المؤلفون: Lengvenyte, Aiste, Aouizerate, Bruno, Aubin, Valerie, Loftus, Joséphine, Marlinge, Emeline, Belzeaux, Raoul, Dubertret, Caroline, Gard, Sebastien, Haffen, Emmanuel, Schwan, Raymund, Llorca, Pierre-Michel, Passerieux, Christine, Roux, Paul, Polosan, Mircea, Etain, Bruno, Leboyer, Marion, Courtet, Philippe, Olié, Emilie

المصدر: Journal of Affective Disorders, Elsevier, 2022, 296, pp.265-276

مصطلحات موضوعية: Quantitative Biology - Neurons and Cognition

الوصف: Background: Bipolar disorder (BD) is a chronic, lifelong condition, associated with increased risk of obesity, cognitive impairment, and suicidal behaviors. Abdominal obesity and a higher risk of violent suicide attempt (SA) seem to be shared correlates with older age, BD, and male sex until middle age when menopause-related female body changes occur. This study aimed at assessing the role of abdominal obesity and cognition in the violent SA burden of individuals with BD.Methods: From the well-defined nationwide cohort FACE-BD (FondaMental Advanced center of Expertise for Bipolar Disorders), we extracted data on 619 euthymic BD patients that were 50 years or older at inclusion. Cross-sectional clinical, cognitive, and metabolic assessments were performed. SA history was based on self-report.Results: Violent SA, in contrast to non-violent and no SA, was associated with higher waist circumference, abdominal obesity and poorer California Verbal Learning Test short-delay free recall (CVLT-SDFR) (ANOVA, p < .001, p = .014, and p = .006). Waist circumference and abdominal obesity were associated with violent SA history independently of sex, BD type and anxiety disorder (Exp(B) 1.02, CI 1.00-1.05, p = .018; Exp(B) 2.16, CI 1.00-4.64, p = .009, accordingly). In an exploratory model, waist circumference and CVLT-SDFR performance mediated the association between male sex and violent SA.Limitations: Cross-sectional design and retrospective reporting.Conclusions: Violent SA history was associated with abdominal obesity and poorer verbal memory in older age BD patients. These factors were interlinked and might mediate the association between male sex and violent SA.

الوصول الحر: http://arxiv.org/abs/2208.12508Test

المؤلفون: Strumila, Robertas, Lengvenytė, Aistė, Zdanavičius, Linas, Badaras, Robertas, Dlugauskas, Edgaras, Lesinskienė, Sigita, Matiekus, Eimantas, Marcinkevičius, Martynas, Vencevičienė, Lina, Utkus, Algirdas, Kaminskas, Andrius, Petrėnas, Tomas, Songailienė, Jurgita, Vitkus, Dalius, Ambrozaitytė, Laima

المصدر: Comprehensive psychoneuroendocrinology., Amsterdam : Elsevier, 2024, vol. 19, art. no. 100235, p. [1-8]. ; eISSN 2666-4976

مصطلحات موضوعية: suicidal ideation, adrenocorticotropic hormone (ACTH), hypothalamic-pituitary-adrenal (HPA) axis, cortisol, antidepressants, major depressive disarded (MDD), biomarkers, inflammation (IL6 and TNF alpha), stress response, beck scale for suicide ideation/suicide severity, index (BSS/SSI)

الوصف: Introduction Suicidal ideation, an important risk factor for suicide attempts, has an unclear neurobiological basis and is potentially linked to the dysregulation of the hypothalamic-pituitary-adrenal (HPA) axis and immune-inflammatory systems. While inflammatory markers have been associated with suicide attempts and, to a lower extent suicidal ideation, the data on the role of a stress-response system is less robust, with most studies carried out with cortisol showing inconsistent results. The present study extends on the previous studies implicating stress-response and immune-inflammatory systems in suicidal thoughts and behaviours, focusing on the associations of several stress-response (adrenocorticotropic hormone (ACTH), cortisol, and dehydroepiandrosterone (DHEA)) and immune-inflammatory (C-reactive protein (CRP),interle ukin-6 (IL-6), and tumour necrosis factor-alpha (TNF-alpha)) with suicidal ideation severity in recent suicide attempters, patients with major depressive disorder, and non-psychiatric controls. Methods This observational study included 156 adults from three Vilnius hospitals, recruited into one of the three groups in equal parts: recent suicide attempters, patients with major depressive disorder in current depressive episode, and non-psychiatric controls. Measures included the Hamilton Depression Rating Scale (HDRS-17) and the Beck Scale for Suicide Ideation/Suicide Severity Index (BSS/SSI), alongside sociodemographic data, alcohol, tobacco use, and morning blood samples, measuring plasma ACTH, cortisol, DHEA, CRP, and IL-6. Data were analysed with non-parametric tests, Kendall's tau correlation, and multivariate linear regression adjusted for confounders. Results We found a negative correlation between the plasma ACTH levels and suicidal ideation severity (tau = −0.130, p = 0.033), which was driven by the patients with major depressive disorder (tau = −0.237, p = 0.031). Suicidal ideation severity was also negatively correlated with TNF-alpha (tau = −0.231; p < 0.001), positively ...

وصف الملف: application/pdf

العلاقة: https://epublications.vu.lt/object/elaba:195453450/195453450.pdfTest; https://repository.vu.lt/VU:ELABAPDB195453450&prefLang=en_USTest

الإتاحة: https://doi.org/10.1016/j.cpnec.2024.100235Test
https://repository.vu.lt/VU:ELABAPDB195453450&prefLang=en_USTest

المؤلفون: Velasco, A, Lengvenytė, Aistė, Rodriguez-Revuelta, J, Jimenez-Treviño, L, Courtet, P, Garcia-Portilla, MP, Bobes, J, Sáiz, PA

المصدر: European psychiatry., Cambridge : Cambridge University Press, 2023, Early Access, p. [1-25].

مصطلحات موضوعية: neutrophil/lymphocyte ratio, platelet/lymphocyte ratio, monocyte/lymphocyte ratio, suicidal behavior, depression

الوصف: Background: Inflammatory biomarkers are reportedly increased in depressed patients. Several studies have been conducted using neutrophil/lymphocyte ratio (NLR), platelet/lymphocyte ratio (PLR), and monocyte/lymphocyte ratio (MLR). The objective of this systematic review was to study the relationship between these peripheral biomarkers and suicidality in depressed patients with/without suicidal behavior, including suicide attempts and ideation, and healthy controls. Methods: We searched the following relevant terms in the PubMed, Web of Science, and Scopus databases published in the last five years. We ssessed the methodological quality of included studies using the Oxford criteria and reviewed the evidence following PRISMA guidelines. Results: Eleven studies were retained for the data synthesis, with a total sample of 1,701 participants, of which the majority (819) were patients with depression and suicidal behavior, 494 were depressed patients without suicidal behavior, and only 388 were healthy participants. Our results reinforce the idea that NLR could be an attractive, convenient, and cost-ffective trait marker of suicidal vulnerability in patients with major depressive disorder (MDD). Conclusion: Future large-scale replication studies are needed to examine the apparently understudied role of PLR and MLR in depressed patients in greater depth.

وصف الملف: application/pdf

العلاقة: https://epublications.vu.lt/object/elaba:179600564/179600564.pdfTest; https://repository.vu.lt/VU:ELABAPDB179600564&prefLang=en_USTest

الإتاحة: https://doi.org/10.1192/j.eurpsy.2023.18Test
https://repository.vu.lt/VU:ELABAPDB179600564&prefLang=en_USTest

المؤلفون: Brouillet, Julie Z., Boltri, Margherita, Lengvenytė, Aistė, Lajnef, Mohamed, Richard, Jean-Romain, Barrau, Caroline, Strumila, Robertas, Coyac, Manon, Wu, Ching-Lien, Boukouaci, Wahid, Sugunasabesan, Sobika, Bouassida, Jihène, Guillaume, Sébastien, Sénèque, Maude, Olié, Emilie, Leboyer, Marion, Courtet, Philippe, Tamouza, Ryad

المصدر: Journal of affective disorders reports., Amsterdam : Elsevier B.V., 2023, vol. 14, art. no. 100624, p. 1-9. ; eISSN 2666-9153

مصطلحات موضوعية: CRP, IFABP, Inflammation, Intestinal permeability, Mood disorders, Suicide

الوصف: Background: Patients with major mood disorders are at high risk of suicidal behavior compared to the general population. Suicide is a public health concern, accounting for around 1.2% of deaths worldwide. Understanding its underlying mechanisms may help identify predictive biomarkers and design novel targeted treatments. Immune dysfunctions, in particular affecting the gut-brain axis, are of interest given their dual involvement in mood disorders and suicidal behavior. We thus explored the possible relationships between suicide attempt (SA) and circulating biomarkers of intestinal permeability and systemic inflammation in patients with major depressive disorder (MDD) or bipolar disorder (BD) with and without a history of SA. Method: 137 patients with BD and 168 with MDD were included, and among them, 133 had a history of SA and 172 did not. Among them, 104 were males (34%) and 201 females (66%). Depressive symptoms were evaluated using the Inventory of Depressive Symptomatology clinical scale (IDS-C30). Circulating levels of intestinal fatty acid binding protein (IFABP), calprotectin, apolipoprotein E (ApoE), lipopolysaccharides binding protein (LBP), lipopolysaccharides (LPS), soluble beta-2-microglobulin (B2m), and C-reactive protein (CRP), were determined. Multivariate linear regressions were performed according to the gender status given the proportion of the herein studied male and female individuals and the higher propensity of females to experience SA as compared to males. Results: After adjusting for confounding variables, patients in the SA group had significantly higher CRP, and lower IFABP levels in comparison to the NSA group. Limitations: The unavailability of confounding variables such as dietary habits, should be noted. In addition, the cross-sectional nature of the study hampers the identification of causative effects. Conclusion: Although preliminary, our observations revealed associations between markers of inflammation and intestinal permeability in patients with suicidal behavior warranting ...

وصف الملف: application/pdf

العلاقة: https://epublications.vu.lt/object/elaba:179598505/179598505.pdfTest; https://repository.vu.lt/VU:ELABAPDB179598505&prefLang=en_USTest

الإتاحة: https://doi.org/10.1016/j.jadr.2023.100624Test
https://repository.vu.lt/VU:ELABAPDB179598505&prefLang=en_USTest

المؤلفون: LENGVENYTE, Aiste, STRUMILA, Robertas, BELZEAUX, Raoul, AOUIZERATE, Bruno, DUBERTRET, Caroline, HAFFEN, Emmanuel, LLORCA, Pierre-Michel, ROUX, Paul, POLOSAN, Mircea, SCHWAN, Raymund, WALTER, Michel, D'AMATO, Thierry, JANUEL, Dominique, LEBOYER, Marion, BELLIVIER, Frank, ETAIN, Bruno, NAVICKAS, Alvydas, OLIÉ, Emilie, COURTET, Philippe

مصطلحات موضوعية: Bipolar disorder, Blood cells, Depression, Heterogeneity, Inflammation, Sciences du Vivant [q-bio]/Neurosciences [q-bio.NC]

الوصف: Evidences suggest that inflammation is increased in a subgroup of patients with depression. Moreover, increased peripheral inflammatory markers (cells and proteins) are associated with some, but not all depressive symptoms. On the other hand, similar studies on bipolar disorders mainly focused on blood cytokines. Here, we analysed data from a large (N = 3440), well-characterized cohort of individuals with bipolar disorder using Kendall partial rank correlation, multivariate linear regression, and network analyses to determine whether peripheral blood cell counts are associated with depression severity, its symptoms, and dimensions. Based on the self-reported 16-Item Quick Inventory of Depressive Symptomatology questionnaire scores, we preselected symptom dimensions based on literature and data-driven principal component analysis. We found that the counts of all blood cell types were only marginally associated with depression severity. Conversely, white blood cell count was significantly associated with the sickness dimension and its four components (anhedonia, slowing down, fatigue, and appetite loss). Platelet count was associated with the insomnia/restlessness dimension and its components (initial, middle, late insomnia and restlessness). Principal component analyses corroborated these results. Platelet count was also associated with suicidal ideation. In analyses stratified by sex, the white blood cell count-sickness dimension association remained significant only in men, and the platelet count-insomnia/restlessness dimension association only in women. Without implying causation, these results suggest that peripheral blood cell counts might be associated with different depressive symptoms in individuals with bipolar disorder, and that white blood cells might be implicated in sickness symptoms and platelets in insomnia/agitation and suicidal ideation. ; Sorbonne Universités à Paris pour l'Enseignement et la Recherche ; FondaMental-Cohortes

العلاقة: https://oskar-bordeaux.fr/handle/20.500.12278/182449Test

الإتاحة: https://doi.org/20.500.12278/182449Test
https://doi.org/10.1016/j.bbi.2022.12.002Test
https://oskar-bordeaux.fr/handle/20.500.12278/182449Test
https://hdl.handle.net/20.500.12278/182449Test

المؤلفون: Strumila, Robertas, Lengvenyte, Aiste, Zdanavicius, Linas, Badaras, Robertas, Dlugauskas, Edgaras, Lesinskiene, Sigita, Matiekus, Eimantas, Marcinkevicius, Martynas, Venceviciene, Lina, Utkus, Algirdas, Kaminskas, Andrius, Petrenas, Tomas, Songailiene, Jurgita, Ambrozaityte, Laima

المصدر: Journal of Psychiatric Research ; volume 158, page 245-254 ; ISSN 0022-3956

مصطلحات موضوعية: Biological Psychiatry, Psychiatry and Mental health

الإتاحة: https://doi.org/10.1016/j.jpsychires.2022.12.043Test
https://api.elsevier.com/content/article/PII:S0022395622007269?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S0022395622007269?httpAccept=text/plainTest

المؤلفون: Lengvenyte, Aiste, Belzeaux, Raoul, Olié, Emilie, Hamzeh-Cognasse, Hind, Sénèque, Maude, Strumila, Robertas, Cognasse, Fabrice, Courtet, Philippe

المصدر: Brain, Behavior, and Immunity ; volume 114, page 242-254 ; ISSN 0889-1591

مصطلحات موضوعية: Behavioral Neuroscience, Endocrine and Autonomic Systems, Immunology

الإتاحة: https://doi.org/10.1016/j.bbi.2023.08.025Test
https://api.elsevier.com/content/article/PII:S0889159123002568?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S0889159123002568?httpAccept=text/plainTest

المؤلفون: Lengvenyte, Aiste, Sarchiapone, Marco, Iosue, Miriam, Courtet, Philippe

المصدر: Mental Health Research and Practice ; page 259-276 ; ISBN 9781009067287 9781009065979

الإتاحة: https://doi.org/10.1017/9781009067287.016Test
https://www.cambridge.org/core/services/aop-cambridge-core/content/view/E9716CC0A9AD3BC901EB651E066B143BTest

المؤلفون: Shoib, Sheikh, Chandradasa, Miyuru, Lengvenyte, Aiste, Armiya’u, Aishatu Yusha’u, Saleem, Tamkeen, Ahmed, Saeed, Noor, Isa Multazam, Nazari, Sardar khan, De Berardis, Domenico, Park, Chan, Gürcan, Ahmet, Saeed, Fahimeh

المصدر: Asian Journal of Psychiatry ; volume 93, page 103914 ; ISSN 1876-2018

مصطلحات موضوعية: Psychiatry and Mental health, General Psychology, General Medicine

الإتاحة: https://doi.org/10.1016/j.ajp.2024.103914Test
https://api.elsevier.com/content/article/PII:S1876201824000066?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S1876201824000066?httpAccept=text/plainTest

المؤلفون: Shoib, Sheikh, Hussaini, Syed Sameer, Chandradasa, Miyuru, Saeed, Fahimeh, Khan, Tuba, Swed, Sarya, Lengvenytė, Aistė

المصدر: Annals of medicine and surgery., Oxford : Elsevier Science Ltd, 2022, vol. 80, art. no. 104153, p. [1-4]. ; ISSN 2049-0801

وصف الملف: application/pdf

العلاقة: https://epublications.vu.lt/object/elaba:152333382/152333382.pdfTest; https://repository.vu.lt/VU:ELABAPDB152333382&prefLang=en_USTest

الإتاحة: https://doi.org/10.1016/j.amsu.2022.104153Test
https://repository.vu.lt/VU:ELABAPDB152333382&prefLang=en_USTest