المؤلفون: Caruso, Rosario, Di Muzio, Marco, Di Simone, Emanuele, Dionisi, Sara, Magon, Arianna, Conte, Gianluca, Stievano, Alessandro, Girani, Emanuele, Boveri, Sara, Menicanti, Lorenzo, Dolansky, Mary A

المساهمون: R. Caruso, M. Di Muzio, E. Di Simone, S. Dionisi, A. Magon, G. Conte, A. Stievano, E. Girani, S. Boveri, L. Menicanti, M.A. Dolansky

مصطلحات موضوعية: COVID-19, ICD-10, International Classification of Diseases, Tenth Revision, TriNetX, curve-fitting analyse, health care quality, health care safety, incidence rate, safety, Settore MED/45 - Scienze Infermieristiche Generali, Cliniche e Pediatriche

الوصف: Background: The COVID-19 pandemic has sharpened the focus on health care safety and quality, underscoring the importance of using standardized metrics such as the International Classification of Diseases, Tenth Revision (ICD-10). In this regard, the ICD-10 cluster Y62-Y69 serves as a proxy assessment of safety and quality in health care systems, allowing researchers to evaluate medical misadventures. Thus far, extensive research and reports support the need for more attention to safety and quality in health care. The study aims to leverage the pandemic's unique challenges to explore health care safety and quality trends during prepandemic, intrapandemic, and postpandemic phases, using the ICD-10 cluster Y62-Y69 as a key tool for their evaluation. Objective: This research aims to perform a comprehensive retrospective analysis of incidence rates associated with ICD-10 cluster Y62-Y69, capturing both linear and nonlinear trends across prepandemic, intrapandemic, and postpandemic phases over an 8-year span. Therefore, it seeks to understand how these trends inform health care safety and quality improvements, policy, and future research. Methods: This study uses the extensive data available through the TriNetX platform, using an observational, retrospective design and applying curve-fitting analyses and quadratic models to comprehend the relationships between incidence rates over an 8-year span (from 2015 to 2023). These techniques will enable the identification of nuanced trends in the data, facilitating a deeper understanding of the impacts of the COVID-19 pandemic on medical misadventures. The anticipated results aim to outline complex patterns in health care safety and quality during the COVID-19 pandemic, using global real-world data for robust and generalizable conclusions. This study will explore significant shifts in health care practices and outcomes, with a special focus on geographical variations and key clinical conditions in cardiovascular and oncological care, ensuring a comprehensive analysis of the ...

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/38630516; volume:13; firstpage:1; lastpage:8; numberofpages:8; journal:JMIR RESEARCH PROTOCOLS; https://hdl.handle.net/2434/1046648Test

الإتاحة: https://doi.org/10.2196/54838Test
https://hdl.handle.net/2434/1046648Test

المؤلفون: Riva, Alessandra, Saitta, Simone, Sturla, Francesco, Disabato, Giandomenico, Tondi, Lara, Camporeale, Antonia, Giese, Daniel, Castelvecchio, Serenella, Menicanti, Lorenzo, Redaelli, Alberto, Lombardi, Massimo, Votta, Emiliano

المصدر: Journal of Cardiovascular Magnetic Resonance ; volume 26, page 100362 ; ISSN 1097-6647

مصطلحات موضوعية: Cardiology and Cardiovascular Medicine, Radiology, Nuclear Medicine and imaging, Radiological and Ultrasound Technology

الإتاحة: https://doi.org/10.1016/j.jocmr.2024.100362Test
https://api.elsevier.com/content/article/PII:S1097664724003533?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S1097664724003533?httpAccept=text/plainTest

المؤلفون: Madè, Alisia, Bibi, Alessia, Garcia-Manteiga, Jose Manuel, Tascini, Anna Sofia, Piella, Santiago Nicolas, Tikhomirov, Roman, Voellenkle, Christine, Gaetano, Carlo, Leszek, Przemyslaw, Castelvecchio, Serenella, Menicanti, Lorenzo, Martelli, Fabio, Greco, Simona

المساهمون: A. Madè, A. Bibi, J.M. Garcia-Manteiga, A.S. Tascini, S.N. Piella, R. Tikhomirov, C. Voellenkle, C. Gaetano, P. Leszek, S. Castelvecchio, L. Menicanti, F. Martelli, S. Greco

مصطلحات موضوعية: ceRNA network, circBPTF, circRNA, circular RNA, heart failure, noncoding RNA, Settore MED/11 - Malattie dell'Apparato Cardiovascolare, Settore BIO/11 - Biologia Molecolare

الوصف: Noncoding RNAs (ncRNAs), which include circular RNAs (circRNAs) and microRNAs (miRNAs), regulate the development of cardiovascular diseases (CVD). Notably, circRNAs can interact with miRNAs, influencing their specific mRNA targets' levels and shaping a competing endogenous RNAs (ceRNA) network. However, these interactions and their respective functions remain largely unexplored in ischemic heart failure (IHF). This study is aimed at identifying circRNA-centered ceRNA networks in non-end-stage IHF. Approximately 662 circRNA-miRNA-mRNA interactions were identified in the heart by combining state-of-the-art bioinformatics tools with experimental data. Importantly, KEGG terms of the enriched mRNA indicated CVD-related signaling pathways. A specific network centered on circBPTF was validated experimentally. The levels of let-7a-5p, miR-18a-3p, miR-146b-5p, and miR-196b-5p were enriched in circBPTF pull-down experiments, and circBPTF silencing inhibited the expression of HDAC9 and LRRC17, which are targets of miR-196b-5p. Furthermore, as suggested by the enriched pathway terms of the circBPTF ceRNA network, circBPTF inhibition elicited endothelial cell cycle arrest. circBPTF expression increased in endothelial cells exposed to hypoxia, and its upregulation was confirmed in cardiac samples of 36 end-stage IHF patients compared to healthy controls. In conclusion, circRNAs act as miRNA sponges, regulating the functions of multiple mRNA targets, thus providing a novel vision of HF pathogenesis and laying the theoretical foundation for further experimental studies.

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/37947656; info:eu-repo/semantics/altIdentifier/wos/WOS:001099515100001; volume:12; issue:21; firstpage:1; lastpage:24; numberofpages:24; journal:CELLS; https://hdl.handle.net/2434/1040174Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85176396217

الإتاحة: https://doi.org/10.3390/cells12212578Test
https://hdl.handle.net/2434/1040174Test

المؤلفون: Baldassarre, Damiano, Iacoviello, Licia, Baetta, Roberta, Roncaglioni, Maria Carla, Condorelli, Gianluigi, Remuzzi, Giuseppe, Gensini, Gianfranco, Frati, Luigi, Ricciardi, Walter, Conaldi, Pier Giulio, Uccelli, Antonio, Blandini, Fabio, Bosari, Silvano, Scambia, Giovanni, Fini, Massimo, Di Malta, Antonio, Amato, Mauro, Veglia, Fabrizio, Bonomi, Alice, Klersy, Catherine, Colazzo, Francesca, Pengo, Martino, Gorini, Francesca, Auteri, Luciana, Ferrante, Giuseppe, Baviera, Marta, Ambrosio, Giuseppe, Catapano, Alberico, Gialluisi, Alessandro, Malavazos, Alexis Elias, Castelvecchio, Serenella, Corsi-Romanelli, Massimiliano Marco, Cardani, Rosanna, Rovere, Maria Teresa La, Agnese, Valentina, Pane, Bianca, Prati, Daniele, Spinardi, Laura, Liuzzo, Giovanna, Arbustini, Eloisa, Volterrani, Maurizio, Visconti, Marco, Werba, José Pablo, Genovese, Stefano, Bilo, Grzegorz, Invitti, Cecilia, Di Blasio, Anna, Lombardi, Carolina, Faini, Andrea, Rosa, Debora, Ojeda-Fernández, Luisa, Foresta, Andreana, De Curtis, Amalia, Di Castelnuovo, Augusto, Scalvini, Simonetta, Pierobon, Antonia, Gorini, Alessandra, Valenti, Luca, Luzi, Livio, Racca, Annarosa, Bandi, Manuela, Tremoli, Elena, Menicanti, Lorenzo, Parati, Gianfranco, Pompilio, Giulio

المساهمون: D. Baldassarre, L. Iacoviello, R. Baetta, M.C. Roncaglioni, G. Condorelli, G. Remuzzi, G. Gensini, L. Frati, W. Ricciardi, P.G. Conaldi, A. Uccelli, F. Blandini, S. Bosari, G. Scambia, M. Fini, A. Di Malta, M. Amato, F. Veglia, A. Bonomi, C. Klersy, F. Colazzo, M. Pengo, F. Gorini, L. Auteri, G. Ferrante, M. Baviera, G. Ambrosio, A. Catapano, A. Gialluisi, A.E. Malavazo, S. Castelvecchio, M.M. Corsi-Romanelli, R. Cardani, M.T.L. Rovere, V. Agnese, B. Pane, D. Prati, L. Spinardi, G. Liuzzo, E. Arbustini, M. Volterrani, M. Visconti, J.P. Werba, S. Genovese, G. Bilo, C. Invitti, A. Di Blasio, C. Lombardi, A. Faini, D. Rosa, L. Ojeda-Fernández, A. Foresta, A. De Curti, A. Di Castelnuovo, S. Scalvini, A. Pierobon, A. Gorini, L. Valenti, L. Luzi, A. Racca, M. Bandi, E. Tremoli, L. Menicanti, G. Parati, G. Pompilio

مصطلحات موضوعية: Cardiac Epidemiology, Clinical trial, Health informatic, Preventive Medicine, Settore BIO/14 - Farmacologia

الوصف: Introduction: Prevention of cardiovascular disease (CVD) is of key importance in reducing morbidity, disability and mortality worldwide. Observational studies suggest that digital health interventions can be an effective strategy to reduce cardiovascular (CV) risk. However, evidence from large randomised clinical trials is lacking. Methods and analysis: The CV-PREVITAL study is a multicentre, prospective, randomised, controlled, open-label interventional trial designed to compare the effectiveness of an educational and motivational mobile health (mHealth) intervention versus usual care in reducing CV risk. The intervention aims at improving diet, physical activity, sleep quality, psycho-behavioural aspects, as well as promoting smoking cessation and adherence to pharmacological treatment for CV risk factors. The trial aims to enrol approximately 80 000 subjects without overt CVDs referring to general practitioners' offices, community pharmacies or clinics of Scientific Institute for Research, Hospitalization and Health Care (Italian acronym IRCCS) affiliated with the Italian Cardiology Network. All participants are evaluated at baseline and after 12 months to assess the effectiveness of the intervention on short-term endpoints, namely improvement in CV risk score and reduction of major CV risk factors. Beyond the funded life of the study, a long-term (7 years) follow-up is also planned to assess the effectiveness of the intervention on the incidence of major adverse CV events. A series of ancillary studies designed to evaluate the effect of the mHealth intervention on additional risk biomarkers are also performed. Ethics and dissemination: This study received ethics approval from the ethics committee of the coordinating centre (Monzino Cardiology Center; R1256/20-CCM 1319) and from all other relevant IRBs and ethics committees. Findings are disseminated through scientific meetings and peer-reviewed journals and via social media. Partners are informed about the study's course and findings through regular ...

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/37451717; info:eu-repo/semantics/altIdentifier/wos/WOS:001042144500003; volume:13; issue:7; firstpage:1; lastpage:58; numberofpages:58; journal:BMJ OPEN; https://hdl.handle.net/2434/986434Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85164752943; https://bmjopen.bmj.com/content/13/7/e072040.longTest

الإتاحة: https://doi.org/10.1136/bmjopen-2023-072040Test
https://hdl.handle.net/2434/986434Test
https://bmjopen.bmj.com/content/13/7/e072040.longTest

المؤلفون: Ranucci, Marco, Casalino, Stefano, Frigiola, Alessandro, Diena, Marco, Parolari, Alessandro, Boveri, Sara, Menicanti, Lorenzo, de Vincentiis, Carlo

المساهمون: M. Ranucci, S. Casalino, A. Frigiola, M. Diena, A. Parolari, S. Boveri, L. Menicanti, C. de Vincentiis

مصطلحات موضوعية: cardiac surgery, daytime variation, morbidity, mortality, outcome, Settore MED/23 - Chirurgia Cardiaca

الوصف: Objectives: The quality of the outcome after cardiac surgery with cardiopulmonary bypass depends on the patient demographics, co-morbidities, complexity of the surgical procedure, and expertise of surgeons and the whole staff. The purpose of the present study is to analyze the timing of surgery (morning vs afternoon) with respect to morbidity and mortality in adult cardiac surgery. Methods: The primary end-point was the incidence of major morbidity defined according to a modified Society of Thoracic Surgeon criterion. We consecutively included all the adult (> 18 years) patients receiving a cardiac surgery operation at our Institution. Results: From 2017 through 2019 a total of 4,003 cardiac surgery patients were operated. With a propensity-matching technique a final patient population of 1600 patients was selected, with 800 patients in the first-case surgery group and 800 in the second-case surgery group. Patients in the second-case group had a major morbidity rate of 13% vs 8.8% in the first-case group (P = 0.006), and a higher rate of 30-days mortality (4.1% vs 2.3%, P = 0.033). After correction for EuroSCORE and operating surgeon, the second-case group confirmed a higher rate of major morbidity (odds ratio 1.610, 95% confidence interval 1.16-2.23, P = 0.004). Conclusion: Our study suggests that patients operated as second cases are exposed to an increased morbidity and mortality probably due to fatigue, loss of attention and hurriedness in the operating room, and decreased human resources in the intensive care unit.

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/36892436; info:eu-repo/semantics/altIdentifier/wos/WOS:001016364900002; firstpage:1; lastpage:34; numberofpages:34; journal:EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY; https://hdl.handle.net/2434/978288Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85163921220

الإتاحة: https://doi.org/10.1093/ejcts/ezad089Test
https://hdl.handle.net/2434/978288Test

المؤلفون: Santarpino, Giuseppe, Di Mauro, Michele, De Feo, Marisa, Paparella, Domenico, Menicanti, Lorenzo, Mastroroberto, Pasquale, Speziale, Giuseppe, Pollari, Francesco, Mauro, Marianna, Giancotti, Monica, Cardetta, Francesco, Torella, Michele, Coscioni, Enrico, Barili, Fabio, Parolari, Alessandro

المساهمون: Santarpino, Giuseppe, Di Mauro, Michele, De Feo, Marisa, Paparella, Domenico, Menicanti, Lorenzo, Mastroroberto, Pasquale, Speziale, Giuseppe, Pollari, Francesco, Mauro, Marianna, Giancotti, Monica, Cardetta, Francesco, Torella, Michele, Coscioni, Enrico, Barili, Fabio, Parolari, Alessandro

الوصف: The choice of the mechanical/biological heart valve prosthesis is a topic currently debated in the light of the transcatheter prosthetic models and the results obtained/expected with the new biological valve models. Consequently, it seems that increasingly younger patients would be indicated for an implantation of a biological prosthesis. This is also in order to improve the quality of life of patients who want to avoid oral anticoagulant therapy. On the other hand, the guidelines for the treatment of heart valve disease assign a central role to the use of mechanical valve prostheses, particularly for certain patient subsets and age groups. This means that mechanical prostheses are still widely used worldwide, especially in non-European or North American regions. The cardiac surgery community therefore seems to be very interested in biological prostheses and transcatheter implants and scarcely interested in mechanical prostheses, including possible strategies for self-management of anticoagulant therapy. Recently, the Italian Society of Cardiac Surgery promoted a survey among its members to stimulate interest in the cardiac surgery community. This review article aims to summarize the most current results recorded with the use of mechanical prostheses and possible strategies, especially for the management of oral anticoagulant therapy, which can improve the patient's quality of life.

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/38140996; info:eu-repo/semantics/altIdentifier/wos/WOS:001157429700006; volume:25; issue:1; firstpage:36; lastpage:41; numberofpages:6; journal:GIORNALE ITALIANO DI CARDIOLOGIA; https://hdl.handle.net/11591/517369Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85181176647

الإتاحة: https://doi.org/10.1714/4165.41590Test
https://hdl.handle.net/11591/517369Test

المؤلفون: Santarpino, Giuseppe, Di Mauro, Michele, De Feo, Marisa, Menicanti, Lorenzo, Paparella, Domenico, Mastroroberto, Pasquale, Speziale, Giuseppe, Pollari, Francesco, Mauro, Marianna, Torella, Michele, Coscioni, Enrico, Barili, Fabio, Parolari, Alessandro

المساهمون: Santarpino, Giuseppe, Di Mauro, Michele, De Feo, Marisa, Menicanti, Lorenzo, Paparella, Domenico, Mastroroberto, Pasquale, Speziale, Giuseppe, Pollari, Francesco, Mauro, Marianna, Torella, Michele, Coscioni, Enrico, Barili, Fabio, Parolari, Alessandro

مصطلحات موضوعية: anticoagulation, mechanical heart valve, quality of life

الوصف: In the latest European guidelines for the management of valvular heart disease, mechanical valve prostheses maintain a strategic role, particularly for certain patient subsets and age groups. Despite the high number of devices implanted in clinical practice, particularly in non-European and North American regions, current scientific literature and debate seem to suggest a limited use of mechanical heart valves. The cardiac surgery community seems to be highly interested in biological and transcatheter valve prostheses but less interested in mechanical heart valves, including possible strategies for self-management of anticoagulation therapy. In this respect, the Italian Society of Cardiac Surgery (SICCH), in particular the Italian Group of Research for Outcome in Cardiac Surgery (GIROC), has promoted a survey among its members to stimulate the interest in this topic and express their opinion on this issue that, due to the prevalence of the affected population and the new treatment options for improving patients' quality of life, should be more appraised and debated in the cardiac surgery community. The recorded results, obtained on the answers to 111 questionnaires, seem to divide the specialists into 'pros' and 'contras' on a useful tool for the entire cardiac surgery community. For this reason, SICCH proposes in conclusion to declare its unified and institutional opinion on this topic.

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/38051658; info:eu-repo/semantics/altIdentifier/wos/WOS:001122893600005; volume:25; issue:1; firstpage:38; lastpage:43; numberofpages:6; journal:JOURNAL OF CARDIOVASCULAR MEDICINE; https://hdl.handle.net/11591/517373Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85179803088

الإتاحة: https://doi.org/10.2459/JCM.0000000000001525Test
https://hdl.handle.net/11591/517373Test

المؤلفون: Garoffolo, Gloria, Casaburo, Manuel, Amadeo, Francesco, Salvi, Massimo, Bernava, Giacomo, Piacentini, Luca, Chimenti, Isotta, Zaccagnini, Germana, Milcovich, Gesmi, Zuccolo, Estella, Agrifoglio, Marco, Ragazzini, Sara, Baasansuren, Otgon, Cozzolino, Claudia, Chiesa, Mattia, Ferrari, Silvia, Carbonaro, Dario, Santoro, Rosaria, Manzoni, Martina, Casalis, Loredana, Raucci, Angela, Molinari, Filippo, Menicanti, Lorenzo, Pagano, Francesca, Ohashi, Toshiro, Martelli, Fabio, Massai, Diana, Colombo, Gualtiero I., Messina, Elisa, Morbiducci, Umberto, Pesce, Maurizio

المساهمون: Garoffolo, Gloria, Casaburo, Manuel, Amadeo, Francesco, Salvi, Massimo, Bernava, Giacomo, Piacentini, Luca, Chimenti, Isotta, Zaccagnini, Germana, Milcovich, Gesmi, Zuccolo, Estella, Agrifoglio, Marco, Ragazzini, Sara, Baasansuren, Otgon, Cozzolino, Claudia, Chiesa, Mattia, Ferrari, Silvia, Carbonaro, Dario, Santoro, Rosaria, Manzoni, Martina, Casalis, Loredana, Raucci, Angela, Molinari, Filippo, Menicanti, Lorenzo, Pagano, Francesca, Ohashi, Toshiro, Martelli, Fabio, Massai, Diana, Colombo, Gualtiero I., Messina, Elisa, Morbiducci, Umberto, Pesce, Maurizio

مصطلحات موضوعية: fibrosi, heart failure, myofibroblast, stromal cell, transcription factors

الوصف: Background: Conversion of cardiac stromal cells into myofibroblasts is typically associated with hypoxia conditions, metabolic insults, and/or inflammation, all of which are predisposing factors to cardiac fibrosis and heart failure. We hypothesized that this conversion could be also mediated by response of these cells to mechanical cues through activation of the Hippo transcriptional pathway. The objective of the present study was to assess the role of cellular/nuclear straining forces acting in myofibroblast differentiation of cardiac stromal cells under the control of YAP (yes-associated protein) transcription factor and to validate this finding using a pharmacological agent that interferes with the interactions of the YAP/TAZ (transcriptional coactivator with PDZ-binding motif) complex with their cognate transcription factors TEADs (TEA domain transcription factors), under high-strain and profibrotic stimulation. Methods: We employed high content imaging, 2-dimensional/3-dimensional culture, atomic force microscopy mapping, and molecular methods to prove the role of cell/nuclear straining in YAP-dependent fibrotic programming in a mouse model of ischemia-dependent cardiac fibrosis and in human-derived primitive cardiac stromal cells. We also tested treatment of cells with Verteporfin, a drug known to prevent the association of the YAP/TAZ complex with their cognate transcription factors TEADs. Results: Our experiments suggested that pharmacologically targeting the YAP-dependent pathway overrides the profibrotic activation of cardiac stromal cells by mechanical cues in vitro, and that this occurs even in the presence of profibrotic signaling mediated by TGF-β1 (transforming growth factor beta-1). In vivo administration of Verteporfin in mice with permanent cardiac ischemia reduced significantly fibrosis and morphometric remodeling but did not improve cardiac performance. Conclusions: Our study indicates that preventing molecular translation of mechanical cues in cardiac stromal cells reduces the impact of ...

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/35770662; info:eu-repo/semantics/altIdentifier/wos/WOS:000827794600009; volume:131; issue:3; firstpage:239; lastpage:257; numberofpages:19; journal:CIRCULATION RESEARCH; https://hdl.handle.net/11573/1649844Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85134855424

الإتاحة: https://doi.org/10.1161/CIRCRESAHA.121.319373Test
https://hdl.handle.net/11573/1649844Test

المؤلفون: Attanasio, Andrea, Tondi, Lara, Castelvecchio, Serenella, Pazzanese, Vittorio, Palmisano, Anna, Esposito, Antonio, Ameri, Pietro, Canale, Claudia, Cappelletti, Alberto, Alberti, Luca P, Tavano, Davide, Camporotondo, Rita, Costantino, Ilaria, Campodonico, Jenness, Pontone, Gianluca, Villani, Alessandra, Gallone, Gianluca Pio, Montone, Rocco A, Niccoli, Giampaolo, Gargiulo, Paola, Punzo, Bruna, Vicenzi, Marco, Carugo, Stefano, Disabato, Giandomenico, Guida, Gianluigi, Camporeale, Antonia, Carrafiello, Gianpaolo, Spagnolo, Pietro, Menicanti, Lorenzo, Ambrosio, Giuseppe, Piepoli, Massimo, Lombardi, Massimo, Camici, Paolo G

المساهمون: A. Attanasio, L. Tondi, S. Castelvecchio, V. Pazzanese, A. Palmisano, A. Esposito, P. Ameri, C. Canale, A. Cappelletti, L.P. Alberti, D. Tavano, R. Camporotondo, I. Costantino, J. Campodonico, G. Pontone, A. Villani, G.P. Gallone, R.A. Montone, G. Niccoli, P. Gargiulo, B. Punzo, M. Vicenzi, S. Carugo, G. Disabato, G. Guida, A. Camporeale, G. Carrafiello, P. Spagnolo, L. Menicanti, G. Ambrosio, M. Piepoli, M. Lombardi, P.G. Camici

مصطلحات موضوعية: Settore MED/11 - Malattie dell'Apparato Cardiovascolare

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/38381565; info:eu-repo/semantics/altIdentifier/wos/WOS:001180951400001; firstpage:1; lastpage:3; numberofpages:3; journal:EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY; https://hdl.handle.net/2434/1036549Test

الإتاحة: https://doi.org/10.1093/eurjpc/zwae072Test
https://hdl.handle.net/2434/1036549Test

المؤلفون: Santarpino, Giuseppe, Di Mauro, Michele, De Feo, Marisa, Paparella, Domenico, Menicanti, Lorenzo, Mastroroberto, Pasquale, Speziale, Giuseppe, Pollari, Francesco, Mauro, Marianna, Giancotti, Monica, Cardetta, Francesco, Torella, Michele, Coscioni, Enrico, Barili, Fabio, Parolari, Alessandro

المصدر: Santarpino , G , Di Mauro , M , De Feo , M , Paparella , D , Menicanti , L , Mastroroberto , P , Speziale , G , Pollari , F , Mauro , M , Giancotti , M , Cardetta , F , Torella , M , Coscioni , E , Barili , F & Parolari , A 2024 , ' Il ruolo delle protesi valvolari meccaniche oggi. Dalla letteratura alla situazione italiana ' , Giornale Italiano di Cardiologia , vol. 25 , no. 1 , pp. 36-41 . https://doi.org/10.1714/4165.41590Test

مصطلحات موضوعية: Anticoagulation, Mechanical heart valves, Quality of life, ORAL ANTICOAGULANT-THERAPY, REPLACEMENT, MANAGEMENT, INTENSITY, CHILDREN, SAFETY

الوصف: The choice of the mechanical/biological heart valve prosthesis is a topic currently debated in the light of the transcatheter prosthetic models and the results obtained/expected with the new biological valve models. Consequently, it seems that increasingly younger patients would be indicated for an implantation of a biological prosthesis. This is also in order to improve the quality of life of patients who want to avoid oral anticoagulant therapy. On the other hand, the guidelines for the treatment of heart valve disease assign a central role to the use of mechanical valve prostheses, particularly for certain patient subsets and age groups. This means that mechanical prostheses are still widely used worldwide, especially in non-European or North American regions. The cardiac surgery community therefore seems to be very interested in biological prostheses and transcatheter implants and scarcely interested in mechanical prostheses, including possible strategies for self-management of anticoagulant therapy. Recently, the Italian Society of Cardiac Surgery promoted a survey among its members to stimulate interest in the cardiac surgery community. This review article aims to summarize the most current results recorded with the use of mechanical prostheses and possible strategies, especially for the management of oral anticoagulant therapy, which can improve the patient's quality of life.

العلاقة: https://cris.maastrichtuniversity.nl/en/publications/8bad08d1-5b0b-48f5-9ca3-fdf993f1293aTest

الإتاحة: https://doi.org/10.1714/4165.41590Test
https://cris.maastrichtuniversity.nl/en/publications/8bad08d1-5b0b-48f5-9ca3-fdf993f1293aTest