المؤلفون: Lewis, K.D., Peris, K., Sekulic, A., Stratigos, A.J., Dunn, L., Eroglu, Z., Chang, A.L.S., Migden, M.R., Yoo, S.-Y., Mohan, K., Coates, E., Okoye, E., Bowler, T., Baurain, J.-F., Bechter, O., Hauschild, A., Butler, M.O., Hernandez-Aya, L., Licitra, L., Neves, R.I., Ruiz, E.S., Seebach, F., Lowy, I., Goncalves, P., Fury, M.G.

المساهمون: Regeneron Pharmaceuticals, Sanofi

المصدر: Annals of Oncology ; volume 35, issue 2, page 221-228 ; ISSN 0923-7534

مصطلحات موضوعية: Oncology, Hematology

الإتاحة: https://doi.org/10.1016/j.annonc.2023.10.123Test
https://api.elsevier.com/content/article/PII:S0923753423043296?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S0923753423043296?httpAccept=text/plainTest

المؤلفون: Robert, C., Lewis, K.D., Gutzmer, R., Stroyakovskiy, D., Gogas, H., Protsenko, S., Pereira, R.P., Eigentler, T., Rutkowski, P., Demidov, L., Caro, I., Forbes, H., Shah, K., Yan, Y., Li, H., McArthur, G.A., Ascierto, P.A.

المساهمون: F. Hoffmann-La Roche Ltd

المصدر: Annals of Oncology ; volume 33, issue 5, page 544-555 ; ISSN 0923-7534

مصطلحات موضوعية: Oncology, Hematology

الإتاحة: https://doi.org/10.1016/j.annonc.2022.01.076Test
https://api.elsevier.com/content/article/PII:S092375342200103X?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S092375342200103X?httpAccept=text/plainTest

المؤلفون: D'Angelo, S.P., Bhatia, S., Brohl, A.S., Hamid, O., Mehnert, J.M., Terheyden, P., Shih, K.C., Brownell, I., Lebbé, C., Lewis, K.D., Linette, G.P., Milella, M., Xiong, H., Guezel, G., Nghiem, P.T.

المساهمون: Merck, Merck KGaA, Pfizer

المصدر: ESMO Open ; volume 6, issue 6, page 100290 ; ISSN 2059-7029

مصطلحات موضوعية: Cancer Research, Oncology

الإتاحة: https://doi.org/10.1016/j.esmoop.2021.100290Test
https://api.elsevier.com/content/article/PII:S2059702921002520?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S2059702921002520?httpAccept=text/plainTest

المؤلفون: Ascierto, P.A., Lewis, K.D., Di Giacomo, A.M., Demidov, L., Mandalà, M., Bondarenko, I., Herbert, C., Mackiewicz, A., Rutkowski, P., Guminski, A., Simmons, B., Ye, C., Hooper, G., Wongchenko, M.J., Goodman, G.R., Yan, Y., Schadendorf, D.

المساهمون: F. Hoffman-La Roche Ltd, Roche, Genentech, AMD, Bristol-Myers Squibb, Pierre Fabre, GlaxoSmithKline, Merck Sharp & Dohme, Novartis, Merck KGaA, Sun Pharma, Pfizer, Sanofi, Regeneron, Amgen, Boehringer Ingelheim, Leo Pharma, AstraZeneca, Array

المصدر: Annals of Oncology ; volume 31, issue 1, page 153-159 ; ISSN 0923-7534

الإتاحة: https://doi.org/10.1016/j.annonc.2019.10.002Test
https://api.elsevier.com/content/article/PII:S0923753419354079?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S0923753419354079?httpAccept=text/plainTest

المؤلفون: Stratigos, A.J., Sekulic, A., Peris, K., Bechter, O., Dutriaux, C., Kaatz, M., Lewis, K.D., Basset-Seguin, N., Chang, A.L.S., Dalle, S., Fernandez-Orland, A., Licitra, L., Robert, C., Ulrich, C., Hauschild, A., Migden, M.R., Dummer, R., Li, S., Bowler, T., Fury, M.G.

المساهمون: Regeneron Pharmaceuticals, Sanofi

المصدر: Annals of Oncology ; volume 31, page S1175-S1176 ; ISSN 0923-7534

مصطلحات موضوعية: Oncology, Hematology

الإتاحة: https://doi.org/10.1016/j.annonc.2020.08.2277Test
https://api.elsevier.com/content/article/PII:S0923753420423592?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S0923753420423592?httpAccept=text/plainTest

المؤلفون: Dummer, R., Guminksi, A., Gutzmer, R., Lear, J.T., Lewis, K.D., Chang, A.L.S., Combemale, P., Dirix, L., Kaatz, M., Kudchadkar, R., Loquai, C., Plummer, R., Schulze, H.‐J., Stratigos, A.J., Trefzer, U., Squittieri, N., Migden, M.R.

المساهمون: Novartis Pharmaceuticals Corporation

المصدر: British Journal of Dermatology ; volume 182, issue 6, page 1369-1378 ; ISSN 0007-0963 1365-2133

الإتاحة: https://doi.org/10.1111/bjd.18552Test

المؤلفون: Rischin, D., Khushalani, N.I., Schmults, C.D., Guminski, A., Chang, A.L.S., Lewis, K.D., Lim, A.M., Hernandez-Aya, L., Hughes, B.G.M., Schadendorf, D., Hauschild, A., Stankevich, E., Booth, J., Li, S., Chen, Z., Desai, J., Lowy, I., Fury, M.G., Migden, M.R.

المصدر: Annals of Oncology ; volume 30, page xi35-xi36 ; ISSN 0923-7534

مصطلحات موضوعية: Oncology, Hematology

الإتاحة: https://doi.org/10.1093/annonc/mdz451.006Test
https://api.elsevier.com/content/article/PII:S0923753420344847?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S0923753420344847?httpAccept=text/plainTest
http://academic.oup.com/annonc/article-pdf/30/Supplement_11/mdz451.006/31507865/mdz451.006.pdfTest

المؤلفون: Lewis, K.D., Fury, M.G., Stankevich, E., Mathias, M., Mohan, K.K., Li, S., Nunnink, K., Perry, C., Narwal, A.

المصدر: Annals of Oncology ; volume 29, page viii440 ; ISSN 0923-7534

مصطلحات موضوعية: Oncology, Hematology

الإتاحة: https://doi.org/10.1093/annonc/mdy288.111Test
https://api.elsevier.com/content/article/PII:S0923753419496956?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S0923753419496956?httpAccept=text/plainTest
http://academic.oup.com/annonc/article-pdf/29/suppl_8/mdy288.111/26138280/mdy288.111.pdfTest

المؤلفون: Lear, J.T., Migden, M.R., Lewis, K.D., Chang, A.L.S., Guminski, A., Gutzmer, R., Dirix, L., Combemale, P., Stratigos, A., Plummer, R., Castro, H., Yi, T., Mone, M., Zhou, J., Trefzer, U., Kaatz, M., Loquai, C., Kudchadkar, R., Sellami, D., Dummer, R.

المساهمون: Novartis Pharmaceuticals Corporation

المصدر: Journal of the European Academy of Dermatology and Venereology ; volume 32, issue 3, page 372-381 ; ISSN 0926-9959 1468-3083

الوصف: Background Patients with locally advanced basal cell carcinoma (laBCC) or metastatic BCC (mBCC), two difficult‐to‐treat populations, have had limited treatment options. Sonidegib, a hedgehog pathway inhibitor (HPI), was approved in laBCC based on results from the BOLT trial. Objective To evaluate long‐term efficacy and safety of sonidegib in laBCC and mBCC in the BOLT 18‐ and 30‐month analyses. Methods BOLT (NCT01327053, ClinicalTrials.gov), a double‐blind phase 2 study, enrolled patients from July 2011 until January 2013. Eligible HPI‐treatment–naïve patients with laBCC not amenable to curative surgery/radiotherapy or mBCC were randomized 1 : 2 to sonidegib 200 mg (laBCC, n = 66; mBCC, n = 13) or 800 mg (laBCC, n = 128; mBCC, n = 23). Tumour response was assessed per central and investigator review. Results With 30 months of follow‐up, among patients treated with sonidegib 200 mg (approved dose), objective response rates were 56.1% (central) and 71.2% (investigator) in laBCC and 7.7% (central) and 23.1% (investigator) in mBCC. Tumour responses were durable as follows: median duration of response was 26.1 months (central) and 15.7 months (investigator) in laBCC and 24.0 months (central) and 18.1 months (investigator) in mBCC. Five patients with laBCC and three with mBCC in the 200‐mg arm died. Median overall survival was not reached in either population; 2‐year overall survival rates were 93.2% (laBCC) and 69.3% (mBCC). In laBCC, efficacy was similar regardless of aggressive or non‐aggressive histology. Sonidegib 200 mg continued to have a better safety profile than 800 mg, with lower rates of grade 3/4 adverse events (43.0% vs. 64.0%) and adverse events leading to discontinuation (30.4% vs. 40.0%). Conclusion Sonidegib continued to demonstrate long‐term efficacy and safety in these populations. These data support the use of sonidegib 200 mg per local treatment guidelines.

الإتاحة: https://doi.org/10.1111/jdv.14542Test

المؤلفون: Grob, J.J., Hodi, S., Chiarion-Sileni, V., Lewis, K.D., Rutkowski, P., Lao, C.D., Cowey, C.L., Schadendorf, D., Wagstaff, J., Dummer, R., Queirolo, P., Smylie, M., Butler, M.O., Hill, A.G., Márquez-Rodas, I., Haanen, J.B., Durani, P., Wang, P., Wolchok, J.D., Larkin, J.

المصدر: Annales de Dermatologie et de Vénéréologie - FMC ; volume 2, issue 8, page A130 ; ISSN 2667-0623

مصطلحات موضوعية: Ocean Engineering, Safety, Risk, Reliability and Quality

الإتاحة: https://doi.org/10.1016/j.fander.2022.09.171Test
https://api.elsevier.com/content/article/PII:S2667062322004457?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S2667062322004457?httpAccept=text/plainTest