المؤلفون: Sim, PYJ, Singh, GHH, Lie, AKW, CHER, CY, Leung, AYH, Liang, RHS, WONG, KF, SIU, LLP, TSUI, CSP, So, JCC, WONG, HWW, YIP, SF, LEE, HKK, LIU, HSY, LAU, JSM, LUK, TH, LAU, TK, Kwong, YL, LIN, SY, LEUNG, GMK, AU, CH, CHAN, TL, MA, ESK

الوصف: Clinical outcome and mutations of 96 core-binding factor acute myeloid leukemia (AML) patients 18-60 years old were examined. Complete remission (CR) after induction was 94.6%. There was no significant difference in CR, leukemia-free-survival (LFS) and overall survival (OS) between t(8;21) (N=67) and inv(16) patients (N=29). Univariate analysis showed hematopoietic stem cell transplantation at CR1 as the only clinical parameter associated with superior LFS. Next-generation sequencing based on a myeloid gene panel was performed in 72 patients. Mutations in genes involved in cell signaling were associated with inferior LFS and OS, whereas those in genes involved in DNA methylation were associated with inferior LFS. KIT activation loop (AL) mutations occurred in 25 patients, and were associated with inferior LFS (P=0.003) and OS (P=0.001). TET2 mutations occurred in 8 patients, and were associated with significantly shorter LFS (P=0.015) but not OS. Patients negative for KIT-AL and TET2 mutations (N=41) had significantly better LFS (P<0.001) and OS (P=0.012) than those positive for both or either mutation. Multivariate analysis showed that KIT-AL and TET2 mutations were associated with inferior LFS, whereas age ⩾40 years and marrow blast ⩾70% were associated with inferior OS. These observations provide new insights that may guide better treatment for this AML subtype. ; published_or_final_version

العلاقة: Blood Cancer Journal; Blood Cancer Journal, 2016, v. 6, p. e442; e442; 259630; http://hdl.handle.net/10722/227368Test

الإتاحة: https://doi.org/10.1038/bcj.2016.51Test
http://hdl.handle.net/10722/227368Test

المؤلفون: Liang, RHS, Fung, TK, Leung, AYH

الوصف: Oral Presentation ; INTRODUCTION: The nucleoporin gene nup98 is important for the regulation of cytoplasmic-nuclear trafficking. Frequent disruptions of NUP98 during chromosomal translocation in acute myeloid leukaemia suggest that it may play a role in normal haematopoiesis. nup98-knockout mice has resulted in early embryonic lethality. Therefore, its role in embryonic haematopoiesis remains unclear. In this study, we have cloned a zebrafish nup98 gene and examined its role in embryonic development, with particular reference to haematopoiesis. METHODS: Two expressed sequence tags with translated sequence homologous to human NUP98 were identified. The gene was cloned by PCR from cDNA of zebrafish embryos. Expression of nup98 in zebrafish embryos was investigated spatially by whole-mount in-situ hybridisation and temporally by RT-PCR. The functions of nup98 were examined by morpholino knockdown and the effects on embryonic development evaluated by gene expression studies and confocal microscopy. Cellular functions of zebrafish nup98 were investigated in HeLa cells. RESULTS: Zebrafish nup98 gene shared 65% identity to human NUP98 homolog in protein sequence. The gene was expressed during early embryonic development since 1-cell stage and diffusely in eyes and the developing brain since 18 hpf. About 30% nup98-knockdown embryos developed intracranial haemorrhage at 48 hpf, resulting from disrupted blood vessels. nup98-knockdown upregulated pu.1 and scl as evaluated by quantitative RT-PCR. Moreover, ectopic expression of zebrafish nup98 rescued the defective mRNA export due to NUP98 knockdown in HeLa cells. CONCLUSION: A novel zebrafish nup98 gene was shown to exhibit conserved function in mRNA trafficking. Its role in embryonic development should be further evaluated. ; published_or_final_version

العلاقة: Hong Kong Medical Journal; The 15th Medical Research Conference (MRC 2010), Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, 16 January 2010. In Hong Kong Medical Journal, 2010, v. 16 suppl. 1, p. 21, abstract no. 25; 21, abstract no. 25; 224778; 173544; suppl. 1; http://hdl.handle.net/10722/190069Test; 16

الإتاحة: http://hdl.handle.net/10722/190069Test

المؤلفون: Ma, ACH, Leung, AYH, Liang, RHS, Yang, D, Lin, RHC, Chung, MIS

الوصف: Oral presentation ; INTRODUCTION: Methionine aminopeptidase 2 (MetAP-2) is known to be the target of an anti-angiogenesis compound fumagillin and has been investigated for its robust expression in human cancers and its antiproliferative effects on endothelial cells. Together with a related member MetAP-1, they are proteases which remove the initiator NH2-terminal methionine from the nascent peptides during protein translation. Despite its pathogenetic significance in cancers, the physiological role of MetAP-2, particularly during embryonic … ; published_or_final_version ; The 15th Annual Research Conference of the Department of Medicine, The University of Hong Kong, Hong Kong, 16 January 2010. In Hong Kong Medical Journal, 2010, v. 16, suppl. 1, p. 44, abstract no. 72

العلاقة: Hong Kong Medical Journal; The 15th Medical Research Conference (MRC 2010) of the Department of Medicine, The University of Hong Kong, Hong Kong, 16 January 2010. In Hong Kong Medical Journal, 2010, v. 16, suppl. 1, p. 44, abstract no. 72; 44, abstract no. 72; 183033; suppl. 1; http://hdl.handle.net/10722/126351Test; 16

الإتاحة: http://hdl.handle.net/10722/126351Test

المؤلفون: Liang, RHS, Chan, GCF, Fung, KL

الوصف: SIOP 41st Congress Meeting Abstracts ; Link_to_subscribed_fulltext

العلاقة: Pediatric Blood & Cancer; The 41st Annual Conference of the International Society of Paediatric Oncology (SIOP 2009), Sao Paulo, Brazil, 5-9 October 2009. In Pediatric Blood & Cancer, 2009, v. 53 n. 5, p. 764, abstract no. PA.011; 764, abstract no. PA.011; 167890; http://hdl.handle.net/10722/102109Test; 53

الإتاحة: https://doi.org/10.1002/pbc.22234Test
http://hdl.handle.net/10722/102109Test

المؤلفون: Liang, RHS

الوصف: Conference Theme: 2006-2009 Now We Know T-cell Lymphomas Better ; Open Access Journal ; NK (natural killer) neoplasm is rare and extranodal NK/T-cell lymphoma, nasal type, is the commonest NK cell neoplasm. Historically, different names have been used to describe this extraordinary nasal lesion. It has been called lethal midline granuloma, midline malignant reticulosis and polymorphic reticulosis.1-4 The lesion was not specifically categorized in the previous lymphoma classification systems: Rappaport, Kiel or Working Formulation. In the REAL Classification, it has been called angiocentric lymphoma but angiocentricity is by no means pathognomonic of NK neoplasms.5 In the Revised WHO classification, two NK neoplasms are described: extra-nodal NK/Tcell lymphoma, nasal type and aggressive NK cell leukaemia. ; link_to_OA_fulltext

العلاقة: Hematology Meeting Reports; http://www.scopus.com/mlt/select.url?eid=2-s2.0-69749092019&selection=ref&src=s&origin=recordpageTest; The 2009 International T-cell Lymphomas Conference, Bologna, Italy, 16-18 March 2009. In Haematologica Meeting Reports, 2009, v. 3 n. 1, p. 16-19; 19; 162194; 162196; eid_2-s2.0-69749092019; 16; http://hdl.handle.net/10722/62352Test

الإتاحة: https://doi.org/10.4081/hmr.v3i1.523Test
http://hdl.handle.net/10722/62352Test

المؤلفون: Moon Kyoo Jang, Shuk Han Cheng, Tak Yeung Leung, Ze Zhou, Wanxia Gai, John Wong, Peiyong Jiang, Chiu Rwk, Stephen L. Chan, Ma Esk, Yanqin Yang, Wai Kong Chan, Sheng Lian, Lo Ymd, Sean Agbor-Enoh, Hannah A. Valantine, Xiaodan Fan, Chan Kca, Liang Rhs

مصطلحات موضوعية: Transplantation, medicine.anatomical_structure, Placenta, Cancer screening, medicine, Cancer research, Methylation, Epigenetics, Biology, Allele, medicine.disease, Genome, Lymphoma

الوصف: We developed Genetic-Epigenetic Tissue Mapping (GETMap) to determine the tissue composition of plasma DNA carrying genetic variants not present in the constitutional genome through comparing their methylation profiles with relevant tissues. We validated this approach by showing that, in pregnant women, circulating DNA carrying fetal-specific alleles was entirely placenta-derived. In lung-transplant recipients, we showed that, at 72 hours after transplantation, the lung contributed only a median of 17% to the plasma DNA carrying donor-specific alleles and hematopoietic cells contributed a median of 78%. In hepatocellular cancer patients, the liver was identified as the predominant source of plasma DNA carrying tumor-specific mutations. In a pregnant woman with lymphoma, plasma DNA molecules carrying cancer mutations and fetal-specific alleles were accurately shown to be derived from the lymphocytes and placenta, respectively. Analysis of tissue origin for plasma DNA carrying genetic variants is potentially useful for noninvasive prenatal testing, transplantation monitoring and cancer screening.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::7675cde9f58d3e8040703c07c77fe444Test
https://doi.org/10.1101/2020.11.13.381178Test

المؤلفون: Cheung, BMY, Liang, RHS, Ambekar, CS, Kumana, CR

مصطلحات موضوعية: Medical sciences

الوصف: published_or_final_version

وصف الملف: 9488 bytes; 27436 bytes; 229190 bytes; 12429 bytes; application/pdf; text/plain

العلاقة: Hong Kong Medical Journal; The 8th Medical Research Conference (MRC 2003), Hong Kong, China, 25-26 January 2003. In Hong Kong Medical Journal, 2003, v. 9 n. 1 suppl. 1, p. 63, abstract no. HO-14; 63, abstract no. HO-14; 95902; 1 suppl. 1; http://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1024-2708&volume=9&issue=1Test Supp 1&spage=63&epage=&date=2003&atitle=Traditional+Chinese+medicine:+effect+on+bone+marrow+and+peripheral+blood+cell+counts+and+enzyme+induction; http://hdl.handle.net/10722/46922Test

الإتاحة: http://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1024-2708&volume=9&issue=1Test Supp 1&spage=63&epage=&date=2003&atitle=Traditional+Chinese+medicine:+effect+on+bone+marrow+and+peripheral+blood+cell+counts+and+enzyme+induction
http://hdl.handle.net/10722/46922Test

المؤلفون: Liang, RHS, Ambekar, CS, Kumana, CR, Cheung, BMY

مصطلحات موضوعية: Medical sciences

الوصف: published_or_final_version

وصف الملف: 9488 bytes; 27341 bytes; 229190 bytes; 12429 bytes; text/plain; application/pdf

العلاقة: Hong Kong Medical Journal; The 8th Medical Research Conference (MRC 2003), Hong Kong, China, 25-26 January 2003. In Hong Kong Medical Journal, 2003, v. 9 n. 1 suppl. 1, p. 64, abstract no. HO-15; 64, abstract no. HO-15; 86638; 95900; 1 suppl. 1; http://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1024-2708&volume=9&issue=1Test Supp 1&spage=64&epage=&date=2003&atitle=Chloramphenicol+succinate+a+competitive+substrate+and+inhibitor+of+succinate+dehydrogenase:+relation+to+its+mechanisms+of+toxicity; http://hdl.handle.net/10722/46921Test

الإتاحة: http://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1024-2708&volume=9&issue=1Test Supp 1&spage=64&epage=&date=2003&atitle=Chloramphenicol+succinate+a+competitive+substrate+and+inhibitor+of+succinate+dehydrogenase:+relation+to+its+mechanisms+of+toxicity
http://hdl.handle.net/10722/46921Test

المؤلفون: Kung, AWC, Au, WY, Ha, SY, Chan, GCF, Liang, RHS

العلاقة: Hong Kong Practitioner; The 7th Medical Research Conference (MRC 2002), Department of Medicine, The University of Hong Kong, Queen Mary Hospital, Hong Kong, 26-27 January 2002. In Hong Kong Practitioner, 2002, v. 24 n. 2 suppl., p. 47, abstract no. C-H-6; 47, abstract no. C-H-6; 65431; 2 suppl.; http://hdl.handle.net/10722/102777Test; 24

الإتاحة: http://hdl.handle.net/10722/102777Test

المؤلفون: Lie, AKW, Au, WY, Chan, EC, Ma, ESK, Kwong, YL, Liang, RHS, Wan, TSK

الوصف: published_or_final_version

العلاقة: Hong Kong Practitioner; The 7th Medical Research Conference (MRC 2002), Hong Kong, China, 26-27 January 2002. In Hong Kong Practitioner, v. 24 n. 2 suppl., p. 44, abstract no. C-H-1; 44, abstract no. C-H-1; 87412; 2 suppl.; http://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1027-3948&volume=24&issue=2Test Suppl&spage=44&epage=&date=2002&atitle=Tyrosine+kinase+inhibitor+STI571+in+the+treatment+of+Philadelphia+chromosome+positive+leukaemia+relapsing+from+myeloablative+stem+cell+transplantation; http://hdl.handle.net/10722/54159Test; 24

الإتاحة: http://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1027-3948&volume=24&issue=2Test Suppl&spage=44&epage=&date=2002&atitle=Tyrosine+kinase+inhibitor+STI571+in+the+treatment+of+Philadelphia+chromosome+positive+leukaemia+relapsing+from+myeloablative+stem+cell+transplantation
http://hdl.handle.net/10722/54159Test