المؤلفون: Ni, Bin, Liu, Jing-wen, Fan, Xue-qiang, He, Bin, Nie, Qiang-qiang, Ye, Zhi-dong, Liu, Peng, Wen, Jian-yan

المساهمون: Major New Drug Creation Special Project, National Natural Science Foundation of China, the International S&T cooperation program, National High Level Hospital Clinical Research Funding

المصدر: Journal of International Medical Research ; volume 52, issue 1 ; ISSN 0300-0605 1473-2300

مصطلحات موضوعية: Biochemistry (medical), Cell Biology, Biochemistry, General Medicine

الوصف: Objective To evaluate the safety and efficacy of bleomycin polidocanol foam (BPF) sclerotherapy for venous malformations (VMs) and analyze the associated clinical outcomes and predictors. Methods We retrospectively assessed BPF sclerotherapy outcomes in 138 patients with VMs. We analyzed pain levels, lesion volume reduction, and subjective perception of response. Logistic regression analysis was performed to identify potential predictors of treatment outcome. Additionally, we carefully monitored and recorded complications. Results There was a notable average reduction in lesion volume by 78.50% ± 15.71%. The pain numerical rating scale (NRS) score decreased from 4.17 ± 2.63 prior to treatment to 1.05 ± 1.54 afterward, and 70.3% of the patients experienced effective relief after a single BPF treatment. Multivariate analysis revealed that a high baseline NRS (odds ratio [OR]: 4.026) and elevated activated partial thromboplastin time (APTT, OR: 1.200) were positive predictors of pain reduction. Additionally, a high baseline NRS score (OR: 1.992) and elevated thrombocytocrit (PCT, OR: 2.543) were positive predictors of incomplete postoperative pain relief. Minor complications occurred in 31 (22.46%) patients. Conclusion BPF sclerotherapy is safe and effective for VMs, resulting in significant reduction in lesion volume, improved symptoms, and minimal complications. APTT and PCT levels are important predictors of pain outcomes following BPF treatment.

الإتاحة: https://doi.org/10.1177/03000605231223441Test

المؤلفون: Liu, Jing-wen, Ni, Bin, Gao, Xi-xi, He, Bin, Nie, Qiang-qiang, Fan, Xue-qiang, Ye, Zhi-dong, Wen, Jian-yan, Liu, Peng

المصدر: Journal of Vascular Surgery: Venous and Lymphatic Disorders ; volume 12, issue 2, page 101697 ; ISSN 2213-333X

الإتاحة: https://doi.org/10.1016/j.jvsv.2023.101697Test
https://api.elsevier.com/content/article/PII:S2213333X23003979?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S2213333X23003979?httpAccept=text/plainTest

المؤلفون: Liu‐Jing Wen, Yue‐Sheng Wang, Jie Zhang

المصدر: IET Nanobiotechnology, Vol 17, Iss 2, Pp 49-60 (2023)

مصطلحات موضوعية: breast cancer, doxorubicin, drug loaded hybrid micelles, elacridar, gold nanoparticles, Biotechnology, TP248.13-248.65

الوصف: Abstract The aim of this study was to provide a new effective carrier for rescuing the sensitivity of drug‐resistant in breast cancer cells. Nano‐gold micelles loaded with Dox and Elacridar (FP‐ssD@A‐E) were chemically synthesised. With the increase in the amount of Dox and Elacridar, the encapsulation rate of FP‐ssD@A‐E gradually increased, and the drug loading rate gradually decreased. FP‐ss@A‐E had a sustained‐release effect. Dox, Elacridar, FP‐ss@AuNPs, and FP‐ssD@A‐E significantly improved cell apoptosis, in which, FP‐ssD@A‐E was the most significant. FP‐ssD@A‐E significantly decreased the cell viability and improved the Dox uptake. The levels of VEGFR‐1, P‐gp, IL‐6, and i‐NOS were significantly decreased after Dox, Dox + Elacridar, FP‐ss@AuNPs, and FP‐ssD@A‐E treatment. It was worth noting that FP‐ssD@A‐E had the most significant effects. The prepared FP‐ssD@A‐E micelles, which were spherical in shape, uniform in particle size distribution, and had good drug loading performance and encapsulation efficiency.

وصف الملف: electronic resource

العلاقة: https://doaj.org/toc/1751-8741Test; https://doaj.org/toc/1751-875XTest

الوصول الحر: https://doaj.org/article/37f344a0694843dfb4284ece6e85c60eTest

المؤلفون: Che, Li-Heng, Liu, Jing-Wen, Huo, Jian-Ping, Luo, Rong, Xu, Rui-Min, He, Cai, Li, Yu-Qing, Zhou, Ai-Jun, Huang, Piao, Chen, Yong-Yu, Ni, Wen, Zhou, Yun-Xia, Liu, Yuan-Yuan, Li, Hui-Yan, Zhou, Rong, Mo, Hui, Li, Jian-Ming

المصدر: Cell Discovery ; volume 9, issue 1 ; ISSN 2056-5968

مصطلحات موضوعية: Cell Biology, Genetics, Molecular Biology, Biochemistry

الإتاحة: https://doi.org/10.1038/s41421-023-00537-zTest
https://www.nature.com/articles/s41421-023-00537-z.pdfTest
https://www.nature.com/articles/s41421-023-00537-zTest

المؤلفون: Yang, Song-hong, Tao, Gabriel, Yang, Liu, Wu, Xiaohui, Liu, Jing-wen, Dagher, Fatima, Ou, Shi-yi, Song, Yuan, Huang, Jun-qing

المصدر: Frontiers in Nutrition ; volume 10 ; ISSN 2296-861X

مصطلحات موضوعية: Nutrition and Dietetics, Endocrinology, Diabetes and Metabolism, Food Science

الوصف: Plant-based functional foods have attracted increasing research interest to validate their use in preventing metabolic disease. Since it is increasingly recognized that inflammation, oxidative stress, and circadian rhythm play vital roles in various metabolic diseases, including diabetes, obesity and non-alcoholic liver disease, plant proteins, protein hydrolysates, and food extracts that intervene in these biological processes are promising dietary supplements to prevent metabolic diseases. Here, we reviewed the recent research on plant-based foods used for metabolic disease prevention and provided new perspectives regarding the current study gaps and future directions in this field.

الإتاحة: https://doi.org/10.3389/fnut.2023.1089487Test

المؤلفون: Hu, Ya-Fen, Liu, Jing-Wen, Luo, Xing-Xing, Xu, Zhao-Huan, Xia, Ji-Wen, Zhang, Xiu-Guo, Castañeda-Ruíz, Rafael F., Ma, Jian

المساهمون: Anderson, Matthew Zack, MOST | National Natural Science Foundation of China

المصدر: Microbiology Spectrum ; volume 11, issue 6 ; ISSN 2165-0497

الوصف: Plant debris are habitat favoring the growth of various microbial species. Over the course of our mycological surveys in Jiangxi and Yunnan Provinces, China, eight new Distoseptispora species, viz. D. gasaensis , D. guanshanensis , D. jinghongensis , D. longnanensis , D. menghaiensis , D. menglunensis , D. nanchangensis , and D. yichunensis collected on dead branches of unidentified plants, were introduced by morphological and molecular phylogenetic analyses. Multi-locus (LSU, ITS, TEF1 , and RPB2 ) phylogenetic analyses were performed using maximum-likelihood and Bayesian inference to infer their taxonomic positions within Distoseptispora . Both molecular phylogenetic analyses and morphological characters supported them as eight independent taxa within Distoseptispora . This work improves our understanding of the diversity of Distoseptispora in southern China. IMPORTANCE Distoseptispora as a single genus in Distoseptisporaceae was introduced by morphological and phylogenetic analyses. Members of this genus occur mainly as asexual morphs, forming effuse, hairy colonies on decaying wood, plant stems, bamboo culms, and fallen leaves and shafts in terrestrial and freshwater habitats. In the present study, saprobic hyphomycetes from plant debris were investigated, and eight new Distoseptispora species were introduced based on morphology and phylogenetic analyses of LSU, ITS, TEF1 , and RPB2 sequence data. This study provides important data on the species diversity, ecological environment, and geographical area of Distoseptispora , greatly updates the classification of Distoseptispora , and improves our understanding of the taxonomy of Distoseptispora .

الإتاحة: https://doi.org/10.1128/spectrum.02468-23Test

المؤلفون: Liu, Jing-Wen, 劉靜雯

مرشدي الرسالة: Pao, Li-Heng, 鮑力恒

الوصف: 101
中文摘要 近年來，中藥所致腎臟損害日益受到人們的重視。多數藥物吸收後，主要經腎小球濾過、近曲小管分泌、遠曲小管重吸收和小管上皮細胞降解等代謝過程排出體外。在這一過程中均可累積腎毒性而發生結構和功能改變，導致腎臟損傷。中藥腎毒性已經成為制約中藥現代化和臨床應用的一大障礙。為了確保中藥的安全使用，有必要加強中藥的毒理學研究。然而，中藥製劑在台灣之使用相當普遍，因此中藥對腎臟之傷害機制尤其值得作深入之探討。 研究發現馬兜鈴(Aristolochia)會造成腎臟損害，但中藥是否仍含其他成分會導致腎毒性，目前我國僅有少數相關文獻與研究。因此本篇研究目的為，挑選出使用較多之複方濃縮中藥，每種複方濃縮中藥選自三家藥廠之產品，主要以市售三大廠為主。中藥腎病變之可能機轉主要是與腎絲球過濾和腎小管分泌有關，因此當中藥傷害腎臟時最主要受到影響的地方便是腎絲球及腎小管。所以本篇研究採用近端腎小管細胞(LLC-PK1)與遠端腎小管細胞(MDCK) 來進行體外細胞模式及以SD大鼠為體內動物模式的篩選評估。 體外細胞模式以模擬人體每日服用複方濃縮中藥之最大劑量且完全吸收，並進行劑量效應探討，以50%及10%濃度稀釋複方濃縮中藥之最大劑量，最後以10%處理濃度進行細胞存活率實驗，若細胞存活率低於75%，則判定此複方濃縮中藥可能具有腎毒性複方濃縮中藥經口服吸收後，除考慮口服吸收率與會經血液稀釋外，尚會與血中蛋白質結合，也會經血液分佈到各組織器官，故接觸到腎臟細胞之濃度相對降低許多，而以稀釋至10% 的處理濃度進行細胞毒性之篩選。體外篩藥結果顯示，A廠小建中湯、桃仁承氣湯、小柴胡湯，B廠桑菊飲，C廠上中下通用痛風丸具細胞毒性傷害之風險。 體內動物模式以餵食SD大鼠A廠之複方濃縮中藥，連續14天，於犧牲前一天收集SD大鼠之血液與尿液，檢測美國食品藥物管理局(FDA)建議之七種生物標誌物(biomarkers)及血清肌酸酐(Creatinine)， 來評估複方中藥對腎之傷害，同時針對腎臟進行組織切片，進行病理分析。體內篩藥結果顯示，並不會造成大鼠腎臟之損傷。 另依據細胞實驗之結果，挑選幾種複方濃縮中藥，經人類腎小管細胞(HK2)之細胞存活試驗，其實驗結果之細胞存活率與近端腎小管細胞(LLCPK1)相似，未來近端腎小管細胞之試驗結果應可作為人類腎小管細胞之試驗結果之代表。 Abstract In recent years, Chinese herbal medicine induce renal damage caused growing attention. Most drugs were absorbed by glomerular filtration, proximal tubule secretion, distal tubule reabsorption and epithlial tubular cell degradation and other metabolic processes excreted. In this process, drugs are cumulatived nephrotoxicity and changed kidney of structure and function, therefore leading to kidney damage. Chinese herbal medicine has become a restriction of renal toxicity and the obstacle of clinical application. In order to ensure the safely use of traditional Chinese herbal medicine, it is necessary to strengthen Chinese herbal medicine of toxicology studies. However, the use of Chinese herbal medicine in Taiwan is common, so the herbs on the renal damage mechanisms of particular in-depth study. Study found that aristolochic acid(Aristolochia) caused renal damage, but it still contains other ingredients of Chinese herbal medicine caused renal toxicity, currently only a view of relevant literature and research. Therefore, the purpose of this study, the Chinese herbal medicine was selected because usually using in Taiwan, each Chinese herbal medicine was selected from three pharmaceutical companies. Chinese herbal medicine nephropathy mechanisms possibly associated with glomerular filtration and tubular secretion, and therefore damage the kidneys when the medicine most affected the glomerule and tubule. Therefore, this study using the proximal tubular cells (LLC-PK1) and distal tubule cells(MDCK) for in vitro cell models and in SD rats as animal models in vivo screening assessment. In vitro cell models to simulate the human daily maximum dose of Chinese herbal medicine and completely absorbed, and conduct dose dependent, 50% and 10% concentrations of diluted the maximum dose of medicine, and finally the 10% concentration for cell viability experiments, cell viability was below 75%, it is determined this Chinese herbal medicine potentially nephrotoxicity. Chinese herbal medicine orally absorbed, in addition to considering the orally absorption rate and hemodilution, but still with the blood protein binding, also the blood distributed to various tissues and organs, the renal cells exposed to relatively reduce the number density, so this study selected the 10% concentration of medicine to consider that if Chinese herbal medicine cause nephrotoxicity or not. The results showed that in vitro drug screening, Chinese herbal medicine probally caused nephrotoxicity containing Sheau Jiann Jong Tang, Tao Ren Cheng Chi Tang and Sheau Chair Hwu Tang in company A, Shang Ju Yin in company B, Shang Zhong Xia Tong Yong Tang Feng Wan in company C. In vivo animal models to SD rats fed Chinese herbal medicine of pharmaceutical company A for 14 days, the study collected the blood and urine of SD rats before sacrifice them. According Food and Drug Administration (FDA) proposed seven kinds of biomarkers ( biomarkers) and serum creatinine (Creatinine), to evaluate the Chinese herbal medicine for kidney damage, and for kidney biopsy performed for pathological analysis. The results showed that in vivo drug screening, the medicine did not cause damage to the kidney in rats. In addition, according to the results of in vitro experiments, the selection of several Chinese herbal medicine to cell survival test by human renal tubular cells (HK2), the results of cell viability is similar proximal tubular cells (LLCPK1). In the future, the cell survival test representative that proximal tubule cells(LLCPK1) should be used as the human renal tubular cells(HK2).

وصف الملف: 163

الإتاحة: http://ndltd.ncl.edu.tw/handle/06998104477989907569Test

المؤلفون: Zhang, Juan, Liu, Jing, Liu, Jing-Wen, Zhu, Qi-Meng, Zhang, Min, Zhang, Rui, Ma, Xiao-Chi, Lv, Xia, Yu, Zhen-Long, Sun, Cheng-Peng

المصدر: Journal of Ethnopharmacology ; volume 319, page 117358 ; ISSN 0378-8741

مصطلحات موضوعية: Drug Discovery, Pharmacology

الإتاحة: https://doi.org/10.1016/j.jep.2023.117358Test
https://api.elsevier.com/content/article/PII:S037887412301228X?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S037887412301228X?httpAccept=text/plainTest

المؤلفون: Zhu, Qi-Meng, Wang, Chao, Liu, Jing-Wen, Zhang, Rui, Xin, Xiu-Lan, Zhang, Juan, Sun, Cheng-Peng, Ma, Xiao-Chi

المصدر: Journal of Hazardous Materials ; volume 461, page 132617 ; ISSN 0304-3894

مصطلحات موضوعية: Health, Toxicology and Mutagenesis, Pollution, Waste Management and Disposal, Environmental Chemistry, Environmental Engineering

الإتاحة: https://doi.org/10.1016/j.jhazmat.2023.132617Test
https://api.elsevier.com/content/article/PII:S0304389423019003?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S0304389423019003?httpAccept=text/plainTest

المؤلفون: Potortì, Francesco, Park, Sangjoon, Crivello, Antonino, Palumbo, Filippo, GIROLAMI, MICHELE, Barsocchi, Paolo, Lee, Soyeon, Torres-Sospedra, Joaquín, Jimenez Ruiz, Antonio Ramon, Perez-Navarro, Antoni, Mendoza-Silva, Germán Martín, Seco, Fernando, ortiz, miguel, PERUL, Johan, Renaudin, Valerie, Kang, Hyunwoong, Park, Soyoung, Lee, Jae Hong, Park, Chan Gook, Ha, Jisu, Han, JaeSeung, Park, Changjun, Kim, Keunhye, Lee, Yonghyun, Gye, Seunghun, lee, keumryeol, Kim, Eunjee, Choi, Jeongsik, choi, Yang-Seok, Talwar, Shilpa, Cho, Seong Yun, Ben-Moshe, Boaz, Scherbakov, Alex, Antsfeld, Leonid, Sansano-Sansano, Emilio, Chidlovskii, Boris, Kronenwett, Nikolai, Prophet, Silvia, Landay, Yael, Marbel, Revital, Zheng, Lingxiang, Peng, Ao, Lin, Zhichao, Wu, Bang, Ma, Chengqi, Poslad, Stefan, Selviah, David, Wu, Wei, Ma, Zixiang, Zhang, Wenchao, Wei, Dongyan, Yuan, Hong, Jiang, Jun-Bang, Huang, Shao-Yung, Liu, Jing-Wen, Su, Kuan-Wu, Leu, Jenq-Shiou, Nishiguchi, Kazuki, BOUSSELHAM, Walid, Uchiyama, Hideaki, Thomas, Diego, Shimada, Atsushi, Taniguchi, Rin-ichiro, Cortés Puschel, Vicente, Lungenstrass, Tomás, Ashraf, Imran, Lee, Chanseok, Ali, Muhammad Usman, Im, Yeongjun, Kim, Gunzung, Eom, Jeongsook, Hur, Soojung, Park, Yongwan, Opiela, Miroslav, Moreira, Adriano, Nicolau, Maria João, Pendão, Cristiano, Silva, Ivo, Meneses, Filipe, Costa, António, Trogh, Jens, Plets, David, Chien, Ying-Ren, Chang, Tzu-Yu, Fang, Shih-Hau, Tsao, Yu

مصطلحات موضوعية: indoor localisation, indoor navigation, competition, benchmarking, smartphone-based positioning, foot-mounted pedestrian dead reckoning, Wi-Fi fingerprinting, magnetic field, camera-based positioning, inertial-based positioning, sensor fusion, Kalman filter, particle filter, stakeholders, atmospheric measurements, particle measurements, real-time systems, wireless fidelity, sensor systems

الوصف: IPIN 2019 Competition, sixth in a series of IPIN competitions, was held at the CNR Research Area of Pisa (IT), integrated into the program of the IPIN 2019 Conference. It included two on-site real-time Tracks and three off-site Tracks. The four Tracks presented in this paper were set in the same environment, made of two buildings close together for a total usable area of 1000 m 2 outdoors and and 6000 m 2 indoors over three floors, with a total path length exceeding 500 m. IPIN competitions, based on the EvAAL framework, have aimed at comparing the accuracy performance of personal positioning systems in fair and realistic conditions: past editions of the competition were carried in big conference settings, university campuses and a shopping mall. Positioning accuracy is computed while the person carrying the system under test walks at normal walking speed, uses lifts and goes up and down stairs or briefly stops at given points. Results presented here are a showcase of state-of-the-art systems tested side by side in real-world settings as part of the on-site real-time competition Tracks. Results for off-site Tracks allow a detailed and reproducible comparison of the most recent positioning and tracking algorithms in the same environment as the on-site Tracks.

وصف الملف: application/pdf

العلاقة: Development of human enhancement fire helmet and fire suppression support system; Basic Science Research Program; ICT Research and Development Program of MSIP/IITP (Development of Precise Positioning Technology for the Enhancement of Pedestrian Position/Spatial Cognition and Sports Competition Analysis); MICROCEBUS; REPNIN PLUS; TECHNOFUSION(III)CM; Development of wireless communication tracking-based location information system in disaster scene for fire-fighters and person who requested rescue; Strategic Priority Research Program; IEEE Access, Vol. 8 (2020); F. Potortì et al., "The IPIN 2019 Indoor Localisation Competition—Description and Results," in IEEE Access, vol. 8, pp. 206674-206718, 2020, doi:10.1109/ACCESS.2020.3037221.; http://hdl.handle.net/10234/200929Test

الإتاحة: https://doi.org/10.1109/ACCESS.2020.3037221Test
http://hdl.handle.net/10234/200929Test