المؤلفون: Christopher Hollister, Jennifer M. K. Jensen

المصدر: Journal of Librarianship and Scholarly Communication, Vol 11, Iss 1 (2023)

مصطلحات موضوعية: scholarly communication librarians, research productivity, imposter syndrome, library education, Bibliography. Library science. Information resources

الوصف: Introduction: A growing number of academic libraries have specialized their support for scholarly communication by creating new positions or by expanding units with a focus on providing relevant services. This study was undertaken to explore the extent to which librarians with scholarly communication responsibilities produce research and scholarship, their motivations for doing so, the nature of that productivity, and the perceived impact of that activity on their professional responsibilities. Methods: The authors administered a survey of librarians who identified as having their primary job responsibilities in scholarly communication. Results: Almost all study participants produced their own scholarly work. However, a high percentage indicated that they received no relevant training in their library degree programs, and the majority experienced imposter syndrome pertaining to their own scholarship. Although most respondents were motivated to produce research by institutional expectations for promotion and tenure, greater percentages were driven by personal or professional interests. In addition, participants indicated a strong correlation between producing their own scholarship and their ability to effectively carry out their professional responsibilities. Discussion: There may be an emerging convention for scholarly communication librarianship, i.e., one that includes open education services. Findings suggest a need for scholarly communication training to be more prominent in library degree programs. They also point to the utility of making research production a job requirement, regardless of institutional expectations for professional advancement. Conclusion: The authors argue for adjustments in library education curricula and the inclusion of research production in the portfolios of scholarly communication librarians. Future research directions are proposed.

وصف الملف: electronic resource

العلاقة: https://www.iastatedigitalpress.com/jlsc/article/id/15621Test/; https://www.iastatedigitalpress.com/jlsc/article/15621/galley/14446/downloadTest/; https://doaj.org/toc/2162-3309Test

الوصول الحر: https://doaj.org/article/8aee266c516f447a9a4d9ffbff3f84acTest

المؤلفون: C R Zoerner, J P Pallisgaard, A M Schjerning, M K Jensen, J Toennesen, L D Riis-Vestergaard, C Middelfart, P V Rasmussen, G Gislason, M L Hansen

المصدر: Europace. 25

مصطلحات موضوعية: Physiology (medical), Cardiology and Cardiovascular Medicine

الوصف: Funding Acknowledgements Type of funding sources: None. Background Hypertrophic cardiomyopathy (HCM) is a common genetic cardiovascular disorder; however, detection rates remain low. While most patients are only mildly symptomatic, some develop serious complications such as heart failure (HF), atrial fibrillation (AF), and sudden cardiac death (SCD). Given the possibility of severe outcome, a large focus is put on early detection and prevention of possible HCM related complications. Syncope has long been one of these factors associated with increased risk of SCD, however little concrete data on the impact and consequences of prior syncope in a large HCM population exist. Objectives To determine the risk of ventricular tachycardia (VT), cardiac arrest (CA) and death in patients with HCM and prior history of syncope compared to HCM patients without syncope. Methods All patients aged ≥16 years diagnosed with HCM from 2005 - 2018 were identified in the Danish National Registers and included at first time diagnosis. All admissions or prior presentation of syncope were registered and analyzed for the outcome of a combined endpoint comprising occurrence of VT, CA or death. The association between HCM, syncope and the combined endpoint were investigated using multivariable cox proportional-hazard analysis adjusted for gender, age, and comorbidities. Cumulative incidence of the combined endpoint was calculated using the Aalen-Johansen estimator. Results In this study 3,856 HCM patients were included (median age 68 years [IQR 56-78]) with near equal gender distribution (males 53%, females 47%). Overall 361 (9%) of patients had a registered contact for syncope prior to HCM diagnosis. A total of 1356 patients (35%) reached the combined endpoint. Of those patients with prior syncope 163 patients (45%) reached the endpoint, compared to 1193 patients (34%) who had no registered syncope prior to HCM diagnosis. Univariate analysis showed a significantly increased risk (HR 1.5 (CI 1.3-1.8) p = Conclusion Although there was a significant increased rate of HCM patients with prior syncope reaching the combined endpoint of ventricular tachycardia, cardiac arrest and death, multivariate analysis showed this association to be mainly driven by comorbidity and age. In this cohort males with prior syncope were at a significantly higher risk of reaching the combined endpoint. More research will be needed to explore this disparity.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::c3474d64f8422424c521276b2862deedTest
https://doi.org/10.1093/europace/euad122.228Test

المؤلفون: C R Zoerner, J L Pallisgaard, A M Schjerning, J Toennesen, M K Jensen, G Gislason, M L Hansen

المصدر: European Heart Journal. 43

مصطلحات موضوعية: Cardiology and Cardiovascular Medicine

الوصف: Background The majority of patients with Hypertrophic cardiomyopathy (HCM) are mildly symptomatic or unaware of their condition, but some develop serious complications such as heart failure, atrial fibrillation (AF) as well as sudden cardiac death. Previous studies have suggested that HCM detection-rates in women are significantly lower than in men. This leads to diagnosis often being delayed to later stages of the disease in women, where symptoms are more severe. Further characterization of HCM patients to improve early detection of adverse outcomes and warning signs might improve long-term outcomes. Purpose To describe the characteristics of Danish patients diagnosed with HCM between 2005–2018 and determine trends and changes in these factors over time. Methods All patients aged 16 years or older with a diagnosis of HCM between the 1st of January 2005 and the 31st of December 2018 were identified in Danish nationwide administrative registers and included in the study. Time trends were calculated, and differences analyzed using the Cochran-Armitage trend test and linear regression. Results A total of 3856 patients were diagnosed with HCM in the study period and included in the study. The median age at diagnosis was 68 years (IQR 56 and 78 years), 53% were male, and 44% were diagnosed with obstructive HCM, while the number of patients diagnosed with HCM each year overall increased. At the time of diagnosis, 22,3% patients were previously diagnosed with ischemic heart disease, 17% with AF, 7,5% with ischemic stroke, 13,6% with heart failure. Median age and gender distribution remained stable over time, while the proportion of obstructive HCM among the newly diagnosed decreased (p = Conclusion Despite previous studies describing a gender gap in patients diagnosed with HCM, gender distribution was near equal in this cohort. The number of patients diagnosed with non-obstructive HCM is increasing and the prevalence of comorbidities such as heart failure, ischemic heart disease, and COPD decreased over time. Whether these findings are the result of improved early detection of HCM warrants further research and examination. Funding Acknowledgement Type of funding sources: Public hospital(s). Main funding source(s): Herlev-Gentofte Hospital, Denmark

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::225915d190a2e6f2a6c55b1fa6abfb43Test
https://doi.org/10.1093/eurheartj/ehac544.1737Test

المؤلفون: A Dybro, T B Rasmussen, R R Nielsen, A L D Pedersen, M J Andersen, M K Jensen, S H Poulsen

المصدر: European Heart Journal. 43

مصطلحات موضوعية: Cardiology and Cardiovascular Medicine

الوصف: Background Hypertrophic cardiomyopathy (HCM) patients with outflow obstruction often experience symptoms of heart failure upon exertion. We aimed to characterize left ventricular (LV) systolic function by segmental and global longitudinal strain echocardiography, and to investigate changes in relation to exercise, and the effect of standard treatment with beta-blockers. Method Twenty-nine patients with obstructive HCM and New York Heart Association (NYHA) class ≥ II symptoms were enrolled in a double-blind, placebo-controlled, randomized crossover trial. Patients received metoprolol 150 mg or placebo for two consecutive two-week periods in random order. Echocardiographic assessment with speckle-tracking derived longitudinal strain (LS) was performed at rest and during peak exercise at the end of each treatment period. Segmental LS was calculated as the mean of the six apical, mid, and basal segments. Results During placebo treatment resting values of segmental LS showed an apical-basal difference of −10.3% (95% confidence interval (CI): −12.7 to −7.8; p Conclusion Segmental LS of the LV in obstructive HCM showed an abnormal apical-basal difference. Exercise was associated with a reduction in LV GLS, illustrating an impaired myocardial functional reserve capacity. Metoprolol significantly improved LS of the apical and mid segments of the LV at rest and LV GLS during exercise. Funding Acknowledgement Type of funding sources: Foundation. Main funding source(s): Novo nordic foundation

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::35b888b58349a05b1b41d03b35d2a5cfTest
https://doi.org/10.1093/eurheartj/ehac544.1713Test

المؤلفون: Jennifer M. K. Jensen, Rupesh Kumar Pati, Shailly Chaurasia, Nagesh Gavirneni, Sidhartha S. Padhi

المصدر: Decision Sciences. 53:630-645

مصطلحات موضوعية: Sustainable development, Economic growth, Information Systems and Management, Nutraceutical, Management of Technology and Innovation, Strategy and Management, Global Hunger Index, Business, General Business, Management and Accounting

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::78477d4f94edd340f32ac0a350fafe50Test
https://doi.org/10.1111/deci.12515Test

المؤلفون: A M Dybro, T B Rasmussen, R R Nielsen, M J Andersen, M K Jensen, S H Poulsen

المصدر: European Heart Journal. 42

مصطلحات موضوعية: Cardiology and Cardiovascular Medicine

الوصف: Background Treatment with beta blockers (BB) has been used for symptomatic relief in patients with obstructive hypertrophic cardiomyopathy (HCM) for decades. Even so, the guideline recommendation for the use of BB rests on expert opinions and observational cohort studies. Providing comprehensive high-quality data on the effects of BB in obstructive HCM is essential, especially in the context of newly developed pharmacological treatment strategies specifically targeting this disease (1). Purpose The study aimed to investigate the effects of metoprolol on left ventricular outflow tract (LVOT) obstruction, symptoms, and exercise capacity in patients with obstructive HCM. Methods This double-blinded, placebo-controlled, randomized crossover trial enrolled 30 patients with obstructive HCM and New York Heart Association (NYHA) class ≥ II symptoms from 1 May 2018 to 1 September 2020. Patients received metoprolol or placebo for two consecutive two-week periods in random order. The effect parameters were LVOT gradients, NYHA class, Canadian Cardiovascular Society (CCS) grading angina class, Kansas City Cardiomyopathy Questionnaire Overall Summary Score (KCCQ-OSS), and cardiopulmonary exercise testing. Results Compared with placebo, the LVOT gradient during metoprolol was lower at rest (25 [15–58] mmHg versus 72 [28–87] mmHg; p=0.007), at peak exercise (28 [18–40] mmHg versus 62 [31–113] mmHg; p Conclusion Compared with placebo, metoprolol reduced LVOT obstruction at rest and during exercise, provided symptom relief, and improved quality of life in patients with obstructive HCM. However, exercise capacity remained unchanged. Findings from the present study support the guideline recommendations that BB should be the first drug of choice in patients with obstructive HCM who develop symptoms. Funding Acknowledgement Type of funding sources: Foundation. Main funding source(s): Novo nordic foundation, Skibsreder Per Henriksen, R. og hustrus Foundation

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::129641bece63fbc2de385c69f03e1bdeTest
https://doi.org/10.1093/eurheartj/ehab724.1769Test

المؤلفون: M. K. Jensen, S. S. Andersen, C. H. Liboriussen, M. R. Jochumsen, S. Kristensen

المصدر: Annals of the Rheumatic Diseases. 81:569.2-570

مصطلحات موضوعية: Rheumatology, Immunology, Immunology and Allergy, General Biochemistry, Genetics and Molecular Biology

الوصف: BackgroundRheumatoid arthritis (RA) and systemic lupus erythematosus (SLE) are chronic autoimmune diseases associated with a reduced function of the autonomic nervous system including an impaired function of the vagus nerve (VN). The VN has potential anti-inflammatory effects, which could be utilized in a new treatment approach using vagus nerve stimulation (VNS). Different types of VNS exist, but no direct comparison has been made of the methods in patients with RA and SLE.ObjectivesThe aim of this study was to compare the effect of transcutaneous auricular VNS (taVNS) and deep breathing (DB) on vagal tone in patients with RA or SLE and healthy participants and to investigate the washout effect assessed through time domain heart rate variability (HRV) measures (RMSSD (root-mean-square of successive differences), SDNN (standard deviation of N-N intervals), and PNN50 (percentage of adjacent N-N intervals that differ from each other by more than 50 milliseconds)).MethodsThe study was designed as an open label cross-over study. 42 healthy participants and 52 patients with RA or SLE performed two interventions, 30 minutes of taVNS and 30 minutes of DB. The interventions were separated by at least 24 hours. Before each intervention, two 5-minutes ECG-recordings were made to determine the participants’ baseline HRV. After each intervention three 5-minutes ECG-recordings were conducted in the following 30 minutes to investigate the potential washout effect.ResultsHealthy participants: A significant increase in SDNN, RMSSD, and PNN50 were found after DB. SDNN increased significantly immediately after taVNS. SDNN was significantly higher after DB compared to taVNS. Otherwise, there were no significant differences between the effects of the two interventions. Patients: A significant increase in SDNN, RMSSD, and PNN50 were present after both DB and taVNS. No significant differences were found between the effects of the two interventions. The effects of the interventions were still measurable 30 minutes after intervention, indicating no washout.ConclusionDB causes the greatest increase in HRV for healthy participants, while both DB and taVNS can equally elevate HRV in patients with RA and SLE, which support their use as a potential new treatment approach. However, their clinical effect needs to be investigated in future studies.AcknowledgementsThe authors thank patients and research personnel at Aalborg University Hospital.Disclosure of InterestsNone declared

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::885ed7bdc4fbde33909f524317472549Test
https://doi.org/10.1136/annrheumdis-2022-eular.2650Test

المؤلفون: C. H. Liboriussen, S. S. Andersen, M. K. Jensen, M. R. Jochumsen, S. Kristensen

المصدر: Annals of the Rheumatic Diseases. 81:1262.2-1263

مصطلحات موضوعية: Rheumatology, Immunology, Immunology and Allergy, General Biochemistry, Genetics and Molecular Biology

الوصف: BackgroundPatients with Rheumatoid Arthritis (RA) and Systemic Lupus Erythematosus (SLE) are known to have an autonomic dysfunction, especially reduced parasympathetic activity. The dysfunction can be measured through heart rate variability (HRV), an indicator of vagus nerve tone. Studies have found a potential anti-inflammatory effect of the vagus nerve and proposed vagus nerve stimulation (VNS) as an anti-inflammatory treatment. A way of stimulating the vagus nerve non-invasively could be through deep breathing (DB).ObjectivesThe aims of this study were to examine the dose-response of DB on HRV in healthy participants and to examine the reliability of the effect of DB on HRV in patients with RA and SLE across two days.MethodsThe study was designed as an interventional study, more specifically the healthy subjects participated in a dose-response study and the patients with RA and SLE participated in a study of reliability. Forty-one healthy participants performed DB for 5, 15, and 30 minutes (4 seconds of inspiration and 6 seconds of expiration) in a randomized order on three different days. Fifty-two patients with RA and SLE performed the optimal dose of DB found in healthy participants, and the intervention was repeated on two different days to examine the reliability of the effect. The outcome measure was HRV, which was derived from a 5-minute electrocardiogram recording measured twice before and three times after DB. The extracted HRV measures included in the further analysis were the time domain parameters: a) The standard deviation of the R-R intervals (SDNN), b) the root mean square of successive R-R intervals (RMSSD), and c) the proportion of NN50 (pairs of successive R-R intervals that differ more than 50 milliseconds) divided by the total number of R-R intervals (PNN50).ResultsThirty minutes of DB increased HRV and was the optimal dose of DB in healthy participants. In patients with RA and SLE 30 minutes of DB increased all HRV-parameters similarly across two days indicating reliability, see Figure 1. The effect of DB remained for at least 30 minutes after the intervention.Figure 1.Bar chart showing the heart rate variability-parameters plotted as mean ± standard error in patients with RA and SLE. RA: Rheumatoid Arthritis. SLE: Systemic Lupus Erythematosus. SDNN: The standard deviation of the R-R intervals. RMSSD: The root mean square of successive R-R intervals. PNN50: The proportion of NN50 (pairs of successive R-R intervals that differ more than 50 milliseconds) divided by the total number of R-R intervals.ConclusionDB increases HRV in healthy participants and in patients with RA and SLE, indicating a stimulation of the vagus nerve. Future studies are needed to investigate the potential anti-inflammatory effect as well.AcknowledgementsThe authors thank patients and research personnel at Aalborg University Hospital, Denmark.Disclosure of InterestsNone declared

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::aeb6a0145b620d0eaf715f752c3ecd69Test
https://doi.org/10.1136/annrheumdis-2022-eular.2737Test

المؤلفون: S. Aslibekyan, M. K. Jensen, H. Campos, C. D. Linkletter, E. B. Loucks, J. M. Ordovas, R. Deka, E. B. Rimm, A. Baylin, Jill Barnholtz-sloan, Cheryl L. Thompson, Department Of

المساهمون: The Pennsylvania State University CiteSeerX Archives

المصدر: ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/60/46/Front_Genet_2012_May_3_3_72.tar.gz

الوصف: doi:10.3389/fgene.2012.00072 Fatty acid desaturase gene variants, cardiovascular risk factors, and myocardial infarction in the Costa Rica Study

وصف الملف: application/zip

العلاقة: http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.270.4000Test

المؤلفون: A P Roday, M K Jensen

المساهمون: The Pennsylvania State University CiteSeerX Archives

المصدر: https://pamelanorris.files.wordpress.com/2010/11/t2-j-2009-06-roday-ijhmt-study-critical-heat-ii.pdfTest.

الوصف: a b s t r a c t This study's objective was to better understand the CHF condition in microchannels. The effect of different operating parameters -mass flux, inlet subcooling, exit quality, heated length and diameter -were assessed in detail in Part I of the study and compared to the behavior in conventional sized channels. Part II of the study compares the water and R-123 data with existing micro/macrochannel correlations. Existing correlations for predicting CHF in large-sized channels do not seem to be applicable to microchannels. This study has provided new subcooled CHF data for low mass fluxes and the earlier available subcooled boiling CHF correlation for microchannels (based on the data available for very high mass fluxes) is not suitable to predict such data. Based on the new subcooled CHF data, a correlation to predict CHF in lowflow subcooled boiling has been developed.

وصف الملف: application/pdf

العلاقة: http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.1088.4750Test