المؤلفون: McCarter, Kaitlin R., Arabelovic, Senada, Wang, Xiaosong, Wolfgang, Taylor, Yoshida, Kazuki, Qian, Grace, Kowalski, Emily N., Vanni, Kathleen M.M., LeBoeuf, Nicole R., Buchbinder, Elizabeth I., Gedmintas, Lydia, MacFarlane, Lindsey A., Rao, Deepak A., Shadick, Nancy A., Gravallese, Ellen M., Sparks, Jeffrey A.

المساهمون: National Institute of Arthritis and Musculoskeletal and Skin Diseases, Burroughs Wellcome Fund, Genentech, Rheumatology Research Foundation

المصدر: Seminars in Arthritis and Rheumatism ; volume 64, page 152335 ; ISSN 0049-0172

مصطلحات موضوعية: Anesthesiology and Pain Medicine, Rheumatology

الإتاحة: https://doi.org/10.1016/j.semarthrit.2023.152335Test
https://api.elsevier.com/content/article/PII:S0049017223001774?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S0049017223001774?httpAccept=text/plainTest

المؤلفون: Cheema, Haadiya, Brophy, Robert, Collins, Jamie, Cox, Charles L., Guermazi, Ali, Kumara, Mahima, Levy, Bruce A., MacFarlane, Lindsey, Mandl, Lisa A., Marx, Robert, Selzer, Faith, Spindler, Kurt, Katz, Jeffrey N., Murray, Eleanor J.

المساهمون: National Institute of Arthritis and Musculoskeletal and Skin Diseases

المصدر: Osteoarthritis and Cartilage ; volume 32, issue 3, page 319-328 ; ISSN 1063-4584

مصطلحات موضوعية: Orthopedics and Sports Medicine, Biomedical Engineering, Rheumatology

الإتاحة: https://doi.org/10.1016/j.joca.2023.10.007Test
https://api.elsevier.com/content/article/PII:S1063458423009597?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S1063458423009597?httpAccept=text/plainTest

المؤلفون: Bass, Anne R, Abdel-Wahab, Noha, Reid, Pankti D, Sparks, Jeffrey A, Calabrese, Cassandra, Jannat-Khah, Deanna P, Ghosh, Nilasha, Rajesh, Divya, Aude, Carlos Andres, Gedmintas, Lydia, MacFarlane, Lindsey, Arabelovic, Senada, Falohun, Adewunmi, Mushtaq, Komal, Haj, Farah Al, Diab, Adi, Shah, Ami A, Bingham, Clifton O, Chan, Karmela Kim, Cappelli, Laura C

مصطلحات موضوعية: Inflammatory arthritis

الوصف: Objectives To compare the safety and effectiveness of biologic and conventional disease-modifying antirheumatic drugs (DMARDs) for immune checkpoint inhibitor-associated inflammatory arthritis (ICI-IA). Methods The retrospective multicentre observational study included patients with a diagnosis of ICI-IA treated with a tumour necrosis factor inhibitor (TNFi), interleukin-6 receptor inhibitor (IL6Ri) and/or methotrexate (MTX); patients with pre-existing autoimmune disease were excluded. The primary outcome was time to cancer progression from ICI initiation; the secondary outcome was time to arthritis control from DMARD initiation. Cox proportional hazard models were used to compare medication groups, adjusting for confounders. Results 147 patients were included (mean age 60.3 (SD 11.9) years, 66 (45%) women). ICI-IA treatment was TNFi in 33 (22%), IL6Ri 42 (29%) and MTX 72 (49%). After adjustment for time from ICI initiation to DMARD initiation, time to cancer progression was significantly shorter for TNFi compared with MTX (HR 3.27 (95% CI 1.21 to 8.84, p=0.019)) while the result for IL6Ri was HR 2.37 (95% CI 0.94 to 5.98, p=0.055). Time to arthritis control was faster for TNFi compared with MTX (HR 1.91 (95% CI 1.06 to 3.45, p=0.032)) while the result for IL6Ri was HR 1.66 (95% CI 0.93 to 2.97, p=0.089). A subset analysis in patients with melanoma gave similar results for both cancer progression and arthritis control. Conclusion The treatment of ICI-IA with a biologic DMARD is associated with more rapid arthritis control than with MTX, but may be associated with a shorter time to cancer progression.

وصف الملف: text/html

العلاقة: http://ard.bmj.com/cgi/content/short/82/7/920Test; http://dx.doi.org/10.1136/ard-2023-223885Test

الإتاحة: https://doi.org/10.1136/ard-2023-223885Test
http://ard.bmj.com/cgi/content/short/82/7/920Test

المؤلفون: MacFarlane, Lindsey A., Opare-Addo, Maame B., Katz, Jeffrey N., Collins, Jamie E., Losina, Elena, Tedeschi, Sara K.

المصدر: Osteoarthritis Imaging ; volume 3, issue 3, page 100164 ; ISSN 2772-6541

الإتاحة: https://doi.org/10.1016/j.ostima.2023.100164Test
https://api.elsevier.com/content/article/PII:S277265412300082X?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S277265412300082X?httpAccept=text/plainTest

المؤلفون: MacFarlane, Lindsey A., Mass, Hanna, Collins, Jamie E., Losina, Elena, Katz, Jeffrey N., Chen, Antonia F.

المصدر: Osteoarthritis and Cartilage Open ; volume 5, issue 2, page 100361 ; ISSN 2665-9131

مصطلحات موضوعية: General Medicine

الإتاحة: https://doi.org/10.1016/j.ocarto.2023.100361Test
https://api.elsevier.com/content/article/PII:S2665913123000286?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S2665913123000286?httpAccept=text/plainTest

المؤلفون: Yavuz Saricay, Leyla, Saeed, Hajirah, Yoon, Michael, Stagner, Anna M., MacFarlane, Lindsey A., Gaier, Eric D., Yin, Jia, Hunter, David G.

المصدر: Journal of American Association for Pediatric Ophthalmology and Strabismus ; page 103920 ; ISSN 1091-8531

مصطلحات موضوعية: Ophthalmology, Pediatrics, Perinatology and Child Health

الإتاحة: https://doi.org/10.1016/j.jaapos.2024.103920Test
https://api.elsevier.com/content/article/PII:S1091853124001903?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S1091853124001903?httpAccept=text/plainTest

المؤلفون: Selzer, Faith, Zarra, Michael B., MacFarlane, Lindsey A., Song, Shuang, McHugh, Claire G., Bronsther, Corin, Huizinga, Jamie, Losina, Elena, Katz, Jeffrey N.

المصدر: Osteoarthritis and Cartilage Open ; volume 4, issue 4, page 100311 ; ISSN 2665-9131

مصطلحات موضوعية: General Medicine

الإتاحة: https://doi.org/10.1016/j.ocarto.2022.100311Test
https://api.elsevier.com/content/article/PII:S2665913122000796?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S2665913122000796?httpAccept=text/plainTest

المؤلفون: Moreno, Mar, McCormick, Kenny, Macfarlane, Lindsey, Scrivens, Alexandra

مصطلحات موضوعية: Sutton Coldfield, UK

الوصف: Aims We aim to evaluate the efficacy and safety of Numeta G13%E preterm neonatal parenteral nutrition (PN) in our neonatal population. In September 2017 a National Patient Safety Alert (NPSA) highlighted the risk of harm to babies when lipid was mistakenly run at the rate intended for the aqueous component resulting in significant lipid overdose. Although we have worked to implement many of the alert’s recommendations, we feel we can avoid this risk further by using an all-in-one PN solution.1 Numeta meets current nutritional guidelines as per British Association of Perinatal Medicine (BAPM) but this project allows comparison of outcomes important to both patient and service between those achieved with our current regimen and those with the all-in-one regimen.2 Methods We carried out a quality improvement project from April 2018 to April 2019. We collected data from 330 babies in our neonatal unit during six months before (154 babies) and after (176 babies) the adoption of the all-in-one solution. Our previous PN regimen consisted of a ‘menu’ of aqueous bags (starter, maintenance, ‘light’ and bespoke) and a separate lipid solution. All of them were suitable for peripheral or central administration. Numeta came with similar choices: starter, maintenance -for central administration only- and ‘lite’ and Numeta peripheral, suitable for peripheral administration. Bespoke bags were also available if clinically indicated. We set out our desired outcomes and measured parameters accordingly: Patient outcomes Metabolic stability: electrolyte, glucose, bilirubin and lipid measurements summarised by the need to change from standard PN regimen and/or requirement for insulin. Fluid balance summarised by the lowest weight during the first two weeks of life and time taken to regain birth weight. Growth summarised by change of standard deviation score of weight and head circumference between birth and discharge or transfer back to local hospital. Liver tolerance of lipid solutions summarised by incidence ...

وصف الملف: text/html

العلاقة: http://adc.bmj.com/cgi/content/short/105/9/e25-aTest; http://dx.doi.org/10.1136/archdischild-2020-NPPG.45Test

الإتاحة: https://doi.org/10.1136/archdischild-2020-NPPG.45Test
http://adc.bmj.com/cgi/content/short/105/9/e25-aTest

المؤلفون: MacFarlane, Lindsey A., Arant, Kaetlyn R., Kostic, Aleksandra M., Mass, Hanna, Jones, Morgan H., Collins, Jamie E., Losina, Elena, Katz, Jeffrey N.

المصدر: Arthritis Care & Research; Aug2023, Vol. 75 Issue 8, p1783-1787, 5p

مصطلحات موضوعية: LEUKOCYTE count, SYNOVITIS, SYNOVIAL fluid, KNEE pain, MAGNETIC resonance imaging, KNEE osteoarthritis, INFLAMMATION

مستخلص: Objective: Inflammation is a potential pain generator and treatment target in knee osteoarthritis (OA). Inflammation can be detected on magnetic resonance imaging (MRI) and by synovial fluid white blood cell count (WBC). However, the performance characteristics of synovial fluid WBC for the detection of synovitis have not been established. This study was undertaken to determine the sensitivity and specificity of synovial fluid WBC in identifying inflammation in knee OA using MRI effusion‐synovitis as the gold standard. Methods: We identified records of patients seen at an academic center with a diagnosis code for knee OA, a procedural code for knee aspiration, and a laboratory order for synovial fluid WBC in the same encounter, as well as an MRI within 12 months of the aspiration. MRIs were read for effusion‐synovitis using the MRI OA Knee Score (MOAKS). We dichotomized effusion‐synovitis as 1) none or small, or 2) medium or large. We calculated the sensitivity and specificity of synovial fluid WBC using MRI effusion‐synovitis (medium/large) as the gold standard. We used the Youden index to identify the best cut point. Results: We included 75 patients. Mean ± SD age was 63 ± 12 years, and 69% were female. The synovial fluid WBC was higher in the medium/large effusion‐synovitis group (median 335 [interquartile range (IQR) 312]) than in the none/small group (median 194 [IQR 272]). The optimal cut point was 242, yielding a sensitivity of 71% (95% confidence interval [95% CI] 56–83%) and specificity of 63% (95% CI 41–81%). Conclusion: The sensitivity and specificity of synovial fluid WBC in identifying effusion‐synovitis on MRI were limited. Further research is needed to better understand the association between MRI and effusion‐synovitis measured by synovial fluid and to determine which measure more strongly relates to synovial histopathology and patient outcomes. [ABSTRACT FROM AUTHOR]

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المؤلفون: Wang, Runci, Singaraju, Anvita, Marks, Kathryne E., Shakib, Lorien, Dunlap, Garrett, Adejoorin, Ifeoluwakiisi, Greisen, Stinne R., Chen, Lin, Tirpack, Aidan K., Aude, Carlos, Fein, Miriam R., Todd, Derrick J., MacFarlane, Lindsey, Goodman, Susan M., DiCarlo, Edward F., Massarotti, Elena M., Sparks, Jeffrey A., Jonsson, A. Helena, Brenner, Michael B., Postow, Michael A., Chan, Karmela K., Bass, Anne R., Donlin, Laura T., Rao, Deepak A.

المصدر: Wang , R , Singaraju , A , Marks , K E , Shakib , L , Dunlap , G , Adejoorin , I , Greisen , S R , Chen , L , Tirpack , A K , Aude , C , Fein , M R , Todd , D J , MacFarlane , L , Goodman , S M , DiCarlo , E F , Massarotti , E M , Sparks , J A , Jonsson , A H , Brenner , M B , Postow , M A , Chan , K K , Bass , ....

الوصف: Immune checkpoint inhibitor (ICI) therapies used to treat cancer, such as anti-PD-1 antibodies, can induce autoimmune conditions in some individuals. The T cell mechanisms mediating such iatrogenic autoimmunity and their overlap with spontaneous autoimmune diseases remain unclear. Here, we compared T cells from the joints of 20 patients with an inflammatory arthritis induced by ICI therapy (ICI-arthritis) with two archetypal autoimmune arthritides, rheumatoid arthritis (RA) and psoriatic arthritis (PsA). Single-cell transcriptomic and antigen receptor repertoire analyses highlighted clonal expansion of an activated effector CD8 T cell population in the joints and blood of patients with ICI-arthritis. These cells were identified as CD38hiCD127- CD8 T cells and were uniquely enriched in ICI-arthritis joints compared with RA and PsA and also displayed an elevated interferon signature. In vitro, type I interferon induced CD8 T cells to acquire the ICI-associated CD38hi phenotype and enhanced cytotoxic function. In a cohort of patients with advanced melanoma, ICI therapy markedly expanded circulating CD38hiCD127- T cells, which were frequently bound by the therapeutic anti-PD-1 drug. In patients with ICI-arthritis, drug-bound CD8 T cells in circulation showed marked clonal overlap with drug-bound CD8 T cells from synovial fluid. These results suggest that ICI therapy directly targets CD8 T cells in patients who develop ICI-arthritis and induces an autoimmune pathology that is distinct from prototypical spontaneous autoimmune arthritides.

العلاقة: https://pure.au.dk/portal/en/publications/29b29817-d38c-49fb-8af4-b136c1780c05Test

الإتاحة: https://doi.org/10.1126/sciimmunol.add1591Test
https://pure.au.dk/portal/en/publications/29b29817-d38c-49fb-8af4-b136c1780c05Test
http://www.scopus.com/inward/record.url?scp=85166002457&partnerID=8YFLogxKTest