المؤلفون: Lamis Khidher Mohammed, Issam Merzah Abdullah, Kasem Ahmed Abeas, Arkan M Al Azzawi

المصدر: Medical Journal of Babylon, Vol 20, Iss 4, Pp 757-761 (2023)

مصطلحات موضوعية: saddle angle, sagittal, skeletal classes, Medicine

الوصف: Background: The cranial base has a substantial role in determining how the maxilla and mandible are related to each other and its growth influences the maxillo-mandibular growth. Aim: The main aim of this study was to evaluate and assess the relationship of the saddle angle (NSAr) with different patterns of the sagittal interarch skeletal relationship for the Iraqi population and detect the effect of gender on it. Materials and Methods: The samples included 125 true lateral cephalometric radiographs for Iraqi patients of both genders (male and female) between the age of 18–25 years obtained from the clinic’s archives of the Orthodontic Department at the Dentistry Teaching Hospital of the Faculty of Dentistry, Baghdad University, Iraq, who was looking for orthodontic therapy. The samples were divided according to the value of ANB angle into skeletal Cl I (33 females and 14 males), skeletal Cl II (27 females, 14 males), and skeletal Cl III (17 females and 20 males) groups, then the saddle angle were digitized and recorded using AutoCAD 2012 computer program, the data then analyzed by SPSS version 24 (2016) computerized statistical analysis. Results: The results clarified that the mean value of saddle angle was smaller in the skeletal Cl III group for both genders, with females showed the smallest value with no significant difference, and the larger value of saddle angle was in the skeletal Cl II group for both genders with females showed the largest value with no significant difference. Conclusion: The sagittal skeletal relationship tends to alter from skeletal Cl III to Cl II with progressive flattening of the cranial base and vice-versa. The effect of gender on saddle angle was more than that of sagittal skeletal classes.

وصف الملف: electronic resource

العلاقة: http://www.medjbabylon.org/article.asp?issn=1812-156X;year=2023;volume=20;issue=4;spage=757;epage=761;aulast=MohammedTest; https://doaj.org/toc/1812-156XTest; https://doaj.org/toc/2312-6760Test

الوصول الحر: https://doaj.org/article/4976272d6c6e43b18d9e4fe527b4ccdcTest

المؤلفون: Arfan A. Meeto, Zaid M. M. Al-Azzawi

المصدر: Eurasian Research Bulletin ; Vol. 24 (2023): ERB; 34-41 ; 2795-7675

مصطلحات موضوعية: pre-weaning, characteristic, daily gain, economic

الوصف: The study was conducted at the private Rasan Agricultural Station for the breeding of Saanen goats in Halabja Governorate, located east of Sulaymaniyah Governorate in the Kurdistan Region of Iraq. The research included 268 records belonging to 74 does from the station's records for the seasons 2021 and 2022. The station was established in 2020 by importing 500 heads of the Saanen goats from the Netherlands, with the aim of estimating the direct genetic gain and the response associated with selection at different ranges of selection intensity (70 and 50%) and comparing them according to Different selection methods depending on the phenotypic values of total milk yield, birth weight and the economic value resulting from them, as well as the total milk yield and preweaning average daily gain and the economic value calculated from them. The direct genetic gain ratios for does and bucks were 3.79, 5.83 and 4.75, 6.68%, depending on total milk yield, 2.86, 4.71 and 3.48, 5.34% depending on birth weight, 3.65, 5.69 and 4.61, 6.54% depending on economic value calculated from them at a selection rate of 70 and 50%, respectively. The direct genetic gain ratios for does and bucks were 3.44, 5.44 and 3.68, 6.43% depending on the pre-weaning average daily gain 0.41, 1.1 8 and 0.97, 1.80% depending on Total milk yield and pre-weaning average daily gain at a selection rate of 70 and 50%, respectively, The values of family selection efficiency for total milk yield, birth weight and pre-weaning average daily gain were 0.204, 0.190 and 0.201, respectively. The study showed the superiority of bucks over does by the direct genetic gain and the response associated with selection, the resultant depending on the phenotypic value of the characteristic of total milk yield, birth weight and the economic value resulting from them, as well as the phenotypic value of the characteristic of total milk yield, the pre-weaning average daily gain and the economic value resulting from them, in addition to that individual selection (does) is better ...

وصف الملف: application/pdf

العلاقة: https://geniusjournals.org/index.php/erb/article/view/4921/4139Test; https://geniusjournals.org/index.php/erb/article/view/4921Test

الإتاحة: https://geniusjournals.org/index.php/erb/article/view/4921Test

المؤلفون: Khalid R. Aljanabi, Osamah M. AL-Azzawi

المصدر: International Journal of Geo-Engineering, Vol 12, Iss 1, Pp 1-18 (2021)

مصطلحات موضوعية: Maximum wall deflection, Braced excavation, Homogeneous clay, Neural network, Forecasting, Hydraulic engineering, TC1-978

الوصف: Highlights Neural Networks was used to forecast maximum deflection of braced excavation in homogeneous clay and its position. A sensitivity analysis was accomplished to examine the relative significance of the parameters that influence the models. The results confirm that the developed ANN model is able to predict maximum deflection and its position reliably. Design charts were developed based on the ANN model.

وصف الملف: electronic resource

العلاقة: https://doaj.org/toc/2092-9196Test; https://doaj.org/toc/2198-2783Test

الوصول الحر: https://doaj.org/article/3d6713c5d9ed41219bdbe2df76c18427Test

المؤلفون: Mohammed S. M. Al-Azzawi, Daphne Gondhalekar, Jörg E. Drewes

المصدر: Resources; Volume 11; Issue 7; Pages: 64

مصطلحات موضوعية: water reclamation with integrated resource recovery, Water-Energy-Food (WEF) Nexus approach, climate change, wastewater management infrastructure, paradigm shift, circular economy, cities, Germany

جغرافية الموضوع: agris

الوصف: With the rapid expansion of cities due to population growth and urbanization, conventional centralized wastewater collection and treatment systems are slowly becoming a burden; expensive maintenance is required for aging plants and piping infrastructure, the cost of expanding the capacity to cover demand from population growth, and new regulations for tighter control over certain pollutants such as micropollutants. As an alternative to this system, this study discusses the feasibility of decentralized treatment systems at the neighborhood scale. Taking a Water-Energy-Food (WEF) Nexus approach, such systems can support water and energy conservation, recovery of water, energy, and nutrients as well as generation of energy from wastewater, be customized to individual water and energy requirements, and eliminate the need for lengthy pipe networks. The method employed in this study is comparing the economic feasibility of the status quo to a proposed decentralized solution. The study finds that the costs of implementing a hypothetical decentralized water reclamation with an integrated resource recovery system using an anaerobic membrane bioreactor (AnMBR) in a downtown high-density neighborhood of the city of Munich, Germany, can theoretically be recuperated within two years. This alternative system may cost 60% of what it costs to run the centralized system. By linking the AnMBR to a biogas digestor and using systematically harvested organic waste as a co-substrate, the decentralized system can generate enough energy to run itself and even feed some energy to the grid. This study is highly hypothetical, yet generating evidence such as this can support a systemic socio-technical transition towards a more circular economy with optimal resource recovery.

وصف الملف: application/pdf

العلاقة: https://dx.doi.org/10.3390/resources11070064Test

الإتاحة: https://doi.org/10.3390/resources11070064Test

المؤلفون: Raphaella W. L. So, Sai Wai Chung, Heather H. C. Lau, Jeremy J. Watts, Erin Gaudette, Zaid A. M. Al-Azzawi, Jossana Bishay, Lilian Tsai-Wei Lin, Julia Joung, Xinzhu Wang, Gerold Schmitt-Ulms

المصدر: Molecular Neurodegeneration, Vol 14, Iss 1, Pp 1-16 (2019)

مصطلحات موضوعية: CRISPR-Cas9, Functional genetics, sgRNA, CRISIPR KO, CRISPRi, CRISPRa, Neurology. Diseases of the nervous system, RC346-429, Geriatrics, RC952-954.6

الوصف: Abstract The adoption of CRISPR-Cas9 technology for functional genetic screens has been a transformative advance. Due to its modular nature, this technology can be customized to address a myriad of questions. To date, pooled, genome-scale studies have uncovered genes responsible for survival, proliferation, drug resistance, viral susceptibility, and many other functions. The technology has even been applied to the functional interrogation of the non-coding genome. However, applications of this technology to neurological diseases remain scarce. This shortfall motivated the assembly of a review that will hopefully help researchers moving in this direction find their footing. The emphasis here will be on design considerations and concepts underlying this methodology. We will highlight groundbreaking studies in the CRISPR-Cas9 functional genetics field and discuss strengths and limitations of this technology for neurological disease applications. Finally, we will provide practical guidance on navigating the many choices that need to be made when implementing a CRISPR-Cas9 functional genetic screen for the study of neurological diseases.

وصف الملف: electronic resource

العلاقة: http://link.springer.com/article/10.1186/s13024-019-0343-3Test; https://doaj.org/toc/1750-1326Test

الوصول الحر: https://doaj.org/article/3ec4297f568f430e9abc28d7d2b76c06Test

المؤلفون: Hamza Arshad, Zeel Patel, Genki Amano, Le yao Li, Zaid A. M. Al‐Azzawi, Surachai Supattapone, Gerold Schmitt‐Ulms, Joel C. Watts

المصدر: Journal of Neurochemistry. 165:230-245

مصطلحات موضوعية: Cellular and Molecular Neuroscience, Biochemistry

الوصف: The bank vole (BV) prion protein (PrP) can function as a universal acceptor of prions. However, the molecular details of BVPrP's promiscuity for replicating a diverse range of prion strains remain obscure. To develop a cultured cell paradigm capable of interrogating the unique properties of BVPrP, we generated monoclonal lines of CAD5 cells lacking endogenous PrP but stably expressing either hamster (Ha), mouse (Mo), or BVPrP (M109 or I109 polymorphic variants) and then challenged them with various strains of mouse or hamster prions. Cells expressing BVPrP were susceptible to both mouse and hamster prions, whereas cells expressing MoPrP or HaPrP could only be infected with species-matched prions. Propagation of mouse and hamster prions in cells expressing BVPrP resulted in strain adaptation in several instances, as evidenced by alterations in conformational stability, glycosylation, susceptibility to anti-prion small molecules, and the inability of BVPrP-adapted mouse prion strains to infect cells expressing MoPrP. Interestingly, cells expressing BVPrP containing the G127V prion gene variant, identified in individuals resistant to kuru, were unable to become infected with prions. Moreover, the G127V polymorphic variant impeded the spontaneous aggregation of recombinant BVPrP. These results demonstrate that BVPrP can facilitate cross-species prion replication in cultured cells and that a single amino acid change can override the prion-permissive nature of BVPrP. This cellular paradigm will be useful for dissecting the molecular features of BVPrP that allow it to function as a universal prion acceptor.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b5e2cb3cc1710d56693d433da99b6d8Test
https://doi.org/10.1111/jnc.15739Test

المؤلفون: Omar I Ahmed, Lehadh M Al-Azzawi

المصدر: Journal of Baghdad College of Dentistry, Vol 32, Iss 3 (2020)

مصطلحات موضوعية: Dentistry, RK1-715

الوصف: Background: The grading systems of salivary mucoepidermoid carcinoma depend on different histologic and morphologic features. The aim of this study was to compare between Auclair and Brandwein systems according to their histologic criteria, and the type of cell predominant. Materials and Methods: Twenty-one case included hematoxylin-eosin (H&E) stained tissue slides that were diagnosed as MEC, originally categorized into low and high grade type regardless of the grading system, have meticulously undergone histopathologic review. The sample was graded according to criteria owing to Auclair and Brandwein methods. The predominant type of cells was determined by microscopic examination according to grade of tumor. Results: Regarding the Auclair method, 10 cases (47.6%) were low grade tumor, 11 cases (52.2%) were high grade type and none of them were intermediate type. By using Brandwein system for the same sample, 4 cases (19%) were low grade, 13 cases (61%) were a high grade tumor, and 4 cases (19%) were intermediate type. Even though, for both systems more than 35% of cases were predominated with epidermoid cells, and 30% were exhibited a mixed type of tumor cells. However, there was a significant correlation between the grading systems applied and the type of cell predominance (p-value

وصف الملف: electronic resource

العلاقة: https://jbcd.uobaghdad.edu.iq/index.php/jbcd/article/view/2895Test; https://doaj.org/toc/2311-5270Test

الوصول الحر: https://doaj.org/article/560c132bcde74332a808920998e953f6Test

المؤلفون: M Al Azzawi, O Kelly, I Welaratne, A Sartini Bhrearhnach, A McGuire, E Stanley, M Kell, M Stokes, M Barry, S Walsh, A Heeney

المصدر: British Journal of Surgery. 110

مصطلحات موضوعية: Surgery

الوصف: Introduction Magnetic seeds (Magseeds) are becoming increasingly used as a method of localising non-palpable breast lesions. The cost effectiveness and reduced scheduling conflicts in comparison with wire localization has led to increased popularity in recent years. There's a paucity of data on outcomes when using multiple magseeds in one breast. In this study, we assess the radiological, operative and pathological outcomes of inserting multiple magseeds in the same breast. Methods A retrospective analysis of all magseed guided excisions preformed at the MMUH breast surgery department between January 2020 and December 2022. 40 patients with more than one magseed inserted unilaterally were included. Primary outcome measures were successful excision of lesion(s) and magseed retrieval. Secondary outcomes included re-excision rate and perioperative complications. Results The mean distance between magseeds was 48.3 and 42.5 mm on ML and CC views respectively. 9/40 used magseeds for bracketing while the rest used for excision of discrete lesions. Mean operative time was 56.65 minutes and 55% of the procedures were wide local excisions. There was no reported difficulties identifying magseeds intra-operatively or in the specimen mammogram. The mean specimen size is 33.42 mm while the mean size of the final lesion is 15.49 mm. Invasive ductal carcinoma was the commonest pathological outcome. The rate of positive margins was 20% and re-excision was 15%. One patient proceeded to completion mastectomy. Conclusion Multiple magseed localisation is a feasible, safe and effective method when utilized in bracketing a unifocal lesion or separate lesion excisions in unilateral breast surgery.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::c703b8d34a374bd52f64208fbaa56639Test
https://doi.org/10.1093/bjs/znad101.074Test

المؤلفون: Zaid A M, Al-Azzawi, Saman, Arfaie, Ziv, Gan-Or

المصدر: Journal of Parkinson's Disease. 12:S53-S64

مصطلحات موضوعية: Inflammation, Cellular and Molecular Neuroscience, Immune System, Mutation, Glucosylceramidase, Humans, Parkinson Disease, Neurology (clinical)

الوصف: It is clear that the immune system and inflammation have a role in Parkinson’s disease (PD), including sporadic PD and some genetic forms such as LRRK2-associated PD. One of the most important genes associated with PD is GBA1, as variants in this gene are found in 5–20% of PD patients in different populations worldwide. Biallelic variants in GBA1 may cause Gaucher disease, a lysosomal storage disorder with involvement of the immune system, and other lines of evidence link GBA1 to the immune system and inflammation. In this review, we discuss these different pieces of evidence and whether the interplay between GBA1 and the immune system may have a role in PD.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff2497038b44c735059e4a0ae8abef6fTest
https://doi.org/10.3233/jpd-223423Test

المؤلفون: Mohammed S. M. Al-Azzawi, Simone Kefer, Jana Weißer, Julia Reichel, Christoph Schwaller, Karl Glas, Oliver Knoop, Jörg E. Drewes

المصدر: Water; Volume 12; Issue 9; Pages: 2445

مصطلحات موضوعية: microplastics, wastewater, Fenton reaction, hydrogen peroxide, digestion methods, sample preparation

جغرافية الموضوع: agris

الوصف: There is a growing interest in monitoring microplastics in the environment, corresponding to increased public concerns regarding their potential adverse effects on ecosystems. Monitoring microplastics in the environment is difficult due to the complex matrices that can prevent reliable analysis if samples are not properly prepared first. Unfortunately, sample preparation methods are not yet standardized, and the various efforts to validate them overlook key aspects. The goal of this study was to develop a sample preparation method for wastewater samples, which removes natural organic matter without altering the properties of microplastics. Three protocols, based on KOH, H2O2, and Fenton reactions, were chosen out of ten protocols after a literature review and pre-experiments. In order to investigate the effects of these reagents on seven polymers (PS, PE, PET, PP, PA, PVC, and PLA), this study employed µFTIR, laser diffraction-based particle size analysis, as well as TD-Pyr-GC/MS. Furthermore, the study discussed issues and inconsistencies with the Fenton reactions reported in the literature in previous validation efforts. The findings of this study suggest that both H2O2 and Fenton reactions are most effective in terms of organic matter removal from microplastic samples while not affecting the tested polymers, whereas KOH dissolved most PLA and PET particles.

وصف الملف: application/pdf

العلاقة: Water Quality and Contamination; https://dx.doi.org/10.3390/w12092445Test

الإتاحة: https://doi.org/10.3390/w12092445Test