المؤلفون: Harry, Sarah W., Tingstrom, Daniel H., Dufrene, Brad A., Dart, Evan H., Radley, Keith C., Lum, John D. K., Bates-Brantley, Kayla E.

المصدر: Journal of Behavioral Education. Sep 2023 32(3):565-584.

تمت مراجعته من قبل الزملاء: Y

Page Count: 20

الواصفات: Learner Engagement, Student Behavior, Behavior Problems, High School Students, Peer Evaluation, Positive Reinforcement, Prosocial Behavior, Disclosure, Program Effectiveness, Bulletin Boards

مستخلص: A traditional tootling procedure was implemented along with a public posting component to determine the effects on academically engaged, disruptive, and passive off-task behaviors in four general education high school classrooms. Students in the traditional tootling phase were instructed to report on their peers' positive, prosocial behaviors. At the end of the class period, the teacher read through the tootles and added the total toward the group goal. When the class achieved their goal, they were rewarded, and the goal was reset. During the tooting with public posting phase, the teacher or primary researcher posted the tootles on a designated bulletin board. The results indicated that increases in academically engaged behaviors were maintained in both phases, whereas disruptive and passive off-task behaviors decreased. The differences between phases were minimal, suggesting little additive effect. Social validity measures indicated that intervention was acceptable in terms of effectiveness and utility. This study suggests the benefits of implementing tootling in a high school setting, demonstrating increases in classwide academically engaged behaviors.

Abstractor: As Provided

المؤلفون: Ekhlaspour, Laya, Raghinaru, Dan, Forlenza, Gregory, Isganaitis, Elvira, Kudva, Yogish, Lam, David, Levister, Camilla, OMalley, Grenye, Church, Mei, Lum, John, Buckingham, Bruce, Brown, Sue

المصدر: DST. 17(4)

مصطلحات موضوعية: closed-loop control, continuous glucose monitoring, efficacy, insulin pump, multiple daily injection, Humans, Diabetes Mellitus, Type 1, Hypoglycemic Agents, Blood Glucose Self-Monitoring, Blood Glucose, Insulin, Insulin, Regular, Human, Insulin Infusion Systems

الوصف: BACKGROUND: We investigated the potential benefits of automated insulin delivery (AID) among individuals with type 1 diabetes (T1D) in sub-populations of baseline device use determined by continuous glucose monitor (CGM) use status and insulin delivery via multiple daily injections (MDI) or insulin pump. MATERIALS AND METHODS: In a six-month randomized, multicenter trial, 168 individuals were assigned to closed-loop control (CLC, Control-IQ, Tandem Diabetes Care), or sensor-augmented pump (SAP) therapy. The trial included a two- to eight-week run-in phase to train participants on study devices. The participants were stratified into four subgroups: insulin pump and CGM (pump+CGM), pump-only, MDI and CGM (MDI+CGM), and MDI users without CGM (MDI-only) users. We compared glycemic outcomes among four subgroups. RESULTS: At baseline, 61% were pump+CGM users, 18% pump-only users, 10% MDI+CGM users, and 11% MDI-only users. Mean time in range 70-180 mg/dL (TIR) improved from baseline in the four subgroups using CLC: pump+CGM, 62% to 73%; pump-only, 61% to 70%; MDI+CGM, 54% to 68%; and MDI-only, 61% to 69%. The reduction in time below 70 mg/dL from baseline was comparable among the four subgroups. No interaction effect was detected with baseline device use for TIR (P = .67) or time below (P = .77). On the System Usability Questionnaire, scores were high at 26 weeks for all subgroups: pump+CGM: 87.2 ± 12.1, pump-only: 89.4 ± 8.2, MDI+CGM 87.2 ± 9.3, MDI: 78.1 ± 15. CONCLUSIONS: There was a consistent benefit in patients with T1D when using CLC, regardless of baseline insulin delivery modality or CGM use. These data suggest that this CLC system can be considered across a wide range of patients.

وصف الملف: application/pdf

الوصول الحر: https://escholarship.org/uc/item/3cf3h4vgTest

المؤلفون: Wadwa, R, Reed, Zachariah, Buckingham, Bruce, DeBoer, Mark, Ekhlaspour, Laya, Forlenza, Gregory, Schoelwer, Melissa, Lum, John, Kollman, Craig, Beck, Roy, Breton, Marc

المصدر: New England Journal of Medicine. 388(11)

مصطلحات موضوعية: Child, Child, Preschool, Humans, Blood Glucose, Blood Glucose Self-Monitoring, Diabetes Mellitus, Type 1, Glycated Hemoglobin, Hypoglycemic Agents, Insulin, Insulin Infusion Systems

الوصف: BACKGROUND: Closed-loop control systems of insulin delivery may improve glycemic outcomes in young children with type 1 diabetes. The efficacy and safety of initiating a closed-loop system virtually are unclear. METHODS: In this 13-week, multicenter trial, we randomly assigned, in a 2:1 ratio, children who were at least 2 years of age but younger than 6 years of age who had type 1 diabetes to receive treatment with a closed-loop system of insulin delivery or standard care that included either an insulin pump or multiple daily injections of insulin plus a continuous glucose monitor. The primary outcome was the percentage of time that the glucose level was in the target range of 70 to 180 mg per deciliter, as measured by continuous glucose monitoring. Secondary outcomes included the percentage of time that the glucose level was above 250 mg per deciliter or below 70 mg per deciliter, the mean glucose level, the glycated hemoglobin level, and safety outcomes. RESULTS: A total of 102 children underwent randomization (68 to the closed-loop group and 34 to the standard-care group); the glycated hemoglobin levels at baseline ranged from 5.2 to 11.5%. Initiation of the closed-loop system was virtual in 55 patients (81%). The mean (±SD) percentage of time that the glucose level was within the target range increased from 56.7±18.0% at baseline to 69.3±11.1% during the 13-week follow-up period in the closed-loop group and from 54.9±14.7% to 55.9±12.6% in the standard-care group (mean adjusted difference, 12.4 percentage points [equivalent to approximately 3 hours per day]; 95% confidence interval, 9.5 to 15.3; P

وصف الملف: application/pdf

الوصول الحر: https://escholarship.org/uc/item/53h9d0w8Test

المؤلفون: Pinsker, Jordan, Dassau, Eyal, Deshpande, Sunil, Raghinaru, Dan, Buckingham, Bruce, Kudva, Yogish, Laffel, Lori, Levy, Carol, Church, Mei, Desrochers, Hannah, Ekhlaspour, Laya, Kaur, Ravinder, Levister, Camilla, Shi, Dawei, Lum, John, Kollman, Craig, Doyle, Francis

المصدر: Diabetes Technology and Therapeutics. 24(9)

مصطلحات موضوعية: Adaptation, Artificial pancreas, Automated insulin delivery, Glycemic control, Type 1 diabetes, Adult, Blood Glucose, Cross-Over Studies, Diabetes Mellitus, Type 1, Humans, Hypoglycemic Agents, Infant, Newborn, Insulin, Insulin Infusion Systems, Insulin, Regular, Human, Middle Aged, Outpatients, Young Adult

الوصف: Background: Automated insulin delivery (AID) systems have proven effective in increasing time-in-range during both clinical trials and real-world use. Further improvements in outcomes for single-hormone (insulin only) AID may be limited by suboptimal insulin delivery settings. Methods: Adults (≥18 years of age) with type 1 diabetes were randomized to either sensor-augmented pump (SAP) (inclusive of predictive low-glucose suspend) or adaptive zone model predictive control AID for 13 weeks, then crossed over to the other arm. Each week, the AID insulin delivery settings were sequentially and automatically updated by an adaptation system running on the study phone. Primary outcome was sensor glucose time-in-range 70-180 mg/dL, with noninferiority in percent time below 54 mg/dL as a hierarchical outcome. Results: Thirty-five participants completed the trial (mean age 39 ± 16 years, HbA1c at enrollment 6.9% ± 1.0%). Mean time-in-range 70-180 mg/dL was 66% with SAP versus 69% with AID (mean adjusted difference +2% [95% confidence interval: -1% to +6%], P = 0.22). Median time

وصف الملف: application/pdf

الوصول الحر: https://escholarship.org/uc/item/76x9t6n0Test

المؤلفون: Ekhlaspour, Laya, Town, Marissa, Raghinaru, Dan, Lum, John, Brown, Sue, Buckingham, Bruce

المصدر: Diabetes Technology and Therapeutics. 24(8)

مصطلحات موضوعية: Closed-loop system, Continuous glucose monitoring, Glycemic management, International Diabetes Closed-Loop Trial, Time in range, Type 1 diabetes, Blood Glucose, Blood Glucose Self-Monitoring, Diabetes Mellitus, Type 1, Glycated Hemoglobin, Humans, Hyperglycemia, Hypoglycemia, Hypoglycemic Agents, Insulin, Insulin Infusion Systems

الوصف: Using a closed-loop system significantly improves time in range (TIR) 70-180 mg/dL in patients with type 1 diabetes (T1D). In a 6-month RCT, 112 subjects were randomly assigned to closed-loop control (Tandem Control-IQ) after obtaining 2 weeks of baseline Continuous glucose monitoring (CGM) data from sensor-augmented pump therapy. We compared glycemic outcomes from baseline to end of study among subgroups classified by baseline HbA1c levels. All HbA1c subgroups showed an improvement in TIR due to reduction of both hyperglycemia and hypoglycemia. Those with HbA1c

وصف الملف: application/pdf

الوصول الحر: https://escholarship.org/uc/item/2zk1901gTest

المؤلفون: Hood, Korey K., Schneider-Utaka, Aika K., Reed, Zachariah W., Buckingham, Bruce A., Cobry, Erin, DeBoer, Mark D., Ekhlaspour, Laya, Schoelwer, Melissa, Paul Wadwa, R., Lum, John, Kollman, Craig, Beck, Roy W., Breton, Marc D.

المساهمون: Juvenile Diabetes Research Foundation United States of America, National Institutes of Health, Novo Nordisk, National Institute of Diabetes and Digestive and Kidney Diseases, Medtronic

المصدر: Diabetes Research and Clinical Practice ; volume 208, page 111114 ; ISSN 0168-8227

مصطلحات موضوعية: Endocrinology, General Medicine, Endocrinology, Diabetes and Metabolism, Internal Medicine

الإتاحة: https://doi.org/10.1016/j.diabres.2024.111114Test
https://api.elsevier.com/content/article/PII:S0168822724000275?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S0168822724000275?httpAccept=text/plainTest

المؤلفون: Brown, Sue, Beck, Roy, Raghinaru, Dan, Buckingham, Bruce, Laffel, Lori, Wadwa, R, Kudva, Yogish, Levy, Carol, Pinsker, Jordan, Dassau, Eyal, Doyle, Francis, Ambler-Osborn, Louise, Anderson, Stacey, Church, Mei, Ekhlaspour, Laya, Forlenza, Gregory, Levister, Camilla, Simha, Vinaya, Breton, Marc, Kollman, Craig, Lum, John, Kovatchev, Boris

المصدر: Diabetes reviews (Alexandria, Va.). 43(8)

مصطلحات موضوعية: Adolescent, Adult, Aged, Blood Glucose, Blood Glucose Self-Monitoring, Diabetes Mellitus, Type 1, Female, Humans, Hypoglycemia, Injections, Subcutaneous, Insulin, Insulin Infusion Systems, Intention to Treat Analysis, Male, Middle Aged, Prognosis, Treatment Outcome, United States, Young Adult

الوصف: OBJECTIVE: Limited information is available about glycemic outcomes with a closed-loop control (CLC) system compared with a predictive low-glucose suspend (PLGS) system. RESEARCH DESIGN AND METHODS: After 6 months of use of a CLC system in a randomized trial, 109 participants with type 1 diabetes (age range, 14-72 years; mean HbA1c, 7.1% [54 mmol/mol]) were randomly assigned to CLC (N = 54, Control-IQ) or PLGS (N = 55, Basal-IQ) groups for 3 months. The primary outcome was continuous glucose monitor (CGM)-measured time in range (TIR) for 70-180 mg/dL. Baseline CGM metrics were computed from the last 3 months of the preceding study. RESULTS: All 109 participants completed the study. Mean ± SD TIR was 71.1 ± 11.2% at baseline and 67.6 ± 12.6% using intention-to-treat analysis (69.1 ± 12.2% using per-protocol analysis excluding periods of study-wide suspension of device use) over 13 weeks on CLC vs. 70.0 ± 13.6% and 60.4 ± 17.1% on PLGS (difference = 5.9%; 95% CI 3.6%, 8.3%; P < 0.001). Time >180 mg/dL was lower in the CLC group than PLGS group (difference = -6.0%; 95% CI -8.4%, -3.7%; P < 0.001) while time

وصف الملف: application/pdf

الوصول الحر: https://escholarship.org/uc/item/7zr2k8qmTest

المؤلفون: Kovatchev, Boris, Anderson, Stacey, Raghinaru, Dan, Kudva, Yogish, Laffel, Lori, Levy, Carol, Pinsker, Jordan, Wadwa, R, Buckingham, Bruce, Doyle, Francis, Brown, Sue, Church, Mei, Dadlani, Vikash, Dassau, Eyal, Ekhlaspour, Laya, Forlenza, Gregory, Isganaitis, Elvira, Lam, David, Lum, John, Beck, Roy

المصدر: Diabetes reviews (Alexandria, Va.). 43(3)

مصطلحات موضوعية: Adolescent, Adult, Aged, Biosensing Techniques, Blood Glucose, Blood Glucose Self-Monitoring, Diabetes Mellitus, Type 1, Female, Humans, Hypoglycemic Agents, Insulin, Insulin Infusion Systems, Insulin, Regular, Human, Male, Middle Aged, Mobile Applications, Pancreas, Artificial, Telemedicine, United States, Young Adult

الوصف: OBJECTIVE: Assess the efficacy of inControl AP, a mobile closed-loop control (CLC) system. RESEARCH DESIGN AND METHODS: This protocol, NCT02985866, is a 3-month parallel-group, multicenter, randomized unblinded trial designed to compare mobile CLC with sensor-augmented pump (SAP) therapy. Eligibility criteria were type 1 diabetes for at least 1 year, use of insulin pumps for at least 6 months, age ≥14 years, and baseline HbA1c

وصف الملف: application/pdf

الوصول الحر: https://escholarship.org/uc/item/6zz540wmTest

المؤلفون: Levy, Carol J., Bailey, Ryan, Laffel, Lori M., Forlenza, Gregory, DiMeglio, Linda A., Hughes, Michael S., Brown, Sue A., Aleppo, Grazia, Bhargava, Anuj, Shah, Viral N., Clements, Mark A., Kipnes, Mark, Bruggeman, Brittany, Daniels, Mark, Rodriguez, Henry, Calhoun, Peter, Lum, John W., Sasson-Katchalski, Ravid, Pinsker, Jordan E., Pollom, Robyn, Beck, Roy W.

المصدر: Diabetes Technology & Therapeutics ; ISSN 1520-9156 1557-8593

الإتاحة: https://doi.org/10.1089/dia.2024.0048Test

المؤلفون: Lum, John D. K., Radley, Keith C., Tingstrom, Daniel H., Dufrene, Brad A., Olmi, D. Joe, Wright, Sarah J.

المصدر: Journal of Positive Behavior Interventions. Apr 2019 21(2):93-105.

تمت مراجعته من قبل الزملاء: Y

Page Count: 13

الواصفات: Peer Mediation, Intervention, Behavior Problems, Behavior Change, Randomized Controlled Trials, High School Students, Rewards, Effect Size, Classroom Techniques, Learner Engagement, Rating Scales, Teacher Education, Classroom Observation Techniques, Outcomes of Education, Algebra, English Instruction, Acceleration (Education), Secondary School Teachers, Student Attitudes, Validity

مستخلص: The present study examined the effects of tootling, a peer-mediated positive behavior intervention, on students' classwide disruptive and academically engaged behavior in three general education high school classrooms. A withdrawal design was used to assess the effects of the intervention. Students wrote tootles anonymously on paper slips and placed them into a marked container. A randomized independent group contingency was used to reward students. At the end of the class period, teachers randomly drew three of the submitted tootles and rewarded students about whom the tootles were written. Teachers also randomly drew the names of two students who submitted a tootle and rewarded them as well. All three classrooms displayed decreases in classwide disruptive behavior and increases in academically engaged behavior during intervention phases. Effect size calculations for both disruptive and academically engaged behavior indicated very large overall effects. The results of this study suggest that a modified tootling procedure utilizing a randomized independent group contingency can be an effective intervention for teachers to improve the classwide behavior of students in high school classrooms. Teachers found the intervention at least moderately socially valid and students rated it highly acceptable.

Abstractor: As Provided