulla-Marie, Cilio, Corrado, Ericson-Hallström, Emelie, Fransson, Lina, Gard, Thomas, Gerardsson, Joanna, Bennet, Rasmus, Hansen, Monica, Hyberg, Susanne, Johansen, Fredrik, Larsson, Helena Elding, Lindström, Marielle, Månsson-Martinez, Maria, Markan, Maria, Melin, Jessica, Mestan, Zeliha, Ottosson, Karin, Rahmati, Kobra, Ramelius, Anita, Salami, Falastin, Sibthorpe, Sara, Sjöberg, Birgitta, Swartling, Ulrica, Amboh, Evelyn Tekum, Törn, Carina, Wallin, Anne, Wimar, Åsa, Åberg, Sofie, Killian, Michael, Crouch, Claire Cowen, Skidmore, Jennifer, Carson, Josephine, Dalzell, Maria, Dunson, Kayleen, Hervey, Rachel, Johnson, Corbin, Lyons, Rachel, Meyer, Arlene, Mulenga, Denise, Tarr, Alexander, Uland, Morgan, Willis, John, Becker, Dorothy, Franciscus, Margaret, Smith, MaryEllen Dalmagro-Elias, Daftary, Ashi, Klein, Mary Beth, Yates, Chrystal, Abbondondolo, Michael, Austin-Gonzalez, Sarah, Avendano, Maryouri, Baethke, Sandra, Brown, Rasheedah, Burkhardt, Brant, Butterworth, Martha, Clasen, Joanna, Cuthbertson, David, Eberhard, Christopher, Fiske, Steven, Garcia, Dena, Garmeson, Jennifer, Gowda, Veena, Heyman, Kathleen, Laras, Francisco Perez, Lee, Hye-Seung, Liu, Shu, Liu, Xiang, Lynch, Kristian, Malloy, Jamie, McCarthy, Cristina, Meulemans, Steven, Parikh, Hemang, Shaffer, Chris, Smith, Laura, Smith, Susan, Sulman, Noah, Uusitalo, Ulla, Vehik, Kendra, Vijayakandipan, Ponni, Wood, Keith, Yang, Jimin, Yu, Liping, Miao, Dongmei, Bingley, Polly, Williams, Alistair, Chandler, Kyla, Rokni, Saba, Williams, Claire, Wyatt, Rebecca, George, Gifty, Grace, Sian, Erlich, Henry, Mack, Steven J, Fear, Anna Lisa, Ke, Sandra, Mulholland, Niveen, Rich, Stephen S, Chen, Wei-Min, Onengut-Gumuscu, Suna, Farber, Emily, Pickin, Rebecca Roche, Davis, Jordan, Gallo, Dan, Bonnie, Jessica, Campolieto, Paul, Bourcier, Kasia, Briese, Thomas, Johnson, Suzanne Bennett, Triplett, Eric

المساهمون: Klinik und Poliklinik für Kinder- und Jugendmedizin

مصطلحات موضوعية: info:eu-repo/classification/ddc

الوصف: The use of analgesic antipyretics (ANAP) in children have long been a matter of controversy. Data on their practical use on an individual level has, however, been scarce. There are indications of possible effects on glucose homeostasis and immune function related to the use of ANAP. The aim of this study was to analyze patterns of analgesic antipyretic use across the clinical centers of The Environmental Determinants of Diabetes in the Young (TEDDY) prospective cohort study and test if ANAP use was a risk factor for islet autoimmunity.Data were collected for 8542 children in the first 2.5 years of life. Incidence was analyzed using logistic regression with country and first child status as independent variables. Holm's procedure was used to adjust for multiplicity of intercountry comparisons. Time to autoantibody seroconversion was analyzed using a Cox proportional hazards model with cumulative analgesic use as primary time dependent covariate of interest. For each categorization, a generalized estimating equation (GEE) approach was used.Higher prevalence of ANAP use was found in the U.S. (95.7%) and Sweden (94.8%) compared to Finland (78.1%) and Germany (80.2%). First-born children were more commonly given acetaminophen (OR 1.26; 95% CI 1.07, 1.49; p = 0.007) but less commonly Non-Steroidal Anti-inflammatory Drugs (NSAID) (OR 0.86; 95% CI 0.78, 0.95; p = 0.002). Acetaminophen and NSAID use in the absence of fever and infection was more prevalent in the U.S. (40.4%; 26.3% of doses) compared to Sweden, Finland and Germany (p< 0.001). Acetaminophen or NSAID use before age 2.5 years did not predict development of islet autoimmunity by age 6 years (HR 1.02, 95% CI 0.99-1.09; p = 0.27). In a sub-analysis, acetaminophen use in children with fever weakly predicted development of islet autoimmunity by age 3 years (HR 1.05; 95% CI 1.01-1.09; p = 0.024).ANAP use in young children is not a risk factor for seroconversion by age 6 years. Use of ANAP is widespread in young children, and significantly higher in the U.S. ...

العلاقة: https://mediatum.ub.tum.de/1453063Test

الإتاحة: https://doi.org/10.1186/s12887-017-0884-yTest
https://mediatum.ub.tum.de/1453063Test