المؤلفون: A. M. Groves, C. J. Johnston, G. Beutner, J. E. Dahlstrom, M. Koina, M. O'Reilly, B. Marples, G. Porter, P. D. Brophy, A. L. Kent

المصدر: Physiological Reports, Vol 11, Iss 15, Pp n/a-n/a (2023)

مصطلحات موضوعية: acute kidney injury, caffeine, hypoxic ischemic encephalopathy, photobiomodulation, Physiology, QP1-981

الوصف: Abstract Hypoxic ischemic encephalopathy (HIE) occurs in 2–5/1000 births, with acute kidney injury (AKI) occurring in 40%. AKI increases morbidity and mortality. Caffeine, an adenosine receptor antagonist, and photobiomodulation (PBM), working on cytochrome c oxidase, are potential treatments for AKI. To examine effects of caffeine and PBM on AKI in rats, Day 7 pups underwent a HIE intervention (Modified Rice–Vannucci model) replicating pathology observed in humans. Caffeine was administered for 3 days and/or PBM for 5 days following HIE. Weights and urine for biomarkers (NGAL, albumin, KIM‐1, osteopontin) were collected prior to HIE, daily post intervention and at sacrifice. Both treatments reduced kidney injury seen on electron microscopy, but not when combined. HIE elevated urinary NGAL and albumin on Days 1–3 post‐HIE, before returning to control levels. This elevation was significantly reduced by PBM or caffeine. KIM‐1 was significantly elevated for 7 days post‐HIE and was reduced by both treatments. Osteopontin was not altered by HIE or the treatments. Treatments, individually but not in combination, improved HIE‐induced reductions in the enzymatic activity of mitochondrial complexes II‐III. PBM and caffeine also improved weight gain. PBM and caffeine reduces AKI diagnosed by urinary biomarkers and confirmed by EM findings.

وصف الملف: electronic resource

العلاقة: https://doaj.org/toc/2051-817XTest

الوصول الحر: https://doaj.org/article/b80fd1d0af824b9cb58b63ab0b4e672aTest

المؤلفون: C. Roddie, J. Dias, M. O’Reilly, M. Mitsikakou, E. Charalambous, L. Green, M. Vaughan, G. Agliardi, J. Garcia, E. Lewin, M. Lowdell, M. Marzolini, L. Wood, H. Holmes, Y. Ngai, B. Popova, W. Wilson, S. Kunaseelan, V. Spanswick, H. Lowe, L. Ensell, J. Hartley, S. Domning, S. Morley, T. Marafioti, A. Bloor, D. Irvine, K. Orchard, A. Khwaja, D. Linch, M. Pule, K. Peggs

المصدر: HemaSphere, Vol 6, Pp 1341-1342 (2022)

مصطلحات موضوعية: Diseases of the blood and blood-forming organs, RC633-647.5

وصف الملف: electronic resource

العلاقة: http://journals.lww.com/10.1097/01.HS9.0000848692.42285.0cTest; https://doaj.org/toc/2572-9241Test

الوصول الحر: https://doaj.org/article/ccf3e17813454e38bf354af2e1572519Test

المؤلفون: C. Roddie, J. Dias, M. O’Reilly, L. Green, M. Vaughan, G. Agliardi, J. Garcia, E. Lewin, M. Lowdell, M. Mitsikakou, E. Charalambous, A. Hotblack, H. Dreau, M. Marzolini, L. Wood, C. Every-Clayton, A. Lal, Y. Ngai, B. Popova, A. Malhi, S. Kunaseelan, V. Spanswick, H. Lowe, L. Ensell, J. Hartley, S. Domning, L. Thorne, H. Hyare, P. Murphy, D. Linch, C. Fox, K. Peggs, K. Cwynarski, M. Pule

المصدر: HemaSphere, Vol 6, Pp 1342-1343 (2022)

مصطلحات موضوعية: Diseases of the blood and blood-forming organs, RC633-647.5

وصف الملف: electronic resource

العلاقة: http://journals.lww.com/10.1097/01.HS9.0000848696.94414.98Test; https://doaj.org/toc/2572-9241Test

الوصول الحر: https://doaj.org/article/eff212440c544b539e94e6fa1a4e1641Test

المؤلفون: T. de Brún, M. O’Reilly - de Brún, E. Van Weel-Baumgarten, N. Burns, C. Dowrick, C. Lionis, C. O’Donnell, F. S. Mair, M. Papadakaki, A. Saridaki, W. Spiegel, C. Van Weel, M. Van den Muijsenbergh, A. MacFarlane

المصدر: Research Involvement and Engagement, Vol 3, Iss 1, Pp 1-25 (2017)

مصطلحات موضوعية: Medicine, Medicine (General), R5-920

الوصف: Plain English summary It is important for health care workers to know the needs and expectations of their patients. Therefore, service users have to be involved in research. To achieve a meaningful dialogue between service users, healthcare workers and researchers, participatory methods are needed. This paper describes how the application of a specific participatory methodology, Participatory Learning and Action (PLA) can lead to such a meaningful dialogue. In PLA all stakeholders are regarded as equal partners and collaborators in research. During 2011–2015, a European project called RESTORE used PLA in Austria, Greece, Ireland, The Netherlands and the UK to investigate how communication between primary health care workers and their migrant patients could be improved. Seventy eight migrants, interpreters, doctors, nurses and other key stakeholders (see Table 2) participated in 62 PLA sessions. These dialogues (involving discussions, activities, PLA techniques and evaluations) were generally 2–3 h long and were recorded and analysed by the researchers. Participants reported many positive experiences about their dialogues with other stakeholders. There was a positive, trusting atmosphere in which all stakeholders could express their views despite differences in social power. This made for better understanding within and across stakeholder groups. For instance a doctor changed her view on the use of interpreters after a migrant explained why this was important. Negative experiences were rare: some doctors and healthcare workers thought the PLA sessions took a lot of time; and despite the good dialogue, there was disappointment that very few migrants used the new interpreting service. Abstract Background In order to be effective, primary healthcare must understand the health needs, values and expectations of the population it serves. Recent research has shown that the involvement of service users and other stakeholders and gathering information on their perspectives can contribute positively to many aspects of primary healthcare. Participatory methodologies have the potential to support engagement and dialogue between stakeholders from academic, migrant community and health service settings. This paper focuses on a specific participatory research methodology, Participatory Learning and Action (PLA) in which all stakeholders are regarded as equal partners and collaborators in research. Our research question for this paper was: "Does the application of PLA lead to meaningful engagement of all stakeholders, and if so, what elements contribute to a positive and productive inter-stakeholder dialogue?". Methods We explored the use of PLA in RESTORE, a European FP7-funded project, during 2011–2015 in 5 countries: Austria, Greece, Ireland, the Netherlands and the UK. The objective of RESTORE was to investigate and support the implementation of guidelines and training initiatives (G/TIs) to enhance communication in cross-cultural primary care consultations with migrants. Seventy eight stakeholders (migrants, interpreters, doctors, nurses and others – see Table 2) participated in a total of 62 PLA sessions (discussions, activities, evaluations) of approximately 2–3 h’ duration across the five sites. During the fieldwork, qualitative data were generated about stakeholders’ experiences of engagement in this dialogue, by means of various methods including participatory evaluations, researchers’ fieldwork reports and researcher interviews. These were analysed following the principles of thematic analysis. Results Stakeholders involved in PLA inter-stakeholder dialogues reported a wide range of positive experiences of engagement, and very few negative experiences. A positive atmosphere during early research sessions helped to create a sense of safety and trust. This enabled stakeholders from very different backgrounds, with different social status and power, to offer their perspectives in a way that led to enhanced learning in the group – they learned with and from each other. This fostered shifts in understanding – for example, a doctor changed her view on interpreted consultations because of the input of the migrant service-users. Conclusion PLA successfully promoted stakeholder involvement in meaningful and productive inter-stakeholder dialogues. This makes it an attractive approach to enhance the further development of health research partnerships to advance primary healthcare.

وصف الملف: electronic resource

العلاقة: http://link.springer.com/article/10.1186/s40900-017-0077-8Test; https://doaj.org/toc/2056-7529Test

الوصول الحر: https://doaj.org/article/9e29dfb4cc9347b996655ac491b7f4d8Test

المؤلفون: J.S. Doyle, A.L. Bowring, J. Cutts, J. Roney, D.M. Iser, J. Sasadeusz, M. O’Reilly, C. Fairley, E. Gane, J. Hoy, G.V. Matthews, N. Medland, R. Moore, M. Prins, M. Stoové, B.K. Tee, M.E. Hellard

المصدر: Journal of Virus Eradication, Vol 3, Iss , Pp 2- (2017)

مصطلحات موضوعية: Microbiology, QR1-502, Public aspects of medicine, RA1-1270

وصف الملف: electronic resource

العلاقة: http://www.sciencedirect.com/science/article/pii/S2055664020308888Test; https://doaj.org/toc/2055-6640Test

الوصول الحر: https://doaj.org/article/29854c01a9ca4bbc90d3f51ee0ae90d5Test

المؤلفون: M O'Reilly, N Kiyimba

مصطلحات موضوعية: Uncategorized, Children, Conversation analysis, Clinical, Declarative, Questions

الوصف: Objective: In mental health settings, before a child can be diagnosed with a mental health condition, they must initially be assessed. These assessments are characterised by question-answer sequences with the child and family members, and our objective is to explore the function of declarative questions. Methods: Video recordings of mental health assessments from 28 families were collected, each being approximately 90 min. Referred children were aged 6–17-years. Data were transcribed using the Jefferson approach and conversation analysis was used. Results: Attention to question-answer sequences identified that one common type was the declarative question. We focus on three identifiable forms: clean language short declaratives, declaratives with extreme case formulations, and reformulation declaratives. Conclusions: The response to these three types of declaratives formed the basis for subsequent question-answer elaboration sequences. The question functioned both to engage the child directly and align with other family members. Practice implications: Implications for practitioners are that these types of declarative questions offer a resource to engage in fact-checking in a way that is non-face-threatening. Conversation analysis provides a methodological tool for practitioners to engage in reflective practice to enhance their clinical skills in relation to question design.

العلاقة: 2381/25225703.v1; https://figshare.com/articles/journal_contribution/Investigating_question-answer_sequences_in_child_mental_health_assessments_Engaging_children_and_families_through_declarative_question_design/25225703Test

الإتاحة: https://figshare.com/articles/journal_contribution/Investigating_question-answer_sequences_in_child_mental_health_assessments_Engaging_children_and_families_through_declarative_question_design/25225703Test

المؤلفون: Ghassan K. Abou-Alfa, Susan M. Geyer, Andrew B. Nixon, Federico Innocenti, Qian Shi, Priya Kumthekar, Sawyer Jacobson, Imane El Dika, Amin Yaqubie, Juan Lopez, Binhui Huang, Yi-Wei Tang, Yujia Wen, Lawrence H. Schwartz, Anthony B. El-Khoueiry, Jennifer J. Knox, Lakshmi Rajdev, Monica M. Bertagnolli, Jeffrey A. Meyerhardt, Eileen M. O'Reilly, Alan P. Venook

مصطلحات موضوعية: Cancer, Therapeutic Research and Development, Clinical Research and Trials, Gastrointestinal Cancers, Liver cancer, Translational Research, Small Molecule Agents, Kinase inhibitors, Topoisomerase agents, DNA-reactive agents, Chemotherapy, Combination chemotherapy, Clinical-Stage Research, Clinical Trial Results, Phase III clinical trials

الوصف: Supplementary Figure 3. Kaplan-Meier curves for the progression-free survival distributions for patients who have detectable (HCV-D) vs. undetectable (HCV-UN) HCV titer levels on their first evaluated sample, by treatment arm.

العلاقة: https://figshare.com/articles/journal_contribution/Supplementary_Figure_3_from_CALGB_80802_Alliance_Impact_of_Sorafenib_with_and_without_Doxorubicin_on_Hepatitis_C_Infection_in_Patients_with_Advanced_Hepatocellular_Carcinoma/25359909Test

الإتاحة: https://doi.org/10.1158/2767-9764.25359909.v1Test
https://figshare.com/articles/journal_contribution/Supplementary_Figure_3_from_CALGB_80802_Alliance_Impact_of_Sorafenib_with_and_without_Doxorubicin_on_Hepatitis_C_Infection_in_Patients_with_Advanced_Hepatocellular_Carcinoma/25359909Test

المؤلفون: Ghassan K. Abou-Alfa, Susan M. Geyer, Andrew B. Nixon, Federico Innocenti, Qian Shi, Priya Kumthekar, Sawyer Jacobson, Imane El Dika, Amin Yaqubie, Juan Lopez, Binhui Huang, Yi-Wei Tang, Yujia Wen, Lawrence H. Schwartz, Anthony B. El-Khoueiry, Jennifer J. Knox, Lakshmi Rajdev, Monica M. Bertagnolli, Jeffrey A. Meyerhardt, Eileen M. O'Reilly, Alan P. Venook

مصطلحات موضوعية: Cancer, Therapeutic Research and Development, Clinical Research and Trials, Gastrointestinal Cancers, Liver cancer, Translational Research, Small Molecule Agents, Kinase inhibitors, Topoisomerase agents, DNA-reactive agents, Chemotherapy, Combination chemotherapy, Clinical-Stage Research, Clinical Trial Results, Phase III clinical trials

الوصف: Supplementary Figure 4. Kaplan-Meier curves for the overall survival distributions for patients who have detectable (HCV-D) vs. undetectable (HCV-UN) HCV titer levels on their first evaluated sample, by treatment arm.

العلاقة: https://figshare.com/articles/journal_contribution/Supplementary_Figure_4_from_CALGB_80802_Alliance_Impact_of_Sorafenib_with_and_without_Doxorubicin_on_Hepatitis_C_Infection_in_Patients_with_Advanced_Hepatocellular_Carcinoma/25359906Test

الإتاحة: https://doi.org/10.1158/2767-9764.25359906.v1Test
https://figshare.com/articles/journal_contribution/Supplementary_Figure_4_from_CALGB_80802_Alliance_Impact_of_Sorafenib_with_and_without_Doxorubicin_on_Hepatitis_C_Infection_in_Patients_with_Advanced_Hepatocellular_Carcinoma/25359906Test

المؤلفون: Ghassan K. Abou-Alfa, Susan M. Geyer, Andrew B. Nixon, Federico Innocenti, Qian Shi, Priya Kumthekar, Sawyer Jacobson, Imane El Dika, Amin Yaqubie, Juan Lopez, Binhui Huang, Yi-Wei Tang, Yujia Wen, Lawrence H. Schwartz, Anthony B. El-Khoueiry, Jennifer J. Knox, Lakshmi Rajdev, Monica M. Bertagnolli, Jeffrey A. Meyerhardt, Eileen M. O'Reilly, Alan P. Venook

مصطلحات موضوعية: Cancer, Therapeutic Research and Development, Clinical Research and Trials, Gastrointestinal Cancers, Liver cancer, Translational Research, Small Molecule Agents, Kinase inhibitors, Topoisomerase agents, DNA-reactive agents, Chemotherapy, Combination chemotherapy, Clinical-Stage Research, Clinical Trial Results, Phase III clinical trials

الوصف: Supplementary Figure 2. Tile plots of HCV viral ჼ00ter levels over ჼ00me for paჼ00ents treated with Doxorubicin and Sorafenib (A) or Sorafenib alone (B). For sample collected at the progression ჼ00me point, the ჼ00ming of progression is reflected as text in that ჼ00le.

العلاقة: https://figshare.com/articles/journal_contribution/Supplementary_Figure_2_from_CALGB_80802_Alliance_Impact_of_Sorafenib_with_and_without_Doxorubicin_on_Hepatitis_C_Infection_in_Patients_with_Advanced_Hepatocellular_Carcinoma/25359915Test

الإتاحة: https://doi.org/10.1158/2767-9764.25359915.v1Test
https://figshare.com/articles/journal_contribution/Supplementary_Figure_2_from_CALGB_80802_Alliance_Impact_of_Sorafenib_with_and_without_Doxorubicin_on_Hepatitis_C_Infection_in_Patients_with_Advanced_Hepatocellular_Carcinoma/25359915Test

المؤلفون: Ghassan K. Abou-Alfa, Susan M. Geyer, Andrew B. Nixon, Federico Innocenti, Qian Shi, Priya Kumthekar, Sawyer Jacobson, Imane El Dika, Amin Yaqubie, Juan Lopez, Binhui Huang, Yi-Wei Tang, Yujia Wen, Lawrence H. Schwartz, Anthony B. El-Khoueiry, Jennifer J. Knox, Lakshmi Rajdev, Monica M. Bertagnolli, Jeffrey A. Meyerhardt, Eileen M. O'Reilly, Alan P. Venook

مصطلحات موضوعية: Cancer, Therapeutic Research and Development, Clinical Research and Trials, Gastrointestinal Cancers, Liver cancer, Translational Research, Small Molecule Agents, Kinase inhibitors, Topoisomerase agents, DNA-reactive agents, Chemotherapy, Combination chemotherapy, Clinical-Stage Research, Clinical Trial Results, Phase III clinical trials

الوصف: Supplementary Figure 1. CONSORT diagram of those with evaluable sample for the HCV-based analyses for this manuscript

العلاقة: https://figshare.com/articles/journal_contribution/Supplementary_Figure_1_from_CALGB_80802_Alliance_Impact_of_Sorafenib_with_and_without_Doxorubicin_on_Hepatitis_C_Infection_in_Patients_with_Advanced_Hepatocellular_Carcinoma/25359918Test

الإتاحة: https://doi.org/10.1158/2767-9764.25359918.v1Test
https://figshare.com/articles/journal_contribution/Supplementary_Figure_1_from_CALGB_80802_Alliance_Impact_of_Sorafenib_with_and_without_Doxorubicin_on_Hepatitis_C_Infection_in_Patients_with_Advanced_Hepatocellular_Carcinoma/25359918Test