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1دورية أكاديمية
المؤلفون: Lewis, Cora, Torner, James, Felson, David, Yau, Michelle, Okoro, Paul, Haugen, Ida, Nevitt, Michael, Lynch, John
المصدر: Osteoarthritis and Cartilage. 32(5)
مصطلحات موضوعية: Aging, Epigenetics, Osteoarthritis, Humans, Middle Aged, Aging, DNA Methylation, Osteoarthritis, Knee, Risk Factors, Epigenesis, Genetic, Acceleration
الوصف: PURPOSE: Advancing age is one of the strongest risk factors for osteoarthritis (OA). DNA methylation-based measures of epigenetic age acceleration may provide insights into mechanisms underlying OA. METHODS: We analyzed data from the Multicenter Osteoarthritis Study in a subset of 671 participants ages 45-69 years with no or mild radiographic knee OA. DNA methylation was assessed with the Illumina Infinium MethylationEPIC 850K array. We calculated predicted epigenetic age according to Hannum, Horvath, PhenoAge, and GrimAge epigenetic clocks, then regressed epigenetic age on chronological age to obtain the residuals. Associations between the residuals and knee, hand, and multi-joint OA were assessed using logistic regression, adjusted for chronological age, sex, clinical site, smoking status, and race. RESULTS: Twenty-three percent met criteria for radiographic hand OA, 25% met criteria for radiographic knee OA, and 8% met criteria for multi-joint OA. Mean chronological age (SD) was 58.4 (6.7) years. Mean predicted epigenetic age (SD) according to Horvath, Hannum, PhenoAge, and GrimAge epigenetic clocks was 64.9 (6.4), 68.6 (5.9), 50.5 (7.7), and 67.0 (6.2), respectively. Horvath epigenetic age acceleration was not associated with an increased odds of hand OA, odds ratio (95% confidence intervals) = 1.03 (0.99-1.08), with similar findings for knee and multi-joint OA. We found similar magnitudes of associations for Hannum epigenetic age, PhenoAge, and GrimAge acceleration compared to Horvath epigenetic age acceleration. CONCLUSIONS: Epigenetic age acceleration as measured by various well-validated epigenetic clocks based on DNA methylation was not associated with increased risk of knee, hand, or multi-joint OA independent of chronological age.
وصف الملف: application/pdf
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2دورية أكاديمية
المؤلفون: van Buuren, Michiel, Riedstra, Noortje, van den Berg, Myrthe, Boel, Fleur, Ahedi, Harbeer, Arbabi, Vahid, Arden, Nigel, Bierma-Zeinstra, Sita, Boer, Cindy, Cicuttini, Flavia, Cootes, Timothy, Crossley, Kay, Felson, David, Gielis, Willem, Heerey, Joshua, Jones, Graeme, Kluzek, Stefan, Van Meurs, J, Mosler, Andrea, Nelson, Amanda, Nevitt, M, Oei, Edwin, Runhaar, Jos, Tang, Jinchi, Weinans, Harrie, Agricola, Rintje, Lindner, Claudia, Lane, Nancy, Lynch, John
المصدر: BMJ Open. 14(4)
مصطلحات موضوعية: EPIDEMIOLOGY, GENETICS, Hip, RADIOLOGY & IMAGING, RHEUMATOLOGY, Risk Factors, Humans, Female, Male, Osteoarthritis, Hip, Prospective Studies, Radiography, Arthroplasty, Replacement, Hip, Pain, Biomarkers, Osteoarthritis, Knee
الوصف: PURPOSE: Hip osteoarthritis (OA) is a major cause of pain and disability worldwide. Lack of effective therapies may reflect poor knowledge on its aetiology and risk factors, and result in the management of end-stage hip OA with costly joint replacement. The Worldwide Collaboration on OsteoArthritis prediCtion for the Hip (World COACH) consortium was established to pool and harmonise individual participant data from prospective cohort studies. The consortium aims to better understand determinants and risk factors for the development and progression of hip OA, to optimise and automate methods for (imaging) analysis, and to develop a personalised prediction model for hip OA. PARTICIPANTS: World COACH aimed to include participants of prospective cohort studies with ≥200 participants, that have hip imaging data available from at least 2 time points at least 4 years apart. All individual participant data, including clinical data, imaging (data), biochemical markers, questionnaires and genetic data, were collected and pooled into a single, individual-level database. FINDINGS TO DATE: World COACH currently consists of 9 cohorts, with 38 021 participants aged 18-80 years at baseline. Overall, 71% of the participants were women and mean baseline age was 65.3±8.6 years. Over 34 000 participants had baseline pelvic radiographs available, and over 22 000 had an additional pelvic radiograph after 8-12 years of follow-up. Even longer radiographic follow-up (15-25 years) is available for over 6000 of these participants. FUTURE PLANS: The World COACH consortium offers unique opportunities for studies on the relationship between determinants/risk factors and the development or progression of hip OA, by using harmonised data on clinical findings, imaging, biomarkers, genetics and lifestyle. This provides a unique opportunity to develop a personalised hip OA risk prediction model and to optimise methods for imaging analysis of the hip.
وصف الملف: application/pdf
الوصول الحر: https://escholarship.org/uc/item/6n27f4z0Test
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3دورية أكاديمية
المؤلفون: Joseph, Gabby B, Akkaya, Zehra, Sims, Wynton, McCulloch, Charles, Nevitt, Michael, Lynch, John A, Lane, Nancy E, Link, Thomas M
مصطلحات موضوعية: Biomedical and Clinical Sciences, Clinical Sciences, Musculoskeletal, Biomedical Engineering, Human Movement and Sports Sciences, Arthritis & Rheumatology, Clinical sciences, Sports science and exercise
وصف الملف: application/pdf
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4دورية أكاديمية
المؤلفون: Sims, Wynton, Akkaya, Zehra, Joseph, Gabby, Lynch, John A, Gassert, Felix, McCulloch, Charles, Lane, Nancy E, Link, Thomas M
مصطلحات موضوعية: Biomedical and Clinical Sciences, Nutrition and Dietetics, Health Sciences, Biomedical Engineering, Clinical Sciences, Human Movement and Sports Sciences, Arthritis & Rheumatology, Clinical sciences, Sports science and exercise
وصف الملف: application/pdf
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5دورية أكاديمية
المؤلفون: Löffler, Maximilian T, Joseph, Gabby B, Lynch, John A, Lane, Nancy E, Pedoia, Valentina, Majumdar, Sharmila, Nevitt, Michael, McCulloch, Charles, Link, Thomas M
مصطلحات موضوعية: Biomedical and Clinical Sciences, Clinical Sciences, Biomedical Engineering, Human Movement and Sports Sciences, Arthritis & Rheumatology, Clinical sciences, Sports science and exercise
وصف الملف: application/pdf
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6دورية أكاديمية
المؤلفون: Joseph, Gabby B, Akkaya, Zehra, Sims, Wynton, McCulloch, Charles, Nevitt, Michael, Lynch, John A, Lane, Nancy E, Link, Thomas M
مصطلحات موضوعية: Allied Health and Rehabilitation Science, Biomedical and Clinical Sciences, Health Sciences, Biomedical Engineering, Clinical Sciences, Human Movement and Sports Sciences, Arthritis & Rheumatology, Clinical sciences, Sports science and exercise
وصف الملف: application/pdf
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7دورية أكاديمية
المؤلفون: Akkaya, Zehra, Joseph, Gabby B, Lynch, John A, McCulloch, Charles, Gassert, Felix, Pedoia, Valentina, Sims, Wynton, Lane, Nancy E, Link, Thomas M
مصطلحات موضوعية: Biomedical and Clinical Sciences, Nutrition and Dietetics, Biomedical Engineering, Clinical Sciences, Human Movement and Sports Sciences, Arthritis & Rheumatology, Clinical sciences, Sports science and exercise
وصف الملف: application/pdf
الوصول الحر: https://escholarship.org/uc/item/0dr150shTest
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8دورية أكاديمية
المؤلفون: Löffler, Maximilian T, Ngarmsrikam, Chotigar, Giesler, Paula, Joseph, Gabby B, Akkaya, Zehra, Lynch, John A, Lane, Nancy E, Nevitt, Michael, McCulloch, Charles E, Link, Thomas M
المصدر: BMC Musculoskeletal Disorders. 25(1)
مصطلحات موضوعية: Biomedical and Clinical Sciences, Clinical Sciences, Health Sciences, Clinical Research, Biomedical Imaging, Aging, Arthritis, Obesity, Nutrition, Metabolic and endocrine, Humans, Female, Aged, Osteoarthritis, Knee, Overweight, Knee Joint, Subcutaneous Fat, Synovitis, Magnetic Resonance Imaging, Inflammation, Weight Loss, Osteoarthritis, Weight loss, Mediation analysis, Effusion, Hoffa's fat pad, Hoffa’s fat pad, Orthopedics, Clinical sciences, Allied health and rehabilitation science, Sports science and exercise
الوصف: BackgroundObesity influences the development of osteoarthritis via low-grade inflammation. Progression of local inflammation (= synovitis) increased with weight gain in overweight and obese women compared to stable weight. Synovitis could be associated with subcutaneous fat (SCF) around the knee. Purpose of the study was to investigate the effect of weight loss on synovitis progression and to assess whether SCF around the knee mediates the relationship between weight loss and synovitis progression.MethodsWe included 234 overweight and obese participants (body mass index [BMI] ≥ 25 kg/m2) from the Osteoarthritis Initiative (OAI) with > 10% weight loss (n = 117) or stable overweight (
وصف الملف: application/pdf
الوصول الحر: https://escholarship.org/uc/item/8k8262kqTest
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9دورية أكاديمية
المؤلفون: Joseph, Gabby B, Takakusagi, Melia, Arcilla, Gino, Lynch, John A, Pedoia, Valentina, Majumdar, Sharmila, Lane, Nancy E, Nevitt, Michael C, McCulloch, Charles E, Link, Thomas M
المصدر: Osteoarthritis and Cartilage. 31(11)
مصطلحات موضوعية: Biomedical and Clinical Sciences, Health Sciences, Clinical Sciences, Sports Science and Exercise, Osteoarthritis, Aging, Prevention, Clinical Research, Arthritis, Obesity, Nutrition, Aetiology, 2.1 Biological and endogenous factors, Metabolic and endocrine, Musculoskeletal, Humans, Overweight, Osteoarthritis, Knee, Cartilage, Articular, Knee Joint, Subcutaneous Fat, Magnetic Resonance Imaging, Knee subcutaneous fat, Cartilage thickness, Weight change, MRI, Biomedical Engineering, Human Movement and Sports Sciences, Arthritis & Rheumatology, Clinical sciences, Sports science and exercise
الوصف: ObjectiveTo assess (i) the impact of changes in body weight on changes in joint-adjacent subcutaneous fat (SCF) and cartilage thickness over 4 years and (ii) the relation between changes in joint-adjacent SCF and knee cartilage thickness.DesignIndividuals from the Osteoarthritis Initiative (total=399) with > 10% weight gain (n=100) and > 10% weight loss (n=100) over 4 years were compared to a matched control cohort with less than 3% change in weight (n=199). 3.0T Magnetic Resonance Imaging (MRI) of the right knee was performed at baseline and after 4 years to quantify joint-adjacent SCF and cartilage thickness. Linear regression models were used to evaluate the associations between the (i) weight change group and 4-year changes in both knee SCF and cartilage thickness, and (ii) 4-year changes in knee SCF and in cartilage thickness. Analyses were adjusted for age, sex, baseline body mass index (BMI), tibial diameter (and weight change group in analysis (ii)).ResultsIndividuals who lost weight over 4-years had significantly less joint-adjacent SCF (beta range, medial/lateral joint sides: 2.2-4.2 mm, p
وصف الملف: application/pdf
الوصول الحر: https://escholarship.org/uc/item/0k68m86zTest
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10دورية أكاديمية
المؤلفون: Chambers, Caitlin C, Lynch, John A, Feeley, Brian T, Nevitt, Michael C
المصدر: Orthopaedic Journal of Sports Medicine. 11(9)
مصطلحات موضوعية: Biomedical and Clinical Sciences, Ophthalmology and Optometry, Osteoarthritis, Clinical Research, Arthritis, Musculoskeletal, knee osteoarthritis, medial meniscal tear, meniscus root, meniscus root tear, Clinical Sciences, Human Movement and Sports Sciences, Clinical sciences, Sports science and exercise
الوصف: BackgroundMedial meniscus root tears (RTs) are associated with the development and worsening of knee osteoarthritis (OA), but little is known about their progression when compared with meniscal tears that spare the root (nonroot tears; NRTs).PurposeTo compare radiographic worsening of OA in knees with RTs versus NRTs and to identify factors associated with radiographic worsening of OA in knees with RTs.Study designCohort study; Level of evidence, 3.MethodsUsing the Osteoarthritis Initiative database, we included knees with medial meniscus RTs and NRTs present at the baseline visit (baseline tears) and new RTs and NRTs observed at 12- to 48-month annual follow-up visits (incident tears). Worsening of radiographic OA was defined for baseline tears as an increase in Kellgren-Lawrence grade (KLG) during the subsequent 12 months of follow-up; for incident tears, worsening was defined as either concurrent (increase in KLG over the 12 months preceding tear appearance on magnetic resonance imaging) or subsequent (increase in KLG during the 12 months after tear appearance). Odds ratios (ORs), adjusted for covariates, were calculated for the association of worsening by type of tear.ResultsIncluded were 39 knees with baseline RTs, 633 knees with baseline NRTs, 33 knees with incident RTs, and 234 knees with incident NRTs. Radiographic OA worsening subsequent to meniscal tear identification was no different for baseline RTs (15%) or baseline NRTs (14%; adjusted OR, 1.34; 95% CI, 0.52-3.47), nor did subsequent worsening differ for incident RTs (19%) versus incident NRTs (18%; adjusted OR, 0.52; 95% CI, 0.15-1.83). Concurrent radiographic OA worsening was seen at a significantly higher rate for incident RTs (64%) versus incident NRTs (21%; adjusted OR, 3.00; 95% CI, 1.21-7.47). Incident RTs in knees without radiographic OA (KLG 0-1) before the tear had a high rate of worsening (94%, n = 16) and were more likely to worsen than those in knees with radiographic OA (KLG ≥2) present before the tear.ConclusionCompared with NRTs, incident RTs were associated with a significantly increased risk of worsening radiographic OA over a 12-month period concurrent with the appearance of the tear. Incident RTs in knees without radiographic OA at baseline had a high rate of worsening.
وصف الملف: application/pdf
الوصول الحر: https://escholarship.org/uc/item/1tv6h30qTest
