المؤلفون: James, SW, Bullock, KA, Gygax, SE, Kraynack, BA, Matura, RA, MacLeod, JA, McNeal, KK, Prasauckas, KA, Scacheri, PC, Shenefiel, HL, Tobin, HM, Wade, SD

مصطلحات موضوعية: Journal Articles

وصف الملف: text/html

العلاقة: http://jcs.biologists.org/cgi/content/short/112/9/1313Test

الإتاحة: http://jcs.biologists.org/cgi/content/short/112/9/1313Test

المؤلفون: Tang, LP, Macleod, JA, Hobbs, DR, Wharton, BA, Davey Smith, G, Stewart, PM

المصدر: Tang , LP , Macleod , JA , Hobbs , DR , Wharton , BA , Davey Smith , G & Stewart , PM 2004 , ' Fetal origins of adult disease: tracing and recruitment of offspring whose mothers participated in a trial of nutritional supplementation during pregnancy - the Sorrento experience ' , Nutrition Bulletin , vol. 29 (4) , pp. 310 - 316 . https://doi.org/10.1111/j.1467-3010.2004.00449.xTest

العلاقة: https://research-information.bris.ac.uk/en/publications/a58e7cf2-aad5-4f77-8788-49a5e1b0e2a8Test

الإتاحة: https://doi.org/10.1111/j.1467-3010.2004.00449.xTest
https://hdl.handle.net/1983/a58e7cf2-aad5-4f77-8788-49a5e1b0e2a8Test
https://research-information.bris.ac.uk/en/publications/a58e7cf2-aad5-4f77-8788-49a5e1b0e2a8Test
http://bristol.library.ingentaconnect.com/content/bsc/nbu/2004/00000029/00000004/art00007Test

المؤلفون: Tang LP, Macleod JA, Hobbs FDR, Wharton BA, Smith GD, Stewart PM

المصدر: Nutrition Bulletin; Dec2004, Vol. 29 Issue 4, p310-316, 7p

مستخلص: It has been proposed that fetal nutrition is an important determinant of adult health and of inequalities in health between different social groups. Evidence for the 'fetal origins' hypothesis, currently, comes almost exclusively from observational studies relating indices of birth size (which in part reflects fetal nutrition) to adult disease or disease risk markers. Observational associations may not be causal and may have arisen through confounding by factors associated with both smaller size at birth and later disease risk. An experimental study conducted in Birmingham 25 years ago showed that protein-energy supplementation amongst nutritionally at risk mothers increased offspring birth size. The experimental design means that this association is unlikely to have arisen through confounding. Adult offspring of mothers participating in this study are now being assessed to determine effects of supplementation on their current health. This will provide important evidence of the potential to improve public health through improving the nutrition of pregnant women. [ABSTRACT FROM AUTHOR]

: Copyright of Nutrition Bulletin is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

المؤلفون: Cullen JC, MacLeod JA, Williams PD, Williams AR

المصدر: Issues in Comprehensive Pediatric Nursing; 1991, Vol. 14 Issue 3, p193-207, 15p

المؤلفون: MacLeod JA, Blazey M, Johnson F, MacMullen JAS

المصدر: Journal of Nursing Staff Development; 1994 Nov-Dec, Vol. 10 Issue 6, p293-299, 7p

المؤلفون: Blazey ME (AUTHOR), MacLeod JA (AUTHOR)

المصدر: Health Care Supervisor. Jun96, Vol. 14 Issue 4, p47-56. 10p.

المؤلفون: Liu Jinze, Zeng Zheng, Coleman Stephen J, MacLeod James N

المصدر: BMC Bioinformatics, Vol 11, Iss Suppl 4, p O8 (2010)

مصطلحات موضوعية: Computer applications to medicine. Medical informatics, R858-859.7, Biology (General), QH301-705.5

وصف الملف: electronic resource

العلاقة: https://doaj.org/toc/1471-2105Test

الوصول الحر: https://doaj.org/article/cd253fcd5ec84b34a505b1ef82ba1353Test

المؤلفون: Macleod Jana B, Wheatley Matthew A, Creighton Francis X, Leeds Ira L, Srinivasan Jahnavi, Chery Marie P, Master Viraj A

المصدر: BMC Research Notes, Vol 4, Iss 1, p 317 (2011)

مصطلحات موضوعية: Medicine, Biology (General), QH301-705.5, Science (General), Q1-390

الوصف: Abstract Background The hierarchical nature of medical education has been thought necessary for the safe care of patients. In this setting, medical students in particular have limited opportunities for experiential learning. We report on a student-faculty collaboration that has successfully operated an annual, short-term surgical intervention in Haiti for the last three years. Medical students were responsible for logistics and were overseen by faculty members for patient care. Substantial planning with local partners ensured that trip activities supplemented existing surgical services. A case review was performed hypothesizing that such trips could provide effective surgical care while also providing a suitable educational experience. Findings Over three week-long trips, 64 cases were performed without any reported complications, and no immediate perioperative morbidity or mortality. A plurality of cases were complex urological procedures that required surgical skills that were locally unavailable (43%). Surgical productivity was twice that of comparable peer institutions in the region. Student roles in patient care were greatly expanded in comparison to those at U.S. academic medical centers and appropriate supervision was maintained. Discussion This demonstration project suggests that a properly designed surgical trip model can effectively balance the surgical needs of the community with an opportunity to expose young trainees to a clinical and cross-cultural experience rarely provided at this early stage of medical education. Few formalized programs currently exist although the experience above suggests the rewarding potential for broad-based adoption.

وصف الملف: electronic resource

العلاقة: http://www.biomedcentral.com/1756-0500/4/317Test; https://doaj.org/toc/1756-0500Test

الوصول الحر: https://doaj.org/article/20a9c8138fa84ea7a5abe8f24016ad5cTest

المؤلفون: Park Stephen DE, O'Gorman Grace M, MacLeod James N, MacHugh David E, Eivers Suzanne S, McGivney Beatrice A, Katz Lisa M, Hill Emmeline W

المصدر: BMC Genomics, Vol 10, Iss 1, p 638 (2009)

مصطلحات موضوعية: Biotechnology, TP248.13-248.65, Genetics, QH426-470

الوصف: Abstract Background Selection for exercise-adapted phenotypes in the Thoroughbred racehorse has provided a valuable model system to understand molecular responses to exercise in skeletal muscle. Exercise stimulates immediate early molecular responses as well as delayed responses during recovery, resulting in a return to homeostasis and enabling long term adaptation. Global mRNA expression during the immediate-response period has not previously been reported in skeletal muscle following exercise in any species. Also, global gene expression changes in equine skeletal muscle following exercise have not been reported. Therefore, to identify novel genes and key regulatory pathways responsible for exercise adaptation we have used equine-specific cDNA microarrays to examine global mRNA expression in skeletal muscle from a cohort of Thoroughbred horses (n = 8) at three time points (before exercise, immediately post-exercise, and four hours post-exercise) following a single bout of treadmill exercise. Results Skeletal muscle biopsies were taken from the gluteus medius before (T0), immediately after (T1) and four hours after (T2) exercise. Statistically significant differences in mRNA abundance between time points (T0 vs T1 and T0 vs T2) were determined using the empirical Bayes moderated t-test in the Bioconductor package Linear Models for Microarray Data (LIMMA) and the expression of a select panel of genes was validated using real time quantitative reverse transcription PCR (qRT-PCR). While only two genes had increased expression at T1 (P < 0.05), by T2 932 genes had increased (P < 0.05) and 562 genes had decreased expression (P < 0.05). Functional analysis of genes differentially expressed during the recovery phase (T2) revealed an over-representation of genes localized to the actin cytoskeleton and with functions in the MAPK signalling, focal adhesion, insulin signalling, mTOR signaling, p53 signaling and Type II diabetes mellitus pathways. At T1, using a less stringent statistical approach, we observed an over-representation of genes involved in the stress response, metabolism and intracellular signaling. These findings suggest that protein synthesis, mechanosensation and muscle remodeling contribute to skeletal muscle adaptation towards improved integrity and hypertrophy. Conclusions This is the first study to characterize global mRNA expression profiles in equine skeletal muscle using an equine-specific microarray platform. Here we reveal novel genes and mechanisms that are temporally expressed following exercise providing new knowledge about the early and late molecular responses to exercise in the equine skeletal muscle transcriptome.

وصف الملف: electronic resource

العلاقة: http://www.biomedcentral.com/1471-2164/10/638Test; https://doaj.org/toc/1471-2164Test

الوصول الحر: https://doaj.org/article/54132a73e1dc431f8078b87ff0280d38Test

المؤلفون: Stromberg Arnold J, McIlwraith C Wayne, Frisbie David D, Huang Liping, Mienaltowski Michael J, Bathke Arne C, MacLeod James N

المصدر: BMC Medical Genomics, Vol 2, Iss 1, p 60 (2009)

مصطلحات موضوعية: Internal medicine, RC31-1245, Genetics, QH426-470

الوصف: Abstract Background Full-thickness articular cartilage lesions that reach to the subchondral bone yet are restricted to the chondral compartment usually fill with a fibrocartilage-like repair tissue which is structurally and biomechanically compromised relative to normal articular cartilage. The objective of this study was to evaluate transcriptional differences between chondrocytes of normal articular cartilage and repair tissue cells four months post-microfracture. Methods Bilateral one-cm2 full-thickness defects were made in the articular surface of both distal femurs of four adult horses followed by subchondral microfracture. Four months postoperatively, repair tissue from the lesion site and grossly normal articular cartilage from within the same femorotibial joint were collected. Total RNA was isolated from the tissue samples, linearly amplified, and applied to a 9,413-probe set equine-specific cDNA microarray. Eight paired comparisons matched by limb and horse were made with a dye-swap experimental design with validation by histological analyses and quantitative real-time polymerase chain reaction (RT-qPCR). Results Statistical analyses revealed 3,327 (35.3%) differentially expressed probe sets. Expression of biomarkers typically associated with normal articular cartilage and fibrocartilage repair tissue corroborate earlier studies. Other changes in gene expression previously unassociated with cartilage repair were also revealed and validated by RT-qPCR. Conclusion The magnitude of divergence in transcriptional profiles between normal chondrocytes and the cells that populate repair tissue reveal substantial functional differences between these two cell populations. At the four-month postoperative time point, the relative deficiency within repair tissue of gene transcripts which typically define articular cartilage indicate that while cells occupying the lesion might be of mesenchymal origin, they have not recapitulated differentiation to the chondrogenic phenotype of normal articular chondrocytes.

وصف الملف: electronic resource

العلاقة: http://www.biomedcentral.com/1755-8794/2/60Test; https://doaj.org/toc/1755-8794Test

الوصول الحر: https://doaj.org/article/afadef20697e4c27a349614d605f88ccTest