المؤلفون: Mafra, M. R., Igarashi-Mafra, L., Zuim, D. R., Vasques, É. C., Ferreira, M. A.

المصدر: Brazilian Journal of Chemical Engineering. September 2013 30(3)

مصطلحات موضوعية: Orange peel, Adsorption, Dye, Kinetics, Thermodynamics, Wastewater

الوصف: A novel orange peel adsorbent developed from an agricultural waste material was characterised and utilised for the removal of Remazol Brilliant Blue from an artificial textile-dye effluent. The adsorption thermodynamics of this dye-adsorbent pair was studied in a series of equilibrium experiments. The time to reach equilibrium was 15 h for the concentration range of 30 mg L-1 to 250 mg L-1. The adsorption capacity decreased with increasing temperature, from 9.7 mg L-1 at 20 ºC to 5.0 mg L-1 at 60 ºC. Both the Langmuir and Freundlich isotherm models fitted the adsorption data quite reasonably. The thermodynamic analysis of dye adsorption onto the orange peel adsorbent indicated its endothermic and spontaneous nature. Thus, the application of orange peel adsorbent for the removal of dye from a synthetic textile effluent was successfully demonstrated.

وصف الملف: text/html

الوصول الحر: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0104-66322013000300022Test

المؤلفون: Leal, Ema, Caria, João, Almeida, Vasco, Cruz, Claudina, Garrote, Ana Raquel, Mafra, M., Ramirez, Freddy, Póvoas, Diana, Manata, Maria José, Maltez, Fernando

المصدر: Advances in Infectious Diseases ; volume 13, issue 03, page 521-526 ; ISSN 2164-2648 2164-2656

مصطلحات موضوعية: General Medicine

الإتاحة: https://doi.org/10.4236/aid.2023.133042Test

المؤلفون: Soares, T.S., Mafra, M., Lopes de Carvalho, I., Gouveia, C., Brito, M.J.

المساهمون: Repositório Científico do Instituto Nacional de Saúde

مصطلحات موضوعية: Kikuchi Fujimoto's Disease, Fever, Lymphadenitis, Infecções Sistémicas e Zoonoses

الوصف: Kikuchi Fujimoto’s disease (KFD) or histiocytic lymphadenitis is especially rare in paediatrics. Although it is a self-limited and benign disease, its differential diagnose is vast including lymphoma, various infections and autoimmune diseases.

وصف الملف: application/pdf

الإتاحة: http://hdl.handle.net/10400.18/6762Test

المؤلفون: Soares, T.S., Mafra, M., Lopes de Carvalho, I., Gouveia, C., Brito, M.J.

مصطلحات موضوعية: Kikuchi Fujimoto's Disease, Fever, Lymphadenitis, Infecções Sistémicas e Zoonoses

الوصف: Kikuchi Fujimoto’s disease (KFD) or histiocytic lymphadenitis is especially rare in paediatrics. Although it is a self-limited and benign disease, its differential diagnose is vast including lymphoma, various infections and autoimmune diseases. ; N/A

العلاقة: http://hdl.handle.net/10400.18/6762Test

الإتاحة: http://hdl.handle.net/10400.18/6762Test

المؤلفون: Trabulo, C.F.P., Cabral, S.C., Antão, D., Costa, J., Fernandes, M., Marques, J. Passos, Marques, J., Azevedo, A., Nunes, J., Costa, I., Marques, A.R., Serpa, A., Roque, L., Mafra, M., Pina, I.M. Matos, Salgado, D.

المصدر: Annals of Oncology ; volume 34, page S409 ; ISSN 0923-7534

مصطلحات موضوعية: Oncology, Hematology

الإتاحة: https://doi.org/10.1016/j.annonc.2023.09.2963Test
https://api.elsevier.com/content/article/PII:S0923753423038000?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S0923753423038000?httpAccept=text/plainTest

المؤلفون: Brito, C, Azevedo, A, Esteves, S, Martins, C, Mafra, M, Roque, L, Pojo, M

المصدر: Neuro-Oncology ; volume 21, issue Supplement_3, page iii27-iii28 ; ISSN 1522-8517 1523-5866

مصطلحات موضوعية: Cancer Research, Neurology (clinical), Oncology

الوصف: BACKGROUND Gliomas are the most common and lethal malignant tumors of central nervous system. In 2016, World Health Organization (WHO) classification included IDH mutations and 1p/19q codeletion as diagnostic criteria to define glioma entities. However, new biomarkers for diagnosis, prognosis and response to therapy are needed. In this context, PIK3CA mutations have been described as constitutive mutations, which highlights their relevance in gliomas. Here we clarified the clinical relevance of PIK3CA mutations according to the 2016 WHO classification, the potential impact on diagnosis, prognosis, response to therapy, as well as their correlation with EGFR amplification and PTEN deletion. MATERIAL AND METHODS A cohort of 444 adult diffuse glioma samples from Instituto Português de Oncologia Lisboa Francisco Gentil (IPOLFG) was classified according to the 2016 WHO Classification. The mutational status of exon 9 and 20 of PIK3CA was evaluated in molecular subgroups of gliomas by Sanger sequencing. PTEN deletion and EGFR amplification were identified by Fluorescent in situ hybridization (FISH). RESULTS PIK3CA mutations showed a higher frequency in the subgroup of gliomas with IDH mutations and 1p/19q codeletion - oligodendrogliomas (10%). In Glioblastoma (GBM) IDH-mutant and IDH-wildtype these oncogenic mutations were observed in 9% and 3% of cases, respectively. Similar results were obtained using The Cancer Genome Atlas (TCGA) data, which was 8% and 2%, respectively. H1047R and E542K were the most frequent mutations identified in the glioma molecular subgroups. Importantly, we found 3 unreported pathogenic variants in exon 20 of PIK3CA (c.3112T>C, c.2988T>C, c.3040C>T) and one polymorphic variant (c.3210A>G). In addition, PIK3CA mutations, PTEN deletion and EGFR amplification were not mutually exclusive alterations in glioma molecular subgroups. For the first time in gliomas, it was identified the rs45455192 polymorphism at a frequency of 16% in astrocytomas IDH-mutant, 24% in ...

الإتاحة: https://doi.org/10.1093/neuonc/noz126.094Test
http://academic.oup.com/neuro-oncology/article-pdf/21/Supplement_3/iii27/30129288/noz126.094.pdfTest

المؤلفون: Forte, D, Nabais, A, Pontinha, C, Mafra, M, Mateus, L

مصطلحات موضوعية: Adult, Astrocytoma, Brain, Female, HIV Infections, HIV-1, Humans, Infratentorial Neoplasms, Neoplasms, Multiple Primary, Neurofibromatosis 1, Supratentorial Neoplasms, CHLC NCIR, CHLC PAT CLIN

الوصف: BACKGROUND: Neurofibromatosis type 1 (NF1) has been identified as a predisposing factor in the development of pilocytic astrocytoma (PA), a common benign central nervous system tumor. Although this is a common association, simultaneous development of multiple lesions is an infrequent finding, especially in nonoptic and hypothalamic locations. CASE DESCRIPTION: A 41-year-old female patient with NF1 and uncontrolled human immunodeficiency virus (HIV) type 1 infection presented with a first generalized seizure and associated headache and ataxia. Imaging studies revealed 2 large intra-axial PAs, nodular-cystic in the supratentorial compartment and solid in the infratentorial compartment. Both lesions were treated by gross total resection in 2 surgeries performed 1 week apart. Despite their different imaging patterns, the tumors were histologically and genetically identical. CONCLUSIONS: We present a unique case involving 2 histologically and genetically identical PAs occurring simultaneously in supratentorial and infratentorial locations. We suggest that an intrinsic predisposition to tumor development in patients with NF1 might have been enhanced by the HIV-related immunosuppression in this case. Strict oncologic surveillance is essential in patients with a tumor predisposition syndrome combined with immunosuppression. ; info:eu-repo/semantics/publishedVersion

العلاقة: World Neurosurg. 2018 Sep;117:172-177.; http://hdl.handle.net/10400.17/3388Test

الإتاحة: https://doi.org/10.1016/j.wneu.2018.06.011Test
http://hdl.handle.net/10400.17/3388Test

المؤلفون: Frazão, L, Martins, MC, Nunes, VM, Pimentel, J, Faria, C, Miguéns, J, Sagarribay, A, Matos, M, Salgado, D, Nunes, S, Mafra, M, Roque, L

مصطلحات موضوعية: Adolescent, Brain Neoplasms, Child, Preschool, Chromosomes, Human, Pair 9, Cohort Studies, Cyclin-Dependent Kinase Inhibitor p15, Cyclin-Dependent Kinase Inhibitor p16, Female, Gene Deletion, Glioma, Humans, In Situ Hybridization, Fluorescence, Infant, Male, Phosphorylases, Proto-Oncogene Proteins B-raf, Sequence Analysis, DNA, Mutation, HDE NCIR

الوصف: Genetic alterations in pediatric primary brain tumors can be used as diagnostic and prognostic markers and are the basis for the development of new target therapies that, ideally, would be associated with lower mortality and morbidity. This study evaluates the incidence and interplay of the presence of BRAF V600E mutation and chromosomal 9p21 deletions in a series of 100 pediatric gliomas, aiming to determine the role of these alterations in recurrence and malignant transformation, and to verify if they could be used in the clinical set for stratifying patients for tailored therapies and surveillance. ; info:eu-repo/semantics/publishedVersion

العلاقة: BMC Cancer. 2018 Dec 17;18(1):1259; http://hdl.handle.net/10400.17/3239Test

الإتاحة: https://doi.org/10.1186/s12885-018-5120-0Test
http://hdl.handle.net/10400.17/3239Test

المؤلفون: Bilreiro, C, Coiteiro, D, Mafra, M, Borges, A

مصطلحات موضوعية: Hemangiopericytoma, Meningioma, Solitary Fibrous Tumor, Skull Base, Computed Tomography, Magnetic Resonance, Caso Clinico, CHULC ANPAT

الوصف: Meningioma is the most common intracranial tumor affecting the skull base and the diagnosis is usually straightforward on imaging studies. However, other lesions may present similar findings. A 60 year-old-man presented with memory loss and behavioral changes. Computed Tomography (CT) and Magnetic Resonance (MR) imaging disclosed an extra-axial, dural-based lesion of the middle cranial fossa. The lesion was strongly enhanced and of hypervascular nature, peripheral vessels and vasogenic edema of the adjacent brain parenchyma. Although the most common dural-based lesion of the central nervous system (CNS) is the meningioma, radiologists should be aware of other differential diagnoses, particularly when facing atypical imaging features. These comprise metastases, lymphoma and leukemia, histiocytic lesions, sarcoidosis and hemangiopericytoma. Based on imaging findings we were able to suggest the hemangiopericytoma diagnosis and the patient was subject to tumoral resection surgery and adjuvant radiotherapy. A small tumoral residue remains stable on follow-up studies. ; info:eu-repo/semantics/publishedVersion

العلاقة: Acta Radiol Port. 2018; 30(3): 19-22; http://hdl.handle.net/10400.17/3186Test

الإتاحة: http://hdl.handle.net/10400.17/3186Test

المؤلفون: Forte, Da, Irañeta, A, Nabais, A, Figueiredo, A, Mafra, M, Gonçalves, V

مصطلحات موضوعية: CHLC NCIR, CHLC PAT CLIN, Lobular Capillary Hemangioma, Pyogenic Granuloma, Endoscopic Transsphenoidal Pituitary Surgery

الوصف: Background Lobular capillary hemangioma is a rare benign tumor, most frequently located in the head or neck region, the nasal cavity being uncommonly affected. Its etiopathogenesis is not fully established, although traumatic and hormonal factors have been implied. Case Description A 50-year-old female patient underwent an uneventful endoscopic transsphenoidal removal of a pituitary cystic macroadenoma at our institution. Nasal packing was used in postoperative hemostasis. Histopathology was compatible with a gonadotrophin-producing adenoma. One month after the surgery, the patient presented with frequent episodes of epistaxis and a progressively growing nasal mass, which was removed endoscopically. Its pathological examination confirmed a lobular capillary hemangioma. Conclusions The authors present a clinical case combining two possible predisposing factors to the development of a nasal lobular capillary hemangioma: local traumatic injury through surgery and postoperative nasal packing and hormonal influence. This lesion is a rare complication of endoscopic transsphenoidal resections of pituitary adenomas. ; info:eu-repo/semantics/publishedVersion

العلاقة: J Neurol Surg Rep. 2017 Jan;78(1):e59-e61; http://hdl.handle.net/10400.17/2710Test

الإتاحة: https://doi.org/10.1055/s-0037-1600913Test
http://hdl.handle.net/10400.17/2710Test