-
1
المؤلفون: Gericke, M., Amaral, A. J. R., Budtova, T., De Wever, P., Groth, T., Heinze, T., Höfte, H., Huber, A., Ikkala, O., Kapuśniak, J., Kargl, R., Mano, J. F., Másson, M., Matricardi, P., Medronho, B., Norgren, Magnus, 1967, Nypelö, T., Nyström, L., Roig, A., Sauer, M., Schols, H. A., van der Linden, J., Wrodnigg, T. M., Xu, C., Yakubov, G. E., Stana Kleinschek, K., Fardim, P.
المصدر: Carbohydrate Polymers. 326
مصطلحات موضوعية: Bioeconomy, Biomaterials, Biomedical applications, Food and nutrition, Polysaccharides
الوصف: Polysaccharides are among the most abundant bioresources on earth and consequently need to play a pivotal role when addressing existential scientific challenges like climate change and the shift from fossil-based to sustainable biobased materials. The Research Roadmap 2040 of the European Polysaccharide Network of Excellence (EPNOE) provides an expert's view on how future research and development strategies need to evolve to fully exploit the vast potential of polysaccharides as renewable bioresources. It is addressed to academic researchers, companies, as well as policymakers and covers five strategic areas that are of great importance in the context of polysaccharide related research: (I) Materials & Engineering, (II) Food & Nutrition, (III) Biomedical Applications, (IV) Chemistry, Biology & Physics, and (V) Skills & Education. Each section summarizes the state of research, identifies challenges that are currently faced, project achievements and developments that are expected in the upcoming 20 years, and finally provides outlines on how future research activities need to evolve.
وصف الملف: electronic
الوصول الحر: https://urn.kb.se/resolve?urn=urn:nbn:se:miun:diva-50104Test
https://doi.org/10.1016Test/j .carbpol.2023.121633
https://miun.diva-portal.org/smash/get/diva2:1819362/FULLTEXT01.pdfTest -
2كتاب
المؤلفون: Lavrador, P., Borges, J., Gaspar, V. M., Mano, J. F.
الوصف: Soft nanoparticles represent a unique class of nanomaterials that can be engineered to react and adapt distinctly in different biological milieus while modulating the presentation of biochemical and biophysical cues to neighbouring receptive cells. This flexibility has fuelled the development of soft nanoparticle-laden nanocomposite hydrogels that are increasingly sophisticated in stimuli-responsiveness and promising for satisfying a plethora of biomedical applications. Such hybrid platforms can be encoded with intelligent disease-discerning tools, smart adaptability under external triggers for bioactive cargo delivery or be engineered for manipulating biomechanical properties in different tissue microenvironments. In addition, they can be interfaced with biological components(i.e. enzymes, cell membranes) or specific substrates recognisable by biological machinery, yielding biomolecule-responsive systems that perceive changes in their surroundings and alter their therapeutic outputs accordingly. In essence, this chapter highlights the unique opportunities of soft nanoparticles to function as versatile building blocks for programming and modulating a large array of features in hydrogel-based platforms, thus extending their biofunctionality and applicability in tissue engineering and regenerative medicine practices. ; published
العلاقة: info:eu-repo/grantAgreement/FCT/9471 - RIDTI/PTDC%2FQUI-OUT%2F30658%2F2017/PT; info:eu-repo/grantAgreement/FCT/9471 - RIDTI/PTDC%2FBTM-MAT%2F31498%2F2017/PT; info:eu-repo/grantAgreement/FCT/9471 - RIDTI/PTDC%2FBTM-SAL%2F30503%2F2017/PT; info:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F50011%2F2020/PT; info:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDP%2F50011%2F2020/PT; info:eu-repo/grantAgreement/FCT/CEEC IND 2017/CEECIND%2F03202%2F2017%2FCP1459%2FCT0042/PT; info:eu-repo/grantAgreement/FCT/POR_CENTRO/SFRH%2FBD%2F141834%2F2018/PT; http://hdl.handle.net/10773/34186Test
-
3كتاب
المؤلفون: Borges, J., Sousa, C. F. V., Bjorge, I. M., Nadine, S., Correia, C. R., Patrício, S. G., Mano, J. F.
الوصف: Layer-by-layer (LbL) assembly is an easier, inexpensive, and highly versatile bottom-up methodology to modify surfaces and fabricate functional multilayer thin films and nanocomposites with fine-tuned compositions, structures, properties, and functions at the nanoscale. Since the early stages of its development, LbL technology has gathered increasing attention across different fields of application, including in the biomedical field owing to its mild processing conditions. In this chapter, we review the multitude of templates, spanning from the zero-dimensional to the three-dimensional, for shaping a diverse set of multifunctional soft-based LbL structures aiming for biomedical applications. Several examples are given on multilayered structures, including nano-to-macro particles and hollow capsules or tubes, multilayered thin films and free-standing membranes, multicompartmentalized systems, porous scaffolds, and even dynamic living cell platforms, which can act as unprecedented building blocks to create highly complex LbL devices. We envisage that such a multitude of functional LbL devices will stimulate scientists to pursue the further development of LbL technology and foster its effective translation to practical biomedical applications. ; published
العلاقة: info:eu-repo/grantAgreement/FCT/9471 - RIDTI/PTDC%2FQUI-OUT%2F30658%2F2017/PT; info:eu-repo/grantAgreement/FCT/9471 - RIDTI/PTDC%2FBTM-MAT%2F31210%2F2017/PT; info:eu-repo/grantAgreement/FCT/9471 - RIDTI/PTDC%2FBTM-MAT%2F31064%2F2017/PT; info:eu-repo/grantAgreement/FCT/CEEC IND 2017/CEECIND%2F03202%2F2017%2FCP1459%2FCT0042/PT; info:eu-repo/grantAgreement/FCT/POR_CENTRO/SFRH%2FBD%2F129224%2F2017/PT; info:eu-repo/grantAgreement/FCT/POR_CENTRO/SFRH%2FBD%2F130194%2F2017/PT; info:eu-repo/grantAgreement/FCT/3599-PPCDT/ERA-MBT%2F0002%2F2015/PT; info:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F50011%2F2020/PT; info:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDP%2F50011%2F2020/PT; http://hdl.handle.net/10773/34188Test
-
4كتاب
المؤلفون: Rodrigues, João M. M., Castanheira, E. J., Costa, D. C. S., Rocha, D. H. A., Borges, J., Mano, J. F.
الوصف: Natural polysaccharides are a major class of biomacromolecules with a high degree of biocompatibility, biodegradability, and ability to mimic the natural extracellular matrix (ECM) microenvironment and, therefore, have been receiving increasing attention. Polysaccharides often exhibit interesting and advantageous properties, including bioactivity, different functional groups, and bioadhesive properties, as well as easiness in being tailored to different applications by chemical modification. Their bioactivity depends on the chemical structure, monosaccharide composition, and spatial conformation. The chemical modification of polysaccharides and the introduction of specific functional groups significantly increase their structural diversity, by promoting or adding new (bio)functionalities. Polysaccharide-based biomaterials are an emerging class in multiple biomedical applications, including in tissue engineering and regenerative medicine (TERM) and drug delivery. Most of the polysaccharides used in biomedical applications derive from natural sources, mainly from marine environments, particularly, alginate and chitin (CH). This chapter focuses on the recent progress in the field of chemical modification of marine-origin polysaccharides, including i) chitosan (CHT), ii) hyaluronic acid (HA), iii) alginate (ALG), iv) glycosaminoglycans (GAGs) and sulfated glycans, v) laminarin (LAM), and vi) agarose, for the development of biomaterials for biomedical applications. ; published
العلاقة: info:eu-repo/grantAgreement/FCT/3599-PPCDT/ERA-MBT%2F0002%2F2015/PT; info:eu-repo/grantAgreement/FCT/9471 - RIDTI/PTDC%2FQUI-OUT%2F30658%2F2017/PT; info:eu-repo/grantAgreement/FCT/9471 - RIDTI/PTDC%2FQUI-QOR%2F30771%2F2017/PT; info:eu-repo/grantAgreement/FCT/9471 - RIDTI/PTDC%2FBTM-MAT%2F31498%2F2017/PT; info:eu-repo/grantAgreement/FCT/POR_CENTRO/SFRH%2FBD%2F144880%2F2019/PT; info:eu-repo/grantAgreement/FCT/CEEC IND 2017/CEECIND%2F03202%2F2017%2FCP1459%2FCT0042/PT; info:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F50011%2F2020/PT; info:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDP%2F50011%2F2020/PT; http://hdl.handle.net/10773/34187Test
-
5تقرير
المؤلفون: Dias, C. S., Custodio, C. A., Antunes, G. C., da Gama, M. M. Telo, Mano, J. F., Araujo, N. A. M.
الوصف: A critical step in tissue engineering is the design and synthesis of 3D biocompatible matrices (scaffolds) to support and guide the proliferation of cells and tissue growth. Most existing techniques rely on the processing of scaffolds under controlled conditions and then implanting them \textit{in vivo}, with questions related to biocompatibility and the implantation process that are still challenging. As an alternative, it was proposed to assemble the scaffolds \textit{in loco} through the self-organization of colloidal particles mediated by cells. In this study, we combine experiments, particle-based simulations, and mean-field calculations to show that, in general, the size of the self-assembled scaffold scales with the cell-to-particle ratio. However, we found an optimal value of this ratio, for which the size of the scaffold is maximal when cell-cell adhesion is suppressed. These results suggest that the size and structure of the self-assembled scaffolds may be designed by tuning the adhesion between cells in the colloidal suspension.
الوصول الحر: http://arxiv.org/abs/2006.08270Test
-
6دورية أكاديمية
المؤلفون: Petroni S., Tagliaro I., Antonini C., D’Arienzo M., Orsini S. F., Mano J. F., Brancato V., Borges J., Cipolla L.
المساهمون: Petroni, S, Tagliaro, I, Antonini, C, D’Arienzo, M, Orsini, S, Mano, J, Brancato, V, Borges, J, Cipolla, L
مصطلحات موضوعية: 3D printing, chitosan, chitosan-based material, drug delivery, hydrogel, layer-by-layer device, marine-origin polysaccharide, organic–inorganic hybrid, regenerative medicine, tissue engineering
الوصف: Chitosan is a marine-origin polysaccharide obtained from the deacetylation of chitin, the main component of crustaceans’ exoskeleton, and the second most abundant in nature. Although this biopolymer has received limited attention for several decades right after its discovery, since the new millennium chitosan has emerged owing to its physicochemical, structural and biological properties, multifunctionalities and applications in several sectors. This review aims at providing an overview of chitosan properties, chemical functionalization, and the innovative biomaterials obtained thereof. Firstly, the chemical functionalization of chitosan backbone in the amino and hydroxyl groups will be addressed. Then, the review will focus on the bottom-up strategies to process a wide array of chitosan-based biomaterials. In particular, the preparation of chitosan-based hydrogels, organic–inorganic hybrids, layer-by-layer assemblies, (bio)inks and their use in the biomedical field will be covered aiming to elucidate and inspire the community to keep on exploring the unique features and properties imparted by chitosan to develop advanced biomedical devices. Given the wide body of literature that has appeared in past years, this review is far from being exhaustive. Selected works in the last 10 years will be considered.
وصف الملف: ELETTRONICO
العلاقة: info:eu-repo/semantics/altIdentifier/pmid/36976196; info:eu-repo/semantics/altIdentifier/wos/WOS:000960273800001; volume:21; issue:3; journal:MARINE DRUGS; https://hdl.handle.net/10281/411799Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85151471255
-
7كتاب
المؤلفون: Custódio, C. A., Santos, S. C., Monteiro, C. F., Deus, I. A., Gomes, M. C., Mano, J. F.
الوصف: Proteins have long been used in coatings for cell culture plates and to supplement cell culture media. Due to their unmatched biocompatibility, biodegradability, bioactivity and immune-privilege, the interest in proteins rapidly advanced for the design and engineering of more complex substrates for biomedical applications. In this chapter, the proteins typically used in the design and fabrication of biomedical devices are presented and discussed, with particular focus in human-based platforms. However, restrictions in the use of protein-derived materials are associated with their limited processability and stability, but to overcome this, multiple bioconjugation techniques have been described and are herein presented. An overview of current protein-based materials that have found clinical application and that have been commercialized is also provided. ; published
العلاقة: ERC-2014-ADG-669858; POCI-01-0145-FEDER-030869; info:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F50011%2F2020/PT; info:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDP%2F50011%2F2020/PT; info:eu-repo/grantAgreement/FCT/POR_CENTRO/SFRH%2FBD%2F144520%2F2019/PT; info:eu-repo/grantAgreement/FCT/POR_CENTRO/SFRH%2FBD%2F144640%2F2019/PT; http://hdl.handle.net/10773/35372Test
-
8
المؤلفون: Custódio, C. A., Santos, S. C., Monteiro, C. F., Deus, I. A., Gomes, M. C., Mano, J. F.
الوصف: Proteins have long been used in coatings for cell culture plates and to supplement cell culture media. Due to their unmatched biocompatibility, biodegradability, bioactivity and immune-privilege, the interest in proteins rapidly advanced for the design and engineering of more complex substrates for biomedical applications. In this chapter, the proteins typically used in the design and fabrication of biomedical devices are presented and discussed, with particular focus in human-based platforms. However, restrictions in the use of protein-derived materials are associated with their limited processability and stability, but to overcome this, multiple bioconjugation techniques have been described and are herein presented. An overview of current protein-based materials that have found clinical application and that have been commercialized is also provided.
وصف الملف: application/pdf
العلاقة: 978-1-78801-757-2
-
9
المؤلفون: Ferreira, L. P., Monteiro, M. V., Gaspar, V. M., Mano, J. F.
الوصف: The extracellular matrix (ECM) operates as a complex network of cell-supporting macromolecules in tissue homeostasis and disease scenarios. Given ECM structural and bio-signaling roles, understanding and modeling matrix components and their dysfunction in disease is crucial for the development of novel therapeutic approaches for numerous pathologies including pulmonary, renal and intestinal fibrosis, osteoarthritis or cancer. The discovery and preclinical in vitro screening of candidate therapeutics for tackling such conditions remains challenging owing to the lack of in vitro models capable of recapitulating ECM biochemical/biophysical cues and its complex tri-dimensional bioarchitecture in a laboratory setting. Advances in the decellularization, processing and modification of naturally available ECM into cell-free extracellular matrices (dECM) obtained from human or animal tissues, and its processing into designer hydrogels with tunable mechanical/structural features, open opportunities for bioengineering a new generation of more organotypic 3D testing platforms. Herein, we provide an overview of state-of-the-art methodologies employed for the development of dECM-hydrogels showcasing their key applications for generating tumor and fibrotic disease models. Standard and advanced processing technologies for dECM hydrogels such as 3D bioprinting and organ-on-a-chip platforms are also presented and discussed in light of future opportunities and improvements. By taking advantage of the capacity of dECM-hydrogels to closely recapitulate key matrix components, it is foreseeable that in vitro generating organotypic 3D microtissues will better capture key aspects of human diseases and contribute with predictive data on candidate therapeutics bioperformance prior to clinical trials.
وصف الملف: application/pdf
العلاقة: 978-1-78801-757-2
-
10
المؤلفون: Rodrigues, João M. M., Castanheira, E. J., Costa, D. C. S., Rocha, D. H. A., Borges, J., Mano, J. F.
الوصف: Natural polysaccharides are a major class of biomacromolecules with a high degree of biocompatibility, biodegradability, and ability to mimic the natural extracellular matrix (ECM) microenvironment and, therefore, have been receiving increasing attention. Polysaccharides often exhibit interesting and advantageous properties, including bioactivity, different functional groups, and bioadhesive properties, as well as easiness in being tailored to different applications by chemical modification. Their bioactivity depends on the chemical structure, monosaccharide composition, and spatial conformation. The chemical modification of polysaccharides and the introduction of specific functional groups significantly increase their structural diversity, by promoting or adding new (bio)functionalities. Polysaccharide-based biomaterials are an emerging class in multiple biomedical applications, including in tissue engineering and regenerative medicine (TERM) and drug delivery. Most of the polysaccharides used in biomedical applications derive from natural sources, mainly from marine environments, particularly, alginate and chitin (CH). This chapter focuses on the recent progress in the field of chemical modification of marine-origin polysaccharides, including i) chitosan (CHT), ii) hyaluronic acid (HA), iii) alginate (ALG), iv) glycosaminoglycans (GAGs) and sulfated glycans, v) laminarin (LAM), and vi) agarose, for the development of biomaterials for biomedical applications.
وصف الملف: application/pdf
العلاقة: 978-1-78801-757-2
