يعرض 1 - 10 نتائج من 261 نتيجة بحث عن '"Mancini, Irene"', وقت الاستعلام: 0.92s تنقيح النتائج
  1. 1
    دورية أكاديمية
  2. 2
    دورية أكاديمية

    المؤلفون: Mancini, Irene, Marsico, Giuseppina

    المصدر: Memorandum: Memory and History in Psychology ; Vol. 39 (2022) ; Memorandum: Memória e História em Psicologia; v. 39 (2022) ; 1676-1669

    مصطلحات موضوعية: Calvino, Bruner, narração, narrative, narrazioni

    الوصف: It is 1985 and Italo Calvino is committed to writing lectures to be held at Harvard University. It is a cycle of six conferences, the Charles Eliot Norton Poetry Lectures, in which the Italian author would have had to deal with topics related to poetic communication. It is 2001 and Jerome Bruner is invited to hold the first "Italian" lessons of the new millennium at the University of Bologna. Bruner chooses to discuss literature, law and life. The lessons of the first summarize the fundamental nuclei of Calvino's thought; the second orient Bruner's psychological and educational research. In this article, a comparative reading of two texts has been attempted: Italo Calvino's Lezioni Americane (1993) and Bruner's La Fabbrica delle Storie (2002), tracing surprising complementary images that offer valuable insights to understand the importance of narrative in the construction of individual and collective identity. ; È il 1985 ed Italo Calvino si impegna a redigere lezioni da tenere presso l’Università di Harvard. Si tratta di un ciclo di sei conferenze, le Charles Eliot Norton Poetry Lectures, nelle quali l’autore italiano avrebbe dovuto affrontare argomenti legati alla comunicazione poetica. È il 2001 e Jerome Bruner viene invitato a tenere presso l’università di Bologna le prime lezioni “italiane” del nuovo millennio. Bruner sceglie di discutere di letteratura, diritto e vita. Le lezioni del primo sintetizzano nuclei fondamentali del pensiero di Calvino, le seconde orientano le ricerche in campo psicologico ed educativo di Bruner. In questo articolo si è tentata una lettura comparata di due testi: Lezioni Americane di Italo Calvino (1993) e La Fabbrica delle Storie (2002) di Bruner rintracciando sorprendenti immagini complementari che offrono spunti preziosi per comprendere l’importanza della narrazione nella costruzione dell’identità individuale e collettiva. ; È il 1985 ed Italo Calvino si impegna a redigere lezioni da tenere presso l’Università di Harvard. Si tratta di un ciclo di sei conferenze, le Charles ...

    وصف الملف: application/pdf

  3. 3
    دورية أكاديمية

    المساهمون: Ministero della Salute, Horizon 2020, Horizon 2020 Framework Programme, Regione Toscana, Forskningsrådet för Arbetsliv och Socialvetenskap

    المصدر: New Biotechnology ; volume 55, page 19-29 ; ISSN 1871-6784

  4. 4
    دورية أكاديمية

    مصطلحات موضوعية: Cancer Research, Oncology

    الوصف: Fiveâ€year overall survival of stage III colorectal cancer (CRC) patients treated with standard adjuvant chemotherapy (ACHT) is highly variable. Genomic biomarkers and/or transcriptomic profiles identified lack of adequate validation. Aim of our study was to identify and validate molecular biomarkers predictive of ACHT response in stage III CRC patients by a transcriptomic approach. From a series of CRC patients who received ACHT, two stage III extreme cohorts (unfavorable vs. favorable prognosis) were selected. RNAâ€sequencing was performed from fresh frozen explants. Tumors were characterized for somatic mutations. Validation was performed in stage III CRC patients extracted from two GEO datasets. According to diseaseâ€free survival (DFS), 108 differentially expressed genes (104/4 up/downregulated in the unfavorable prognosis group) were identified. Among 104 upregulated genes, 42 belonged to olfactory signaling pathways, 62 were classified as pseudogenes (n = 17), uncharacterized noncoding RNA (n = 10), immune response genes (n = 4), microRNA (n = 1), cancerâ€related genes (n = 14) and cancerâ€unrelated genes (n = 16). Three out of four downâ€regulated genes were cancerâ€related. Mutational status (i.e., RAS, BRAF, PIK3CA) did not differ among the cohorts. In the validation cohort, multivariate analysis showed high PNN and KCNQ1OT1 expression predictive of shorter DFS in ACHT treated patients (p = 0.018 and p = 0.014, respectively); no difference was observed in untreated patients. This is the first study that identifies by a transcriptomic approach and validates PNN and KCNQ1OT1 as molecular biomarkers predictive of chemotherapy response in stage III CRC patients. After a further validation in an independent cohort, PNN and KCNQ1OT1 evaluation could be proposed to prospectively identify stage III CRC patients benefiting from ACHT.

  5. 5
    دورية أكاديمية

    المؤلفون: Rossi, Alessandro, Galderisi, Silvana, Rocca, Paola, Bertolino, Alessandro, Rucci, Paola, Gibertoni, Dino, Stratta, Paolo, Bucci, Paola, Mucci, Armida, Aguglia, Eugenio, Amodeo, Giovanni, Amore, Mario, Bellomo, Antonello, Brugnoli, Roberto, Caforio, Grazia, Carpiniello, Bernardo, Dell'Osso, Liliana, di Fabio, Fabio, di Giannantonio, Massimo, Marchesi, Carlo, Monteleone, Palmiero, Montemagni, Cristiana, Oldani, Lucio, Roncone, Rita, Sacchetti, Emilio, Santonastaso, Paolo, Siracusano, Alberto, Zeppegno, Patrizia, Maj, Mario, Andriola, Ileana, Paladini, Vittoria, Mancini, Marina, Ferrari, Barbara, Vita, Antonio, Barlati, Stefano, Galluzzo, Alessandro, Pinna, Federica, Primavera, Diego, Sanna, Lucia, Signorelli, Maria Salvina, Cannavò, Dario, Minutolo, Giuseppe, Martinotti, Giovanni, Lupi, Matteo, Corbo, Mariangela, Ricca, Valdo, Burchi, Elisabetta, Altamura, Mario, Carnevale, Raffaella, Petito, Annamaria, Murri, Martino Belvederi, Calcagno, Pietro, Corso, Alessandro, Rossetti, Maria Cristina, Rossi, Rodolfo, Santarelli, Valeria, Giusti, Laura, Malavolta, Maurizio, Ussorio, Donatella, Serati, Marta, De Simone, Stefania, Vignapiano, Annarita, Montefusco, Valentina, Plescia, Giuseppe Maria, Palumbo, Davide, Iasevoli, Felice, Gramaglia, Carla, Feggi, Alessandro, Gattoni, Eleonora, Campagnola, Nadia, Collantoni, Enrico, Tenconi, Elena, De Panfilis, Chiara, Tonna, Matteo, Ossola, Paolo, Gesi, Camilla, Rutigliano, Grazia, Landi, Paola, Biondi, Massimo, Girardi, Paolo, Buzzanca, Antonino, Comparelli, Anna, De Carolis, Antonella, Di Lorenzo, Giorgio, Niolu, Cinzia, Ribolsi, Michele, Corrivetti, Giulio, Bartoli, Luca, Diasco, Ferdinando, Fagiolini, Andrea, Goracci, Arianna, Bolognesi, Simone, Bava, Irene, Mancini, Irene, Cardillo, Simona

    المساهمون: Rossi, Alessandro, Galderisi, Silvana, Rocca, Paola, Bertolino, Alessandro, Rucci, Paola, Gibertoni, Dino, Stratta, Paolo, Bucci, Paola, Mucci, Armida, Aguglia, Eugenio, Amodeo, Giovanni, Amore, Mario, Bellomo, Antonello, Brugnoli, Roberto, Caforio, Grazia, Carpiniello, Bernardo, Dell'Osso, Liliana, di Fabio, Fabio, di Giannantonio, Massimo, Marchesi, Carlo, Monteleone, Palmiero, Montemagni, Cristiana, Oldani, Lucio, Roncone, Rita, Sacchetti, Emilio, Santonastaso, Paolo, Siracusano, Alberto, Zeppegno, Patrizia, Maj, Mario, Andriola, Ileana, Paladini, Vittoria, Mancini, Marina, Ferrari, Barbara, Vita, Antonio, Barlati, Stefano, Galluzzo, Alessandro, Pinna, Federica, Primavera, Diego, Sanna, Lucia, Signorelli, Maria Salvina, Cannavã², Dario, Minutolo, Giuseppe, Martinotti, Giovanni, Lupi, Matteo, Corbo, Mariangela, Ricca, Valdo, Burchi, Elisabetta, Altamura, Mario, Carnevale, Raffaella, Petito, Annamaria, Murri, Martino Belvederi, Calcagno, Pietro, Corso, Alessandro, Rossetti, Maria Cristina, Rossi, Rodolfo, Santarelli, Valeria, Giusti, Laura, Malavolta, Maurizio, Ussorio, Donatella, Serati, Marta, De Simone, Stefania, Vignapiano, Annarita, Montefusco, Valentina, Plescia, Giuseppe Maria, Palumbo, Davide, Iasevoli, Felice, Gramaglia, Carla, Feggi, Alessandro, Gattoni, Eleonora, Campagnola, Nadia, Collantoni, Enrico, Tenconi, Elena, De Panfilis, Chiara, Tonna, Matteo, Ossola, Paolo, Gesi, Camilla, Rutigliano, Grazia, Landi, Paola, Biondi, Massimo, Girardi, Paolo, Buzzanca, Antonino, Comparelli, Anna, De Carolis, Antonella, Di Lorenzo, Giorgio, Niolu, Cinzia, Ribolsi, Michele, Corrivetti, Giulio, Bartoli, Luca, Diasco, Ferdinando, Fagiolini, Andrea, Goracci, Arianna, Bolognesi, Simone, Bava, Irene, Mancini, Irene, Cardillo, Simona

    مصطلحات موضوعية: Psychiatry and Mental Health, Biological Psychiatry

    العلاقة: info:eu-repo/semantics/altIdentifier/pmid/28686933; info:eu-repo/semantics/altIdentifier/wos/WOS:000412787700056; volume:256; firstpage:359; lastpage:364; numberofpages:6; journal:PSYCHIATRY RESEARCH; http://hdl.handle.net/2318/1656146Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85021687346; www.elsevier.com/locate/psychres

  6. 6
    دورية أكاديمية

    المساهمون: Righi, Alberto, Mancini, Irene, Gambarotti, Marco, Picci, Piero, Gamberi, Gabriella, Marraccini, Cristina, Dei Tos, Angelo Paolo, Simi, Lisa, Pinzani, Pamela, Franchi, Alessandro

    الوقت: 2734

    الوصف: Mutually exclusive histone 3.3 gene mutations have been recognized in chondroblastoma and giant cell tumor of bone (GCTB), which may be useful for differential diagnostic purposes in morphologically ambiguous cases. Although more than 90% of GCTBs present histone 3.3 variants exclusively in the H3F3A gene, chondroblastoma is mutated mainly in H3F3B. In this study, we examined a series of giant cellâ rich primary bone tumors, aiming to evaluate the possible diagnostic role of histone 3.3 mutations in the differential diagnosis between GCTB and giant cellâ rich sarcomas. Sixteen cases of nonmetastatic GCTB, 9 GCTBs with lung metastases, and 35 giant cellâ rich sarcomas were selected from our institutional archives. Eight chondroblastomas were used as controls. Direct sequencing for the presence of H3F3A and H3F3B variants in coding region between codons 1 and 42, including the hotspot codons (28, 35, and 37), was performed on DNA extracted from formalin-fixed, paraffin-embedded tissue using conventional polymerase chain reaction and fast coamplification at lower denaturation temperatureâ polymerase chain reaction. Overall, 24 GCTBs (96%) presented a mutation in the H3F3A gene (15 of 16 nonmetastatic and 9 of 9 metastatic). Five sarcomas harbored an H3F3A mutation (3 p.G35W, 1 p.G35L, and 1 p.G35E), and these were all secondary malignant GCTBs. In conclusion, we confirm that H3F3A mutational testing may be a useful adjunct to differentiate GCTB from giant cellâ rich sarcomas. Although the presence of H3F3A mutations does not exclude with certainty a diagnosis of sarcoma, the possibility of a malignant evolution of GCTB should also be considered.

    وصف الملف: STAMPA

    العلاقة: info:eu-repo/semantics/altIdentifier/pmid/28899740; info:eu-repo/semantics/altIdentifier/wos/WOS:000416883100018; volume:68; firstpage:128; lastpage:135; numberofpages:8; journal:HUMAN PATHOLOGY; https://hdl.handle.net/11568/884918Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85031121870; http://www.elsevier.com/inca/publications/store/6/2/3/1/3/9/index.httTest

  7. 7
    دورية أكاديمية

    المساهمون: Gaeta, Raffaele, Righi, Alberto, Gambarotti, Marco, Aretini, Paolo, Lessi, Francesca, Mazzanti, Chiara Maria, Mancini, Irene, Pinzani, Pamela, Belgio, Beatrice, Sbaraglia, Marta, Tos, Angelo Paolo Dei, Franchi, Alessandro

    الوصف: Objective Chondroblastoma-like osteosarcoma (CBLOS) is a rare and poorly understood variant of OS. We examined the clinicopathological, immunohistochemical and molecular features of six CBLOSs to highlight the differences with conventional high-grade OS (CHGOS) and CB, including CB with aggressive features. Methods We performed histone 3.3 mutation analysis by gene sequencing and/or immunohistochemistry in all cases, while whole exome sequencing (WES) was performed on two CB-like osteosarcomas and 11 conventional high-grade OS. Results CBLOSs were predominantly localised at acral sites and involved mainly male subjects with a mean age of 29 years. One patient who had metastases at presentation died of disease, while another patient who developed multiple local recurrences and lung metastases was alive with no evidence of disease (ANED) at 294 months. The remaining patients were ANED after a mean interval of 70.8 months. Histologically, all CBLOS presented aggressive features, including nuclear atypia and infiltrative growth. Immunohistochemistry with H3F3 K36M mutant antibody was negative in all CBLOSs, and none of the five tumours tested by gene sequencing had H3F3B mutations. Conversely, all CBs presented the H3F3B K36M variant and were positive for immunostaining with the H3F3 K36M antibody. Two CBLOSs analysed by WES differed in amount and type of mutation from 11 cases of CHGOS. Moreover, CBLOSs showed lower copy number alteration (CNA) score values than CHGOSs. Conclusions CBLOS presents a different genetic background and a less aggressive clinical behaviour in comparison with CHGOS. Search of the H3F3B K36M mutation is useful in the differential diagnosis with CB.

    العلاقة: info:eu-repo/semantics/altIdentifier/pmid/35791778; info:eu-repo/semantics/altIdentifier/wos/WOS:000827016200001; volume:81; issue:3; firstpage:389; lastpage:401; numberofpages:13; journal:HISTOPATHOLOGY; https://hdl.handle.net/11568/1151062Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85134151201

  8. 8
    دورية أكاديمية

    المصدر: Prodan Žitnik , I , Černe , D , Mancini , I , Simi , L , Pazzagli , M , Di Resta , C , Podgornik , H , Repič Lampret , B , Trebušak Podkrajšek , K , Sipeky , C , Van Schaik , R , Brandslund , I , Vermeersch , P , Schwab , M & Marc , J 2018 , ' Personalized laboratory medicine : A patient-centered future approach ' , Clinical Chemistry and Laboratory Medicine , vol. 56 , no. 12 , pp. 1981–1991 . https://doi.org/10.1515/cclm-2018-0181Test

    الوصف: In contrast to population-based medical decision making, which emphasizes the use of evidence-based treatment strategies for groups of patients, personalized medicine is based on optimizing treatment at the level of the individual patient. The creation of molecular profiles of individual patients was made possible by the advent of "omics" technologies, based on high throughput instrumental techniques in combination with biostatistics tools and artificial intelligence. The goal of personalized laboratory medicine is to use advanced technologies in the process of preventive, curative or palliative patient management. Personalized medicine does not rely on changes in concentration of a single molecular marker to make a therapeutic decision, but rather on changes of a profile of markers characterizing an individual patient's status, taking into account not only the expected response to treatment of the disease but also the expected response of the patient. Such medical approach promises a more effective diagnostics with more effective and safer treatment, as well as faster recovery and restoration of health and improved cost effectiveness. The laboratory medicine profession is aware of its key role in personalized medicine, but to empower the laboratories, at least an enhancement in cooperation between disciplines within laboratory medicine will be necessary.

    وصف الملف: application/pdf

  9. 9
    دورية أكاديمية
  10. 10

    المؤلفون: Mancini, Irene, Marsico, Giuseppina

    المصدر: Memorandum: Memory and History in Psychology ; Vol. 39 (2022)
    Memorandum: Memória e História em Psicologia; v. 39 (2022)
    Memorandum (Belo Horizonte)
    Universidade Federal de Minas Gerais (UFMG)
    instacron:UFMG

    مصطلحات موضوعية: narrative, narração, narrazioni, Calvino, Bruner

    الوصف: It is 1985 and Italo Calvino is committed to writing lectures to be held at Harvard University. It is a cycle of six conferences, the Charles Eliot Norton Poetry Lectures, in which the Italian author would have had to deal with topics related to poetic communication. It is 2001 and Jerome Bruner is invited to hold the first "Italian" lessons of the new millennium at the University of Bologna. Bruner chooses to discuss literature, law and life. The lessons of the first summarize the fundamental nuclei of Calvino's thought; the second orient Bruner's psychological and educational research. In this article, a comparative reading of two texts has been attempted: Italo Calvino's Lezioni Americane (1993) and Bruner's La Fabbrica delle Storie (2002), tracing surprising complementary images that offer valuable insights to understand the importance of narrative in the construction of individual and collective identity. È il 1985 ed Italo Calvino si impegna a redigere lezioni da tenere presso l’Università di Harvard. Si tratta di un ciclo di sei conferenze, le Charles Eliot Norton Poetry Lectures, nelle quali l’autore italiano avrebbe dovuto affrontare argomenti legati alla comunicazione poetica. È il 2001 e Jerome Bruner viene invitato a tenere presso l’università di Bologna le prime lezioni “italiane” del nuovo millennio. Bruner sceglie di discutere di letteratura, diritto e vita. Le lezioni del primo sintetizzano nuclei fondamentali del pensiero di Calvino, le seconde orientano le ricerche in campo psicologico ed educativo di Bruner. In questo articolo si è tentata una lettura comparata di due testi: Lezioni Americane di Italo Calvino (1993) e La Fabbrica delle Storie (2002) di Bruner rintracciando sorprendenti immagini complementari che offrono spunti preziosi per comprendere l’importanza della narrazione nella costruzione dell’identità individuale e collettiva. È il 1985 ed Italo Calvino si impegna a redigere lezioni da tenere presso l’Università di Harvard. Si tratta di un ciclo di sei conferenze, le Charles Eliot Norton Poetry Lectures, nelle quali l’autore italiano avrebbe dovuto affrontare argomenti legati alla comunicazione poetica. È il 2001 e Jerome Bruner viene invitato a tenere presso l’università di Bologna le prime lezioni “italiane” del nuovo millennio. Bruner sceglie di discutere di letteratura, diritto e vita. Le lezioni del primo sintetizzano nuclei fondamentali del pensiero di Calvino, le seconde orientano le ricerche in campo psicologico ed educativo di Bruner. In questo articolo si è tentata una lettura comparata di due testi: Lezioni Americane di Italo Calvino (1993) e La Fabbrica delle Storie (2002) di Bruner rintracciando sorprendenti immagini complementari che offrono spunti preziosi per comprendere l’importanza della narrazione nella costruzione dell’identità individuale e collettiva.

    وصف الملف: application/pdf