المؤلفون: Chiesa, Scott, Benitez-Aguirre, Paul, Cameron, Fergus J, Craig, Maria, Couper, Jennifer J, Davis, Elizabeth A, Dalton, R Neil, Daneman, Denis, Donaghue, Kim C, Jones, Timothy J, Mahmud, Farid H, Marshall, Sally M, Neil, H Andrew, Deanfield, John E, Marcovecchio, M Loredana

المصدر: Presented at: ISPAD 23, Rotterdam, Netherlands. (2023)

مصطلحات موضوعية: type 1 diabetes, vascular ageing, adolescents

الوصف: Introduction: Childhood-onset type 1 diabetes (T1D) is associated with an increased risk of premature cardiovascular mortality. / Objectives: This study aimed to assess the evolution of subclinical vascular damage in young people with T1D as they transitioned through adolescence. / Methods: Repeated vascular phenotyping was performed in early adolescence (age 13), late adolescence (age 17), and young adulthood (age 23) in 288 adolescents with T1D (52% male) recruited to the Adolescent Type 1 Diabetes Intervention Trial Follow-Up Study (AdDIT Follow-Up). Carotid remodelling was assessed via measures of lumen diameter, intima-media thickness (IMT), and beta stiffness index; aortic stiffness via carotid-femoral pulse wave velocity (PWV); and endothelial function via flow-mediated dilation (FMD). Repeated measures ANOVA were used to assess vascular changes over time, and unpaired t-tests used to compare vascular phenotypes measured in young adulthood to an age- and sex-matched group without T1D (n = 292; 49% male). / Results: In individuals with T1D, progressive stiffening of both the carotid artery and aorta was observed across the 9-year follow-up (e.g. PWV mean [95%CI] change = 1.1 [0.9, 1.3] m/s). In the transition from late adolescence to young adulthood, IMT also increased (+0.04 [0.03, 0.06] mm) and FMD decreased (-1.0 [-0.8, -1.2] %). As a result, young adults with T1D had carotid arteries that were narrower, thicker (IMT = +0.3 [0.2, 0.4] mm), and stiffer (beta stiffness index = +0.3 [0.1, 0.5]) than those without T1D. Aortic stiffness was also higher (PWV = +0.8 [0.6, 0.9] m/s) in T1D, while a compromised FMD (-2.8 [-2.0, -3.6]%) indicated the presence of systemic endothelial dysfunction. / Conclusions: Young people with T1D demonstrate accelerated arterial ageing as they transition adolescence. As a result, these individuals enter young adulthood with arteries that are already smaller, thicker, stiffer, and with evidence of profound endothelial dysfunction when compared to young adults without T1D.

وصف الملف: slideshow

العلاقة: https://discovery.ucl.ac.uk/id/eprint/10182152/1/Scott%20Chiesa.pptxTest; https://discovery.ucl.ac.uk/id/eprint/10182152Test/

الإتاحة: https://discovery.ucl.ac.uk/id/eprint/10182152/1/Scott%20Chiesa.pptxTest
https://discovery.ucl.ac.uk/id/eprint/10182152Test/

المؤلفون: Mahmud, Farid H, Clarke, Antoine BM, Elia, Yesmino, Curtis, Jacqueline, Benitez-Aguirre, Paul, Cameron, Fergus J, Chiesa, Scott, Clarson, Cheril, Couper, Jennifer J, Craig, Maria E, Dalton, R Neil, Daneman, Denis, Davis, Elizabeth A, Deanfield, John E, Donaghue, Kim C, Jones, Timothy W, Marshall, Sally M, Neil, H Andrew W, Marcovecchio, M Loredana

المصدر: BMC Medicine , 21 , Article 506. (2023)

الوصف: Background: Given limited data regarding the involvement of disadvantaged groups in paediatric diabetes clinical trials, this study aimed to evaluate the socioeconomic representativeness of participants recruited into a multinational clinical trial in relation to regional and national type 1 diabetes reference populations. Methods: Retrospective, cross-sectional evaluation of a subset of adolescent type 1 diabetes cardiorenal intervention trial (AdDIT) participants from Australia (n = 144), Canada (n = 312) and the UK (n = 173). Validated national measures of deprivation were used: the Index of Relative Socioeconomic Disadvantage (IRSD) 2016 (Australia), the Material Resources (MR) dimension of the Canadian Marginalisation index 2016 (Canada) and the Index of Multiple Deprivation (IMD) 2015 (UK). Representativeness was assessed by comparing the AdDIT cohort’s distribution of deprivation quintiles with that of the local paediatric type 1 diabetes population (regional), and the broader type 1 diabetes population for which the trial’s intervention was targeted (national). Results: Recruited study cohorts from each country had higher proportions of participants with higher SES, and significant underrepresentation of lower SES, in relation to their national references. The socioeconomic make-up in Australia mirrored that of the regional population (p = 0.99). For Canada, the 2nd least deprived (p = 0.001) and the most deprived quintiles (p < 0.001) were over- and under-represented relative to the regional reference, while the UK featured higher regional and national SES bias with over-representation and under-representation from the least-deprived and most-deprived quintiles (p < 0.0001). Conclusions: Significant national differences in trial participation of low SES participants were observed, highlighting limitations in access to clinical research and the importance of reporting sociodemographic representation in diabetes clinical trials. Trial registration: NCT01581476. Registered on 20 April 2012.

وصف الملف: text

العلاقة: https://discovery.ucl.ac.uk/id/eprint/10183414/1/s12916-023-03222-w.pdfTest; https://discovery.ucl.ac.uk/id/eprint/10183414Test/

الإتاحة: https://discovery.ucl.ac.uk/id/eprint/10183414/1/s12916-023-03222-w.pdfTest
https://discovery.ucl.ac.uk/id/eprint/10183414Test/

المؤلفون: de Bock, Martin, Codner, Ethel, Craig, Maria E., Huynh, Tony, Maahs, David M., Mahmud, Farid H., Marcovecchio, Loredana, DiMeglio, Linda A.

المساهمون: Pediatrics, School of Medicine

المصدر: PMC

مصطلحات موضوعية: Adolescents, Children, Glucose monitoring, Glycemic targets, Type 1 diabetes

وصف الملف: application/pdf

العلاقة: Pediatric Diabetes; de Bock M, Codner E, Craig ME, et al. ISPAD Clinical Practice Consensus Guidelines 2022: Glycemic targets and glucose monitoring for children, adolescents, and young people with diabetes. Pediatr Diabetes. 2022;23(8):1270-1276. doi:10.1111/pedi.13455; https://hdl.handle.net/1805/37467Test

الإتاحة: https://doi.org/10.1111/pedi.13455Test
https://hdl.handle.net/1805/37467Test

المؤلفون: Mahmud, Farid H., Clarke, Antoine B. M., Elia, Yesmino, Curtis, Jacqueline, Benitez-Aguirre, Paul, Cameron, Fergus J., Chiesa, Scott T., Clarson, Cheril, Couper, Jennifer J., Craig, Maria E., Dalton, R. Neil, Daneman, Denis, Davis, Elizabeth A., Deanfield, John E., Donaghue, Kim C., Jones, Timothy W., Marshall, Sally M., Neil, Andrew, Marcovecchio, M. Loredana

المساهمون: Can-SOLVE CKD, Canadian Institute of Health Research – Strategies for Patient Oriented Research, Juvenile Diabetes Research Foundation Canada

المصدر: BMC Medicine ; volume 21, issue 1 ; ISSN 1741-7015

مصطلحات موضوعية: General Medicine

الوصف: Background Given limited data regarding the involvement of disadvantaged groups in paediatric diabetes clinical trials, this study aimed to evaluate the socioeconomic representativeness of participants recruited into a multinational clinical trial in relation to regional and national type 1 diabetes reference populations. Methods Retrospective, cross-sectional evaluation of a subset of adolescent type 1 diabetes cardiorenal intervention trial (AdDIT) participants from Australia ( n = 144), Canada ( n = 312) and the UK ( n = 173). Validated national measures of deprivation were used: the Index of Relative Socioeconomic Disadvantage (IRSD) 2016 (Australia), the Material Resources (MR) dimension of the Canadian Marginalisation index 2016 (Canada) and the Index of Multiple Deprivation (IMD) 2015 (UK). Representativeness was assessed by comparing the AdDIT cohort’s distribution of deprivation quintiles with that of the local paediatric type 1 diabetes population (regional), and the broader type 1 diabetes population for which the trial’s intervention was targeted (national). Results Recruited study cohorts from each country had higher proportions of participants with higher SES, and significant underrepresentation of lower SES, in relation to their national references. The socioeconomic make-up in Australia mirrored that of the regional population ( p = 0.99). For Canada, the 2nd least deprived ( p = 0.001) and the most deprived quintiles ( p < 0.001) were over- and under-represented relative to the regional reference, while the UK featured higher regional and national SES bias with over-representation and under-representation from the least-deprived and most-deprived quintiles ( p < 0.0001). Conclusions Significant national differences in trial participation of low SES participants were observed, highlighting limitations in access to clinical research and the importance of reporting sociodemographic representation in diabetes clinical trials. Trial registration NCT01581476. Registered on 20 April 2012.

الإتاحة: https://doi.org/10.1186/s12916-023-03222-wTest

المؤلفون: Babalola, Funmbi, Hamilton, Jill, Zappitelli, Michael, Elia, Yesmino, Curtis, Jacqueline, Moineddin, Rahim, Mahmud, Farid H.

المصدر: Clinical Diabetes & Endocrinology; 5/25/2024, Vol. 10 Issue 1, p1-10, 10p

المؤلفون: De Biasio, Michael J., Furman, Michelle, Clarke, Antoine, Hui, Wei, Elia, Yesmino, Baranger, Jerome, Villemain, Olivier, Mertens, Luc, Mahmud, Farid H.

المصدر: Cardiovascular Diabetology; 5/24/2024, Vol. 23 Issue 1, p1-10, 10p

مصطلحات موضوعية: TYPE 1 diabetes, YOUNG adults, CAROTID intima-media thickness, PULSE wave analysis, ULTRASONIC imaging

مستخلص: Background: Cardiovascular disease (CVD) remains the leading cause of morbidity and mortality in patients with Type 1 Diabetes (T1D). Early markers of CVD include increased carotid intima-media thickness (CIMT) and pulse wave velocity (PWV), but these existing ultrasound technologies show limited spatial and temporal resolution in young adults. The purpose of this study is to evaluate the utility of high-resolution ultrasound modalities, including high frequency ultrasound CIMT (hfCIMT) and ultrafast ultrasound PWV (ufPWV), in young adults with Type 1 Diabetes. Methods: This is a prospective single-center observational cohort study including 39 participants with T1D and 25 age and sex matched controls. All participants underwent hfCIMT and ufPWV measurements. hfCIMT and ufPWV measures of T1D were compared with controls and associations with age, sex, BMI, A1c, blood pressure, and lipids were studied. Results: Mean age was 24.1 years old in both groups. T1D had a greater body mass index (27.7 [5.7] vs 23.1 [3.2] kg/m²), LDL Cholesterol, and estimated GFR, and had a mean A1c of 7.4 [1.0] % (57 mmol/mol) and diabetes duration of 16.1 [3.7] years with 56% using insulin pumps. In T1D, hfCIMT was significantly increased as compared to controls (0.435 ± 0.06 mm vs 0.379 ± 0.06 mm respectively, p < 0.01). ufPWV measures were significantly increased in T1D (systolic foot PWV: 5.29 ± 0.23 m/s vs 5.50 ± 0.37 m/s, p < 0.01; dicrotic notch PWV = 7.54 ± 0.46 m/s vs 7.92 ± 0.41 m/s, p < 0.01). Further, there was an impact of A1c-measured glycemia on hfCIMT, but this relationship was not seen with ufPWV. No significant statistical correlations between hfCIMT and ufPWV measures in either T1D or healthy controls were observed. Conclusion: Young adults with T1D present with differences in arterial thickness and stiffness when compared with controls. Use of novel high-resolution ultrasound measures describe important relationships between early structural and vascular pathophysiologic changes and are promising tools to evaluate pre-clinical CVD risk in youth with T1D. Trial Registration: ISRCTN91419926. [ABSTRACT FROM AUTHOR]

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المؤلفون: Verbeeten, Kate C., Tang, Ken, Courtney, Jennilea M., Bradley, Brenda J., McAssey, Karen, Clarson, Cheril, Kirsch, Susan, Curtis, Jacqueline R., Mahmud, Farid H., Richardson, Christine, Cooper, Tammy, Lawson, Margaret L.

المصدر: Canadian Journal of Diabetes ; ISSN 1499-2671

مصطلحات موضوعية: Endocrinology, General Medicine, Endocrinology, Diabetes and Metabolism, Internal Medicine

الإتاحة: https://doi.org/10.1016/j.jcjd.2024.04.007Test
https://api.elsevier.com/content/article/PII:S149926712400073X?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S149926712400073X?httpAccept=text/plainTest

المؤلفون: Deveci, Arin C., Gurnani, Muskaan, Wolfe-Wylie, Margaret C., Regina, Andrea, Cordeiro, Kristina, Dave, Malini G., Mahmud, Farid H., Hamilton, Jill

المصدر: Canadian Journal of Diabetes ; volume 48, issue 2, page 112-119.e3 ; ISSN 1499-2671

مصطلحات موضوعية: Endocrinology, General Medicine, Endocrinology, Diabetes and Metabolism, Internal Medicine

الإتاحة: https://doi.org/10.1016/j.jcjd.2023.11.004Test
https://api.elsevier.com/content/article/PII:S1499267123007190?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S1499267123007190?httpAccept=text/plainTest

المؤلفون: Marcovecchio, Maria Loredana, Colombo, Marco, Dalton, Raymond Neil, McKeigue, Paul M., Benitez-Aguirre, Paul, Cameron, Fergus J., Chiesa, Scott T., Couper, Jennifer J., Craig, Maria E., Daneman, Denis, Davis, Elizabeth A., Deanfield, John E., Donaghue, Kim C., Jones, Timothy W., Mahmud, Farid H., Marshall, Sally M., Neil, Andrew, Colhoun, Helen M., Dunger, David B.

المصدر: Marcovecchio , M L , Colombo , M , Dalton , R N , McKeigue , P M , Benitez-Aguirre , P , Cameron , F J , Chiesa , S T , Couper , J J , Craig , M E , Daneman , D , Davis , E A , Deanfield , J E , Donaghue , K C , Jones , T W , Mahmud , F H , Marshall , S M , Neil , A & Colhoun , H M & Dunger , D B 2022 , ' Biomarkers associated with early stages of ....

مصطلحات موضوعية: adolescents, biomarkers, complications, GFR, kidney disease, /dk/atira/pure/subjectarea/asjc/2700/2724, name=Internal Medicine, /dk/atira/pure/subjectarea/asjc/2700/2735, name=Pediatrics, Perinatology, and Child Health, /dk/atira/pure/subjectarea/asjc/2700/2712, name=Endocrinology, Diabetes and Metabolism

الوصف: Objectives: To identify biomarkers of renal disease in adolescents with type 1 diabetes (T1D) and to compare findings in adults with T1D. Methods: Twenty-five serum biomarkers were measured, using a Luminex platform, in 553 adolescents (median [interquartile range] age: 13.9 [12.6, 15.2] years), recruited to the Adolescent Type 1 Diabetes Cardio-Renal Intervention Trial. Associations with baseline and final estimated glomerular filtration rate (eGFR), rapid decliner and rapid increaser phenotypes (eGFR slopes <−3 and > 3 mL/min/1.73m 2 /year, respectively), and albumin-creatinine ratio (ACR) were assessed. Results were also compared with those obtained in 859 adults (age: 55.5 [46.1, 64.4) years) from the Scottish Diabetes Research Network Type 1 Bioresource. Results: In the adolescent cohort, baseline eGFR was negatively associated with trefoil factor-3, cystatin C, and beta-2 microglobulin (B2M) (B coefficient[95%CI]: −0.19 [−0.27, −0.12], P = 7.0 × 10 −7 ; −0.18 [−0.26, −0.11], P = 5.1 × 10 −6 ; −0.12 [−0.20, −0.05], P = 1.6 × 10 −3 ), in addition to clinical covariates. Final eGFR was negatively associated with osteopontin (−0.21 [−0.28, −0.14], P = 2.3 × 10 −8 ) and cystatin C (−0.16 [−0.22, −0.09], P = 1.6 × 10 −6 ). Rapid decliner phenotype was associated with osteopontin (OR: 1.83 [1.42, 2.41], P = 7.3 × 10 −6 ), whereas rapid increaser phenotype was associated with fibroblast growth factor-23 (FGF-23) (1.59 [1.23, 2.04], P = 2.6 × 10 −4 ). ACR was not associated with any of the biomarkers. In the adult cohort similar associations with eGFR were found; however, several additional biomarkers were associated with eGFR and ACR. Conclusions: In this young population with T1D and high rates of hyperfiltration, osteopontin was the most consistent biomarker associated with prospective changes in eGFR. FGF-23 was associated with eGFR increases, whereas trefoil factor-3, cystatin C, and B2M were associated with baseline eGFR.

وصف الملف: application/pdf

العلاقة: https://discovery.dundee.ac.uk/en/publications/1f593d77-50e5-40fe-a1ae-e5682be26122Test

الإتاحة: https://doi.org/10.1111/pedi.13095Test
https://discovery.dundee.ac.uk/en/publications/1f593d77-50e5-40fe-a1ae-e5682be26122Test
https://discovery.dundee.ac.uk/ws/files/84133994/Pediatric_Diabetes_2020_Marcovecchio_Biomarkers_associated_with_early_stages_of_kidney_disease_in_adolescents_with.pdfTest
http://www.scopus.com/inward/record.url?scp=85089441364&partnerID=8YFLogxKTest

المؤلفون: Abraham, Mary B., Karges, Beate Maria, Dovc, Klemen, Naranjo, Diana, Arbelaez, Ana Maria, Mbogo, Joyce, Javelikar, Ganesh, Jones, Timothy W., Mahmud, Farid H.

المصدر: Pediatric diabetes 23(8), 1322-1340 (2022). doi:10.1111/pedi.13443

جغرافية الموضوع: DE

العلاقة: info:eu-repo/semantics/altIdentifier/issn/1399-543X; info:eu-repo/semantics/altIdentifier/pmid/pmid:36537534; info:eu-repo/semantics/altIdentifier/issn/1399-5448; info:eu-repo/semantics/altIdentifier/wos/WOS:000911258700012; https://publications.rwth-aachen.de/record/889489Test; https://publications.rwth-aachen.de/search?p=id:%22RWTH-CONV-250588%22Test

الإتاحة: https://doi.org/10.1111/pedi.13443Test
https://doi.org/10.18154/RWTH-CONV-250588Test
https://publications.rwth-aachen.de/record/889489Test
https://publications.rwth-aachen.de/search?p=id:%22RWTH-CONV-250588%22Test