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1دورية أكاديمية
المؤلفون: Taghavi, Maxime, Jabrane, Abla, Jacobs, Lucas, Mesquita, Maria, Demulder, Anne, Nortier, Joëlle
المصدر: Antibodies, 13 (1
مصطلحات موضوعية: Néphrologie - urologie, Immunologie, antiphospholipid antibodies, antiphospholipid syndrome, arteriovenous fistula, hemodialysis, maturation failure, stenosis, thrombosis
الوصف: Antiphospholipid antibody (aPL)-persistent positivity is frequent in hemodialysis (HD) patients. Native arteriovenous fistula (AVF) complications such as stenosis and thrombosis are among the most important causes of morbidity and mortality in hemodialysis patients. The association between aPL positivity and AVF thrombosis seems to now be well established. However, whether aPL positivity is associated with other AVF complications, such as maturation failure or stenosis, is not well known. Given the significant impact of AVF failure on patient’s prognosis, it is of interest to further investigate this particular point in order to improve prevention, surveillance and treatment, and, ultimately, the patient’s outcome. This literature review aims to report the recent literature on aPL-associated native AVF complications. ; SCOPUS: re.j ; info:eu-repo/semantics/published
وصف الملف: 1 full-text file(s): application/pdf
العلاقة: uri/info:doi/10.3390/antib13010001; uri/info:pii/antib13010001; uri/info:scp/85188796030; https://dipot.ulb.ac.be/dspace/bitstream/2013/366743/3/antibodies-13-00001-v2.pdfTest; http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/366743Test
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2كتاب
المؤلفون: Wilschut, Esther D, de Winter, Eduard P, Bos, Ernst J, Putter, Hein, Rotmans, Joris I, van der Bogt, Koen E A
المصدر: Eur J Vasc Endovasc Surg ; ISSN:1532-2165 ; Volume:67 ; Issue:5
مصطلحات موضوعية: Arteriovenous fistula, Maturation, Maturation failure, Prehabilitation. Radiocephalic fistula
العلاقة: https://doi.org/10.1016/j.ejvs.2024.01.090Test; https://pubmed.ncbi.nlm.nih.gov/38316352Test
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3دورية أكاديمية
المؤلفون: Maria Barahona, MD, Britt Tonnessen, MD, Jonathan Cardella, MD, Anushree Shirali, MD, Juan Carlos Perez-Lozada, MD, Cassius Iyad Ochoa Chaar, MD, MS, RPVI
المصدر: Journal of Vascular Surgery Cases and Innovative Techniques, Vol 8, Iss 1, Pp 42-44 (2022)
مصطلحات موضوعية: Arteriovenous fistula, Maturation failure, Preservation of conduits, Venous outflow banding, Surgery, RD1-811, Diseases of the circulatory (Cardiovascular) system, RC666-701
الوصف: In the present report, we have described venous outflow banding as a technique to assist with maturation of a percutaneous arteriovenous fistula (pAVF) without sacrificing potential target veins for future access. A 47-year-old obese man had undergone pAVF creation between the right ulnar vessels with coil embolization of the brachial vein. Follow-up imaging demonstrated the median cubital vein briskly filling the cephalic and basilic veins. The basilic vein was banded with the patient under local anesthesia successfully. Banding of the superficial veins provides an alternative after creation of a pAVF to preserve veins that could be used as conduits for future access.
وصف الملف: electronic resource
العلاقة: http://www.sciencedirect.com/science/article/pii/S2468428721002112Test; https://doaj.org/toc/2468-4287Test
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4دورية أكاديمية
المؤلفون: Vikrant Rai, Harbinder Singh, Devendra K. Agrawal
المصدر: International Journal of Molecular Sciences; Volume 23; Issue 19; Pages: 12012
مصطلحات موضوعية: AVF maturation failure, chronic inflammation, immune cell infiltration, pro-inflammatory cytokines, resolvins, VSMCs phenotypes
جغرافية الموضوع: agris
الوصف: Plaque formation, thrombosis, and embolism are the underlying causes of acute cardiovascular events such as myocardial infarction and stroke while early thrombosis and stenosis are common pathologies for the maturation failure of arteriovenous fistula (AVF). Chronic inflammation is a common underlying pathogenesis mediated by innate and adaptive immune response involving infiltration of immune cells and secretion of pro- and anti-inflammatory cytokines. Impaired immune cell infiltration and change in vascular smooth muscle cell (VSMC) phenotype play a crucial role in the underlying pathophysiology. However, the change in the phenotype of VSMCs in a microenvironment of immune cell infiltration and increased secretion of cytokines have not been investigated. Since change in VSMC phenotype regulates vessel remodeling after intimal injury, in this study, we investigated the effect of macrophages and pro-inflammatory cytokines, IL-6, IL-1β, and TNF-α, on the change in VSMC phenotype under in vitro conditions. We also investigated the expression of the markers of VSMC phenotypes in arteries with atherosclerotic plaques and VSMCs isolated from control arteries. We found that the inhibition of cytokine downstream signaling may mitigate the effect of cytokines on the change in VSMCs phenotype. The results of this study support that regulating or targeting immune cell infiltration and function might be a therapeutic strategy to mitigate the effects of chronic inflammation to attenuate plaque formation, early thrombosis, and stenosis, and thus enhance AVF maturation.
وصف الملف: application/pdf
العلاقة: Molecular Endocrinology and Metabolism; https://dx.doi.org/10.3390/ijms231912012Test
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5دورية أكاديمية
المؤلفون: Trung Hoang Anh, Phung-Anh Nguyen, Anh Duong, I-Jen Chiu, Chu-Lin Chou, Yu-Chen Ko, Tzu-Hao Chang, Chih-Wei Huang, Mai-Szu Wu, Chia-Te Liao, Yung-Ho Hsu
المصدر: International Journal of Environmental Research and Public Health; Volume 19; Issue 11; Pages: 6842
مصطلحات موضوعية: contact laxatives, arteriovenous fistula, maturation failure, end-stage kidney disease, hemodialysis
جغرافية الموضوع: agris
الوصف: Laxatives are commonly prescribed for constipation management; however, they are recognized as an independent factor associated with cardiovascular diseases. Arteriovenous fistula (AVF) is the closest to the ideal model of hemodialysis (HD) vascular access and part of the cardiovascular system. Our study aims to explore the association of contact laxative use with AVF maturation outcomes in patients undergoing HD. We conducted a multi-center cohort study of 480 contact laxative users and 472 non-users who had undergone initial AVF creation. All patients were followed until the outcomes of AVF maturation were confirmed. Multivariable logistic regression models were performed to evaluate the risk of AVF maturation failure imposed by laxatives. Here, we found that patients who used contact laxatives were significantly associated with an increased risk of AVF maturation failure compared to non-users (adjusted odds ratio, 1.64; p = 0.003). Notably, the risk of AVF maturation failure increased when increasing their average daily doses and cumulative treatment days. In conclusion, our study found a significant dose- and duration-dependent relationship between contact laxative use and an increased risk of AVF maturation failure. Thus, laxatives should be prescribed with caution in this population. Further studies are needed to validate these observations and investigate the potential mechanisms.
وصف الملف: application/pdf
العلاقة: Disease Prevention; https://dx.doi.org/10.3390/ijerph19116842Test
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6دورية أكاديمية
المؤلفون: Vikrant Rai, Devendra K. Agrawal
المصدر: Proteomes; Volume 10; Issue 2; Pages: 14
مصطلحات موضوعية: arteriovenous fistula, early thrombosis, epigenetic regulation, maturation failure, microRNAs, transcription factors, transcriptional regulation
الوصف: Arteriovenous fistulas (AVFs), created for hemodialysis in end-stage renal disease patients, mature through the outward remodeling of the outflow vein. However, early thrombosis and chronic inflammation are detrimental to the process of AVF maturation and precipitate AVF maturation failure. For the successful remodeling of the outflow vein, blood flow through the fistula is essential, but early arterial thrombosis attenuates this blood flow, and the vessels become thrombosed and stenosed, leading to AVF failure. The altered expression of various proteins involved in maintaining vessel patency or thrombosis is regulated by genes of which the expression is regulated by transcription factors and microRNAs. In this study, using thrombosed and stenosed arteries following AVF creation, we delineated transcription factors and microRNAs associated with differentially expressed genes in bulk RNA sequencing data using upstream and causal network analysis. We observed changes in many transcription factors and microRNAs that are involved in angiogenesis; vascular smooth muscle cell proliferation, migration, and phenotypic changes; endothelial cell function; hypoxia; oxidative stress; vessel remodeling; immune responses; and inflammation. These factors and microRNAs play a critical role in the underlying molecular mechanisms in AVF maturation. We also observed epigenetic factors involved in gene regulation associated with these molecular mechanisms. The results of this study indicate the importance of investigating the transcriptional and epigenetic regulation of AVF maturation and maturation failure and targeting factors precipitating early thrombosis and stenosis.
وصف الملف: application/pdf
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7دورية أكاديمية
المؤلفون: Vikrant Rai, Devendra K. Agrawal
المصدر: Biomedicines; Volume 10; Issue 2; Pages: 433
مصطلحات موضوعية: adventitial inflammation, arteriovenous fistula, chronic inflammation, early thrombosis, fibrosis, maturation, maturation failure, perivascular cuffing
الوصف: Arteriovenous fistula (AVF) is vascular access created for hemodialysis in end-stage renal disease patients. AVF creation causes increased blood flow in the outflow vein with increased pressure. Increased blood flow, blood volume, and shear stress causes outward remodeling so that the outflow vein can withstand the increased pressure. Outward remodeling of the vein involved in AVF is necessary for AVF maturation, however, inward remodeling due to excessive neointimal hyperplasia (NIH) and chronic inflammation may end up with vessel thrombosis and AVF maturation failure. Early thrombosis of the vessel may be due to the luminal factors including NIH and chronic inflammation or due to chronic inflammation of the adventitial due to perivascular cuffing. Inflammation may either be due to an immune response to the vascular injury during AVF creation or injury to the surrounding muscles and fascia. Several studies have discussed the role of inflammation in vascular thrombosis due to intimal injury during AVF creation, but there is limited information on the role of inflammation due to surrounding factors like a muscle injury. The concept of perivascular cuffing has been reported in the nervous system, but there is no study of perivascular cuffing in AVF early thrombosis. We performed the bulk RNA sequencing of the femoral arterial tissue and contralateral arteries as we found thrombosed arteries after AVF creation. RNA sequencing revealed several significantly differentially expressed genes (DEGs) related to chronic inflammation and perivascular cuffing, including tripartite motif-containing protein 55 (TRIM55). Additionally, DEGs like myoblast determination protein 1 (MYOD1) increased after muscle injury and relates to skeletal muscle differentiation, and network analysis revealed regulation of various genes regulating inflammation via MYOD1. The findings of this study revealed multiple genes with increased expression in the AVF femoral artery and may provide potential therapeutic targets or biomarkers of early ...
وصف الملف: application/pdf
العلاقة: Molecular and Translational Medicine; https://dx.doi.org/10.3390/biomedicines10020433Test
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8
المؤلفون: Letty V. van Vliet, Niek Zonnebeld, Lee H. Bouwman, Philippe W. Cuypers, Laurens C. Huisman, Susan Lemson, Felix J. Schlösser, André A. de Smet, Raechel J. Toorop, Maarten G. Snoeijs, Tammo Delhaas, Stefan G. Heinen, Wouter Huberts, Barend M. Mees, Jan H. Tordoir
المصدر: European Journal of Vascular and Endovascular Surgery. 65:555-562
مصطلحات موضوعية: Re-operation, Angioplasty, SALVAGE, Cohort studies, Surgery, Cardiology and Cardiovascular Medicine, STENOSIS, Renal dialysis, MATURATION FAILURE, Arteriovenous fistula
الوصف: Objective: Although observational cohort studies report that interventions to achieve functionality are clinically successful in 85% of patients, the proportion of newly created autologous arteriovenous fistulas that result in functional vascular access typically is only 70 -80%. To address this discrepancy, the selection and outcomes of interventions to achieve functionality in a multicentre prospective cohort study were analysed. Methods: The Shunt Simulation Study enrolled 222 patients who needed a first arteriovenous fistula in nine dialysis units in The Netherlands from 2015 to 2018 and followed these patients until one year after access creation. In this observational study, the technical and clinical success rates of interventions to achieve functionality based on lesion and intervention characteristics were analysed and the clinical outcomes of arteriovenous fistulas with assisted and unassisted functionality were compared. Results: For patients who were on dialysis treatment at the end of the study, unassisted fistula functionality was 54% and overall fistula functionality was 78%. Thirty-four per cent of arteriovenous fistulas required an intervention to achieve functionality, 68% of which eventually became functional. Seventy-five per cent of these interventions were percutaneous balloon angioplasties of vascular access stenoses. Patients with clinically successful interventions to achieve functionality had larger pre-operative vein diameters (2.8 + 1.0 mm vs. 2.3 + 0.6 mm, p = .036) and less often presented with thrombosed fistulas than patients with unsuccessful interventions (7% vs. 43%, p = .006). Arteriovenous fistulas with assisted functionality had similar secondary patency as fistulas with unassisted functionality (100% and 98% at six months, p = .44), although they required more interventions to maintain function (2.6 vs. 1.7 per year; rate ratio 1.52, 95% CI 1.04 -2.18, p = .032). Conclusion: Interventions to achieve functionality were needed in about a third of newly created arteriovenous fistulas. Most thrombosed fistulas were abandoned, and when selected for thrombectomy rarely reached clinical success. On the other hand, interventions to achieve functionality of patent fistulas had high clinical success rates and therefore can be done repeatedly until the fistula has become functional.
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::976efa1c33b62586b0d9bf2b74e99d88Test
https://doi.org/10.1016/j.ejvs.2023.01.007Test -
9رسالة جامعية
المؤلفون: Dhellemmes, Magali
المساهمون: Institute for Advanced Biosciences / Institut pour l'Avancée des Biosciences (Grenoble) (IAB), Centre Hospitalier Universitaire CHU Grenoble (CHUGA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Etablissement français du sang - Auvergne-Rhône-Alpes (EFS)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA), Université Grenoble Alpes 2020-., Christophe Arnoult
المصدر: https://theses.hal.science/tel-04166245Test ; Biologie cellulaire. Université Grenoble Alpes [2020-.], 2023. Français. ⟨NNT : 2023GRALV020⟩.
مصطلحات موضوعية: Patl2, Oocyte maturation, Oocyte maturation failure, Oocyte quality, Early embryo development, Maturation ovocytaire, Echec de maturation ovocytaire, Qualité ovocytaire, Développement embryonnaire préimplantatoire, [SDV.BC]Life Sciences [q-bio]/Cellular Biology
الوصف: At birth, female ovarian reserve is composed of approximately 1 million primary oocytes arrested in prophase of first meiosis. These oocytes, stored in an immature state, will have to go through several stages before becoming able to support the development of an embryo. A first period, called the growth phase, is characterized by a significant increase in oocyte volume. It is followed by meiotic maturation which begins with germinal vesicle breakdown and completion of the first meiosis, marked with the extrusion of the first polar body. The oocyte becomes an egg, blocked in metaphase of second meiosis, and capable of being fertilized. After fertilization, the second polar body extrusion marks the second meiotic division achievement.The oocyte growth phase is characterized by intense transcriptional activity and the production of numerous messenger RNAs. From meiotic maturation, transcription is stopped and will not resume until the activation of the embryonic genome, at the 2-cell stage in mice, and between the 4 and 8-cell stage in women. Synthesis of proteins necessary for meiotic maturation, fertilization and embryonic development until embryonic genome activation depends on the mRNAs accumulated during oocyte growth. The correct regulation of mRNAs storage, their translation at the appropriate time but also their degradation when they are not necessary anymore, are essential elements to produce competent eggs.Oocyte maturation failure is a type of female infertility characterized by the production of immature eggs, unable to be fertilized. A PATL2 variant, leading to the production of truncated and non-functional PATL2 proteins, has been identified and is responsible for this type of infertility. PATL2’s xenopus orthologue is a ribonucleoprotein highly expressed in oocytes, which contribute to regulate maternal mRNA translation. In Mammals, PATL2 function is poorly characterized. In this project, I showed that PATL2 is expressed in mouse oocytes and embryos up to the 2-cell stage and is essential for the ...
العلاقة: NNT: 2023GRALV020; tel-04166245; https://theses.hal.science/tel-04166245Test; https://theses.hal.science/tel-04166245/documentTest; https://theses.hal.science/tel-04166245/file/DHELLEMMES_2023_archivage.pdfTest
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10رسالة جامعية
المؤلفون: Dhellemmes, Magali
المساهمون: Université Grenoble Alpes, Arnoult, Christophe
مصطلحات موضوعية: Patl2, Maturation ovocytaire, Echec de maturation ovocytaire, Qualité ovocytaire, Développement embryonnaire préimplantatoire, Oocyte maturation, Oocyte maturation failure, Oocyte quality, Early embryo development
الوقت: 570
الوصف: A la naissance, la réserve ovarienne de la femme est composée d’environ 1 million d’ovocytes primaires, arrêtés en prophase de première méiose. Ces ovocytes, stockés dans un état immature, vont devoir réaliser plusieurs étapes avant de devenir aptes à soutenir le développement d’un embryon. Une première phase, dite phase de croissance, est caractérisée par une élévation importante du volume ovocytaire. Elle est suivie d’une phase de maturation méiotique qui débute par la rupture de la vésicule germinale et l’achèvement de la première méiose, étape marquée par l’extrusion du premier globule polaire. L’ovocyte devient alors un ovule mature, bloqué en métaphase de seconde méiose, et capable d’être fécondé. La dernière étape de maturation ovocytaire dépend de facteurs apportés par le spermatozoïde et ne sera réalisée qu’après la fécondation. La formation du second globule polaire marque alors l’achèvement de la seconde division méiotique.La phase de croissance ovocytaire est caractérisée par une activité transcriptionnelle intense permettant la production de nombreux ARNm. A partir de la maturation méiotique, la transcription est arrêtée, elle ne reprendra qu’à l’activation du génome embryonnaire, au stade 2-cellules chez la souris, et entre les stades 4 et 8-cellules chez la femme. La production des protéines nécessaires à la maturation méiotique, à la fécondation et au développement embryonnaire jusqu’à l’activation du génome embryonnaire dépend alors des ARNm accumulés au cours de la croissance ovocytaire. La régulation de leur stockage, de leur traduction au moment opportun, mais aussi de leur dégradation lorsqu’ils ne sont plus nécessaires, sont des éléments essentiels à la production d’ovules capables de se développer.L’échec de maturation ovocytaire est un type d’infertilité féminine caractérisé par la production d’ovules immatures, incapables d’être fécondés. Un variant du gène Patl2, responsable de la production de protéines PATL2 tronquées et non fonctionnelles, a été identifié comme responsable de ce type ...
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