المؤلفون: Debanjan Rana, Philipp M. Pflüger, Niklas P. Hölter, Guangying Tan, Frank Glorius

المصدر: ACS Central Science, Vol 10, Iss 4, Pp 899-906 (2024)

مصطلحات موضوعية: Chemistry, QD1-999

وصف الملف: electronic resource

العلاقة: https://doaj.org/toc/2374-7951Test

الوصول الحر: https://doaj.org/article/82eb5009381d40a8863f42235d2ff303Test

المؤلفون: M Pflüger, F Leo, P Seipp, S Darb-Esfahani, H Kreipe, D Wormanns, C Grohé

المصدر: 63. Kongress der Deutschen Gesellschaft für Pneumologie und Beatmungsmedizin e. V..

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::cbe13992efb54f1a57cf122a419a8b5bTest
https://doi.org/10.1055/s-0043-1761125Test

المؤلفون: A Bach, Joachim Steffens, Jennifer Kranz, J. Rosellen, M Pflüger

المصدر: Der Urologe. 59:1371-1376

مصطلحات موضوعية: Gynecology, 03 medical and health sciences, medicine.medical_specialty, 0302 clinical medicine, business.industry, Geriatric care, 030220 oncology & carcinogenesis, Urology, 030232 urology & nephrology, Medicine, Treatment strategy, business

الوصف: Penile Paraffinome sind Folge einer Injektion von Mineralolen zur Augmentation. Als Folge der Fremdkorperreaktion kommt es hiernach regelhaft zu lokalen Komplikationen, welche eine plastisch-rekonstruktive Intervention erfordern. In unserer Klinik wurden im Zeitraum von 20 Jahren 8 Falle operativ versorgt. Die operativen Therapieoptionen bei penilen Paraffinomen sowie deren Indikation und moglichen Komplikationen werden im Rahmen dieses Manuskriptes systematisch dargestellt. Wir fuhrten eine Recherche der themenrelevanten Literatur durch und analysierten die Daten unseres eigenen Patientenguts. Insgesamt stellten sich seit 1999 8 Patienten mit einem Lipogranulom zur operativen Behandlung im St.-Antonius Hospital in Eschweiler vor. Die Wahl des plastisch-rekonstruktiven Verfahrens ist abhangig vom Ausmas des Paraffinoms. Bei einem isolierten Befall der Vorhaut ist eine radikale Zirkumzision zielfuhrend, bei einer Ausdehnung auf die Penisschafthaut erfolgt nach der Resektion eine plastische Defektdeckung mit Spalt- oder Vollhaut oder einer skrotalen Lappenplastik. Bei koinzidenten komplexen Pathologien wie einer Harnrohrenfistel kommen zusatzliche rekonstruktive Verfahren zur Anwendung. Zur Erzielung eines bestmoglichen kosmetischen und funktionellen Resultats muss der Operateur ein breites Spektrum an plastisch-rekonstruktiven Techniken beherrschen. In ausgewahlten komplexen Fallen kann ein interdisziplinares Vorgehen zwischen Urologen und plastischen Chirurgen notwendig sein.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::fcd822379edbebad0b5b764560fef421Test
https://doi.org/10.1007/s00120-020-01322-6Test

المؤلفون: J, Rosellen, M, Pflüger, A, Bach, J, Steffens, J, Kranz

المصدر: Der Urologe. Ausg. A. 59(11)

مصطلحات موضوعية: Male, Foreskin, Scrotum, Humans, Plastic Surgery Procedures, Surgical Flaps, Penis

الوصف: Penile paraffinomas are a consequence of an injection of mineral oils for augmentation. As an result of the foreign body reaction local complications regularly occur, which require a plastic reconstructive intervention. So far 8 cases have been treated in our clinic over the last 20 years.Presentation of the operative treatment techniques for penile paraffinoma as well as the indications and complications.After reviewing the relevant literature, we analyzed the data of our own patient cohort. Since 1999 a total of 8 patients with lipogranuloma underwent surgical treatment at the St. Antonius Hospital in Eschweiler.The choice of a plastic reconstructive treatment depends on the extent of the paraffinoma. If it is limited to the foreskin, a radical circumcision is sufficient but if it extends to the skin of the penile shaft, a plastic defect coverage with a mesh graft, a full skin graft or a scrotal skin flap is required. In cases with additional pathologies, such as urethral fistulas, auxiliary reconstructive procedures should be performed.For optimal cosmetic and functional results, the surgeon must master a broad spectrum of plastic reconstructive techniques. In selected complex cases an interdisciplinary approach consisting of urologists and plastic surgeons can be necessary.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=pmid________::a8eb28333976e83fbeec8f2fa35e15e9Test
https://pubmed.ncbi.nlm.nih.gov/32930825Test

المؤلفون: Victor A. David, Solveig M. Pflueger, Kerstin Lindblad-toh, Claire M. Wade C, Stephen J. O’brien A, Warren E. Johnson A

المساهمون: The Pennsylvania State University CiteSeerX Archives

المصدر: http://media.washingtonpost.com/wp-srv/nation/science/documents/031708/sciencedirect2.pdfTest.

مصطلحات موضوعية: evolved members of the Felidae, a family that has generated

الوصف: Available online at www.sciencedirect.com

وصف الملف: application/pdf

العلاقة: http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.324.5112Test; http://media.washingtonpost.com/wp-srv/nation/science/documents/031708/sciencedirect2.pdfTest

الإتاحة: http://media.washingtonpost.com/wp-srv/nation/science/documents/031708/sciencedirect2.pdfTest

المؤلفون: Peter Dal-Bianco, P Mattos, Johann Lehrner, Gisela Pusswald, Andreas Gleiss, Eduard Auff, M Pflüger, Elisabeth Stögmann, G Coutinho, Doris Moser

المصدر: International Psychogeriatrics. 29:1123-1135

مصطلحات موضوعية: Male, medicine.medical_specialty, Vocabulary, media_common.quotation_subject, Disease, Neuropsychological Tests, Audiology, 050105 experimental psychology, 03 medical and health sciences, 0302 clinical medicine, Alzheimer Disease, Memory, Humans, Medicine, Dementia, Semantic memory, Cognitive Dysfunction, 0501 psychology and cognitive sciences, Prospective Studies, Cognitive decline, Association (psychology), Depressive symptoms, Aged, media_common, Depression, business.industry, 05 social sciences, Middle Aged, medicine.disease, Semantics, Psychiatry and Mental health, Clinical Psychology, Logistic Models, Austria, Case-Control Studies, Female, Geriatrics and Gerontology, Alzheimer's disease, business, Gerontology, 030217 neurology & neurosurgery

الوصف: Background:Semantic memory may be impaired in clinically recognized states of cognitive impairment. We investigated the relationship between semantic memory and depressive symptoms (DS) in patients with cognitive impairment.Methods:323 cognitively healthy controls and 848 patients with subjective cognitive decline (SCD), mild cognitive impairment (MCI), and Alzheimer's disease (AD) dementia were included. Semantic knowledge for famous faces, world capitals, and word vocabulary was investigated.Results:Compared to healthy controls, we found a statistically significant difference of semantic knowledge in the MCI groups and the AD group, respectively. Results of the SCD group were mixed. However, two of the three semantic memory measures (world capitals and word vocabulary) showed a significant association with DS.Conclusions:We found a difference in semantic memory performance in MCI and AD as well as an association with DS. Results suggest that the difference in semantic memory is due to a storage loss rather than to a retrieval problem.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4445bfb6208a5b61fad46487c8c9aed3Test
https://doi.org/10.1017/s1041610217000394Test

المؤلفون: Eduard Auff, Andreas Gleiss, Elisabeth Stögmann, Peter Dal-Bianco, Johann Lehrner, Gisela Pusswald, Doris Moser, M Pflüger

المصدر: International Psychogeriatrics. 28:2045-2054

مصطلحات موضوعية: Male, Health Status, Context (language use), Diagnostic Self Evaluation, 03 medical and health sciences, Cognition, 0302 clinical medicine, Quality of life, Alzheimer Disease, Interview, Psychological, medicine, Humans, Dementia, Cognitive Dysfunction, Cognitive decline, Aged, 030214 geriatrics, Depression, business.industry, Neuropsychology, Mental Status and Dementia Tests, medicine.disease, Mental health, Psychiatry and Mental health, Clinical Psychology, Austria, Quality of Life, Female, Geriatrics and Gerontology, Alzheimer's disease, business, Gerontology, 030217 neurology & neurosurgery, Clinical psychology

الوصف: Background:Health-related quality of life (HRQOL) is an important issue in the context of dementia care. The purpose of this study was to investigate the association between HRQOL and depressive symptoms in patients with subjective cognitive decline (SCD) and subtypes of mild cognitive impairment (MCI) and Alzheimer´s disease (AD).Methods:In this cross-sectional, observational study, a control group and four experimental groups (SCD, non-amnestic MCI, amnesticMCI, AD) were compared. Neuropsychological measurers (NTBV) and psychological questionnaires were used for data collection.Results:The control group scored higher than patients with SCD, naMCI, aMCI, or AD for the Mental Health Component Score (MHCS) of the Short Form of the Health Survey (SF-36). The Physical Health Component Score (PHCS) of the SF-36 differed only between some groups. Furthermore, cognitive variables were more strongly associated with the physical aspects of HRQOL, whereas depressive symptoms were more strongly related with the mental aspects of HRQOL.Conclusions:HRQOL and depressive symptoms are closely related in patients with cognitive impairments. Therefore, it is of great importance to assess patients with subjective impairment carefully in terms of depressive symptoms.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83dcef7a8d730472a4c3b1007c6f5a37Test
https://doi.org/10.1017/s1041610216001289Test

المؤلفون: Walter Pirker, L. Schröder, Jakob Pietschnig, Ilse Kryspin-Exner, Johann Lehrner, M Pflüger, Doris Moser, Eduard Auff, I. Ratheiser, Gisela Pusswald

المصدر: International Psychogeriatrics. 28:1165-1179

مصطلحات موضوعية: Male, medicine.medical_specialty, Parkinson's disease, Emotions, Statistics as Topic, Disease, Neuropsychological Tests, Audiology, 050105 experimental psychology, Developmental psychology, 03 medical and health sciences, Cognition, Sex Factors, 0302 clinical medicine, Task Performance and Analysis, mental disorders, Humans, Medicine, 0501 psychology and cognitive sciences, In patient, Association (psychology), Depression (differential diagnoses), Aged, medicine.diagnostic_test, Depression, business.industry, 05 social sciences, Age Factors, Beck Depression Inventory, Parkinson Disease, Neuropsychological test, Middle Aged, Mental Status and Dementia Tests, medicine.disease, Psychiatry and Mental health, Clinical Psychology, Austria, Female, Geriatrics and Gerontology, business, Facial Recognition, Gerontology, 030217 neurology & neurosurgery

الوصف: Background:Impairments in facial emotion recognition (FER) have been detected in patients with Parkinson disease (PD). Presently, we aim at assessing differences in emotion recognition performance in PD patient groups with and without mild forms of cognitive impairment (MCI) compared to healthy controls.Methods:Performance on a concise emotion recognition test battery (VERT-K) of three groups of 97 PD patients was compared with an age-equivalent sample of 168 healthy controls. Patients were categorized into groups according to two well-established classifications of MCI according to Petersen's (cognitively intact vs. amnestic MCI, aMCI, vs. non-amnestic MCI, non-aMCI) and Litvan's (cognitively intact vs. single-domain MCI, sMCI, vs. multi-domain MCI, mMCI) criteria. Patients and controls underwent individual assessments using a comprehensive neuropsychological test battery examining attention, executive functioning, language, and memory (Neuropsychological Test Battery Vienna, NTBV), the Beck Depression Inventory, and a measure of premorbid IQ (WST).Results:Cognitively intact PD patients and patients with MCI in PD (PD-MCI) showed significantly worse emotion recognition performance when compared to healthy controls. Between-groups effect sizes were substantial, showing non-trivial effects in all comparisons (Cohen's ds from 0.31 to 1.22). Moreover, emotion recognition performance was higher in women, positively associated with premorbid IQ and negatively associated with age. Depressive symptoms were not related to FER.Conclusions:The present investigation yields further evidence for impaired FER in PD. Interestingly, our data suggest FER deficits even in cognitively intact PD patients indicating FER dysfunction prior to the development of overt cognitive dysfunction. Age showed a negative association whereas IQ showed a positive association with FER.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25fef0e9f4a77f46a5b2738f1c44ae43Test
https://doi.org/10.1017/s104161021600034xTest

المؤلفون: Michael Hummel, M Pflüger, Sandra Hummel, Anette-G. Ziegler, Ezio Bonifacio

المصدر: Diabetes Care. 34:1301-1305

مصطلحات موضوعية: medicine.medical_specialty, Endocrinology, Diabetes and Metabolism, medicine.medical_treatment, medicine.disease_cause, law.invention, Autoimmunity, Randomized controlled trial, law, Internal medicine, Diabetes mellitus, Internal Medicine, medicine, Family history, Advanced and Specialized Nursing, chemistry.chemical_classification, Type 1 diabetes, geography, geography.geographical_feature_category, business.industry, Insulin, medicine.disease, Islet, Gluten, chemistry, Immunology, business

الوصف: OBJECTIVE To determine whether delaying the introduction of gluten in infants with a genetic risk of islet autoimmunity is feasible, safe, and may reduce the risk of type 1 diabetes–associated islet autoimmunity. RESEARCH DESIGN AND METHODS A total of 150 infants with a first-degree family history of type 1 diabetes and a risk HLA genotype were randomly assigned to a first gluten exposure at age 6 months (control group) or 12 months (late-exposure group) and were followed 3 monthly until the age of 3 years and yearly thereafter for safety (for growth and autoantibodies to transglutaminase C [TGCAs]), islet autoantibodies to insulin, GAD, insulinoma-associated protein 2, and type 1 diabetes. RESULTS Adherence to the dietary-intervention protocol was reported from 70% of families. During the first 3 years, weight and height were similar in children in the control and late-exposure groups, as was the probability of developing TGCAs (14 vs. 4%; P = 0.1). Eleven children in the control group and 13 children in the late-exposure group developed islet autoantibodies (3-year risk: 12 vs. 13%; P = 0.6). Seven children developed diabetes, including four in the late-exposure group. No significant differences were observed when children were analyzed as per protocol on the basis of the reported first gluten exposure of the children. CONCLUSIONS Delaying gluten exposure until the age of 12 months is safe but does not substantially reduce the risk for islet autoimmunity in genetically at-risk children.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::d8c6845c630fb7af5b0ef4c91d8408daTest
https://doi.org/10.2337/dc10-2456Test

المؤلفون: Anette-G. Ziegler, Christiane Winkler, Sandra Hummel, M. Pflüger

المصدر: Hormone and Metabolic Research. 42:143-148

مصطلحات موضوعية: Adult, Pediatrics, medicine.medical_specialty, Endocrinology, Diabetes and Metabolism, Clinical Biochemistry, Breastfeeding, World Health Organization, Communicable Diseases, Biochemistry, Body Mass Index, Young Adult, Child Development, Endocrinology, Risk Factors, medicine, Humans, Life Tables, Family history, Young adult, First-degree relatives, Infant Nutritional Physiological Phenomena, Type 1 diabetes, Milk, Human, business.industry, Biochemistry (medical), Infant, Newborn, Infant, General Medicine, medicine.disease, Anti-Bacterial Agents, Breast Feeding, Diabetes Mellitus, Type 1, Child, Preschool, Dietary Supplements, Female, Infant Food, business, Breast feeding, Body mass index

الوصف: Infant diet affects health and development. The aim of our study was to investigate WHO infant feeding compliance in children who have a first degree family history of type 1 diabetes (T1D). One hundred and fifty children who were first degree relatives of patients with T1D were intensively followed from birth in the BABYDIET intervention study. Infant feeding, infections, and medication were recorded daily by participating families. Weight and length of children were obtained from paediatric records. Only 5% of the families followed the WHO recommendations for infant feeding that include full breastfeeding for at least 6 months (18.8% of children) and introduction of complementary foods under continued breastfeeding thereafter (22.2% of children). Maternal age in the first quartile (29 years; p0.0001), and maternal smoking (p0.0001) were associated with an earlier introduction of solid food and reduced breastfeeding. Full breastfeedingor =6 months was associated with reduced frequency of gastrointestinal infections (12 vs. 38%, p=0.02) and antibiotic treatment (24 vs. 48%, p=0.04). Our findings indicate that WHO infant feeding recommendations were poorly followed by families with a family history of T1D. Action to improve levels of infant feeding behaviour is essential, especially among young mothers with T1D.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f68f3faaf504934ac15db85f2fbaaaeTest
https://doi.org/10.1055/s-0029-1241830Test