المؤلفون: Joseph J. Hanly, Caroline M. Francescutti, Ling S. Loh, Olaf B.W.H. Corning, Derek J. Long, Marshall A. Nakatani, Adam H. Porter, Arnaud Martin

المصدر: Cell Reports, Vol 42, Iss 8, Pp 112820- (2023)

مصطلحات موضوعية: CP: Genomics, Biology (General), QH301-705.5

الوصف: Summary: Continuous color polymorphisms can serve as a tractable model for the genetic and developmental architecture of traits. Here we investigated continuous color variation in Colias eurytheme and Colias philodice, two species of sulphur butterflies that hybridize in sympatry. Using quantitative trait locus (QTL) analysis and high-throughput color quantification, we found two interacting large-effect loci affecting orange-to-yellow chromaticity. Knockouts of red Malpighian tubules (red), likely involved in endosomal maturation, result in depigmented wing scales. Additionally, the transcription factor bric-a-brac can act as a modulator of orange pigmentation. We also describe the QTL architecture of other continuously varying traits, together supporting a large-X effect model where the genetic control of species-defining traits is enriched on sex chromosomes. This study sheds light on the range of possible genetic architectures that can underpin a continuously varying trait and illustrates the power of using automated measurement to score phenotypes that are not always conspicuous to the human eye.

وصف الملف: electronic resource

العلاقة: http://www.sciencedirect.com/science/article/pii/S2211124723008318Test; https://doaj.org/toc/2211-1247Test

الوصول الحر: https://doaj.org/article/7326cedead304afd95851cca608b3865Test

المؤلفون: Khalid A. Hureibi, Elgeilani M. Elzaidi, Osama Al Suindar, Ling S. Wong, Nigel M. Williams

المصدر: Journal of Coloproctology, Vol 40, Iss 2, Pp 179-188 (2020)

مصطلحات موضوعية: Anorretal, Benigna, Bibliométrica, Citações, Clássicos, Diseases of the digestive system. Gastroenterology, RC799-869

الوصف: Background & aim: Bibliometric analysis is used to explore the historical development in a particular field. The aim is to identify and analyse most cited papers in benign anorectal disease in the last 7 decades (1950–2018). Method: Thomson Reuters Web of Science database was used to find the top 100 cited articles in benign anorectal conditions. Papers were independently extracted by two investigators. The top 100 cited articles were identified and ranked according to number of citations. The articles were then sorted by author, journal, institution, country and publication date. The study subject was divided into 5 groups. Results: The most frequently cited article received 1307 citations whereas the least cited received 154 citations. The earliest recorded article was published in 1960 and the most recent was from 2010. More than half of the articles addressed faecal incontinence and sphincter related literature (n = 54). The articles were published in 29 different journals. A majority (69%) of manuscripts originated from the USA (n = 35; 9221 citations) and UK (n = 34; 7796 citations). The origin of these top 100 classic papers was from 53 different institutions. St. Mark's Hospital in the UK had the highest number of articles (n = 21), followed by Cleveland clinic (n = 5) and University of Minnesota (n = 5). Conclusion: The most highly cited manuscripts in benign anorectal disease cover a wide range of topics. Faecal incontinence and sphincter related articles had the highest number of citations. This review serves as a reference for researchers to find the influential papers in this field. Resumo: Justificativa e objetivo: A análise bibliométrica é usada para explorar o desenvolvimento histórico em um campo específico. O objetivo é identificar e analisar os artigos mais citados em doença anorretal benigna nas últimas 7 décadas (1950–2018). Método: A base de dados Thomson Reuters Web of Science foi usada para encontrar os 100 artigos mais citados em doenças anorretais benignas. Os artigos foram extraídos de forma independente por dois pesquisadores. Os 100 artigos mais citados foram identificados e classificados de acordo com o número de citações. Os artigos foram classificados por autor, revista médica, instituição, país e data de publicação. Os sujeitos do estudo foram divididos em cinco grupos. Resultados: O artigo mais citado recebeu 1.307 citações, enquanto o menos citado recebeu 154 citações. O artigo mais antigo foi publicado em 1960 e o mais recente a partir de 2010. Mais da metade dos artigos abordou a incontinência fecal e a literatura relacionada ao esfíncter (n = 54). Os artigos foram publicados em 29 revistas diferentes. A maioria (69%) dos manuscritos é originária dos EUA (n = 35; 9.221 citações) e do Reino Unido (n = 34; 7.796 citações). Os 100 artigos clássicos mais citados são originários de 53 instituições diferentes. O St. Mark’s Hospital, no Reino Unido, teve o maior número de artigos (n = 21), seguido pela Clínica de Cleveland (n = 5) e pela Universidade de Minnesota (n = 5). Conclusão: Os manuscritos mais citados em doença anorretal benigna abrangem uma grande variedade de tópicos. Os artigos relacionados à incontinência fecal e ao esfíncter tiveram o maior número de citações. Esta revisão serve de referência para os pesquisadores encontrarem os artigos influentes nesse campo.

وصف الملف: electronic resource

العلاقة: http://www.sciencedirect.com/science/article/pii/S2237936319301273Test; https://doaj.org/toc/2237-9363Test

الوصول الحر: https://doaj.org/article/04f658e8b66040f290e258fa4f2e936bTest

المؤلفون: Malone, Hui-Ling S, Player, Grace D, San Pedro, Timothy

المصدر: Equity & Excellence in Education, vol ahead-of-print, iss ahead-of-print

مصطلحات موضوعية: Education Systems, Education, Quality Education, Specialist Studies in Education, Education systems

وصف الملف: application/pdf

الوصول الحر: https://escholarship.org/uc/item/9tt1n8gnTest

المؤلفون: Malone, Hui-Ling S., Player, Grace D., San Pedro, Timothy

المصدر: Equity & Excellence in Education. 2023 56(3):479-491.

تمت مراجعته من قبل الزملاء: Y

Page Count: 13

الواصفات: Educational Research, Epistemology, Research Methodology, Racism, Intersectionality, Family Relationship, Caring, Trust (Psychology), Minority Groups

مستخلص: This article resulted from an American Education Research Association (AERA) conference presentation that consisted of a dialogue between three scholar-siblings of color who use methodological pathways that intentionally center relationality, mutuality, and care in educational research. The authors do this work understanding that familial ways of knowing and being are resources that contribute to the survival and thriving of BIPOC communities in the face of white supremacist structures. The authors' conversation discusses how they disrupt the white western gaze by relying on the critical mass of Black, Indigenous, and other scholars of color who refuse exploitive methods and, instead, charted new methodological pathways that (re)center cultural, familial, and tribal ways of knowing. Given the authors' positionalities, the communities and families that collectively raised them, and the extended scholarly family who have nurtured and supported them in their efforts to push against extractive research practices, the authors attend to the ways knowledge is shaped at the intersections of race and gender. This dialogue contends that there are sophisticated knowledges, ways of knowing, and ways of being rooted in the experience of marginalized families caring for one another and fighting for each other's rights.

Abstractor: As Provided

المؤلفون: Öling, S., Struck, E., Noreen-Thorsen, M., Zwahlen, M., von Feilitzen, K., Odeberg, J., Pontén, Fredrik, Lindskog, Cecilia, Uhlén, M., Dusart, P., Butler, L. M.

مصطلحات موضوعية: Cell profiling, Gene enrichment, Bulk RNAseq, Stomach, Cell and Molecular Biology, Cell- och molekylärbiologi

الوصف: Background The identification of cell type-specific genes and their modification under different conditions is central to our understanding of human health and disease. The stomach, a hollow organ in the upper gastrointestinal tract, provides an acidic environment that contributes to microbial defence and facilitates the activity of secreted digestive enzymes to process food and nutrients into chyme. In contrast to other sections of the gastrointestinal tract, detailed descriptions of cell type gene enrichment profiles in the stomach are absent from the major single-cell sequencing-based atlases. Results Here, we use an integrative correlation analysis method to predict human stomach cell type transcriptome signatures using unfractionated stomach RNAseq data from 359 individuals. We profile parietal, chief, gastric mucous, gastric enteroendocrine, mitotic, endothelial, fibroblast, macrophage, neutrophil, T-cell, and plasma cells, identifying over 1600 cell type-enriched genes. Conclusions We uncover the cell type expression profile of several non-coding genes strongly associated with the progression of gastric cancer and, using a sex-based subset analysis, uncover a panel of male-only chief cell-enriched genes. This study provides a roadmap to further understand human stomach biology.

وصف الملف: application/pdf

العلاقة: BMC Biology, 2024, 22:1; orcid:0000-0003-0703-3940; orcid:0000-0001-5611-1015; http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-524333Test; PMID 38355543; ISI:001162444800002

الإتاحة: https://doi.org/10.1186/s12915-024-01812-5Test
http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-524333Test

المؤلفون: Prasad, R.R.R., Boyadjieva, S.S., Zhou, G., Tan, J., Firth, F.C.N., Ling, S., Huang, Z., Cliffe, M.J., Foster, J.A., Forgan, R.S.

الوصف: Two-dimensional metal-organic nanosheets (MONs) have emerged as attractive alternatives to their three-dimensional metal-organic framework (MOF) counterparts for heterogeneous catalysis due to their greater external surface areas and higher accessibility of catalytically active sites. Zr MONs are particularly prized because of their chemical stability and high Lewis and Brønsted acidities of the Zr clusters. Herein, we show that careful control over modulated self-assembly and exfoliation conditions allows the isolation of the first example of a two-dimensional nanosheet wherein Zr6 clusters are linked by dicarboxylate ligands. The hxl topology MOF, termed GUF-14 (GUF = Glasgow University Framework), can be exfoliated into monolayer thickness hns topology MONs, and acid-induced removal of capping modulator units yields MONs with enhanced catalytic activity toward the formation of imines and the hydrolysis of an organophosphate nerve agent mimic. The discovery of GUF-14 serves as a valuable example of the undiscovered MOF/MON structural diversity extant in established metal-ligand systems that can be accessed by harnessing the power of modulated self-assembly protocols.

وصف الملف: text

العلاقة: https://eprints.whiterose.ac.uk/211509/1/prasad-et-al-2024-modulated-self-assembly-of-catalytically-active-metal-organic-nanosheets-containing-zr6-clusters-and.pdfTest; Prasad, R.R.R. orcid.org/0000-0002-8724-6358 , Boyadjieva, S.S., Zhou, G. et al. (7 more authors) (2024) Modulated self-assembly of catalytically active metal–organic nanosheets containing Zr6 clusters and dicarboxylate ligands. ACS Applied Materials & Interfaces, 16 (14). pp. 17812-17820. ISSN 1944-8244

الإتاحة: https://eprints.whiterose.ac.uk/211509Test/
https://eprints.whiterose.ac.uk/211509/1/prasad-et-al-2024-modulated-self-assembly-of-catalytically-active-metal-organic-nanosheets-containing-zr6-clusters-and.pdfTest

المؤلفون: Zou P, Iuga D, Ling S, Brown AJ, Chen S, Zhang M, Han Y, Fortes AD, Howard CM, Tao S

العلاقة: urn:ISSN:2041-1723; Nat Commun; http://purl.org/net/epubs/series/11229085Test; Science and Technology Facilities Council (2007- ); ISIS (1984- ); ISIS - HRPD; http://purl.org/net/epubs/work/56879010Test

الإتاحة: http://purl.org/net/epubs/work/56879010Test

المؤلفون: Yodoshi, T, John, T, Stunguris, J, De Angelis, M, Van Roestel, K, Hensley, J, Avitzur, Y, Bandsma, R, Jones, N, Kamath, B M, Ling, S, Miserachs, M, Ghanekar, A, Cattral, M, Sayed, B, Ng, V L

المصدر: Journal of the Canadian Association of Gastroenterology ; volume 7, issue Supplement_1, page 248-249 ; ISSN 2515-2084 2515-2092

مصطلحات موضوعية: General Earth and Planetary Sciences, General Environmental Science

الوصف: Background Since our first pediatric anonymous non-directed live donor liver transplant (A-LDLT) performed in April 2005, 62 children have undergone live donor liver transplant (LDLT) with an anonymous non-directed graft. Anon-LDLT organs being allocated as per our deceased donor liver transplant (DDLT) wait list. Aims To evaluate clinical outcomes, recipient characteristics and social determinants of health of pediatric recipients of A-LDLT in comparison to those who received a directed LDLT (Dir-LDLT) and DDLT. Methods Retrospective analysis of all recipients of LDLT performed between January 2005 and March 2023. Demographic and clinical data included age, sex, race, ethnicity, single-parent households, primary diagnosis, recipient blood type, time on waiting list, post-LT intensive care unit (ICU) length of stay (LOS), time to extubation, and post-transplant comorbidities were assessed as covariates. A comparative analysis was conducted between children receiving A-LDLT, Dir-LDLT versus DDLT. Results A total of 422 (50% male, 57% white, 23% Asian, 7% Black, 5% indigenous) childrenunderwent LT during the study period. Biliary atresia (40%) and metabolic diseases (19%) were the commonest primary indications. A-LDLT was done in 62 children (15%) with no directed donor options. Dir-LDLT was in 174 children (41%). Of 186 DDLTs (44%), 25% were split grafts, 26% reduced, and 49% whole liver grafts. In A-LDLT recipients, the primary diseases were more frequently characterized by metabolic disorders (31%), while the incidence of acute liver failure was notably lower (0%). Recipients of Anon-LDLT were more often Indigenous recipients in comparison to Dir-LDLT or DDLT recipients (p=0.044). Anon-LDLT recipients were more frequently living in single parent households (18% vs 3% vs 10%, pampersand:003C0.001) and to require interpreter assistance (11% vs 3% vs 0.5%, pampersand:003C0.001) (Table), compared to children who received Dir-LDLT or DDLT. Median time on the wait list was longer for Anon-LDLT (92 days) ...

الإتاحة: https://doi.org/10.1093/jcag/gwad061.305Test
https://academic.oup.com/jcag/article-pdf/7/Supplement_1/248/56927203/gwad061.305.pdfTest

المؤلفون: Ling, S., Phonetip, K., Sitthivong, K., Chaisy, S., Barney, K.

المساهمون: Australian Centre for International Agricultural Research

المصدر: Australian Forestry ; volume 87, issue 1, page 26-36 ; ISSN 0004-9158 2325-6087

الإتاحة: https://doi.org/10.1080/00049158.2023.2293593Test

المؤلفون: Durant, ST, Zheng, L, Wang, YC, Chen, K, Zhang, LL, Zhang, TW, Yang, ZF, Riches, L, Trinidad, AG, Fok, JHL, Hunt, T, Pike, KG, Wilson, J, Smith, A, Colclough, N, Reddy, VP, Sykes, A, Janefeldt, A, Johnstrom, P, Varnas, K, Takano, A, Ling, S, Orme, J, Stott, J, Roberts, C, Barrett, I, Jones, G, Roudier, M, Pierce, A, Allen, J, Kahn, J, Sule, A, Karlin, J, Cronin, A, Chapman, M, Valerie, K, Illingworth, R, Pass, M

المصدر: Science advances. 4(6)

مصطلحات موضوعية: Medicin och hälsovetenskap

الوصول الحر: http://kipublications.ki.se/Default.aspx?queryparsed=id:139086923Test