المؤلفون: Yu Wang, Qiaofang Yang, Luwen Wang, Qingwei Zhang, Yingli Li

المصدر: BMC Nursing, Vol 23, Iss 1, Pp 1-9 (2024)

مصطلحات موضوعية: Job crafting, Emergency nurses, Hierarchical regression model, fsQCA model, Factors, Configuration, Nursing, RT1-120

الوصف: Abstract Background Job crafting is defined as a series of proactive behaviors exhibited by employees in order to balance work resources and needs, which has a significant positive impact on the nurses. It is necessary to find the core factors that influence the job crafting, as emergency nurses deal with the most complex tasks, so as to improve their job satisfaction. Objectives To investigate the core factors of job crafting among emergency nurses. Methods A cross-sectional design was used in the study. A total of 255 nurses were recruited from two hospitals in Zhengzhou and Shenzhen, China in December 2021. 255 nurses completed an online questionnaire. Hierarchical regression models and fsQCA models were used to explore the factors influencing job crafting among emergency nurses and helped us to identify core factors. Results The hierarchical regression model and the fsQCA model found that the occupational benefit, psychological empowerment, and research experience were the core factors affecting their job crafting. Job involvement was not significant in the regression model, but the QCA model indicated that it needs to be combined with other factors to impact on job crafting. The QCA model uncovered seven key conditional configurations that led to high and low job crafting among emergency nurses, explaining 80.0% of the results for high job crafting and 82.6% of the results for the low job crafting, respectively. Conclusions The results of this study provide valuable insights into the job crafting experienced by emergency nurses. Junior emergency nurses should be granted a high level of psychological empowerment without assigning them overly complex tasks, such as research tasks, as these challenges can stop their job crafting. Intermediate and senior emergency nurses, on the other hand, can be assigned research tasks coupled with high psychological empowerment to enhance their job crafting.

وصف الملف: electronic resource

العلاقة: https://doaj.org/toc/1472-6955Test

الوصول الحر: https://doaj.org/article/aec67ba1a5194086895433c5627d99fcTest

المؤلفون: Hang Yu, Hongguo Zhao, Dongxia Liu, Yanhua Dong, Manman Nai, Yikun Song, Jiaxi Liu, Luwen Wang, Lei Li, Xinbin Li

المصدر: Heliyon, Vol 10, Iss 11, Pp e31928- (2024)

مصطلحات موضوعية: Myofascial pelvic pain syndrome, Random forest, Logistic regression, Modified Oxford muscle strength grading, Pelvic floor pressure assessment, Science (General), Q1-390, Social sciences (General), H1-99

الوصف: [Abstract]: Objective: The objective is to construct a random forest model for predicting the occurrence of Myofascial pelvic pain syndrome (MPPS) and compare its performance with a logistic regression model to demonstrate the superiority of the random forest model. Methods: We retrospectively analyze the clinical data of female patients who underwent pelvic floor screening due to chronic pelvic pain at the Pelvic Floor Rehabilitation Center of the Third Affiliated Hospital of Zhengzhou University from January 2021 to December 2023. A total of 543 female patients meeting the study's inclusion and exclusion criteria are randomly selected from this dataset and allocated to the MPPS group. Furthermore, 702 healthy female patients who underwent pelvic floor screening during routine physical examinations within the same timeframe are randomly selected and assigned to the non-MPPS group. Chi-square test and rank-sum test are used to select demographic variables, pelvic floor pressure assessment data variables, and modified Oxford muscle strength grading data for logistic univariate analysis. The selected variables are further subjected to multivariate logistic regression analysis, and a random forest model is also established. The predictive performance of the two models is evaluated by comparing their accuracy, sensitivity, specificity, precision, receiver operating characteristic (ROC) curve, and area under the curve (AUC) area. Results: Based on a dataset of 1245 cases, we implement the random forest algorithm for the first time in the screening of MPPS. In this investigation, the Logistic regression model forecasts the accuracy, sensitivity, specificity, and precision of MPPS at 69.96 %, 57.46 %, 79.63 %, and 68.57 % respectively, with an AUC of the ROC curve at 0.755. Conversely, the random forest prediction model exhibits accuracy, sensitivity, specificity, and precision rates of 87.11 %, 90.66 %, 90.91 %, and 83.51 % respectively, with an AUC of the ROC curve at 0.942. The random forest model showcases exceptional predictive performance during the initial screening of MPPS. Conclusion: The random forest model has exhibited exceptional predictive performance in the initial screening evaluation of MPPS disease. The development of this predictive framework holds significant importance in refining the precision of MPPS prediction within clinical environments and elevating treatment outcomes. This research carries profound global implications, given the potentially elevated misdiagnosis rates and delayed diagnosis proportions of MPPS on a worldwide scale, coupled with a potential scarcity of seasoned healthcare providers. Moving forward, continual refinement and validation of the model will be imperative to further augment the precision of MPPS risk assessment, thereby furnishing clinicians with more dependable decision-making support in clinical practice.

وصف الملف: electronic resource

العلاقة: http://www.sciencedirect.com/science/article/pii/S2405844024079593Test; https://doaj.org/toc/2405-8440Test

الوصول الحر: https://doaj.org/article/b4363562c72845cfa0fefe2f7a836fcfTest

المؤلفون: Guorui Li, Tuck-Whye Wong, Benjamin Shih, Chunyu Guo, Luwen Wang, Jiaqi Liu, Tao Wang, Xiaobo Liu, Jiayao Yan, Baosheng Wu, Fajun Yu, Yunsai Chen, Yiming Liang, Yaoting Xue, Chengjun Wang, Shunping He, Li Wen, Michael T. Tolley, A-Man Zhang, Cecilia Laschi, Tiefeng Li

المصدر: Nature Communications, Vol 14, Iss 1, Pp 1-10 (2023)

مصطلحات موضوعية: Science

الوصف: Abstract The deep ocean, Earth’s untouched expanse, presents immense challenges for exploration due to its extreme pressure, temperature, and darkness. Unlike traditional marine robots that require specialized metallic vessels for protection, deep-sea species thrive without such cumbersome pressure-resistant designs. Their pressure-adaptive forms, unique propulsion methods, and advanced senses have inspired innovation in designing lightweight, compact soft machines. This perspective addresses challenges, recent strides, and design strategies for bioinspired deep-sea soft robots. Drawing from abyssal life, it explores the actuation, sensing, power, and pressure resilience of multifunctional deep-sea soft robots, offering game-changing solutions for profound exploration and operation in harsh conditions.

وصف الملف: electronic resource

العلاقة: https://doaj.org/toc/2041-1723Test

الوصول الحر: https://doaj.org/article/7b39c63b584d4855bf2245c0871bceafTest

المؤلفون: Juan Peng, Shuqing Li, Luwen Wang, Li Yang, Manman Nai, Qingqing Xu, Yuxi Jin, Peng Liu, Lei Li

المصدر: Scientific Reports, Vol 13, Iss 1, Pp 1-9 (2023)

مصطلحات موضوعية: Medicine, Science

الوصف: Abstract To compare the clinical efficacy of laparoscopic pectopexy and laparoscopic high uterosacral ligament suspension in women suffering from apical prolapse. The clinical data of 170 patients with apical prolapse (POP-Q score ≥ II) treated in the Third Affiliated Hospital of Zhengzhou University from January 2018 to July 2020 were retrospectively analyzed to assess the clinical efficacy of three surgical methods [laparoscopic pectopexy with uterine preservation, laparoscopic pectopexy with hysterectomy, laparoscopic high uterosacral ligament suspension (LHUSLS) with hysterectomy]. Patients were divided into three groups depending on Surgical methods: laparoscopic uterine pectopexy group (n = 23), laparoscopic pectopexy with hysterectomy group (n = 78) and LHUSLS with hysterectomy group (n = 69). The POP-Q points before and after operation were analyzed. The operation-related indices, perioperative periods and post-operative complications were compared. 1. The operation time of laparoscopic uterine pectopexy group was the shortest (p 0.05). 2. The POP-Q points (Aa, Ba, C) in the three groups were better than those before operation (p

وصف الملف: electronic resource

العلاقة: https://doaj.org/toc/2045-2322Test

الوصول الحر: https://doaj.org/article/c2c5c7da95814aa0a65c3e6961934034Test

المؤلفون: Pan Cao, Qian Chen, Chunxia Shi, Luwen Wang, Zuojiong Gong

المصدر: Gut Pathogens, Vol 14, Iss 1, Pp 1-17 (2022)

مصطلحات موضوعية: Acute liver failure, Energy metabolism, Gut-liver axis, Fusobacterium nucleatum, Inflammation, Diseases of the digestive system. Gastroenterology, RC799-869

الوصف: Abstract Background Acute liver failure (ALF) patients are often accompanied by severe energy metabolism abnormalities and intestinal microecological imbalance. The intestinal mucosal barrier is severely damaged. Intestinal endotoxin can induce intestinal endotoxemia through the "Gut-Liver axis". More and more evidence shows that members of the gut microbiota, especially Fusobacterium nucleatum (F. nucleatum), are related to inflammatory bowel disease, but whether F. nucleatum is involved in the development of ALF and whether it affects the liver energy metabolism is unclear. Methods This study first detected the abundance of F. nucleatum and its effect on ALF disease, and explored whether F. nucleatum aggravated liver inflammation in vitro and in vivo. Results Our data showed that liver tissues of ALF patients contained different abundances of F. nucleatum, which were related to the degree of liver inflammation. In addition, we found that F. nucleatum infection affected the energy metabolism of the liver during the development of ALF, inhibited the synthesis pathway of nicotinamide adenine dinucleotide (NAD+)'s salvage metabolism, and promoted inflammatory damage in the liver. In terms of mechanism, F. nucleatum inhibited NAD+ and the NAD+-dependent SIRT1/AMPK signaling pathway, and promoted liver damage of ALF. Conclusions Fusobacterium nucleatum coordinates a molecular network including NAD+ and SIRT1 to control the progress of ALF. Detection and targeting of F. nucleatum and its related pathways may provide valuable insights for the treatment of ALF.

وصف الملف: electronic resource

العلاقة: https://doaj.org/toc/1757-4749Test

الوصول الحر: https://doaj.org/article/cdc2d98fd7f84ccf8fd23d742cdfca2cTest

المؤلفون: Xiaojuan Wang, Yisong Chen, Luwen Wang, Zhong Lin, Keqin Hua

المصدر: Clinical and Experimental Obstetrics & Gynecology, Vol 48, Iss 6, Pp 1330-1334 (2021)

مصطلحات موضوعية: fractional co2 laser, vulvar lichen sclerosus, efficacy, Gynecology and obstetrics, RG1-991

الوصف: Background: The CO2 laser has been used to treat vulvar lichen sclerosus (VLS) with a significant reduction in symptoms, and there is a paucity data on the efficacy, sexual function, and quality of life (QOL) improved. This study was to evaluate the efficacy of fractional CO2 laser for VLS and assess sexual function and QOL from multi-centers. Methods: The women with biopsy-proved VLS who were treated with CO2 fractional laser were enrolled between January 2017 and December 2018 from three centers. The visual analogue scale (VAS) was to assess clinical symptoms. The Female sexual distress scale-revised (FSDS) was to evaluate the patients’ sexual activity, and the family Dermatology Life Quality Index (DLQI) was to evaluate the QOL. Results: A total of 119/122 patients (mean 44.5 years, 27–72 years) completed the treatment with fractional CO2 laser and following-up. The clinical symptoms and QOL were improved significantly from baseline to follow-up (3 months and 12 months post-treatment) according to the following measures: itching score, 7.65 (1.07, 0–10) versus 4.52 (1.23, 0–10) versus 0.96 (1.49, 0–4); burning score, 6.9 (1.66, 0–10) versus 3.82 (1.79, 0–8) versus 0.98 (1.42, 0–4); DLQL score, 14.24 (5.64, 0–30) versus 8.7 (1.9, 0–15) versus 5.7 (2.3, 0–10); FSDS score, 15.48 (11.3, 0–51) versus 12.51 (10.59, 0–45) versus 7.87 (9.34, 0–50). Conclusion: In conclusion, the fractional CO2laser was effective and safe for treating VLS, which significantly ameliorated the annoying symptoms and improved the quality of life.

وصف الملف: electronic resource

العلاقة: https://www.imrpress.com/journal/CEOG/48/6/10.31083/j.ceog4806211Test; https://doaj.org/toc/0390-6663Test

الوصول الحر: https://doaj.org/article/4bf5424445b445bab26676f8d7fbdcbeTest

المؤلفون: Fang An, Sha Wang, Zhiqi Wang, Lingying Wu, Qiubo Lv, Aiming Lv, Hongwu Wen, Jinsong Han, Yumei Wu, Yunong Gao, Qing Liu, Sumei Wang, Hongxia Li, Luwen Wang, Yanlong Wang, Ruifang Wu, Huan Li, Xiuli Sun

المصدر: Gynecology and Obstetrics Clinical Medicine, Vol 1, Iss 2, Pp 70-74 (2021)

مصطلحات موضوعية: Cervical cancer, Radical hysterectomy, Lower urinary tract symptoms, Urodynamics, Gynecology and obstetrics, RG1-991

الوصف: Objective: To compare the degree of agreement and consistency of urodynamic studies (UDS) with low urinary tract symptoms (LUTS) questionnaires for evaluating LUTS in cervical cancer patients following radical hysterectomy (RH) and pelvic lymphadenectomy. Methods: From January 2012 to March 2015, 204 cervical cancer patients who underwent RH in 13 hospitals were evaluated using the Incontinence Questionnaire-Female Lower Urinary Tract Symptoms (ICIQ-FLUTS) and the Overactive Bladder Symptom Score (OABSS). Urodynamic tests were also performed on these patients during the same period. Results: Study participants’ age ranged from 23 to 75 years, with a mean (standard deviation) of 48.0 ​± ​9.3 years. Using questionnaires, the prevalence of patients with LUTS symptoms, including storage symptoms, voiding symptoms, stress urinary incontinence (SUI) and overactive bladder (OAB) was 86.3%, 77.0%, 62.7%, 52.9% and 14.7%, respectively. For UDS, the corresponding prevalence was 89.7%, 70.1%, 66.7%, 46.6% and 13.2%, respectively. The diagnostic concordance of questionnaires and UDS for storage symptoms, voiding symptoms, SUI and OAB was 79.9%, 66.7%, 66.7%, 57.4% and 79.9%, respectively. For voiding symptoms, the correlation coefficient was 0.272, which was higher than that of storage symptoms, SUI and OAB. Conclusions: In cervical cancer patients who have undergone RH, there was a moderate degree of agreement between UDS and symptom questionnaires in evaluating LUTS, but the consistency was poor. Medical personnel should be adequately trained in UDS to ensure LUTS are adequately diagnosed in patients.

وصف الملف: electronic resource

العلاقة: http://www.sciencedirect.com/science/article/pii/S2667164621000075Test; https://doaj.org/toc/2667-1646Test

الوصول الحر: https://doaj.org/article/d6b9d8aeefca4723b3ab9ddddfa6d8dfTest

المؤلفون: Chunxia Shi, Fangzhou Jiao, Yao Wang, Qian Chen, Luwen Wang, Zuojiong Gong

المصدر: Frontiers in Physiology, Vol 13 (2022)

مصطلحات موضوعية: 3-TYP, SIRT3, thioacetamide, acute liver failure, inflammation, Physiology, QP1-981

الوصف: The purpose of the study was to explore the effects of SIRT3 inhibitor 3-TYP on acute liver failure (ALF) in mice and its underlying mechanism. The mice were treated with thioacetamide (TAA, 300 mg/kg) for inducing ALF model. 3-TYP (50 mg/kg) was administered 2 h prior to TAA. The liver histological changes were measured by HE staining. Blood samples were collected for analysis of alanine aminotransferase (ALT) and aspartate aminotransferase (AST). MDA and GSH were used to evaluate the oxidative stress of liver. The expression levels of inflammatory cytokines (TNF-α and IL-1β) were measured by ELISA and Western blotting. The cell type expression of IL-1β in liver tissue was detected by immunofluorescent staining. The expression of SIRT3, MnSOD, ALDH2, MAPK, NF-κB, Nrf2/HO-1, p-elF2α/CHOP, and cleaved caspase 3 was determined by Western blotting. TUNEL staining was performed to detect the apoptosis cells of liver tissues. 3-TYP exacerbated the liver injury of ALF mice. 3-TYP increased the inflammatory responses and activation of MAPK and NF-κB pathways. In addition, 3-TYP administration enhanced the damage of oxidative stress, endoplasmic reticulum stress, and promoted hepatocyte apoptosis in ALF mice. 3-TYP exacerbates thioacetamide-induced hepatic injury in mice. Activation of SIRT3 could be a promising target for the treatment of ALF.

وصف الملف: electronic resource

العلاقة: https://www.frontiersin.org/articles/10.3389/fphys.2022.915193/fullTest; https://doaj.org/toc/1664-042XTest

الوصول الحر: https://doaj.org/article/a873a843ac894a7b94dc36eb20b693a4Test

المؤلفون: Yao Wang, Qian Chen, Fangzhou Jiao, Chunxia Shi, Maohua Pei, Luwen Wang, Zuojiong Gong

المصدر: Cell Death and Disease, Vol 12, Iss 1, Pp 1-17 (2021)

مصطلحات موضوعية: Cytology, QH573-671

الوصف: Abstract Pyroptosis is a new necrosis pattern of hepatocyte during liver inflammation in acute liver failure (ALF). Histone deacetylase 2 (HDAC2) is associated with several pathological conditions in the liver system. The aim of this study is to investigate whether knockdown or pharmacological inhibition of HDAC2 could reduce the level of pyroptosis in ALF through ULK1-NLRP3-pyroptosis pathway. The role of HDAC2 on ULK1-NLRP3-pyroptosis pathway during ALF was detected in clinical samples. The mechanism was investigated in transfected cells or in ALF mouse model. The RNA-sequencing results revealed that ULK1 was a negative target regulatory molecule by HDAC2. During the process of pyroptosis, the HDAC2 exerted the antagonistic effect with ULK1 by the K68 acetylation site in L02 cells. Then the role of HDAC2 on ULK1-NLRP3-pyroptosis pathway in ALF mouse model was also detected. Moreover, the related molecules to ULK1-NLRP3-pyroptosis pathway were verified different expression in normal health donors and clinical ALF patients. HDAC2 in hepatocytes plays a pivotal role in an ULK1-NLRP3 pathway driven auto-amplification of pyroptosis in ALF. One of the important mechanisms is that inhibition HDAC2 to reduce pyroptosis may be by modulating the K68 lysine site of ULK1.

وصف الملف: electronic resource

العلاقة: https://doaj.org/toc/2041-4889Test

الوصول الحر: https://doaj.org/article/525112b51a134b10b2ead47a69ba0371Test

المؤلفون: Qian Chen, Yao Wang, Fangzhou Jiao, Chunxia Shi, Maohua Pei, Luwen Wang, Zuojiong Gong

المصدر: Scientific Reports, Vol 10, Iss 1, Pp 1-14 (2020)

مصطلحات موضوعية: Medicine, Science

الوصف: Abstract Previous research has revealed that the gut microbiome has a marked impact on acute liver failure (ALF). Here, we evaluated the impact of betaine on the gut microbiota composition in an ALF animal model. The potential protective effect of betaine by regulating Toll-like receptor 4 (TLR4) responses was explored as well. Both mouse and cell experiments included normal, model, and betaine groups. The rat small intestinal cell line IEC-18 was used for in vitro experiments. Betaine ameliorated the small intestine tissue and IEC-18 cell damage in the model group by reducing the high expression of TLR4 and MyD88. Furthermore, the intestinal permeability in the model group was improved by enhancing the expression of the (ZO)-1 and occludin tight junction proteins. There were 509 operational taxonomic units (OTUs) that were identified in mouse fecal samples, including 156 core microbiome taxa. Betaine significantly improved the microbial communities, depleted the gut microbiota constituents Coriobacteriaceae, Lachnospiraceae, Enterorhabdus and Coriobacteriales and markedly enriched the taxa Bacteroidaceae, Bacteroides, Parabacteroides and Prevotella in the model group. Betaine effectively improved intestinal injury in ALF by inhibiting the TLR4/MyD88 signaling pathway, improving the intestinal mucosal barrier and maintaining the gut microbiota composition.

وصف الملف: electronic resource

العلاقة: https://doaj.org/toc/2045-2322Test

الوصول الحر: https://doaj.org/article/500ddd5cb5704641849232d90fe882b8Test