المؤلفون: Williams, Thomas, Jackson, Sandra, Barr, Ian, Bi, Shabana, Bhiman, Jinal, Ellis, Joanna, von Gottberg, Anne, Lindstrom, Stephen, Peret, Teresa, Rughooputh, Sanjiv, Viegas, Mariana, Hirve, Siddhivinayak, Zambon, Maria, Zhang, Wenqing, Dia, Ndongo, Razanazatovo, Norosoa, Al-Nabet, Ajaeb Dakhilalla M. H., Abubakar, Abdinasir, Tivane, Almiro, Barakat, Amal, Naguib, Amel, Aziz, Ammar, Vicari, Andrea, Moen, Ann, Govindakarnavar, Arunkumar, Hall, Aron, Darmaa, Badarch, Nathalie, Bastien, Herring, Belinda, Caetano, Braulia, Whittaker, Brett, Baumeister, Elsa, Nakouné, Emmanuel, Guthrie, Erica, Inbanathan, Francis, Nair, Harish, Campbell, Harry, Kadjo, Herve, Oumzil, Hicham, Heraud, Jean‐michel, Mott, Joshua, Namulondo, Joyce, Leite, Juliana, Nahapetyan, Karen, Al Ariqi, Lubna, Gazo, Mahmoud Hamad Ibraheem, Chadha, Mandeep, Pisareva, Maria, Venter, Marietjie, Siqueira, Marilda, Lumandas, Mayan, Niang, Mbayame, Albuaini, Mona, Salman, Muhammad, Oberste, Steve, Srikantiah, Padmini, Tang, Patrick, Couto, Paula, Smith, Peter, Coyle, Peter Valentine, Dussart, Philippe, Nguyen, Phuong Nam, Okada, Pilailuk Akkapaiboon, Wijesinghe, Pushpa Ranjan, Samuel, Reuben, Brown, Richard, Pebody, Richard, Fasce, Rodrigo, Jha, Runa, Gerber, Sue, Potdar, Varsha, Dong, Xiaomin, Deng, Yi Mo

المساهمون: University of Edinburgh, Organisation Mondiale de la Santé / World Health Organization Office (OMS / WHO), The Peter Doherty Institute for Infection and Immunity Melbourne, University of Melbourne-The Royal Melbourne Hospital, UK Health Security Agency London (UKHSA), United Kingdom National External Quality Assessment Service (UK NEQAS), National Institute for Communicable Diseases Johannesburg (NICD), University of the Witwatersrand Johannesburg (WITS), Centers for Disease Control and Prevention Atlanta (CDC), Centers for Disease Control and Prevention, University of Texas Medical Branch at Galveston, Ricardo Gutierrez Children's Hospital, Partenaires INRAE, Consejo Nacional de Investigaciones Científicas y Técnicas Buenos Aires (CONICET), The WHO global RSV surveillance project was supported by an award made to the World Health Organization by the Bill and Melinda Gates Foundation (grant no. OPP1127419).

المصدر: ISSN: 1750-2640.

مصطلحات موضوعية: laboratory diagnostics and systems, respiratory diseases, strengthening laboratory capacity for infectious disease control, [SDV]Life Sciences [q-bio]

الوصف: Auteurs : WHO RSV Surveillance Group ; International audience ; BackgroundExternal quality assessments (EQAs) for the molecular detection of human respiratory syncytial virus (RSV) are necessary to ensure the standardisation of reliable results. The Phase II, 2019–2020 World Health Organization (WHO) RSV EQA included 28 laboratories in 26 countries. The EQA panel evaluated performance in the molecular detection and subtyping of RSV-A and RSV-B. This manuscript describes the preparation, distribution, and analysis of the 2019–2020 WHO RSV EQA.MethodsPanel isolates underwent whole genome sequencing and in silico primer matching. The final panel included nine contemporary, one historical virus and two negative controls. The EQA panel was manufactured and distributed by the UK National External Quality Assessment Service (UK NEQAS). National laboratories used WHO reference assays developed by the United States Centers for Disease Control and Prevention, an RSV subtyping assay developed by the Victorian Infectious Diseases Reference Laboratory (Australia), or other in-house or commercial assays already in use at their laboratories.ResultsAn in silico analysis of isolates showed a good match to assay primer/probes. The panel was distributed to 28 laboratories. Isolates were correctly identified in 98% of samples for detection and 99.6% for subtyping.ConclusionsThe WHO RSV EQA 2019–2020 showed that laboratories performed at high standards. Updating the composition of RSV molecular EQAs with contemporary strains to ensure representation of circulating strains, and ensuring primer matching with EQA panel viruses, is advantageous in assessing diagnostic competencies of laboratories. Ongoing EQAs are recommended because of continued evolution of mismatches between current circulating strains and existing primer sets.

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/36824313; hal-04096791; https://hal.science/hal-04096791Test; https://hal.science/hal-04096791/documentTest; https://hal.science/hal-04096791/file/Influenza%20Resp%20Viruses%20-%202023%20-%20Williams%20-%20Results%20from%20the%20second%20WHO%20external%20quality%20assessment%20for%20the%20molecular.pdfTest; PUBMED: 36824313; PUBMEDCENTRAL: PMC9849090

الإتاحة: https://doi.org/10.1111/irv.13073Test
https://hal.science/hal-04096791Test
https://hal.science/hal-04096791/documentTest
https://hal.science/hal-04096791/file/Influenza%20Resp%20Viruses%20-%202023%20-%20Williams%20-%20Results%20from%20the%20second%20WHO%20external%20quality%20assessment%20for%20the%20molecular.pdfTest

المؤلفون: Llamas-Clark, Erlidia F, Heralde, Francisco M, Lumandas, Mayan U, Cagayan, Maria Stephanie Fay S, Villanueva-Uy, Maria Esterlita T, Chavez-Coloma, Leilani C, Valencia, Eleyneth I, Cabana, Charizze Anne S, Espinosa, Lea Bernadette H, Anzures, Cynthia U, Andal, Maria Lu D, Martin, Carolina Paula C, Suarez, Patricia Nevira V, Quanico, Celine D, Beltran, Julia B, de Guzman, Vanessa D, Capitulo, Ryan B, Dominguez, Arlene R, Recio, Abygail L, Feliciano, Jeremiah F, Baja, Emmanuel S, Rosell-Ubial, Paulyn Jean B

المساهمون: The Australian Awards and Alumni Engagement Program, Philippine Council for Health Research and Development, Philippine Obstetrical and Gynecological Society

المصدر: BMJ Open ; volume 13, issue 4, page e070688 ; ISSN 2044-6055 2044-6055

مصطلحات موضوعية: General Medicine

الوصف: Objective To determine the potential risk factors associated with having COVID-19 among unvaccinated pregnant and non-pregnant women. Design A multicentre prospective cohort study among eligible women in Metro Manila, Philippines, from 2020 to 2022. Setting Five national and local hospital research sites altogether recruited and screened 500 consenting eligible individuals. Participants Pregnant and non-pregnant participants meeting the eligibility criteria were admitted for a reverse-transcription PCR determination of SARS-CoV-2, pregnancy testing and ultrasound, and an interview with an administered questionnaire. Exposures Primary exposure was pregnancy; secondary exposures involve sociodemographic, lifestyle and obstetric-gynaecologic factors. Outcome measure Outcome being measured was COVID-19 status. Results The significant COVID-19 risk factors were: pregnancy (PR=1.184, 95% CI 1.096, 1.279), having a white-collar job (PR=1.123, 95% CI 1.02, 1.235), travelling abroad (PR=1.369, 95% CI 1.083, 1.173) and being infected by at least one vaccine-preventable disease (VPD) (PR=1.208, 95% CI 1.113, 1.310). Protective factors included having graduate-level education (PR=0.787, 95% CI 0.649, 0.954), immunisation against a VPD (PR=0.795, 95% CI 0.733, 0.862) and practising contraception (PR=0.889, 95% CI 0.824, 0.960). Conclusion This study is the first in the country to determine the risks influencing COVID-19 infection among unvaccinated pregnant and non-pregnant women. Pregnancy is a significant risk for COVID-19 among women in Metro Manila. Educational attainment and positive health behaviours seem to confer protection. Occupations and activities that increase the frequency of interactions, as well as history of communicable diseases may predispose women to COVID-19. Further studies are needed to elucidate the development of the disease in pregnant women, including the maternal and neonatal effects of COVID-19 via potential vertical mechanisms of transmission.

الإتاحة: https://doi.org/10.1136/bmjopen-2022-070688Test

المؤلفون: Llamas-Clark, Erlidia F., Villanueva-Uy, Maria Esterlita T., Cagayan, Faye Stephanie S., Heralde, Francisco M., Lumandas, Mayan U., Feliciano, Jeremiah F., Rosell-Ubial, Paulyn Jean B., Baja, Emmanuel S.

المساهمون: Philippine Council for Health Research and Development, Department of Science and Technology, Ministry of Science and Technology, India

المصدر: Clinical Epidemiology and Global Health ; volume 23, page 101372 ; ISSN 2213-3984

مصطلحات موضوعية: Infectious Diseases, Microbiology (medical), Public Health, Environmental and Occupational Health, Epidemiology

الإتاحة: https://doi.org/10.1016/j.cegh.2023.101372Test
https://api.elsevier.com/content/article/PII:S2213398423001598?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S2213398423001598?httpAccept=text/plainTest

المؤلفون: Li, Yao-Tsun, Polotan, Francisco Gerardo M., Sotelo, Gerald Ivan S., Alpino, Anne Pauline A., Dolor, Ardiane Ysabelle M., Tujan, Ma. Angelica A., Gomez, Ma. Ricci R., Onza, Othoniel Jan T., Chang, Angela Kae T., Bautista, Criselda T., Carandang, June C., Yangzon, Maria Sofia L., Pangilinan, Elcid Aaron R., Mantaring, Renato Jancito Q., Telles, Alyssa Joyce E., Egana, John Michael C., Endozo, Joshua Jose S., Cruz, Rianna Patricia S., Tablizo, Francis A., Yap, Jan Michael C., Maralit, Benedict A., Ayes, Marc Edsel C., de la Paz, Eva Marie C., Saloma, Cynthia P., Lim, Dodge R., Dancel, Lei Lanna M., Uy-Lumandas, Mayan, Medado, Inez Andrea P., Dizon, Timothy John R., Hampson, Katie, Daldry, Simon, Hughes, Joseph, Brunker, Kirstyn

الوصف: The Omicron SARS-CoV-2 variant led to a dramatic global epidemic wave following detection in South Africa in November, 2021. The Omicron lineage BA.1 was dominant and responsible for most SARS-CoV-2 outbreaks in countries around the world during December 2021-January 2022, whilst other Omicron lineages including BA.2 accounted for the minority of global isolates. Here, we describe the Omicron wave in the Philippines by analysing genomic data. Our results identify the presence of both BA.1 and BA.2 lineages in the Philippines in December 2021, before cases surged in January 2022. We infer that only lineage BA.2 underwent sustained transmission in the country, with an estimated emergence around November 18th, 2021 [95% highest posterior density: November 6-28th], whilst despite multiple introductions BA.1 transmission remained limited. These results suggest the Philippines was one of the earliest areas affected by BA.2, and reiterate the importance of whole-genome sequencing for monitoring outbreaks.

وصف الملف: text

العلاقة: https://eprints.gla.ac.uk/277394/1/277394.pdfTest; Li, Y.-T. et al. (2022) Lineage BA.2 dominated the Omicron SARS-CoV-2 epidemic wave in the Philippines. Virus Evolution , 8(2), veac078. (doi:10.1093/ve/veac078 ) (PMID:36090771) (PMCID:PMC9452094)

الإتاحة: https://doi.org/10.1093/ve/veac078Test
https://eprints.gla.ac.uk/277394Test/
https://eprints.gla.ac.uk/277394/1/277394.pdfTest

المؤلفون: Li, Yao-Tsun, Polotan, Francisco Gerardo M, Sotelo, Gerald Ivan S, Alpino, Anne Pauline A, Dolor, Ardiane Ysabelle M, Tujan, Ma. Angelica A, Gomez, Ma. Ricci R, Onza, Othoniel Jan T, Chang, Angela Kae T, Bautista, Criselda T, Carandang, June C, Yangzon, Maria Sofia L, Pangilinan, Elcid Aaron R, Mantaring, Renato Jacinto, Telles, Alyssa Joyce E, Egana, John Michael C, Endozo, Joshua Jose S, Cruz, Rianna Patricia S, Tablizo, Francis A, Yap, Jan Michael C, Maralit, Benedict A, Ayes, Marc Edsel C, de la Paz, Eva Marie C, Saloma, Cynthia P, Lim, Dodge R, Dancel, Lei Lanna M, Uy-Lumandas, Mayan, Medado, Inez Andrea P, Dizon, Timothy John R, Hampson, Katie, Daldry, Simon, Hughes, Joseph, Brunker, Kirstyn

المساهمون: UK Research and Innovation, Wellcome Trust

المصدر: Virus Evolution ; volume 8, issue 2 ; ISSN 2057-1577

الوصف: The Omicron severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variant led to a dramatic global epidemic wave following detection in South Africa in November 2021. The BA.1 Omicron lineage was dominant and responsible for most SARS-CoV-2 outbreaks in countries around the world during December 2021–January 2022, while other Omicron lineages, including BA.2, accounted for the minority of global isolates. Here, we describe the Omicron wave in the Philippines by analysing genomic data. Our results identify the presence of both BA.1 and BA.2 lineages in the Philippines in December 2021, before cases surged in January 2022. We infer that only the BA.2 lineage underwent sustained transmission in the country, with an estimated emergence around 18 November 2021 (95 per cent highest posterior density: 6–28 November), while despite multiple introductions, BA.1 transmission remained limited. These results suggest that the Philippines was one of the earliest areas affected by BA.2 and reiterate the importance of whole genome sequencing for monitoring outbreaks.

الإتاحة: https://doi.org/10.1093/ve/veac078Test
https://academic.oup.com/ve/article-pdf/8/2/veac078/51786832/veac078.pdfTest

المؤلفون: Llamas-Clark, Erlidia F, Singson, Rebecca B, Heralde, Francisco M, Lumandas, Mayan U, Villanueva-Uy, Maria Esterlita T, Cagayan, Maria Stephanie Fay S, Regencia, Zypher Jude G, Baja, Emmanuel S

المساهمون: Philippine Council for Health Research and Development - Department of Science and Technology, Philippine Obstetrical and Gynecological Society Foundation, Inc., Australia Awards

المصدر: BMJ Open ; volume 12, issue 4, page e053389 ; ISSN 2044-6055 2044-6055

مصطلحات موضوعية: General Medicine

الوصف: Introduction The novel (COVID-19 was first reported to have originated in Wuhan, China, in December 2019. This new strain, SARS‐CoV‐2, has spread rapidly worldwide, prompting the WHO to declare the COVID-19 outbreak a global pandemic. The main objective of this cohort study is to determine the risk factors of COVID-19, the modes of COVID-19 vertical transmission, and the maternal and fetal outcomes among non-pregnant and pregnant women and their fetuses. Methods and analysis This is a multicentre epidemiological study that will involve a prospective cohort. COVID-19 status among consulting non-pregnant and pregnant women in public hospitals in Manila, Philippines, will be determined and monitored for 6–12 months. Swab specimens from the nasopharynx, cervix, rectum, amniotic fluid, placenta, cord blood and breastmilk will be collected during consult and admission for reverse transcription-PCR (RT-PCR) testing. Blood will be collected during the postdelivery period to monitor the women and their neonates for any undue development and determine the antibody development to indicate an infective or non-infective state. Evidence of vertical transmission will be explored with the presence or absence of the virus using the maternal and fetal neonatal RT-PCR and lateral flow antibody status. Descriptive and inferential statistics will be done, including the associations between exposures and risk factors, description of clinical characteristics, and the COVID-19 status of the participants. Ethics and dissemination The Single Joint Research Ethics Board of the Department of Health has approved this protocol (SJREB 2020-30). The study results will be disseminated through conference presentations, peer-reviewed articles, and various stakeholder public forums and activities.

الإتاحة: https://doi.org/10.1136/bmjopen-2021-053389Test