المؤلفون: Hamid Nasrollahi, Susan Andalibi, Mansour Ansari, Maral Mokhtari, Ehsan Mohammad Hosseini, Mina Foroughi, Arman Sourani

المصدر: Clinical Case Reports, Vol 12, Iss 6, Pp n/a-n/a (2024)

مصطلحات موضوعية: brain tumors, lymphoproliferative diseases, Rosai–Dorfman disease, sinus histiocytosis with massive lymphadenopathy, stereotactic biopsy, targeted radiotherapy, Medicine, Medicine (General), R5-920

الوصف: Key Clinical Message Intracranial RDD is rare medical event mimicking different diagnoses. Although the surgical resection is the best treatment option, but radiation therapy can also achieves long‐term suboptimal outcomes. Abstract An 83‐year‐old male with a history of tension‐type headaches was evaluated. He was conscious with no focal neurological deficits. His brain MRI revealed an enhancable bifrontal tumor originating from falx cerebri and superior sagittal sinus dura. Due to the patient's preference and decline for gross total resection, she underwent a stereotactic biopsy. The pathology was positive for Rosai–Dorfman diseases. He received definitive targeted radiation with a total dose of 4500 cGy administered in 200 cGy daily fractions. His 4‐year follow‐up showed regional tumor control with excellent neurological outcome.

وصف الملف: electronic resource

العلاقة: https://doaj.org/toc/2050-0904Test

الوصول الحر: https://doaj.org/article/81814184bf324cdeb4bfeebed7127b9dTest

المؤلفون: Lali G. Babicheva, Alexey V. Luntsov, Gulnara N. Khusainova, Irina V. Poddubnaya

المصدر: Современная онкология, Vol 25, Iss 3, Pp 365-372 (2023)

مصطلحات موضوعية: primary immunodeficiency, secondary immunodeficiency, immunoglobulins, privigen, b-cell lymphoproliferative diseases, infectious complications, lymphoma, multiple myeloma, chronic lymphocytic leukemia, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

الوصف: Immunodeficiency occurs when one or more immune system components do not function properly, resulting in the body's inability to resist mostly infectious agents. Most cases of immunodeficiency in adults are acquired (secondary), but congenital immunodeficiencies are not uncommon. Primary immunodeficiencies are a heterogeneous group of innate immune errors that result in various clinical and laboratory manifestations. In contrast, secondary immunodeficiencies involve an acquired decrease in immune cell count and/or impairment of their function, commonly associated with an antibody level decrease. Secondary immunodeficiency in patients with B-cell hematological malignancies is a common condition attributed to both hematological malignancy and secondary antitumor therapy-related causes. Paradoxically, immunodeficiency, initially attributed to secondary causes, may be due to a previously undiagnosed primary immunodeficiency. Early diagnosis of immunodeficiency and optimization of management strategies with a multidisciplinary approach are critical to providing the most effective specific treatments and reducing the incidence of infection-related complications and mortality. The article addresses clinical practice, recommendations, and problems of immunodeficiency diagnosis and the effectiveness of immunoglobulin replacement therapy illustrated by clinical cases.

وصف الملف: electronic resource

العلاقة: https://modernonco.orscience.ru/1815-1434/article/viewFile/607331/pdfTest; https://doaj.org/toc/1815-1434Test; https://doaj.org/toc/1815-1442Test

الوصول الحر: https://doaj.org/article/74994965972145db9f9ed975af3fac71Test

المؤلفون: Jie Liu, Zhiyuan Jin, Bangzhi Sui, Guangqi Duan

المصدر: Asian Journal of Surgery, Vol 46, Iss 11, Pp 4988-4990 (2023)

مصطلحات موضوعية: Chylous abdomen, Epstein–Barr Virus-Associated T lymphoproliferative diseases, Rare, Children, Case report, Surgery, RD1-811

وصف الملف: electronic resource

العلاقة: http://www.sciencedirect.com/science/article/pii/S1015958423008941Test; https://doaj.org/toc/1015-9584Test

الوصول الحر: https://doaj.org/article/47b94a4aa4c74018a790dfb106b690d8Test

المؤلفون: Raffaele Sciaccotta, Sebastiano Gangemi, Giuseppa Penna, Laura Giordano, Giovanni Pioggia, Alessandro Allegra

المصدر: Antioxidants, Vol 13, Iss 4, p 475 (2024)

مصطلحات موضوعية: reactive oxygen species, chronic lymphocytic leukemia, apoptosis, oxidative stress, lymphoproliferative diseases, Therapeutics. Pharmacology, RM1-950

الوصف: Chronic lymphocytic leukemia, in spite of recent advancements, is still an incurable disease; the majority of patients eventually acquire resistance to treatment through relapses. In all subtypes of chronic lymphocytic leukemia, the disruption of normal B-cell homeostasis is thought to be mostly caused by the absence of apoptosis. Consequently, apoptosis induction is crucial to the management of this illness. Damaged biological components can accumulate as a result of the oxidation of intracellular lipids, proteins, and DNA by reactive oxygen species. It is possible that cancer cells are more susceptible to apoptosis because of their increased production of reactive oxygen species. An excess of reactive oxygen species can lead to oxidative stress, which can harm biological elements like DNA and trigger apoptotic pathways that cause planned cell death. In order to upset the balance of oxidative stress in cells, recent therapeutic treatments in chronic lymphocytic leukemia have focused on either producing reactive oxygen species or inhibiting it. Examples include targets created in the field of nanomedicine, natural extracts and nutraceuticals, tailored therapy using biomarkers, and metabolic targets. Current developments in the complex connection between apoptosis, particularly ferroptosis and its involvement in epigenomics and alterations, have created a new paradigm.

وصف الملف: electronic resource

العلاقة: https://www.mdpi.com/2076-3921/13/4/475Test; https://doaj.org/toc/2076-3921Test

الوصول الحر: https://doaj.org/article/195ff18ddfcc40e887085403bef4af96Test

المؤلفون: V. i. Vasiljev, N. A. Probatova, N. N. Tupitsyn, E. Y. Varlamova, O. A. Logvinenko, A. M. Kovrigina, E. M. Sholohova, M. V. Simonova, T. N. Safonova, V. R. Gorodetsky, N. V. Kokosadze, A. M. Pavlovskaya, T. N. Kondratjeva, Z. G. Kadagidze, E. V. Gayduk

المصدر: Онкогематология, Vol 0, Iss 3, Pp 16-26 (2022)

مصطلحات موضوعية: primary sjogren's syndrome, non-hodgkin's lymphoma, lymphoproliferative diseases, Diseases of the blood and blood-forming organs, RC633-647.5

الوصف: During long term follow up (median 10 years) of 412 patients with primary Sjogren's syndrome (pSS) 46; (11,2%) women developed non-Hodgkin's lymphoma (NHL). Median pSS duration before development of NHL was 17 years. 43 (93,3%) patients had B-cell and 3 (6,7%) - T-cell NHL. All types of NHL were present except precursor cell lymphomas. Diffuse large B-cell lymphoma (LBCL) (39%) and MALT lymphomas (21%) prevailed. Nodal NHL with extranodal involvement (52,2%) were the most frequent. Nodal (21,8%) and extranodal (26%) lymphomas were less frequent. The most frequent target organs in lymphoproliferative disease (LPD) were lymph nodes (74%), salivary glands (45,5%), lungs (26%), bone marrow (19,5%), liver (17,5%), spleen (13%), lachrymal glands (6,5%). Waldeyer's throat ring (4%), oral cavity mucous membrane, ovary and brain (2%) were involved rarely. Immunoglobulin-secreting variant of lymphoma was revealed in 53,7% of cases. LPD developed predominantly in patients with systemic features and late stage of pSS. Significant increase of parotis, mixed monoclonal cryoglobulinemia, generalized lymphadenopathy, presence of more than 5 focuses of lymphoid infiltration in small salivary glands biopsies and thrombocytopenia were predictors of NHL development in pSS (p

وصف الملف: electronic resource

العلاقة: https://oncohematology.abvpress.ru/ongm/article/view/615Test; https://doaj.org/toc/1818-8346Test; https://doaj.org/toc/2413-4023Test

الوصول الحر: https://doaj.org/article/8a947f2af17e42a58b1c3ea1e6aded5bTest

المؤلفون: Martina Pelagalli, Flaminia Tomassetti, Eleonora Nicolai, Alfredo Giovannelli, Silvia Codella, Mariannina Iozzo, Renato Massoud, Roberto Secchi, Adriano Venditti, Massimo Pieri, Sergio Bernardini

المصدر: Diseases, Vol 11, Iss 4, p 169 (2023)

مصطلحات موضوعية: ESR, lymphoproliferative diseases, myeloproliferative diseases, cancer, Medicine

الوصف: (1) Background: The erythrocyte sedimentation rate (ESR) is widely diffused in hematology laboratories to monitor inflammatory statuses, response to therapies (such as antibiotics), and oncologic diseases. However, ESR is not a specific diagnostic marker but needs to be contextualized and compared with clinical and other laboratory findings. This study aimed to investigate the performance of two automated instruments, namely the DIESSE CUBE 30 TOUCH (DIESSE, Siena, Italy) and the Alifax Test 1 (Alifax Srl, Polverara, Italy), in comparison with the gold standard, the Westergren method, in lymphoproliferative and myeloproliferative patients. (2) Methods: 97 EDTA samples were selected from the hematology department of Roma Tor Vergata Hospital and analyzed. Statistical analysis was applied. (3) A good correlation between CUBE 30 TOUCH and the gold standard was observed in the overall sample (R2 = 0.90), as well as in patients with lymphoproliferative diseases (R2 = 0.90) and myeloproliferative diseases (R2 = 0.90). The correlation between Test 1 and the gold standard was observed in the overall sample (R2 = 0.68), as well as in patients with lymphoproliferative diseases (R2 = 0.79) and myeloproliferative diseases (R2 = 0.53). (4) Conclusions: The CUBE 30 TOUCH appears to be a more trustworthy tool for evaluating ESR in these pathologies.

وصف الملف: electronic resource

العلاقة: https://www.mdpi.com/2079-9721/11/4/169Test; https://doaj.org/toc/2079-9721Test

الوصول الحر: https://doaj.org/article/22b8227d8ef04784be6153ba8976a424Test

المؤلفون: Jihong Hao, Gao Jie, Yiping Yang, An Ziyi, Xiaoqiang Lian

المصدر: Turkish Journal of Hematology, Vol 40, Iss 3, Pp 202-203 (2023)

مصطلحات موضوعية: cytoplasmic crystals, chronic lymphocytic leukemia, lymphoproliferative diseases, flow cytometry, Diseases of the blood and blood-forming organs, RC633-647.5

وصف الملف: electronic resource

العلاقة: https://jag.journalagent.com/z4/download_fulltext.asp?pdir=tjh&un=TJH-72098Test; https://doaj.org/toc/1308-5263Test

الوصول الحر: https://doaj.org/article/4edb7104965b499c9e9d2024ed69992fTest

المؤلفون: E. Yu. Salakheeva, I. Ya. Sokolova, O. V. Lyapidevskaya, K. A. Zhbanov, S. A. Tsatsurova, N. I. Kanevskiy, V. O. Stebakova, E. V. Privalova, I. S. Ilgisonis, Yu. N. Belenkov, A. A. Shchendrygina

المصدر: Рациональная фармакотерапия в кардиологии, Vol 18, Iss 4, Pp 385-392 (2022)

مصطلحات موضوعية: left atrial myopathy, lymphoproliferative diseases, phase analysis of the left atrium, supraventricular arrhythmias, systemic inflammation, polychemotherapy, cardiotoxicity, Therapeutics. Pharmacology, RM1-950, Diseases of the circulatory (Cardiovascular) system, RC666-701

الوصف: Aim. To assess the structure and performance of left atrium (LA) before and after 3 cycles of anticancer treatment in lymphoma patients, as well as the incidences of supraventricular arrhythmia (SVA) and the levels of biomarkers of inflammation.Material and Methods. This is a prospective observational study of patients with confirmed diagnosis of lymphoma [n=23; 57% men; median age 52 (34;64) years], who had no prior polychemotherapy. The comparison group included persons without lymphoma [n=18; 50% men; median age 43 (37; 54) years] comparable with the main group in terms of sex, age and risk factors for cardiovascular diseases. Patients with lymphoma underwent 24h-ECG monitoring and advanced transthoracic echocardiography at baseline and after 3 cycles (within 3 months) of anticancer treatment. Biomarkers of inflammation were measured. The results were compared with the data of the comparison group.Results. In lymphoma patients, LA reservoir, conduit, and booster function were found to be impaired at baseline but were comparable with these in matched controls. After 3 cycles of anticancer treatment, a trend to reduction of LA booster and conduit strain was found. The proportion of those with SVA was significantly higher in lymphoma patients before chemotherapy compared to those after anti-cancer treatment or controls: 57% vs 10% and 33% respectively (p

وصف الملف: electronic resource

العلاقة: https://www.rpcardio.online/jour/article/view/2787Test; https://doaj.org/toc/1819-6446Test; https://doaj.org/toc/2225-3653Test

الوصول الحر: https://doaj.org/article/9240aeffbbdc46338439833b544c3365Test

المؤلفون: Tong YU, Yan WANG, Tianyu HONG, Hong ZHANG, Xiaomin DUAN

المصدر: CT Lilun yu yingyong yanjiu, Vol 31, Iss 4, Pp 517-530 (2022)

مصطلحات موضوعية: radiology, child, epstein-barr virus, epstein-barr virus associated lymphoproliferative diseases, Geophysics. Cosmic physics, QC801-809, Medicine (General), R5-920

الوصف: Epstein-Barr virus (EBV), also known as a gamma herpesviru, has the characteristics of lymphophilic tissue. EBV is one of the most common human viruses of the human cold virus group and the first human tumor virus found. Infection with EBV occurs by the oral transfer of saliva and respiratory secretions. Human B-lymphocytes and epithelial cells are EBV-susceptible host cells. First EBV infection often occurs in infancy and in childhood. EBV-associated diseases include infectious mononucleosis, EB virus associated hemophagocytic lymphoproliferative disorder (EBV-HLH), chronic active EBV Infection, EBV infection-associated autoimmune disease. EBV infection can also cause the proliferative diseases of the infected cells, such as various non-malignant lymphoproliferative diseases, lymphomatoid granulomatosis, EBV associated with many more malignant diseases including Burkitt′s lymphoma, Hodgkin′s lymphoma, Diffuse Large B-Cell Lymphoma, NK/T cell lymphoma, nasopharyngeal carcinoma, a subset of gastric carcinomas, and many more. This paper mainly focuses on EBV associated lymphoproliferative diseases and imaging characteristics in children.

وصف الملف: electronic resource

العلاقة: https://doaj.org/toc/1004-4140Test

الوصول الحر: https://doaj.org/article/dac501b75b2140e1b18caba4d25e5a58Test

المؤلفون: B. D. Chaltsev, V. I. Vasilyev, I. O. Avetisov, A. V. Torgashina, E. V. Sokol, Yu. I. Khvan, L. P. Ananyeva

المصدر: Научно-практическая ревматология, Vol 60, Iss 2, Pp 214-227 (2022)

مصطلحات موضوعية: primary sjögren’s syndrome, interstitial lung disease, lymphocytic interstitial pneumonia, lymphoproliferative diseases, rituximab, nintadanib, Diseases of the musculoskeletal system, RC925-935

الوصف: The article provides a literature review on the current understanding of respiratory tract damage in primary Sjögren’s syndrome (pSS) with an emphasis on interstitial lung disease (ILD), as well as approaches to the differential diagnosis, treatment, and screening of pSS-ILD.

وصف الملف: electronic resource

العلاقة: https://rsp.mediar-press.net/rsp/article/view/3155Test; https://doaj.org/toc/1995-4484Test; https://doaj.org/toc/1995-4492Test

الوصول الحر: https://doaj.org/article/f2657e79b7434441bb9a1f91d9dba002Test