المؤلفون: Giulia Alfieri, Monica Mattone, Lucia Manganaro, Francesco Pecorini, Carlo Catalano, Alessandro Napoli

المصدر: Diagnostic and Interventional Radiology in Gynecological and Obstetric Diseases ISBN: 9783031119095

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::8d51aca6afe5f0887ec862c798a83181Test
https://doi.org/10.1007/978-3-031-11910-1_11Test

المؤلفون: Violante Di Donato, Evangelos Kontopantelis, Ilaria Cuccu, Ludovica Sgamba, Tullio Golia D'Augè, Angelina Pernazza, Carlo Della Rocca, Lucia Manganaro, Carlo Catalano, Giorgia Perniola, Innocenza Palaia, Federica Tomao, Andrea Giannini, Ludovico Muzii, Giorgio Bogani

مصطلحات موضوعية: endometrial neoplasms, sentinel lymph node, Oncology, lymph nodes, Obstetrics and Gynecology, uterine cancer, uterine neoplasms

الوصف: ObjectiveEndometrial carcinoma is the most common gynecological tumor in developed countries. Clinicopathological factors and molecular subtypes are used to stratify the risk of recurrence and to tailor adjuvant treatment. The present study aimed to assess the role of radiomics analysis in pre-operatively predicting molecular or clinicopathological prognostic factors in patients with endometrial carcinoma.MethodsLiterature was searched for publications reporting radiomics analysis in assessing diagnostic performance of MRI for different outcomes. Diagnostic accuracy performance of risk prediction models was pooled using the metandi command in Stata.ResultsA search of MEDLINE (PubMed) resulted in 153 relevant articles. Fifteen articles met the inclusion criteria, for a total of 3608 patients. MRI showed pooled sensitivity and specificity 0.785 and 0.814, respectively, in predicting high-grade endometrial carcinoma, deep myometrial invasion (pooled sensitivity and specificity 0.743 and 0.816, respectively), lymphovascular space invasion (pooled sensitivity and specificity 0.656 and 0.753, respectively), and nodal metastasis (pooled sensitivity and specificity 0.831 and 0.736, respectively).ConclusionsPre-operative MRI-radiomics analyses in patients with endometrial carcinoma is a good predictor of tumor grading, deep myometrial invasion, lymphovascular space invasion, and nodal metastasis.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d91b1b6211000c603e3dcfb22cad119bTest
https://hdl.handle.net/11573/1679917Test

المؤلفون: Priyanka Jha, Atul B. Shinagare, Liina Poder, Elizabeth A. Sadowski, Jeanne M. Horowitz, H. A. Vargas, Marcia C. Javitt, Lucia Manganaro, Aki Kido, Katherine E. Maturen, Andrea Rockall, Hye Sun Park, Yulia Lakhman, Olivera Nikolic, Stephanie Nougaret, Isabelle Thomassin-Naggara, Gaiane M. Rauch, Evis Sala, Neil S. Horowitz, Rosemarie Forstner, Olga R. Brook, Susanna I. Lee, Aradhana M. Venkatesan, Caroline Reinhold, S. Wallace

المصدر: Eur Radiol

مصطلحات موضوعية: Ovarian Neoplasms, medicine.medical_specialty, Isoflurophate, Magnetic Resonance Spectroscopy, medicine.diagnostic_test, business.industry, Magnetic resonance imaging, Interventional radiology, General Medicine, Gynecologic oncology, Disease, medicine.disease, Lexicon, Magnetic Resonance Imaging, Article, Humans, Medicine, Female, Radiology, Nuclear Medicine and imaging, Radiology, Tomography, X-Ray Computed, business, Ovarian cancer, Radiation treatment planning, Neuroradiology

الوصف: Objectives Imaging evaluation is an essential part of treatment planning for patients with ovarian cancer. Variation in the terminology used for describing ovarian cancer on computed tomography (CT) and magnetic resonance (MR) imaging can lead to ambiguity and inconsistency in clinical radiology reports. The aim of this collaborative project between Society of Abdominal Radiology (SAR) Uterine and Ovarian Cancer (UOC) Disease-focused Panel (DFP) and the European Society of Uroradiology (ESUR) Female Pelvic Imaging (FPI) Working Group was to develop an ovarian cancer reporting lexicon for CT and MR imaging. Methods Twenty-one members of the SAR UOC DFP and ESUR FPI working group, one radiology clinical fellow, and two gynecologic oncology surgeons formed the Ovarian Cancer Reporting Lexicon Committee. Two attending radiologist members of the committee prepared a preliminary list of imaging terms that was sent as an online survey to 173 radiologists and gynecologic oncologic physicians, of whom 67 responded to the survey. The committee reviewed these responses to create a final consensus list of lexicon terms. Results An ovarian cancer reporting lexicon was created for CT and MR Imaging. This consensus-based lexicon has 6 major categories of terms: general, adnexal lesion-specific, peritoneal carcinomatosis-specific, lymph node-specific, metastatic disease -specific, and fluid-specific. Conclusions This lexicon for CT and MR imaging evaluation of ovarian cancer patients has the capacity to improve the clarity and consistency of reporting disease sites seen on imaging. Key points • This reporting lexicon for CT and MR imaging provides a list of consensus-based, standardized terms and definitions for reporting sites of ovarian cancer on imaging at initial diagnosis or follow-up. • Use of standardized terms and morphologic imaging descriptors can help improve interdisciplinary communication of disease extent and facilitate optimal patient management. • The radiologists should identify and communicate areas of disease, including difficult to resect or potentially unresectable disease that may limit the ability to achieve optimal resection.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e7682f769f8060894e5df1187338d11Test
https://doi.org/10.1007/s00330-021-08390-yTest

المؤلفون: Carlo de Felice, Arianna Cleri, Francesca Maccioni, Luigi Petrucci, Lucia Manganaro, Mariangela Lopez, Carlo Catalano, Alessandro Calabrese, Sara Cardaccio, Gabriela Capriotti, Alessandro Pulsoni

المصدر: Hemato, Vol 2, Iss 41, Pp 635-644 (2021)
Hemato
Volume 2
Issue 4
Pages 41-644

مصطلحات موضوعية: PET-CT, business.industry, PET/CT, non-Hodgkin lymphoma, Lymphoma staging, Diagnostic accuracy, Total body, Gold standard (test), staging, medicine.disease, Lymphoma, medicine, diffusion weighted imaging, Medicine, business, Nuclear medicine, Reference standards, Hodgkin lymphoma, Diffusion MRI, MRI, CT

الوصف: (1) Background: The purpose of this study is to retrospectively compare CT, MRI, and PET/CT in detecting lymphadenopathies and extra-nodal lesions in lymphoma and in disease staging. (2) Methods: Inclusion criteria were the availability of TB (Total Body) CT and/or PET/CT performed before treatment
MRI performed no later than 2 weeks after TBCT
histological confirmation of lymphoma
clinical-diagnostic follow-up. Using these criteria, we included 64/353 patients with TBCT and MRI performed at our hospital
20/64 had PET/CT performed in other hospitals. Histology and follow-up were gold standard. (3) Results: The sensitivity, specificity, and accuracy in lymph nodes detection was 84.5%, 94.4%, and 91% for CT and 95%, 98.9%, and 95.6% for MRI. High agreement was observed between CT and MRI regarding the number and size of positive lymph nodes and for disease staging. MRI identified eight more extra-nodal lesions than CT. In the subgroup of 20 patients, PET/CT did not show a significant superiority in sensitivity, specificity, accuracy, and staging ability than CT and MRI. (4) Conclusions: Our study demonstrates a mild superiority of MRI over CT in lymphoma staging. Although PET/CT remains the reference standard, MRI demonstrated a similar diagnostic accuracy, with the added value of being radiation-free.

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::671abbb5516dc30124b19fa444988b40Test
https://www.mdpi.com/2673-6357/2/4/41Test

المؤلفون: Andrew E. Timms, Danilo Dubocanin, Cira Di Gioia, Rosa Russo, Derek Dang, Kathleen J. Millen, Ozgur Oztekin, Lucia Manganaro, Alexandria H Sjoboen, Brian D Davis, Kimberly A. Aldinger, Fabien Guimiot, Ian A. Glass, Jake Millman, Evelina Silvestri, Homa Adle-Biassette, Mei Deng, Tarika Sivakumar, Parthiv Haldipur, Ferechté Razavi, Kshitij Mankad, Nathalie Roux, Joseph R. Siebert, Silvia Bernardo, Giulia Petrilli, Debora Kidron, Jasmine T. Plummer

المصدر: Acta Neuropathol

مصطلحات موضوعية: Cerebellum, cerebellum, Developmental Disabilities, Biology, Nervous System Malformations, Article, cerebellar vermis hypoplasia, Dandy–Walker malformation, development, rhombic lip, Pathology and Forensic Medicine, Fetal Development, Pathogenesis, Cellular and Molecular Neuroscience, Fetus, medicine, Humans, Rhombic lip, Laser capture microdissection, Progenitor, Infant, Newborn, Anatomy, medicine.disease, Hypoplasia, medicine.anatomical_structure, Dysplasia, Case-Control Studies, Immunohistochemistry, Neurology (clinical), Dandy-Walker Syndrome

الوصف: Dandy-Walker malformation (DWM) and Cerebellar vermis hypoplasia (CVH) are commonly recognized human cerebellar malformations diagnosed following ultrasound and antenatal or postnatal MRI. Specific radiological criteria are used to distinguish them, yet little is known about their differential developmental disease mechanisms. We acquired prenatal cases diagnosed as DWM and CVH and studied cerebellar morphobiometry followed by histological and immunohistochemical analyses. This was supplemented by laser capture microdissection and RNA-sequencing of the cerebellar rhombic lip, a transient progenitor zone, to assess the altered transcriptome of DWM vs control samples. Our radiological findings confirm that the cases studied fall within the accepted biometric range of DWM. Our histopathological analysis points to reduced foliation and inferior vermian hypoplasia as common features in all examined DWM cases. We also find that the rhombic lip, a dorsal stem cell zone that drives the growth and maintenance of the posterior vermis is specifically disrupted in DWM, with reduced proliferation and self-renewal of the progenitor pool, and altered vasculature, all confirmed by transcriptomics analysis. We propose a unified model for the developmental pathogenesis of DWM. We hypothesize that rhombic lip development is disrupted through either aberrant vascularization and/or direct insult which causes reduced proliferation and failed expansion of the rhombic lip progenitor pool leading to disproportionate hypoplasia and dysplasia of the inferior vermis. Timing of insult to the developing rhombic lip (before or after 14 PCW) dictates the extent of hypoplasia and distinguishes DWM from CVH.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e193f803997c3ba3aa6cd76ca148ff1Test
https://doi.org/10.1007/s00401-021-02355-7Test

المؤلفون: GIUSEPPE SPRIANO, GIUSEPPE MERCANTE, LUCIA MANGANARO, Marco Francone, SALVATORE LETTERIO POLITI, Luca Balzarini, Stefano Lusi, GIAN MARCO FRIGERIO, ELENA CASIRAGHI, Caterina Giannitto, giorgia carnicelli

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::ac57267c87b8c56e55344118aac539d6Test
https://doi.org/10.26226/m.6304a252fa816f364423c530Test

المؤلفون: Alessandro Napoli, Carlo Catalano, Francesco Pecorini, Giulia Alfieri, Lucia Manganaro, Fabrizio Andrani, Roberto Scipione

المصدر: Seminars in Ultrasound, CT and MRI. 42:25-36

مصطلحات موضوعية: medicine.medical_specialty, Uterine fibroids, medicine.medical_treatment, Magnetic Resonance Imaging, Interventional, Endometrium, 030218 nuclear medicine & medical imaging, magnetic resonance, 03 medical and health sciences, 0302 clinical medicine, Uterine artery embolization, medicine, Humans, Radiology, Nuclear Medicine and imaging, uterine fibroids, Adverse effect, Ultrasonography, Interventional, neoplasm, myomas, focused ultrasound surgery (FUS), Pregnancy, Hysterectomy, Leiomyoma, medicine.diagnostic_test, business.industry, Uterus, Ultrasound, Magnetic resonance imaging, medicine.disease, Myoma, Treatment Outcome, medicine.anatomical_structure, Uterine Neoplasms, High-Intensity Focused Ultrasound Ablation, Female, Radiology, business, 030217 neurology & neurosurgery

الوصف: Uterine fibroids are the most common neoplasm in women. These lesions may be associated with impaired fertility and adverse obstetric outcomes. Medical treatment, myomectomy, hysterectomy and uterine artery embolization have been employed for the management of uterine fibroids. Focused ultrasound surgery (FUS) is a relatively recent technique that relies on mechanical and thermal energy of ultrasound for the ablation of a target tissue under an imaging guidance, that can be either ultrasound (US-guided FUS, USgFUS) or magnetic resonance (MR-guided FUS, MRgFUS). Pre- and peri-menopausal women are potential candidates for treatment; however, individual criteria need to be evaluated in order to establish the eligibility for the procedure. FUS procedure can be performed in an outpatient setting; it is a safe and effective treatment that has demonstrated to reduce symptoms associated with uterine fibroids. The adverse event rate is 8.7% and only 0.2% of patients experiences major complications. Pregnancy is possible after the treatment, and no damage to the endometrium has been observed following FUS procedure.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04c90cf6fc4c79f19c4dd6ae3dbfb9dfTest
https://doi.org/10.1053/j.sult.2020.08.001Test

المؤلفون: Lucia Manganaro, Valeria Vinci, Antonella Giancotti, Sandro Gerli, Denis A. Cozzi, Teresa Pusiol, Michele Scialpi, Luca Roncati

المصدر: Journal of Obstetrics and Gynaecology, Vol 37, Iss 5, Pp 670-672 (2017)

مصطلحات موضوعية: foetus, magnetic resonance imaging (mri), diffusion-weighted mri (dw-mri), bi-parametric mri (bp-mri), placenta accreta, obstetrics, Gynecology and obstetrics, RG1-991

الوصف: Foetal magnetic resonance imaging (MRI) plays an increasingly important role in the diagnosis of foetal abnormalities. Over the years, we have successfully applied bi-parametric MRI (bp-MRI) to the following obstetric conditions: (1) neurologic vascular diseases; (2) assessment of lung parenchyma maturation; (3) renal pathologies, such as polycystic kidney, suspected renal infarction, unilateral or bilateral renal agenesis; (4) placental pathologies, as twin-twin transfusion syndrome or placenta accreta; (5) benignant and malignant congenital tumours or cysts of the liver, such as haemangioendothelioma, hepatoblastoma or metastatic neuroblastoma, of the kidney (e.g. mesoblastic nephroma) and of the retroperitoneum, such as teratoma. The information derived from bp-MRI, and concerned with water motions in different tissues, improved the morphologic details provided by conventional foetal MRI. It has the potential to increase the value of MRI in the assessment of a wide range of foetal pathologies, particularly in renal diseases, allowing an adequate management decision and therapy.

العلاقة: http://dx.doi.org/10.1080/01443615.2017.1281237Test; https://doaj.org/toc/0144-3615Test; https://doaj.org/toc/1364-6893Test; https://doaj.org/article/8ae9ef38514d4bedb95635d6744f2788Test

الإتاحة: https://doi.org/10.1080/01443615.2017.1281237Test
https://doaj.org/article/8ae9ef38514d4bedb95635d6744f2788Test

المؤلفون: Massimo Caulo, Anthony Odibo, Daniele Di Mascio, Gregor Kasprian, Lucia Manganaro, Giuseppe Rizzo, D Buca, Ilan E. Timor-Tritsch, Maria Elena Flacco, Asma Khalil, F. D'Antonio, M Liberati, Antonella Giancotti

مصطلحات موضوعية: medicine.medical_specialty, Magnetic Resonance Spectroscopy, MEDLINE, CINAHL, Fetal brain, Pregnancy, Reference Values, Medicine, Humans, Radiology, Nuclear Medicine and imaging, Medical physics, Ultrasonography, Radiological and Ultrasound Technology, medicine.diagnostic_test, business.industry, Obstetrics and Gynecology, Brain, Magnetic resonance imaging, General Medicine, Magnetic Resonance Imaging, Regression, central nervous system, charts, fetal brain, growth, magnetic resonance imaging, Reproductive Medicine, Individual study, Sample size determination, Quality Score, Female, business

الوصف: Objective\ud To evaluate the methodology of studies reporting reference ranges for fetal brain structures on magnetic resonance imaging (MRI).\ud \ud Methods\ud MEDLINE, EMBASE, CINAHL and the Web of Science databases were searched electronically up to 31 December 2020 to identify studies investigating biometry and growth of the fetal brain and reporting reference ranges for brain structures using MRI. The primary aim was to evaluate the methodology of these studies. A list of 26 quality criteria divided into three domains, including ‘study design’, ‘statistical and reporting methods’ and ‘specific aspects relevant to MRI’, was developed and applied to evaluate the methodological appropriateness of each of the included studies. The overall quality score of a study, ranging between 0 and 26, was defined as the sum of scores awarded for each quality criterion and expressed as a percentage (the lower the percentage, the higher the risk of bias).\ud \ud Results\ud Fifteen studies were included in this systematic review. The overall mean quality score of the studies evaluated was 48.7%. When focusing on each domain, the mean quality score was 42.0% for ‘study design’, 59.4% for ‘statistical and reporting methods’ and 33.3% for ‘specific aspects relevant to MRI’. For the ‘study design’ domain, sample size calculation and consecutive enrolment of women were the items found to be at the highest risk of bias. For the ‘statistical and reporting methods’ domain, the presence of regression equations for mean and SD for each measurement, the number of measurements taken for each variable and the presence of postnatal assessment information were the items found to be at the highest risk of bias. For the ‘specific aspects relevant to MRI’ domain, whole fetal brain assessment was not performed in any of the included studies and was therefore considered to be the item at the highest risk of bias.\ud \ud Conclusions\ud Most of the previously published studies reporting fetal brain reference ranges on MRI are highly heterogeneous and have low-to-moderate quality in terms of methodology, which is similar to the findings reported for ultrasound studies.

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::603218c38ca4eea26ea6e29eee220ad1Test
https://openaccess.sgul.ac.uk/id/eprint/113596/1/uog.23762.pdfTest

المؤلفون: Stefania Rizzo, Andrea Cozzi, Miriam Dolciami, Filippo Del Grande, Angela L. Scarano, Andrea Papadia, Benedetta Gui, Nicoletta Gandolfo, Carlo Catalano, Lucia Manganaro

المساهمون: S.M.R. Rizzo, A. Cozzi, M. Dolciami, F. Del Grande, A.L. Scarano, A. Papadia, B. Gui, N. Gandolfo, A.C.C. Catalano, L. Manganaro

مصطلحات موضوعية: Settore MED/36 - Diagnostica per Immagini e Radioterapia, Settore MED/40 - Ginecologia e Ostetricia, Settore MED/06 - Oncologia Medica

الوصف: Background US-indeterminate adnexal lesions remain an important indication for gynecologic surgery. MRI can serve as a problem-solving tool through the use of the Ovarian-Adnexal Imaging Reporting and Data System (O-RADS) MRI lexicon, which is based on the ADNEX MR scoring system. Purpose To perform a systematic review and meta-analysis of the diagnostic performance of pelvic MRI interpreted using the ADNEX or O-RADS MRI stratification systems to characterize US-indeterminate adnexal lesions and of the category-wise malignancy rates. Materials and Methods A systematic literature search from May 2013 (publication of the ADNEX MR score) to September 2022 was performed. Studies reporting the use of pelvic MRI interpreted with the ADNEX or O-RADS MRI systems to characterize US-indeterminate adnexal lesions, with pathologic examination and/or follow-up as the reference standard, were included. Summary estimates of diagnostic performance were obtained with the bivariate random-effects model, while category-wise summary malignancy rates of O-RADS MRI 2, 3, 4, and 5 lesions were obtained with a random-effects model. Effects of covariates on heterogeneity and diagnostic performance were investigated through meta-regression. Results Thirteen study parts from 12 studies (3731 women, 4520 adnexal lesions) met the inclusion criteria. Diagnostic performance meta-analysis for 4012 lesions found a 92% summary sensitivity (95% CI: 88, 95) and a 91% summary specificity (95% CI: 89, 93). The meta-analysis of malignancy rates for 3641 lesions showed summary malignancy rates of 0.1% (95% CI: 0, 1) among O-RADS MRI 2 lesions, 6% (95% CI: 3, 9) among O-RADS MRI 3 lesions, 60% (95% CI: 52, 67) among O-RADS MRI 4 lesions, and 96% (95% CI: 92, 99) among O-RADS MRI 5 lesions. Conclusion Pelvic MRI interpreted with the Ovarian-Adnexal Reporting and Data System (O-RADS) MRI lexicon had high diagnostic performance for the characterization of US-indeterminate adnexal lesions. Summary estimates of malignancy rates in the O-RADS MRI 4 and ...

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/36413127; info:eu-repo/semantics/altIdentifier/wos/WOS:000986795600004; journal:RADIOLOGY; https://hdl.handle.net/2434/949468Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85149108074

الإتاحة: https://doi.org/10.1148/radiol.220795Test
https://hdl.handle.net/2434/949468Test