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المؤلفون: M.P.G.M. Lejeune, Natalie D. Luscombe-Marsh, Astrid J. Smeets, Margriet S. Westerterp-Plantenga
المساهمون: Humane Biologie, RS: NUTRIM - R1 - Metabolic Syndrome
المصدر: Physiology & Behavior, 97(3-4), 414-419. Elsevier Science
مصطلحات موضوعية: Adult, Male, medicine.medical_specialty, Energy balance, Enzyme-Linked Immunosorbent Assay, Experimental and Cognitive Psychology, Context (language use), Biology, Statistics, Nonparametric, Young Adult, Behavioral Neuroscience, Oxygen Consumption, Glucagon-Like Peptide 1, Weight loss, Internal medicine, Respiration, Dietary Carbohydrates, medicine, Humans, Single-Blind Method, Pain Measurement, Analysis of Variance, Sex Characteristics, Carbohydrate, medicine.disease, Glucagon-like peptide-1, Obesity, Endocrinology, Body Composition, Female, Dietary Proteins, medicine.symptom, Energy Metabolism, Hormone
الوصف: CONTEXT: Obesity prevalence is generally higher in women than in men, and a paucity of research with sex-specific approaches exists. The question arises whether current weight loss programmes, largely developed and tested on women, are appropriate for men. OBJECTIVE: Investigate 24 h energy metabolism, satiety and related hormones during a diet relatively high in protein (HP), exchanged with carbohydrate compared to an adequate-protein (AP) diet, in a respiration chamber in men, in comparison with previous outcomes in women. DESIGN: Ten healthy males (BMI: 22.5+/-1.6 kg/m(2), age: 25+/-3.5 y) were fed in energy balance with an AP (10/60/30% of energy of protein/carbohydrate/fat) or a HP (30/40/30% of energy of protein/carbohydrate/fat) diet in a randomized cross-over design. RESULTS: During the HP diet, 24 h Energy Expenditure (10.5+/-0.5 versus 10.0+/-0.5 MJ/d; p
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::416dc9a857135ff13ed878889f0230e3Test
https://doi.org/10.1016/j.physbeh.2009.03.010Test -
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المؤلفون: Ananda Hochstenbach-Waelen, K. Diepvens, Margriet A. B. Veldhorst, Margriet S. Westerterp-Plantenga, Stijn Soenen, Astrid J. Smeets, Natalie D. Luscombe-Marsh, Rick Hursel, M.P.G.M. Lejeune
المساهمون: Humane Biologie, RS: NUTRIM - R1 - Metabolic Syndrome
المصدر: Physiology & Behavior, 94(2), 300-7. Elsevier Science
مصطلحات موضوعية: medicine.medical_specialty, Hypertension, Renal, Experimental and Cognitive Psychology, Biology, Satiety Response, Behavioral Neuroscience, Weight loss, Diabetes mellitus, Orexigenic, Internal medicine, Weight Loss, Weight management, medicine, Humans, Gluconeogenesis, Nephrons, medicine.disease, Obesity, Endocrinology, Kidney Diseases, Ghrelin, Dietary Proteins, medicine.symptom, Dieting, medicine.drug
الوصف: Relatively high protein diets, i.e. diets that maintain the absolute number of grams of protein ingested as compared to before dieting, are a popular strategy for weight loss and weight maintenance. Research into multiple mechanisms regulating body weight has focused on the effects of different quantities and types of dietary protein. Satiety and energy expenditure are important in protein-enhanced weight loss and weight maintenance. Protein-induced satiety has been shown acutely, with single meals, with contents of 25% to 81% of energy from protein in general or from specific proteins, while subsequent energy intake reduction was significant. Protein-induced satiety has been shown with high protein ad libitum diets, lasting from 1 to 6 days, up to 6 months. Also significantly greater weight loss has been observed in comparison with control. Mechanisms explaining protein-induced satiety are nutrient-specific, and consist mainly of synchronization with elevated amino acid concentrations. Different proteins cause different nutrient related responses of (an)orexigenic hormones. Protein-induced satiety coincides with a relatively high GLP-1 release, stimulated by the carbohydrate content of the diet, PYY release, while ghrelin does not seem to be especially affected, and little information is available on CCK. Protein-induced satiety is related to protein-induced energy expenditure. Finally, protein-induced satiety appears to be of vital importance for weight loss and weight maintenance. With respect to possible adverse events, chronic ingestion of large amounts of sulphur-containing amino acids may have an indirect effect on blood pressure by induction of renal subtle structural damage, ultimately leading to loss of nephron mass, and a secondary increase in blood pressure. The established synergy between obesity and low nephron number on induction of high blood pressure and further decline of renal function identifies subjects with obesity, metabolic syndrome and diabetes mellitus II as particularly susceptible groups.
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be547032fe32930212a4ba6345341fd0Test
https://doi.org/10.1016/j.physbeh.2008.01.003Test -
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المساهمون: Humane Biologie, RS: NUTRIM School of Nutrition and Translational Research in Metabolism, RS: NUTRIM - R1 - Metabolic Syndrome
المصدر: Physiology & Behavior, 91(2-3), 274-280. Elsevier Science
مصطلحات موضوعية: Adult, Blood Glucose, Leptin, Male, medicine.medical_specialty, Adolescent, Matched-Pair Analysis, Peptide Hormones, medicine.medical_treatment, food.diet, Adipokine, Experimental and Cognitive Psychology, Placebo, Polyethylene Glycols, Behavioral Neuroscience, food, Double-Blind Method, Weight loss, Internal medicine, Weight Loss, Humans, Insulin, Medicine, Obesity, Caloric Restriction, Analysis of Variance, Adiponectin, business.industry, Ghrelin, Recombinant Proteins, Very low calorie diet, Endocrinology, medicine.symptom, Energy Metabolism, business, hormones, hormone substitutes, and hormone antagonists
الوصف: The aim of the study was to investigate the effects of energy restriction with or without pegylated recombinant leptin (PEG-leptin) treatment on ghrelin, adiponectin, insulin and glucose concentrations. A randomized double-blind placebo-controlled trial was performed in 24 moderately overweight/obese men. PEG-leptin or placebo was administered weekly for 6 weeks, combined with a restricted energy intake of 2.1 MJ/d. At days 1, 25, and 46 a blood sample was taken and body-weight (BW) was measured. Days 1-25 was named phase 1, and days 25-46 phase 2. During phase 1 the rate of BW loss was significantly higher in the PEG-leptin compared to the placebo group (0.38+/-0.07 vs 0.32+/-0.06 kg/d, p
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91871e2816000401b5a2f9e0fc0b6db7Test
https://doi.org/10.1016/j.physbeh.2007.03.004Test -
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المؤلفون: Margriet S. Westerterp-Plantenga, K. Diepvens, Nicolaas E. P. Deutz, Klaas R. Westerterp, Mariëlle P.K.J. Engelen, Arie G. Nieuwenhuizen, Daniel Tomé, Natalie D. Luscombe-Marsh, Dalila Azzout-Marniche, M.P.G.M. Lejeune
المساهمون: Humane Biologie, Algemene Heelkunde, RS: NUTRIM School of Nutrition and Translational Research in Metabolism
المصدر: International Journal of Obesity, 30 Suppl 3, S16-23. Nature Publishing Group
مصطلحات موضوعية: medicine.medical_specialty, Nutrition and Dietetics, Endocrinology, Diabetes and Metabolism, Energy balance, Protein metabolism, Medicine (miscellaneous), Metabolism, medicine.disease, Obesity, chemistry.chemical_compound, Endocrinology, chemistry, Weight loss, Internal medicine, medicine, medicine.symptom, Weight gain, Body mass index, Thermogenesis
الوصف: Body-weight management requires a multifactorial approach. Recent findings suggest that an elevated protein intake seems to play a key role herein, through (i) increased satiety related to increased diet-induced thermogenesis; (ii) its effect on thermogenesis; (iii) body composition; and (iv) decreased energy-efficiency, all of which are related to protein metabolism. Supported by these mechanisms, relatively larger weight loss and subsequent stronger body-weight maintenance have been observed. Increased insulin sensitivity may appear, but it is unclear whether this is due to weight loss or type of diet. The phenomenon of increased satiety is utilized in reduced energy-intake diets, mainly in the ad libitum condition, whereby sustained satiety is achieved with sustained absolute protein intake in grams, despite lower energy intake. Elevated thermogenesis and glucagon-like peptide-1 (GLP-1) appear to play a role in high-protein induced satiety. Under conditions of weight maintenance, a high-protein diet shows a reduced energy efficiency related to the body composition of the body weight regained, that is, in favor of fat-free mass. Indeed, during body-weight loss, as well as during weight regain, a high-protein diet preserves or increases fat-free mass and reduces fat mass and improves the metabolic profile. In the short-term this may be supported by a positive protein and a negative fat balance, through increased fat oxidation. As protein intake is studied under various states of energy balance, absolute and relative protein intake needs to be discriminated. In absolute grams, a normal protein diet becomes a relatively high-protein diet in negative energy balance and at weight maintenance. Therefore, 'high protein negative energy balance diets' aim to keep the grams of proteins ingested at the same level as consumed at energy balance, despite lower energy intakes.International Journal of Obesity (2006) 30, S16-S23. doi:10.1038/sj.ijo.0803487. AD - [1] 1Department of Human Biology, Nutrim, Maastricht University, MD Maastricht, The Netherlands [2] 2Wageningen Centre of Food Sciences, Wageningen, The Netherlands.
وصف الملف: application/pdf
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f83e189993c23e3a264bb536fc0fb418Test
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=17130855Test -
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المساهمون: Humane Biologie, RS: NUTRIM School of Nutrition and Translational Research in Metabolism
المصدر: British Journal of Nutrition, 95(1), 160-167. Cambridge University Press
مصطلحات موضوعية: Adult, Blood Glucose, Male, medicine.medical_specialty, media_common.quotation_subject, Appetite, Medicine (miscellaneous), Fatty Acids, Nonesterified, Peptide hormone, Body Mass Index, NEFA, Glucagon-Like Peptide 1, Weight loss, Internal medicine, Weight Loss, medicine, Humans, Insulin, Ingestion, Obesity, media_common, Nutrition and Dietetics, Chemistry, Body Weight, Area under the curve, Middle Aged, Glucagon-like peptide-1, Diet, Endocrinology, Postprandial, Adipose Tissue, Body Composition, Female, Insulin Resistance, medicine.symptom, Energy Intake, Energy Metabolism
الوصف: Glucagon-like peptide 1 (GLP-1) is a peptide hormone that is released in response to nutrient ingestion. Postprandial GLP-1 release has been reported to be attenuated in obese subjects, but reports on the effect of weight loss on GLP-1 are conflicting. The aim of the present study was to clarify the effect of a weight-loss period and a consecutive weight-maintenance period on nutrient-stimulated GLP-1 release in obese subjects. Nutrient-stimulated (standard breakfast; 1.9 MJ) GLP-1 release was investigated in thirty-two obese subjects on three occasions: before weight loss (T1) (BMI 30.0 (sd 2.5) kg/m(2)); after a 6-week very-low-energy diet (VLED) (T2) (BMI 27.6 (sd 2.3) kg/m(2)); after a 3-month weight-maintenance period (T3) (BMI 27.9 (sd 2.3) kg/m(2)). At each occasion, following a fasting blood sample the test meal was fed and blood was drawn every 30 min for 2 h relative to ingestion in order to determine plasma GLP-1, insulin, glucose and NEFA concentrations. Subjects lost 7 (sd 3.4) kg during the VLED (P
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e23979a24e0bbac0db9b2a24c634fa2aTest
https://cris.maastrichtuniversity.nl/en/publications/081505f4-4cf8-4adc-bacd-bcb0a62cf6f7Test -
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المؤلفون: Margriet S. Westerterp-Plantenga, M.P.G.M. Lejeune
المساهمون: Humane Biologie, RS: NUTRIM School of Nutrition and Translational Research in Metabolism
المصدر: Appetite, 45(2), 187-190. Elsevier Science
مصطلحات موضوعية: Food intake, medicine.medical_specialty, Nutrition and Dietetics, Body Weight, Energy metabolism, Protein intake, Body weight, Satiety Response, Body Temperature, Feeding behavior, Endocrinology, Weight loss, Internal medicine, Weight Loss, Body Composition, medicine, Humans, Dietary Proteins, medicine.symptom, Energy Metabolism, Thermogenesis, General Psychology
الوصف: Body-weight management requires a multi-factorial approach. Recent findings suggest that an elevated protein intake seems to play such a key role in body-weight management, through (i) increased satiety related to increased diet-induced thermogenesis, (ii) its effect on thermogenesis, (iii) body composition, and (iv) decreased energy-efficiency. Supported by these mechanisms a relatively larger weight loss and stronger body-weight maintenance thereafter have been observed.
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6fa5e371beed856f96a6aae5b5a47943Test
https://doi.org/10.1016/j.appet.2005.02.005Test -
7
المساهمون: Humane Biologie, RS: NUTRIM School of Nutrition and Translational Research in Metabolism
المصدر: British Journal of Nutrition, 93(2), 281-289. Cambridge University Press
مصطلحات موضوعية: Adult, Male, medicine.medical_specialty, Waist, Adolescent, Diet, Reducing, Medicine (miscellaneous), Overweight, Weight Gain, law.invention, Weight regain, Randomized controlled trial, law, Weight loss, Internal medicine, Weight Loss, medicine, Humans, Obesity, Nutrition and Dietetics, Chemistry, Parallel study, Fasting, Middle Aged, Protein intake, Respiratory quotient, Endocrinology, Dietary Supplements, Body Composition, Body Constitution, Female, Dietary Proteins, medicine.symptom, Energy Intake, Energy Metabolism, Attitude to Health
الوصف: Since long-term weight maintenance (WM) is a major problem, interventions to improve WM are needed. The aim of the study was to investigate whether the addition of protein to the diet might limit weight regain after a weight loss of 5–10 % in overweight subjects. In a randomised parallel study design, 113 overweight subjects (BMI 29·3 (SD 2·5) kg/m2); age 45·1 (SD 10·4) years) followed a very-low-energy diet for 4 weeks, after which there was a 6-month period of WM. During WM, subjects were randomised into either a protein group or a control group. The protein group received 30 g/d protein in addition to their own usual diet. During the very-low-energy diet, no differences were observed between the groups. During WM, the protein group showed a higher protein intake (18 %v.15 %;Pv.3·0 kg;Pv.0·5 (SD 0·5 ) cm;Pv.0·07 0·01; (SD/)P
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6381162739eec684278a4c8c363ad519Test
https://doi.org/10.1079/bjn20041305Test -
8
المساهمون: Humane Biologie, RS: NUTRIM School of Nutrition and Translational Research in Metabolism
المصدر: Obesity Research, 13(7), 1195-1204. North American Association for the Study of Obesity
مصطلحات موضوعية: Adult, Leptin, Male, medicine.medical_specialty, Waist, Adolescent, Diet, Reducing, Endocrinology, Diabetes and Metabolism, Medicine (miscellaneous), Overweight, Satiation, chemistry.chemical_compound, Endocrinology, Oxygen Consumption, Double-Blind Method, Weight loss, Internal medicine, Caffeine, Weight Loss, Medicine, Humans, Resting energy expenditure, Obesity, Tea, business.industry, Public Health, Environmental and Occupational Health, Thermogenesis, Feeding Behavior, Middle Aged, Respiratory quotient, chemistry, Adipose Tissue, Female, Basal Metabolism, medicine.symptom, business, Energy Metabolism, Oxidation-Reduction, Food Science
الوصف: OBJECTIVE: Investigation of the effect of a green tea-caffeine mixture on weight maintenance after body weight loss in moderately obese subjects in relation to habitual caffeine intake. RESEARCH METHODS AND PROCEDURES: A randomized placebo-controlled double blind parallel trial in 76 overweight and moderately obese subjects, (BMI, 27.5 +/- 2.7 kg/m2) matched for sex, age, BMI, height, body mass, and habitual caffeine intake was conducted. A very low energy diet intervention during 4 weeks was followed by 3 months of weight maintenance (WM); during the WM period, the subjects received a green tea-caffeine mixture (270 mg epigallocatechin gallate + 150 mg caffeine per day) or placebo. RESULTS: Subjects lost 5.9 +/-1.8 (SD) kg (7.0 +/- 2.1%) of body weight (p < 0.001). At baseline, satiety was positively, and in women, leptin was inversely, related to subjects' habitual caffeine consumption (p < 0.01). High caffeine consumers reduced weight, fat mass, and waist circumference more than low caffeine consumers; resting energy expenditure was reduced less and respiratory quotient was reduced more during weight loss (p < 0.01). In the low caffeine consumers, during WM, green tea still reduced body weight, waist, respiratory quotient and body fat, whereas resting energy expenditure was increased compared with a restoration of these variables with placebo (p < 0.01). In the high caffeine consumers, no effects of the green tea-caffeine mixture were observed during WM. DISCUSSION: High caffeine intake was associated with weight loss through thermogenesis and fat oxidation and with suppressed leptin in women. In habitual low caffeine consumers, the green tea-caffeine mixture improved WM, partly through thermogenesis and fat oxidation.
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e4c195d3fd687e5650cada6f622794dTest
https://doi.org/10.1038/oby.2005.142Test -
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المؤلفون: Margriet S. Westerterp-Plantenga, E.M.R. Kovacs, Ilse M.T. Nijs, M.P.G.M. Lejeune, A.M.J. van Ooijen
المساهمون: Humane Biologie, RS: NUTRIM School of Nutrition and Translational Research in Metabolism
المصدر: International Journal of Obesity, 28(1), 57-64. Nature Publishing Group
مصطلحات موضوعية: Adult, Leptin, Male, medicine.medical_specialty, Adolescent, Endocrinology, Diabetes and Metabolism, media_common.quotation_subject, Medicine (miscellaneous), Satiation, Body Mass Index, Weight loss, Internal medicine, Weight Loss, Secondary Prevention, Humans, Medicine, Resting energy expenditure, Obesity, Exercise, media_common, Nutrition and Dietetics, business.industry, Body Weight, Appetite, Middle Aged, medicine.disease, Respiratory quotient, Endocrinology, Female, Dietary Proteins, medicine.symptom, Energy Metabolism, business, Attitude to Health, Body mass index, Weight gain
الوصف: BACKGROUND: A relatively high percentage of energy intake as protein has been shown to increase satiety and decrease energy efficiency during overfeeding. AIM: To investigate whether addition of protein may improve weight maintenance by preventing or limiting weight regain after weight loss of 5-10% in moderately obese subjects. DESIGN OF THE STUDY: In a randomized parallel design, 148 male and female subjects (age 44.2 +/- 10.1 y; body mass index (BMI) 29.5 +/- 2.5 kg/m2; body fat 37.2 +/- 5.0%) followed a very low-energy diet (2.1 MJ/day) during 4 weeks. For subsequent 3 months weight-maintenance assessment, they were stratified according to age, BMI, body weight, restrained eating, and resting energy expenditure (REE), and randomized over two groups. Both groups visited the University with the same frequency, receiving the same counseling on demand by the dietitian. One group (n=73) received 48.2 g/day additional protein to their diet. Measurements at baseline, after weight loss, and after 3 months weight maintenance were body weight, body composition, metabolic measurements, appetite profile, eating attitude, and relevant blood parameters. RESULTS: Changes in body mass, waist circumference, REE, respiratory quotient (RQ), total energy expenditure (TEE), dietary restraint, fasting blood-glucose, insulin, triacylglycerol, leptin, beta-hydroxybutyrate, glycerol, and free fatty acids were significant during weight loss and did not differ between groups. During weight maintenance, the 'additional-protein group' showed in comparison to the nonadditional-protein group 18 vs 15 en% protein intake, a 50% lower body weight regain only consisting of fat-free mass, a 50% decreased energy efficiency, increased satiety while energy intake did not differ, and a lower increase in triacylglycerol and in leptin; REE, RQ, TEE, and increases in other blood parameters measured did not differ. CONCLUSION: A 20% higher protein intake, that is, 18% of energy vs 15% of energy during weight maintenance after weight loss, resulted in a 50% lower body weight regain, only consisting of fat-free mass, and related to increased satiety and decreased energy efficiency.
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9c2a4272743ff6104449a16506a6f91Test
https://doi.org/10.1038/sj.ijo.0802461Test -
10
المساهمون: Humane Biologie, RS: NUTRIM School of Nutrition and Translational Research in Metabolism
المصدر: British Journal of Nutrition, 91(3), 431-7. Cambridge University Press
مصطلحات موضوعية: Adult, Male, medicine.medical_specialty, Adolescent, Medicine (miscellaneous), Overweight, Epigallocatechin gallate, Body weight, Placebo, Body Mass Index, chemistry.chemical_compound, Animal science, Weight loss, Caffeine, Weight Loss, medicine, Humans, Obesity, Nutrition and Dietetics, Tea, Body Weight, Middle Aged, medicine.disease, Surgery, chemistry, Body Composition, Female, medicine.symptom, Energy Metabolism, Body mass index, Oxidation-Reduction
الوصف: The present study was conducted to investigate whether green tea may improve weight maintenance by preventing or limiting weight regain after weight loss of 5 to 10% in overweight and moderately obese subjects. The study had a randomised, parallel, placebo-controlled design. A total of 104 overweight and moderately obese male and female subjects (age 18–60 years; BMI 25–35kg/m2) participated. The study consisted of a very-low-energy diet intervention (VLED; 2·1MJ/d) of 4 weeks followed by a weight-maintenance period of 13 weeks in which the subjects received green tea or placebo. The green tea contained caffeine (104mg/d) and catechins (573mg/d, of which 323mg was epigallocatechin gallate). Subjects lost 6·4 (sd 1·9) kg or 7·5 (sd 2·2) % of their original body weight during the VLED (PP
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58fd1a096936a26eb628643886f8b5ceTest
https://doi.org/10.1079/bjn20041061Test
