المؤلفون: Yakhine Diop, Sokhna M. S., Moreno Cruz, Paula, Manrique García, Laura, Gabrielly Pereira, Amanda, Morales García, José Ángel, Corral Nieto, Yaiza, Niso Santano, Mireia, González Polo, Rosa A., Uribe Carretero, Elisabet, Durand, Sylvère, Maiuri, Maria Chiara, Paredes Barquero, Marta, Alegre Cortés, Eva, Canales Cortés, Saray, López de Munain, Adolfo, Pérez Tur, Jordi, Pérez Castillo, Ana, Kroemer, Guido, Fuentes, José M., Bravo San Pedro, José M.

مصطلحات موضوعية: Lipids, Liver, LRRK2, Metabolome, Neurodegeneration, Parkinson, Psicología (Psicología), Veterinaria, 61 Psicología, 3109 Ciencias Veterinarias

الوصف: The identification of Parkinson’s disease (PD) biomarkers has become a main goal for the diagnosis of this neurodegenerative disorder. PD has not only been intrinsically related to neurological problems, but also to a series of alterations in peripheral metabolism. The purpose of this study was to identify metabolic changes in the liver in mouse models of PD with the scope of finding new peripheral biomarkers for PD diagnosis. To achieve this goal, we used mass spectrometry technology to determine the complete metabolomic profile of liver and striatal tissue samples from WT mice, 6-hydroxydopamine-treated mice (idiopathic model) and mice affected by the G2019S-LRRK2 mutation in LRRK2/PARK8 gene (genetic model). This analysis revealed that the metabolism of carbohydrates, nucleotides and nucleosides was similarly altered in the liver from the two PD mouse models. However, long-chain fatty acids, phosphatidylcholine and other related lipid metabolites were only altered in hepatocytes from G2019S-LRRK2 mice. In summary, these results reveal specific differences, mainly in lipid metabolism, between idiopathic and genetic PD models in peripheral tissues and open up new possibilities to better understand the etiology of this neurological disorder. ; Ministerio de Ciencia, Innovación y Universidades (España) ; Instituto de Salud Carlos III ; Centre for Networked Biomedical Research in Neurodegenerative Diseases ; Depto. de Fisiología ; Sección Deptal. de Biología Celular (Medicina) ; Fac. de Medicina ; TRUE ; pub

وصف الملف: application/pdf

العلاقة: PID2019-108827RA-I00; PI15/0034; CB06/05/0041 and 2015/03; https://hdl.handle.net/20.500.14352/72403Test; https://doi.org/10.3390/cells12050806Test; https://www.mdpi.com/2073-4409/12/5/806Test

الإتاحة: https://doi.org/20.500.14352/7240310.3390/cells12050806Test
https://hdl.handle.net/20.500.14352/72403Test
https://www.mdpi.com/2073-4409/12/5/806Test

المؤلفون: Corral Nieto, Yaiza, Yakhine Diop, Sokhna M. S., Moreno Cruz, Paula, Manrique García, Laura, Gabrielly Pereira, Amanda, Morales García, José A., Niso Santano, Mireia, González Polo, Rosa A., Uribe Carretero, Elisabet, Durand, Sylvère, Maiuri, Maria Chiara, Paredes Barquero, Marta, Alegre Cortés, Eva, Canales Cortés, Saray, López de Munain, Adolfo, Pérez Tur, Jordi, Pérez Castillo, Ana María, Kroemer, Guido, Fuentes, José M., Bravo San Pedro, José M.

مصطلحات موضوعية: Lipids, Liver, LRRK2, Metabolome, Neurodegeneration, Parkinson, Veterinaria, 3109 Ciencias Veterinarias

الوصف: The identification of Parkinson’s disease (PD) biomarkers has become a main goal for the diagnosis of this neurodegenerative disorder. PD has not only been intrinsically related to neurological problems, but also to a series of alterations in peripheral metabolism. The purpose of this study was to identify metabolic changes in the liver in mouse models of PD with the scope of finding new peripheral biomarkers for PD diagnosis. To achieve this goal, we used mass spectrometry technology to determine the complete metabolomic profile of liver and striatal tissue samples from WT mice, 6-hydroxydopamine-treated mice (idiopathic model) and mice affected by the G2019S-LRRK2 mutation in LRRK2/PARK8 gene (genetic model). This analysis revealed that the metabolism of carbohydrates, nucleotides and nucleosides was similarly altered in the liver from the two PD mouse models. However, long-chain fatty acids, phosphatidylcholine and other related lipid metabolites were only altered in hepatocytes from G2019S-LRRK2 mice. In summary, these results reveal specific differences, mainly in lipid metabolism, between idiopathic and genetic PD models in peripheral tissues and open up new possibilities to better understand the etiology of this neurological disorder. ; Depto. de Fisiología ; Sección Deptal. de Biología Celular (Medicina) ; Fac. de Medicina ; TRUE ; Instituto de Salud Carlos III (ISCIII)/ FEDER ; CIBERNED-ISCIII ; Ministerio de Ciencia e Innovación ; pub

وصف الملف: application/pdf

العلاقة: PI15/0034; CB06/05/0041 and 2015/03; PID2019-108827RA-I00; https://doi.org/10.3390/cells12050806Test; https://www.mdpi.com/2073-4409/12/5/806Test; https://hdl.handle.net/20.500.14352/72397Test

الإتاحة: https://doi.org/20.500.14352/72397Test
https://doi.org/10.3390/cells12050806Test
https://hdl.handle.net/20.500.14352/72397Test
https://www.mdpi.com/2073-4409/12/5/806Test

المؤلفون: Moreno-Cruz, Paula, Corral Nieto, Yaiza, Manrique Garcia, Laura, Pereira, Amanda Gabrielly, Bravo-San Pedro, José Manuel

المصدر: Cilia: From Mechanisms to Disease - Part A ; Methods in Cell Biology ; page 1-15 ; ISSN 0091-679X ; ISBN 9780443185861

الإتاحة: https://doi.org/10.1016/bs.mcb.2022.10.002Test
https://api.elsevier.com/content/article/PII:S0091679X22001662?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S0091679X22001662?httpAccept=text/plainTest

المؤلفون: Astudillo Calderón, Sergio, De Díez De La Torre, Laura, García Companys, Marina, Ortega Pérez, Nora, Rodríguez Martínez, Víctor, Alzahrani, Sabah, Alonso Valenzuela, Raquel, Ávalos García, Adolfo, Cifuentes, Blanca, Esteban Carrasco, Alberto, Gómez Garay, Aránzazu, Martín Calvarro, Luisa, Martín Gómez, María Soledad, Pérez-Urría Carril, Elena, Pintos López, Beatriz, Solís González, María Teresa, Torres Muñoz, Margarita, Aguado Megías, Gema, Aguilar Rico, Darío, Alonso Mezquita, Cristina, Anaya Chillarón, Elena, Arnal Sierra, Raquel, Bejarano Muñoz, Lara, Briones Rizo, Marina, Cantaragiu, Silvia Gabriela, Casado Sarrión, Celia, Cuevas Medina, Beatriz, De la Hoz Rivera, María, García Lorenzana, Clara, García Vela, Elva Xochil, Gómez Prieto, Ángela, González, Carlos, Herrera Castillo, Lisbeth Carolina, Konarieva, Iulia, Lambea Hernansanz, Manuel, Liébana Alfonso, Alba, Losada Oliva, Paula, Manrique García, Laura, Marín García, María, Martínez San Juan, Ana, Montañés Fuentemilla, María, Montecino Fernández, Laura, Murillo Ambrona, Paula, Poyatos Peláez, Sara, Pujana Zabala, Maialen, Ruiz Matute, Celia, Sánchez Barrientos, Laura, Sánchez León, Rocío, Sánchez-Archidona Benito, Lucía, Villar García, Verónica, Zamorano Domínguez, Elena, Santos De la Sen, Antonio

مصطلحات موضوعية: Higher Education, Learning, Educational systems, Teaching, Creativity, Problem solving, Entrepreneurship, EstuPlan

الوصف: [EN] Creative thinking is necessary to generate novel ideas and solve problems. "EstuPlan" is a methodology in which knowledge and creativity converge for the resolution of scientific problems with social projection. It is a training programme that integrates teachers, laboratory technicians and PhD students, master and undergraduate students which form working groups for the development of projects. Projects have a broad and essential scope and projection in terms of environmental problems, sustainable use of natural resources, food, health, biotechnology or biomedicine. The results show the success of this significant learning methodology using tools to develop creativity in responding to scientific and social demand for problem-solving to transfer academic knowledge to different professional environments. Bioplastics, Second Life of Coffee, LimBio, Algae oils, Ecomers, Caring for the life of your crop and Hate to Deforestate are currently being developed. ; Astudillo Calderón, S.; De Díez De La Torre, L.; García Companys, M.; Ortega Pérez, N.; Rodríguez Martínez, V.; Alzahrani, S.; Alonso Valenzuela, R. (2019). EstuPlan: Methodology for the development of creativity in the resolution of scientific and social problems. En HEAD'19. 5th International Conference on Higher Education Advances. Editorial Universitat Politècnica de València. 711-717. https://doi.org/10.4995/HEAD19.2019.9205Test ; 711 ; 717

العلاقة: HEAD'19. 5th International Conference on Higher Education Advances; Fifth International Conference on Higher Education Advances; Junio 26-28, 2019; València, Spain; http://ocs.editorial.upv.es/index.php/HEAD/HEAD19/paper/view/9205Test; urn:isbn:9788490486610; urn:issn:2603-5871; http://hdl.handle.net/10251/125038Test

الإتاحة: https://doi.org/10.4995/HEAD19.2019.9205Test
http://hdl.handle.net/10251/125038Test