المؤلفون: Smith-Geater, Charlene, Hernandez, Sarah J, Lim, Ryan G, Adam, Miriam, Wu, Jie, Stocksdale, Jennifer T, Wassie, Brook T, Gold, Maxwell Philip, Wang, Keona Q, Miramontes, Ricardo, Kopan, Lexi, Orellana, Iliana, Joy, Shona, Kemp, Paul J, Allen, Nicholas D, Fraenkel, Ernest, Thompson, Leslie M

المصدر: Stem cell reports. 14(3)

مصطلحات موضوعية: Huntington's disease, WNT signaling, adult-onset HD, cell cycle, development, induced pluripotent stem cells, medium spiny neurons, neural stem cells, single-cell RNA-seq, Huntingtons disease, Biochemistry and Cell Biology, Clinical Sciences

وصف الملف: application/pdf

الوصول الحر: https://escholarship.org/uc/item/26m7p12dTest

المؤلفون: Kedaigle, Amanda J, Reidling, Jack C, Lim, Ryan G, Adam, Miriam, Wu, Jie, Wassie, Brook, Stocksdale, Jennifer T, Casale, Malcolm S, Fraenkel, Ernest, Thompson, Leslie M

المصدر: Human Molecular Genetics. 29(2)

مصطلحات موضوعية: Biological Sciences, Genetics, Brain Disorders, Neurosciences, Human Genome, Rare Diseases, Huntington's Disease, Neurodegenerative, 2.1 Biological and endogenous factors, Aetiology, Neurological, Acetylation, Animals, Azepines, Behavior Rating Scale, Behavioral Symptoms, Cerebral Cortex, Chromatin Immunoprecipitation Sequencing, Corpus Striatum, Disease Models, Animal, Energy Metabolism, Epigenesis, Genetic, Gene Expression Regulation, Gene Ontology, Histones, Huntingtin Protein, Huntington Disease, Male, Mice, Mice, Transgenic, Motor Activity, Protein Biosynthesis, RNA-Seq, Signal Transduction, Triazoles, Medical and Health Sciences, Genetics & Heredity

وصف الملف: application/pdf

الوصول الحر: https://escholarship.org/uc/item/0p42w8z5Test

المؤلفون: Ochaba, Joseph, Fote, Gianna, Kachemov, Marketta, Thein, Soe, Yeung, Sylvia Y, Lau, Alice L, Hernandez, Sarah, Lim, Ryan G, Casale, Malcolm, Neel, Michael J, Monuki, Edwin S, Reidling, Jack, Housman, David E, Thompson, Leslie M, Steffan, Joan S

المصدر: Proceedings of the National Academy of Sciences of the United States of America. 116(22)

مصطلحات موضوعية: Biochemistry and Cell Biology, Biomedical and Clinical Sciences, Biological Sciences, Huntington's Disease, Neurosciences, Rare Diseases, Neurodegenerative, Brain Disorders, Orphan Drug, Aetiology, 2.1 Biological and endogenous factors, Neurological, Animals, Autophagy, Corpus Striatum, Disease Models, Animal, Disease Progression, Huntingtin Protein, Huntington Disease, I-kappa B Kinase, Male, Mice, Mice, Knockout, Microglia, Phosphorylation, huntingtin, autophagy, Huntington's disease, neurodegeneration, I kappa B kinase, Huntington’s disease, IκB kinase

وصف الملف: application/pdf

الوصول الحر: https://escholarship.org/uc/item/08v4h5j5Test

المؤلفون: Lim, Ryan G, Al-Dalahmah, Osama, Wu, Jie, Gold, Maxwell P, Reidling, Jack C, Tang, Guomei, Adam, Miriam, Dansu, David K, Park, Hye-Jin, Casaccia, Patrizia, Miramontes, Ricardo, Reyes-Ortiz, Andrea M, Lau, Alice, Hickman, Richard A, Khan, Fatima, Paryani, Fahad, Tang, Alice, Ofori, Kenneth, Miyoshi, Emily, Michael, Neethu, McClure, Nicolette, Flowers, Xena E, Vonsattel, Jean Paul, Davidson, Shawn, Menon, Vilas, Swarup, Vivek, Fraenkel, Ernest, Goldman, James E, Thompson, Leslie M

المساهمون: Massachusetts Institute of Technology. Department of Biological Engineering

المصدر: Nature

وصف الملف: application/pdf

العلاقة: Nature Communications; https://hdl.handle.net/1721.1/147809Test; Lim, Ryan G, Al-Dalahmah, Osama, Wu, Jie, Gold, Maxwell P, Reidling, Jack C et al. 2022. "Huntington disease oligodendrocyte maturation deficits revealed by single-nucleus RNAseq are rescued by thiamine-biotin supplementation." Nature Communications, 13 (1).

الإتاحة: https://hdl.handle.net/1721.1/147809Test

المؤلفون: Matlock, Andrea D., Vaibhav, Vineet, Holewinski, Ronald, Venkatraman, Vidya, Dardov, Victoria, Manalo, Danica-Mae, Shelley, Brandon, Ornelas, Loren, Banuelos, Maria, Mandefro, Berhan, Escalante-Chong, Renan, Li, Jonathan, Finkbeiner, Steve, Fraenkel, Ernest, Rothstein, Jeffrey, Thompson, Leslie, Sareen, Dhruv, Svendsen, Clive N., Van Eyk, Jennifer E., Ho, Ritchie, Wassie, Brook, Patel-Murray, Natasha, Milani, Pamela, Adam, Miriam, Sachs, Karen, Lenail, Alex, Ramamoorthy, Divya, Daigle, Gavin, Hussain, Uzma, Kaye, Julia, Lima, Leandro, Kalra, Jaslin, Coyne, Alyssa, Lim, Ryan G, Wu, Jie, Stocksdale, Jennifer, Thompson, Terri G

المساهمون: U.S. Department of Health & Human Services | National Institutes of Health

المصدر: Scientific Data ; volume 10, issue 1 ; ISSN 2052-4463

مصطلحات موضوعية: Library and Information Sciences, Statistics, Probability and Uncertainty, Computer Science Applications, Education, Information Systems, Statistics and Probability

الإتاحة: https://doi.org/10.1038/s41597-022-01687-7Test
https://www.nature.com/articles/s41597-022-01687-7.pdfTest
https://www.nature.com/articles/s41597-022-01687-7Test

المؤلفون: Holley, Sandra M., Reidling, Jack C., Cepeda, Carlos, Wu, Jie, Lim, Ryan G., Lau, Alice, Moore, Cindy, Miramontes, Ricardo, Fury, Brian, Orellana, Iliana, Neel, Michael, Coleal-Bergum, Dane, Monuki, Edwin S., Bauer, Gerhard, Meshul, Charles K., Levine, Michael S., Thompson, Leslie M.

المساهمون: National Institutes of Health, California Institute for Regenerative Medicine

المصدر: Molecular Therapy ; volume 31, issue 12, page 3545-3563 ; ISSN 1525-0016

مصطلحات موضوعية: Drug Discovery, Pharmacology, Genetics, Molecular Biology, Molecular Medicine

الإتاحة: https://doi.org/10.1016/j.ymthe.2023.10.003Test
https://api.elsevier.com/content/article/PII:S1525001623005440?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S1525001623005440?httpAccept=text/plainTest

المؤلفون: Tsitkov, Stanislav, Valentine, Kelsey, Kozareva, Velina, Donde, Aneesh, Frank, Aaron, Lei, Susan, Workman, Michael J., Lim, Ryan G., Wu, Jie, Wu, Zhuoxing, Ornelas, Loren, Panther, Lindsay, Galvez, Erick, Perez, Daniel, Meepe, Imara, Valencia, Viviana, Gomez, Emilda, Liu, Chunyan, Moran, Ruby, Pinedo, Louis

المصدر: Nature Communications; 5/2/2024, Vol. 15 Issue 1, p1-15, 15p

مصطلحات موضوعية: MOTOR neurons, MOTOR neuron diseases, AMYOTROPHIC lateral sclerosis, NEURODEGENERATION

المؤلفون: Keenan, Alexandra B, Jenkins, Sherry L, Jagodnik, Kathleen M, Koplev, Simon, He, Edward, Torre, Denis, Wang, Zichen, Dohlman, Anders B, Silverstein, Moshe C, Lachmann, Alexander, Kuleshov, Maxim V, Ma'ayan, Avi, Stathias, Vasileios, Terryn, Raymond, Cooper, Daniel, Forlin, Michele, Koleti, Amar, Vidovic, Dusica, Chung, Caty, Schürer, Stephan C, Vasiliauskas, Jouzas, Pilarczyk, Marcin, Shamsaei, Behrouz, Fazel, Mehdi, Ren, Yan, Niu, Wen, Clark, Nicholas A, White, Shana, Mahi, Naim, Zhang, Lixia, Kouril, Michal, Reichard, John F, Sivaganesan, Siva, Medvedovic, Mario, Meller, Jaroslaw, Koch, Rick J, Birtwistle, Marc R, Iyengar, Ravi, Sobie, Eric A, Azeloglu, Evren U, Kaye, Julia, Osterloh, Jeannette, Haston, Kelly, Kalra, Jaslin, Finkbiener, Steve, Li, Jonathan, Milani, Pamela, Adam, Miriam, Escalante-Chong, Renan, Sachs, Karen, Lenail, Alex, Ramamoorthy, Divya, Fraenkel, Ernest, Daigle, Gavin, Hussain, Uzma, Coye, Alyssa, Rothstein, Jeffrey, Sareen, Dhruv, Ornelas, Loren, Banuelos, Maria, Mandefro, Berhan, Ho, Ritchie, Svendsen, Clive N, Lim, Ryan G, Stocksdale, Jennifer, Casale, Malcolm S, Thompson, Terri G, Wu, Jie, Thompson, Leslie M, Dardov, Victoria, Venkatraman, Vidya, Matlock, Andrea, Van Eyk, Jennifer E, Jaffe, Jacob D, Papanastasiou, Malvina, Subramanian, Aravind, Golub, Todd R, Erickson, Sean D, Fallahi-Sichani, Mohammad, Hafner, Marc, Gray, Nathanael S, Lin, Jia-Ren, Mills, Caitlin E, Muhlich, Jeremy L, Niepel, Mario, Shamu, Caroline E, Williams, Elizabeth H, Wrobel, David, Sorger, Peter K, Heiser, Laura M, Gray, Joe W, Korkola, James E, Mills, Gordon B, LaBarge, Mark, Feiler, Heidi S, Dane, Mark A, Bucher, Elmar, Nederlof, Michel, Sudar, Damir, Gross, Sean

المصدر: Cell Systems. 6(1)

مصطلحات موضوعية: Bioengineering, Cancer, Genetics, Biotechnology, 2.1 Biological and endogenous factors, Aetiology, Generic health relevance, Good Health and Well Being, Cataloging, Computational Biology, Databases, Chemical, Gene Expression Profiling, Gene Library, Humans, Information Storage and Retrieval, National Health Programs, National Institutes of Health (U.S.), Systems Biology, Transcriptome, United States, BD2K, L1000, MCF10A, MEMA, P100, data integration, lincsprogram, lincsproject, systems biology, systems pharmacology, Biochemistry and Cell Biology

وصف الملف: application/pdf

الوصول الحر: https://escholarship.org/uc/item/18t2041rTest

المؤلفون: Vatine, Gad D, Al-Ahmad, Abraham, Barriga, Bianca K, Svendsen, Soshana, Salim, Ariel, Garcia, Leslie, Garcia, Veronica J, Ho, Ritchie, Yucer, Nur, Qian, Tongcheng, Lim, Ryan G, Wu, Jie, Thompson, Leslie M, Spivia, Weston R, Chen, Zhaohui, Van Eyk, Jennifer, Palecek, Sean P, Refetoff, Samuel, Shusta, Eric V, Svendsen, Clive N

المصدر: Cell Stem Cell. 20(6)

مصطلحات موضوعية: Biological Sciences, Biomedical and Clinical Sciences, Pediatric, Stem Cell Research - Nonembryonic - Human, Stem Cell Research, Stem Cell Research - Induced Pluripotent Stem Cell - Human, Neurodegenerative, Stem Cell Research - Induced Pluripotent Stem Cell, Neurosciences, Aetiology, 1.1 Normal biological development and functioning, Underpinning research, 2.1 Biological and endogenous factors, Neurological, Blood-Brain Barrier, Cell Line, Female, Humans, Induced Pluripotent Stem Cells, Male, Monocarboxylic Acid Transporters, Neurons, Psychomotor Disorders, Symporters, MCT8, T3, blood brain barrier, disease model, iPSC, induced pluripotent stem cells, monocarboxyl transporter 8, neuronal maturation, thyroid, thyroid hormone, Medical and Health Sciences, Developmental Biology, Biological sciences, Biomedical and clinical sciences

وصف الملف: application/pdf

الوصول الحر: https://escholarship.org/uc/item/8q70k0bnTest

المؤلفون: Lim, Ryan G, Quan, Chris, Reyes-Ortiz, Andrea M, Lutz, Sarah E, Kedaigle, Amanda J, Gipson, Theresa A, Wu, Jie, Vatine, Gad D, Stocksdale, Jennifer, Casale, Malcolm S, Svendsen, Clive N, Fraenkel, Ernest, Housman, David E, Agalliu, Dritan, Thompson, Leslie M

المصدر: Cell Reports. 19(7)

مصطلحات موضوعية: Biological Sciences, Stem Cell Research - Induced Pluripotent Stem Cell - Human, Neurosciences, Huntington's Disease, Rare Diseases, Stem Cell Research - Nonembryonic - Human, Stem Cell Research - Induced Pluripotent Stem Cell, Stem Cell Research, Orphan Drug, Brain Disorders, Neurodegenerative, 2.1 Biological and endogenous factors, Aetiology, Neurological, Blood-Brain Barrier, Endothelial Cells, Gene Regulatory Networks, Humans, Huntington Disease, Induced Pluripotent Stem Cells, Microvessels, Neovascularization, Physiologic, Transcriptome, Transcytosis, Wnt Signaling Pathway, beta Catenin, BMEC, Huntington’s disease, RNA sequencing, WNT signaling, angiogenesis, blood-brain barrier, brain microvascular endothelial cell, epigenetics, induced pluripotent stem cell, neurodegeneration, transcriptome, Biochemistry and Cell Biology, Medical Physiology, Biological sciences

وصف الملف: application/pdf

الوصول الحر: https://escholarship.org/uc/item/6z1351tfTest