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1دورية أكاديمية
المؤلفون: Seefat, M. R., Stege, C. A.M., Lissenberg-Witte, B. I., Levin, M. D., Timmers, G. J., Hoogendoorn, M., Ypma, P. F., Klein, S. K., Velders, G. A., Westerman, M., Strobbe, L., Durdu-Rayman, N., Davidis-van Schoonhoven, M. A., van Kampen, R. J.W., Dijk, A. C., Koster, A., Silbermann, M. H., van der Spek, E., Beeker, A., Erjavec, Z., de Graauw, N. C.H.P., Leys, M. B.L., Sonneveld, P., van de Donk, N. W.C.J., Nasserinejad, K., Blommestein, H. M., Cucchi, D. G.J., Zweegman, S.
المصدر: Seefat , M R , Stege , C A M , Lissenberg-Witte , B I , Levin , M D , Timmers , G J , Hoogendoorn , M , Ypma , P F , Klein , S K , Velders , G A , Westerman , M , Strobbe , L , Durdu-Rayman , N , Davidis-van Schoonhoven , M A , van Kampen , R J W , Dijk , A C , Koster , A , Silbermann , M H , van der Spek , E , Beeker , A , Erjavec , Z , de ....
مصطلحات موضوعية: /dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being, name=SDG 3 - Good Health and Well-being
الوصف: Background: Frailty in newly-diagnosed multiple myeloma (NDMM) patients is associated with treatment-related toxicity, which negatively affects health-related quality of life (HRQoL). Currently, data on changes in HRQoL of frail and intermediate-fit MM patients during active treatment and post-treatment follow-up are absent. Methods: The HOVON123 study (NTR4244) was a phase II trial in which NDMM patients ≥ 75 years were treated with nine dose-adjusted cycles of Melphalan-Prednisone-Bortezomib (MPV). Two HRQoL instruments (EORTC QLQ-C30 and -MY20) were obtained before start of treatment, after 3 and 9 months of treatment and 6 and 12 months after treatment for patients who did not yet start second-line treatment. HRQoL changes and/or differences in frail and intermediate-fit patients (IMWG frailty score) were reported only when both statistically significant (p < 0.005) and clinically relevant (>MID). Results: 137 frail and 71 intermediate-fit patients were included in the analysis. Compliance was high and comparable in both groups. At baseline, frail patients reported lower global health status, lower physical functioning scores and more fatigue and pain compared to intermediate-fit patients. Both groups improved in global health status and future perspective; polyneuropathy complaints worsened over time. Frail patients improved over time in physical functioning, fatigue and pain. Improvement in global health status occurred earlier than in intermediate-fit patients. Conclusion: HRQoL improved during anti-myeloma treatment in both intermediate-fit and frail MM patients. In frail patients, improvement occurred faster and, in more domains, which was retained during follow-up. This implies that physicians should not withhold safe and effective therapies from frail patients in fear of HRQoL deterioration.
وصف الملف: application/pdf
الإتاحة: https://doi.org/10.1016/j.ejca.2024.114153Test
https://pure.eur.nl/en/publications/75adb13f-7de3-40c2-994e-822da7df2829Test
https://pure.eur.nl/ws/files/153652316/Quality_of_life_gains_in_frail_and_intermediate-fit_patients_with_multiple_Myeloma.pdfTest
http://www.scopus.com/inward/record.url?scp=85195564473&partnerID=8YFLogxKTest -
2دورية أكاديمية
المؤلفون: Bleeker, L., Kouwenhoven, M. C. M., de Heer, I., Lissenberg-Witte, B. I., Gijsbers, A. H., Dubbink, H. J., Kros, J. M., Gijtenbeek, J. M. M., Kurt, E., van der Rijt, C. C. D., Swaak-Kragten, A. T., de Vos, F. Y., van der Weide, H. L., French, P. J., van den Bent, M. J., Wesseling, P., Bromberg, J. E. C.
المصدر: Bleeker , L , Kouwenhoven , M C M , de Heer , I , Lissenberg-Witte , B I , Gijsbers , A H , Dubbink , H J , Kros , J M , Gijtenbeek , J M M , Kurt , E , van der Rijt , C C D , Swaak-Kragten , A T , de Vos , F Y , van der Weide , H L , French , P J , van den Bent , M J , Wesseling , P & Bromberg , J E C 2023 , ' Medulloblastoma in adults : ....
الوصف: Purpose: Medulloblastoma is a rare tumor in adults. The objective of this nationwide, multicenter study was to evaluate the toxicity and efficacy of the Dutch treatment protocol for adult medulloblastoma patients. Methods: Adult medulloblastoma patients diagnosed between 2010 and 2018 were identified in the Dutch rare tumors registry or nationwide pathology database. Patients with intention to treat according to the national treatment protocol were included. Risk stratification was performed based on residual disease, histological subtype and extent of disease. All patients received postoperative radiotherapy [craniospinal axis 36 Gy/fossa posterior boost 19.8 Gy (14.4 Gy in case of metastases)]. High-risk patients received additional neoadjuvant (carboplatin-etoposide), concomitant (vincristine) and adjuvant chemotherapy (carboplatin-vincristine-cyclophosphamide) as far as feasible by toxicity. Methylation profiling, and additional next-generation sequencing in case of SHH-activated medulloblastomas, were performed. Results: Forty-seven medulloblastoma patients were identified, of whom 32 were treated according to the protocol. Clinical information and tumor material was available for 28 and 20 patients, respectively. The histological variants were mainly classic (43%) and desmoplastic medulloblastoma (36%). Sixteen patients (57%) were considered standard-risk and 60% were SHH-activated medulloblastomas. Considerable treatment reductions and delays in treatment occurred due to especially hematological and neurotoxicity. Only one high-risk patient could complete all chemotherapy courses. 5-years progression-free survival (PFS) and overall survival (OS) for standard-risk patients appeared worse than for high-risk patients (PFS 69% vs. 90%, OS 81% vs. 90% respectively), although this wasn’t statistically significant. Conclusion: Combined chemo-radiotherapy is a toxic regimen for adult medulloblastoma patients that may result in improved survival.
الإتاحة: https://doi.org/10.1007/s11060-023-04285-8Test
https://research.vumc.nl/en/publications/e03ca2a5-9931-4b4f-b59c-655b1564628aTest
https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85149958987&origin=inwardTest
https://www.ncbi.nlm.nih.gov/pubmed/36920679Test -
3دورية أكاديمية
المؤلفون: Lissenberg-Witte, B. I., Jansen, F., Baatenburg de Jong, R. J., Lamers, F., Leemans, C. R., Oosting, S. F., Takes, R. P., Verdonck-de Leeuw, I. M.
المصدر: Lissenberg-Witte , B I , Jansen , F , Baatenburg de Jong , R J , Lamers , F , Leemans , C R , Oosting , S F , Takes , R P & Verdonck-de Leeuw , I M 2023 , ' The impact of the COVID-19 pandemic on health-related quality of life in head and neck cancer survivors : An observational cohort study ' , Oral Oncology Reports , vol. 7 , 100059 . https://doi.org/10.1016/j.oor.2023.100059Test
الوصف: Objective: To investigate the impact of the COVID-19 pandemic on physical, psychological, and social aspects of health-related quality of life (HRQOL) among head and neck cancer (HNC) survivors. Materials and methods: Prospectively collected data from the NETherlands QUality of life and BIomedical Cohort study in HNC were used. All patients were diagnosed and treated before the COVID-19 pandemic. Patient reported outcome measures (PROMs) collected 24 and 36 months after treatment (M24 and M36) were compared between survivors who completed both assessments before the COVID-19 pandemic and those who completed M24 before but M36 during the pandemic. Personal, clinical, physical, psychological, social, and lifestyle characteristics of the survivors assessed at baseline or M24 were investigated as potential effect modifiers. Results: In total, 318 HNC survivors were included, of which 199 completed both M24 and M36 before the COVID-19 pandemic and 119 completed M24 before but M36 during the pandemic. Changes in HRQOL between 24 and 36 months follow-up did not differ between the two groups for any of the PROMs. Nevertheless, in some subgroups of HNC survivors the COVID-19 pandemic negatively affected the course of HRQOL for several PROMs while it positively affected the course of HRQOL for other PROMs. Conclusions: The COVID-19 pandemic did not affect HRQOL in HNC survivors in general, but some subgroups were affected in a positive and others in a negative way.
الإتاحة: https://doi.org/10.1016/j.oor.2023.100059Test
https://research.vumc.nl/en/publications/634850e7-ee4f-457a-abd6-98afc8f444ebTest
http://www.scopus.com/inward/record.url?scp=85180912813&partnerID=8YFLogxKTest -
4دورية أكاديمية
المؤلفون: Statema-Lohmeijer, C. H., Schats, R., Lissenberg-Witte, B. I., Kostelijk, E. H., Lambalk, C. B., Vergouw, C. G.
المصدر: Statema-Lohmeijer , C H , Schats , R , Lissenberg-Witte , B I , Kostelijk , E H , Lambalk , C B & Vergouw , C G 2023 , ' A short versus a long time interval between semen collection and intrauterine insemination : a randomized controlled clinical trial ' , Human reproduction (Oxford, England) , vol. 38 , no. 5 , pp. 811-819 . https://doi.org/10.1093/humrep/dead044Test
الوصف: STUDY QUESTION: Does a short interval (i.e. ≤90 min), compared to a long interval (i.e. ≥180 min), between semen collection and intrauterine insemination (IUI) increase the cumulative chance of an ongoing pregnancy after six IUI cycles? SUMMARY ANSWER: A long interval between semen collection and IUI resulted in a borderline significant improvement in cumulative ongoing pregnancies and a statistically significant shorter time to pregnancy. WHAT IS KNOWN ALREADY: Retrospective studies assessing the effect of the time interval between semen collection and IUI on pregnancy outcomes have shown inconclusive results. Some studies have indicated a beneficial effect of a short interval between semen collection and IUI on IUI outcomes, while others have not found any differences. To date, no prospective trials have been published on this subject. STUDY DESIGN, SIZE, DURATION: The study was performed as a non-blinded, single-center RCT with 297 couples undergoing IUI treatment in a natural or stimulated cycle. The study was conducted between February 2012 and December 2018. PARTICIPANTS/MATERIALS, SETTING, METHODS: Couples with unexplained or mild male subfertility and an indication for IUI were randomly assigned for up to six IUI cycles into either the control group (long interval, i.e. 180 min or more between semen collection and insemination) or the study group (short interval, i.e. insemination as soon as possible after semen processing and within 90 min of semen collection). The study was carried out in an academic hospital-based IVF center in the Netherlands. The primary endpoint of the study was ongoing pregnancy rate per couple, defined as a viable intrauterine pregnancy at 10 weeks after insemination. MAIN RESULTS AND THE ROLE OF CHANCE: In the short interval group, 142 couples were analyzed versus 138 couples in the long interval group. In the intention-to-treat (ITT) analysis, the cumulative ongoing pregnancy rate was significantly higher in the long interval group (71/138; 51.4%) compared to that in the short ...
الإتاحة: https://doi.org/10.1093/humrep/dead044Test
https://research.vumc.nl/en/publications/78ccd62d-5ac3-453c-90a3-568f4b3e032aTest
http://www.scopus.com/inward/record.url?scp=85159254102&partnerID=8YFLogxKTest -
5دورية أكاديمية
المؤلفون: Bleeker, L, Kouwenhoven, M C M, de Heer, I, Lissenberg-Witte, B I, Gijsbers, A H, Dubbink, H J, Kros, J M, Gijtenbeek, J M M, Kurt, E, van der Rijt, C C D, Swaak-Kragten, A T, de Vos, F Y, van der Weide, H L, French, P J, van den Bent, M J, Wesseling, P, Bromberg, J E C
المساهمون: MS Medische Oncologie, Cancer
مصطلحات موضوعية: Adults, Medulloblastoma, Methylation array, Toxicity, Treatment, Clinical Neurology, Neurology, Oncology, Cancer Research, Journal Article
الوصف: PURPOSE: Medulloblastoma is a rare tumor in adults. The objective of this nationwide, multicenter study was to evaluate the toxicity and efficacy of the Dutch treatment protocol for adult medulloblastoma patients. METHODS: Adult medulloblastoma patients diagnosed between 2010 and 2018 were identified in the Dutch rare tumors registry or nationwide pathology database. Patients with intention to treat according to the national treatment protocol were included. Risk stratification was performed based on residual disease, histological subtype and extent of disease. All patients received postoperative radiotherapy [craniospinal axis 36 Gy/fossa posterior boost 19.8 Gy (14.4 Gy in case of metastases)]. High-risk patients received additional neoadjuvant (carboplatin-etoposide), concomitant (vincristine) and adjuvant chemotherapy (carboplatin-vincristine-cyclophosphamide) as far as feasible by toxicity. Methylation profiling, and additional next-generation sequencing in case of SHH-activated medulloblastomas, were performed. RESULTS: Forty-seven medulloblastoma patients were identified, of whom 32 were treated according to the protocol. Clinical information and tumor material was available for 28 and 20 patients, respectively. The histological variants were mainly classic (43%) and desmoplastic medulloblastoma (36%). Sixteen patients (57%) were considered standard-risk and 60% were SHH-activated medulloblastomas. Considerable treatment reductions and delays in treatment occurred due to especially hematological and neurotoxicity. Only one high-risk patient could complete all chemotherapy courses. 5-years progression-free survival (PFS) and overall survival (OS) for standard-risk patients appeared worse than for high-risk patients (PFS 69% vs. 90%, OS 81% vs. 90% respectively), although this wasn't statistically significant. CONCLUSION: Combined chemo-radiotherapy is a toxic regimen for adult medulloblastoma patients that may result in improved survival.
وصف الملف: application/pdf
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6دورية أكاديمية
المؤلفون: Toorop, A A, Wessels, M H J, Gelissen, L M Y, Hoitsma, E, Zeinstra, E M P E, van Rooij, L C, van Munster, C E P, Vennegoor, A, Mostert, J P, Wokke, B H A, Kalkers, N F, Hoogervorst, E L J, van Eijk, J J J, Roosendaal, C M, Kragt, J J, Eurelings, M, van Genugten, J, Nielsen, J, Sinnige, L G F, Kloosterziel, M E, Arnoldus, E P J, van Dijk, G W, Bouvy, W H, Strijbis, E M M, van Oosten, B W, de Jong, B A, Lissenberg-Witte, B I, Rispens, T, Uitdehaag, B M J, Killestein, J, van Kempen, Z L E
المصدر: J Neurol Sci ; ISSN:1878-5883 ; Volume:462
مصطلحات موضوعية: Extended interval dosing, Multiple sclerosis, Natalizumab, Wearing-off
الوصف: Wearing-off symptoms during natalizumab treatment in multiple sclerosis are characterized by an increase of MS-related symptoms prior to natalizumab administration. The influence of extended interval dosing (EID) on wearing-off symptoms are important to consider, as this might cause hesitancy in initiating or continuing EID.
العلاقة: https://doi.org/10.1016/j.jns.2024.123102Test; https://pubmed.ncbi.nlm.nih.gov/38925067Test
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7دورية أكاديمية
المؤلفون: Caris, M. G., de Jonge, N. A., Punt, H. J., Salet, D. M., de Jong, V. M. T., Lissenberg-Witte, B. I., Zweegman, S., Vandenbroucke-Grauls, C. M. J. E., van Agtmael, M. A., Janssen, J. J. W. M.
المصدر: Caris , M G , de Jonge , N A , Punt , H J , Salet , D M , de Jong , V M T , Lissenberg-Witte , B I , Zweegman , S , Vandenbroucke-Grauls , C M J E , van Agtmael , M A & Janssen , J J W M 2022 , ' Indwelling time of peripherally inserted central catheters and incidence of bloodstream infections in haematology patients : a cohort study ' , Antimicrobial Resistance and Infection Control , vol. 11 , no. 1 , 37 , pp. 37 . https://doi.org/10.1186/s13756-022-01069-zTest
الوصف: Background: We aimed to assess whether longer indwelling time of peripherally inserted central catheters (PICC) increases risk of central line associated bloodstream infections (CLABSI) in haematology patients. Methods: Multicentre retrospective cohort study among haematology patients receiving PICCs between 2013 and 2015. Occurrence of CLABSI based on CDC definitions was assessed. We calculated incidence rates, determined risk factors for CLABSI and used Poisson regression models to assess the risk of developing CLABSI as a function of PICC dwell time. We compared diagnoses and treatment characteristics between 2013–2015 and 2015–2020. Results: 455 PICCs placed in 370 patients were included, comprising 19,063 catheter days. Median indwelling time was 26 days (range 0–385) and CLABSI incidence was 4.0 per 1000 catheter days, with a median time to CLABSI of 33 days (range 18–158). Aplastic anaemia (AA) was associated with an increased risk of CLABSI; patients undergoing autologous stem cell transplantation (SCT) were less likely to develop CLABSI. In the unadjusted analysis, PICCs with an indwelling time of 15–28 days, 29–42 days, 43–56 days and > 56 days each had an increased CLABSI incidence rate ratio of 2.4 (1.2–4.8), 2.2 (0.95–5.0), 3.4 (1.6–7.5) and 1.7 (0.9–3.5), respectively, compared to PICCs in place for < 15 days. However, after adjusting for AA and SCT, there was no significant difference in incidence rates between dwell times (p 0.067). Conclusions: Our study shows that risk of CLABSI does not appear to increase with longer PICC indwelling time. Routine replacement of PICCs therefore is unlikely to prevent CLABSI in this population.
الإتاحة: https://doi.org/10.1186/s13756-022-01069-zTest
https://research.vumc.nl/en/publications/eea58b91-36ab-4c99-9867-9572a9b68799Test
http://www.scopus.com/inward/record.url?scp=85124775478&partnerID=8YFLogxKTest -
8دورية أكاديمية
المؤلفون: Wever, B M M, Bach, S, Tibbesma, M, Ter Braak, T J, Wajon, D, Dickhoff, C, Lissenberg-Witte, B I, Hulbert, A, Kazemier, G, Bahce, I, Steenbergen, R D M
المصدر: Wever , B M M , Bach , S , Tibbesma , M , Ter Braak , T J , Wajon , D , Dickhoff , C , Lissenberg-Witte , B I , Hulbert , A , Kazemier , G , Bahce , I & Steenbergen , R D M 2022 , ' Detection of non-metastatic non-small-cell lung cancer in urine by methylation-specific PCR analysis : A feasibility study ' , Lung Cancer , vol. 170 , pp. 156-164 . https://doi.org/10.1016/j.lungcan.2022.06.013Test
الوصف: Background: Lung cancer has the highest cancer-related mortality worldwide and earlier detection could improve outcomes. Urine circulating tumor DNA (ctDNA) represents a true non-invasive means for ambulant sample collection. In this prospective study, the potential of urine for perioperative detection of non-metastatic non-small cell lung cancer (NSCLC) using ctDNA methylation analysis is evaluated. Methods: Preoperative urine samples of 46 surgical NSCLC patients and 50 sex and age-matched controls were analyzed for DNA methylation of NSCLC-associated methylation markers CDO1, SOX17, and TAC1, using quantitative methylation-specific PCR (qMSP). The accuracy for NSCLC detection was determined by univariable and multivariable logistic regression analysis, followed by leave-one-out cross-validation. Fourteen additional urine samples were collected postoperatively to evaluate whether DNA methylation levels alter after surgery with curative intent. Results: Methylation levels of CDO1 and SOX17 were significantly elevated in patients compared to controls (P =.016 and P <.001, respectively). This marker combination yielded an area under the receiver operating curve (AUC) value of 0.71 upon leave-one-out cross-validation for non-metastatic NSCLC detection in urine. Stage I patients tended to have higher methylation levels of SOX17 as compared to stage III patients. Similar methylation levels were found across the different histological subtypes of NSCLC. In some patients with preoperative elevated methylation levels, reduced methylation levels were found in post-operative urine samples. Conclusions: Urine CDO1 and SOX17 showed increased methylation levels in NSCLC patients as compared to sex- and age-matched controls. This demonstrates that urine ctDNA methylation analysis may provide an interesting non-invasive means to detect non-metastatic NSCLC. Further studies are needed to validate the clinical usefulness of this approach and to assess the potential of post-operative monitoring.
الإتاحة: https://doi.org/10.1016/j.lungcan.2022.06.013Test
https://research.vumc.nl/en/publications/4b2cb35f-fb36-45e4-b89d-5acce40a5dcaTest
http://www.scopus.com/inward/record.url?scp=85133215743&partnerID=8YFLogxKTest -
9دورية أكاديمية
المؤلفون: Burggraaff J., Liu Y., Prieto J. C., Simoes J., de Sitter A., Ruggieri S., Brouwer I., Lissenberg-Witte B. I., Rocca M. A., Valsasina P., Ropele S., Gasperini C., Gallo A., Pareto D., Sastre-Garriga J., Enzinger C., Filippi M., De Stefano N., Ciccarelli O., Hulst H. E., Wattjes M. P., Barkhof F., Uitdehaag B. M. J., Vrenken H., Guttmann C. R. G.
المساهمون: Burggraaff, J., Liu, Y., Prieto, J. C., Simoes, J., de Sitter, A., Ruggieri, S., Brouwer, I., Lissenberg-Witte, B. I., Rocca, M. A., Valsasina, P., Ropele, S., Gasperini, C., Gallo, A., Pareto, D., Sastre-Garriga, J., Enzinger, C., Filippi, M., De Stefano, N., Ciccarelli, O., Hulst, H. E., Wattjes, M. P., Barkhof, F., Uitdehaag, B. M. J., Vrenken, H., Guttmann, C. R. G.
مصطلحات موضوعية: Atrophy, Cognition, Deep grey matter, MRI, Multiple Sclerosi, Segmentation, Thalamus
الوصف: Background and rationale: Thalamus atrophy has been linked to cognitive decline in multiple sclerosis (MS) using various segmentation methods. We investigated the consistency of the association between thalamus volume and cognition in MS for two common automated segmentation approaches, as well as fully manual outlining. Methods: Standardized neuropsychological assessment and 3-Tesla 3D-T1-weighted brain MRI were collected (multi-center) from 57 MS patients and 17 healthy controls. Thalamus segmentations were generated manually and using five automated methods. Agreement between the algorithms and manual outlines was assessed with Bland-Altman plots; linear regression assessed the presence of proportional bias. The effect of segmentation method on the separation of cognitively impaired (CI) and preserved (CP) patients was investigated through Generalized Estimating Equations; associations with cognitive measures were investigated using linear mixed models, for each method and vendor. Results: In smaller thalami, automated methods systematically overestimated volumes compared to manual segmentations [ρ=(-0.42)-(-0.76); p-values < 0.001). All methods significantly distinguished CI from CP MS patients, except manual outlines of the left thalamus (p = 0.23). Poorer global neuropsychological test performance was significantly associated with smaller thalamus volumes bilaterally using all methods. Vendor significantly affected the findings. Conclusion: Automated and manual thalamus segmentation consistently demonstrated an association between thalamus atrophy and cognitive impairment in MS. However, a proportional bias in smaller thalami and choice of MRI acquisition system might impact the effect size of these findings.
وصف الملف: ELETTRONICO
العلاقة: info:eu-repo/semantics/altIdentifier/pmid/33401136; info:eu-repo/semantics/altIdentifier/wos/WOS:000620121700034; volume:29; firstpage:1; lastpage:12; numberofpages:12; journal:NEUROIMAGE. CLINICAL; http://hdl.handle.net/11365/1127373Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85098734638; https://www.sciencedirect.com/science/article/pii/S2213158220303867Test; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7787946Test/
الإتاحة: https://doi.org/10.1016/j.nicl.2020.102549Test
http://hdl.handle.net/11365/1127373Test
https://www.sciencedirect.com/science/article/pii/S2213158220303867Test
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7787946Test/ -
10دورية أكاديمية
المؤلفون: Leurs C. E., Twaalfhoven H. A. M., Lissenberg-Witte B. I., van Pesch V., Dujmovic I., Drulovic J., Castellazzi M., Bellini T., Pugliatti M., Kuhle J., Villar L. M., Alvarez-Cermeno J. C., Alvarez-Lafuente R., Hegen H., Deisenhammer F., Walchhofer L. M., Thouvenot E., Comabella M., Montalban X., Vecsei L., Rajda C., Galimberti D., Scarpini E., Altintas A., Rejdak K., Frederiksen J. L., Pihl-Jensen G., Jensen P. E. H., Khalil M., Voortman M. M., Fazekas F., Saiz A., La Puma D., Vercammen M., Vanopdenbosch L., Uitdehaag B. M. J., Killestein J., Bridel C., Teunissen C.
المساهمون: Leurs, C. E., Twaalfhoven, H. A. M., Lissenberg-Witte, B. I., van Pesch, V., Dujmovic, I., Drulovic, J., Castellazzi, M., Bellini, T., Pugliatti, M., Kuhle, J., Villar, L. M., Alvarez-Cermeno, J. C., Alvarez-Lafuente, R., Hegen, H., Deisenhammer, F., Walchhofer, L. M., Thouvenot, E., Comabella, M., Montalban, X., Vecsei, L., Rajda, C., Galimberti, D., Scarpini, E., Altintas, A., Rejdak, K., Frederiksen, J. L., Pihl-Jensen, G., Jensen, P. E. H., Khalil, M., Voortman, M. M., Fazekas, F., Saiz, A., La Puma, D., Vercammen, M., Vanopdenbosch, L., Uitdehaag, B. M. J., Killestein, J., Bridel, C., Teunissen, C.
مصطلحات موضوعية: biomarker, CSF, KFLC, Multiple sclerosi, OCB
الوصف: Objective: To validate kappa free light chain (KFLC) and lambda free light chain (LFLC) indices as a diagnostic biomarker in multiple sclerosis (MS). Methods: We performed a multicenter study including 745 patients from 18 centers (219 controls and 526 clinically isolated syndrome (CIS)/MS patients) with a known oligoclonal IgG band (OCB) status. KFLC and LFLC were measured in paired cerebrospinal fluid (CSF) and serum samples. Gaussian mixture modeling was used to define a cut-off for KFLC and LFLC indexes. Results: The cut-off for the KFLC index was 6.6 (95% confidence interval (CI) = 5.2-138.1). The cut-off for the LFLC index was 6.9 (95% CI = 4.5-22.2). For CIS/MS patients, sensitivity of the KFLC index (0.88; 95% CI = 0.85-0.90) was higher than OCB (0.82; 95%CI = 0.79-0.85;p < 0.001), but specificity (0.83; 95% CI = 0.78-0.88) was lower (OCB = 0.92; 95% CI = 0.89-0.96;p < 0.001). Both sensitivity and specificity for the LFLC index were lower than OCB. Conclusion: Compared with OCB, the KFLC index is more sensitive but less specific for diagnosing CIS/MS. Lacking an elevated KFLC index is more powerful for excluding MS compared with OCB but the latter is more important for ruling in a diagnosis of CIS/MS.
وصف الملف: STAMPA
العلاقة: info:eu-repo/semantics/altIdentifier/pmid/31066634; info:eu-repo/semantics/altIdentifier/wos/WOS:000547265400007; volume:26; issue:8; firstpage:912; lastpage:923; numberofpages:12; journal:MULTIPLE SCLEROSIS; http://hdl.handle.net/11392/2405226Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85065731162
