يعرض 1 - 10 نتائج من 37 نتيجة بحث عن '"Malhotra, Nikita"', وقت الاستعلام: 1.39s تنقيح النتائج
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    دورية أكاديمية
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    دورية أكاديمية
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    دورية أكاديمية
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    دورية أكاديمية

    المساهمون: Indian Institute of Technology Delhi, Ministry of Human Resource Development

    المصدر: ACS Applied Energy Materials ; volume 6, issue 13, page 6926-6933 ; ISSN 2574-0962 2574-0962

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    دورية أكاديمية
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    دورية أكاديمية
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    دورية أكاديمية

    المصدر: European Heart Journal: Acute Cardiovascular Care ; volume 8, issue 6, page 543-553 ; ISSN 2048-8726 2048-8734

    الوصف: Background: Clinical outcomes in acute coronary syndrome patients treated with P2Y 12 inhibitors who require urgent coronary artery bypass grafting (CABG) have not been well studied. Methods: We examined clinical outcomes in acute coronary syndrome patients in relation to the timing of CABG following P2Y 12 inhibitor discontinuation (<72 h, 72 h to five days, >5 days). The primary ischemic outcome was a composite of death, reinfarction, need for revascularization, or stroke. The primary safety outcome was bleeding of at least moderate severity as defined by a Universal Definition of Perioperative Bleeding class ≥2. Results: Among 508 patients (95 ticagrelor, 413 clopidogrel), the timing of CABG following P2Y 12 inhibitor discontinuation was <72 h in 32.1%, 72 h to five days in 23.2% and >5 days in 44.7%. Compared with CABG within 72 h, CABG 72 h to five days (adjusted odds ratio (OR) 0.35; 95% confidence interval (CI) 0.14–0.85; p=0.02) but not >5 days (adjusted OR 0.62; 95% CI 0.33–1.16; p=0.14) after P2Y 12 inhibitor discontinuation was associated with lower odds of the primary ischemic outcome. Compared with CABG within 72 h, CABG 72 h to five days (adjusted OR 0.38; 95% CI 0.22–0.66; p=0.001) and >5 days (adjusted OR 0.33; 95% CI 0.20–0.53; p<0.001) after P2Y 12 inhibitor discontinuation were associated with lower rates of Universal Definition of Perioperative Bleeding class ≥2 bleeding. Conclusions: CABG within 72 h after P2Y 12 inhibitor discontinuation is associated with excess ischemia and bleeding. The rates of ischemic and bleeding events were comparable in patients undergoing CABG 72 h to five days compared with >5 days after P2Y 12 inhibitor discontinuation.

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    دورية أكاديمية
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