المؤلفون: Silva, Fábio Silvestre, Oliveira, Francisco Helder da Silva, Piccione, Marcelo Arruda, Lemos, Roberta Freitas

المصدر: Psicologia: Ciência e Profissão. January 2008 28(4)

مصطلحات موضوعية: Futebol, Medidas socioeducativas, Adolescente, Adolescente em conflito com a lei

الوصف: Baseados na Constituição de 1988 e no Estatuto da Criança e do Adolescente, de 1990, o Centro de Defesa dos Direitos da Criança e do Adolescente de Interlagos (CEDECA Interlagos) traz um relato de experiência de uma metodologia alternativa de acompanhamento de adolescentes inseridos em medidas socioeducativas em meio aberto na região da Capela do Socorro e Parelheiros. Essa proposta utiliza o futebol como meio que possibilita ao adolescente refletir sobre sua realidade e suas práticas cotidianas, reconhecendo suas possibilidades de se desenvolver como sujeito de direito e de se tornar protagonista no que diz respeito às ações que busquem sua promoção social e a construção e o exercício da cidadania ativa. É possível observar que, com esse tipo de linguagem, mais próximo do desejo desses jovens, os mesmos atribuem um novo sentido ao acompanhamento a que foram submetidos. Na lógica socioeducativa, procuram superar obstáculos no sentido de buscar cada vez mais seu protagonismo, sua autoria, para reafirmar o que o ato infracional revelou, que é a busca por ser sujeito.

وصف الملف: text/html

الوصول الحر: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1414-98932008000400014Test

المؤلفون: Nicolas, Gaël, Sanchez-Contreras, Monica, Ramos, Eliana, Marisa, Lemos, Roberta, R, Ferreira, Joana, Moura, Denis, Sobrido, Maria, J, Richard, Anne-Claire, Lopez, Alma, Rosa, Legati, Andrea, Deleuze, Jean-François, Boland, Anne, Quenez, Olivier, Krystkowiak, Pierre, Favrole, Pascal, Geschwind, Daniel, H, Aran, Adi, Segel, Reeval, Levy-Lahad, Ephrat, Dickson, Dennis, W, Coppola, Giovanni, Rademakers, Rosa, de Oliveira, João, R M

المساهمون: Centre national de référence pour les malades Alzheimer jeunes (CNRMAJ), Génomique et Médecine Personnalisée du Cancer et des Maladies Neuropsychiatriques (GPMCND), Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Normandie Université (NU)-Institut National de la Santé et de la Recherche Médicale (INSERM), Service de génétique Rouen, CHU Rouen, Normandie Université (NU)-Normandie Université (NU)-Université de Rouen Normandie (UNIROUEN), Normandie Université (NU), David Geffen School of Medicine Los Angeles, University of California Los Angeles (UCLA), University of California (UC)-University of California (UC), Universidade Federal de Pernambuco Recife (UFPE), Interdisciplinary Institute for Neuroscience Bordeaux (IINS), Université de Bordeaux (UB)-Centre National de la Recherche Scientifique (CNRS), Federal University of Pernambuco Recife, Semel Institute for Neuroscience and Human Behavior Los Angeles, Ca, Centre National de Recherche en Génomique Humaine (CNRGH), Institut de Biologie François JACOB (JACOB), Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Laboratoire de Neurosciences Fonctionnelles et Pathologies - UR UPJV 4559 (LNFP), Université de Picardie Jules Verne (UPJV), Service de Neurologie Aix-en-Provence, Centre Hospitalier du Pays d'Aix, Shaare Zedek Medical Center Jerusalem, Israel, The Hebrew University Hadassah Medical School, Mayo Clinic Jacksonville, University of California (UC), Conseil Régional de Haute Normandie —APERC 2014 no. 2014-19, Morris K. Udall Parkinson’s Disease Research Center of Excellence (NINDS P50NS072187), CPNq (480255/2013-0, 440770/2016-5, 470781/2014-9, and 307909/2012-3)

المصدر: EISSN: 2376-7839 ; Neurology Genetics ; https://cea.hal.science/cea-04513458Test ; Neurology Genetics, 2024, 3 (4), ⟨10.1212/nxg.0000000000000166⟩ ; https://www.neurology.org/doi/10.1212/NXG.0000000000000166Test

مصطلحات موضوعية: [SDV]Life Sciences [q-bio], [SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]

الوصف: International audience ; Objective:To assess the potential connection between PCDH12 and brain calcifications in a patient carrying a homozygous nonsense variant in PCDH12 and in adult patients with brain calcifications.Methods:We performed a CT scan in 1 child with a homozygous PCDH12 nonsense variant. We screened DNA samples from 53 patients with primary familial brain calcification (PFBC) and 26 patients with brain calcification of unknown cause (BCUC).Results:We identified brain calcifications in subcortical and perithalamic regions in the patient with a homozygous PCDH12 nonsense variant. The calcification pattern was different from what has been observed in PFBC and more similar to what is described in in utero infections. In patients with PFBC or BCUC, we found no protein-truncating variant and 3 rare (minor allele frequency <0.001) PCDH12 predicted damaging missense heterozygous variants in 3 unrelated patients, albeit with no segregation data available.Conclusions:Brain calcifications should be added to the phenotypic spectrum associated with PCDH12 biallelic loss of function, in the context of severe cerebral developmental abnormalities. A putative role for PCDH12 variants remains to be determined in PFBC.

العلاقة: cea-04513458; https://cea.hal.science/cea-04513458Test; https://cea.hal.science/cea-04513458/documentTest; https://cea.hal.science/cea-04513458/file/NXG.0000000000000166.pdfTest

الإتاحة: https://doi.org/10.1212/nxg.0000000000000166Test
https://doi.org/10.1212/NXG.0000000000000166Test
https://cea.hal.science/cea-04513458Test
https://cea.hal.science/cea-04513458/documentTest
https://cea.hal.science/cea-04513458/file/NXG.0000000000000166.pdfTest

المؤلفون: Lemos, Roberta Freitas

مرشدي الرسالة: Todorov, João Claudio

المصدر: Repositório Institucional da UnBUniversidade de BrasíliaUNB.

مصطلحات موضوعية: Análise do comportamento, Questão social, Bolsa Família, Metacontingência, Comportamento social, Políticas públicas

الوصف: Tese (doutorado)—Universidade de Brasília, Instituto de Psicologia, Departamento de Processos Psicológicos Básicos, Programa de Pós-Graduação em Ciências do Comportamento, 2018.
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Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES).
Este trabalho explora a contribuição da Análise do Comportamento para promover mudanças sociais em larga escala, por meio de um caminho didático. Em primeiro lugar, propõe-se a identificação de questões sociais como os efeitos sociais acumulados da emissão de padrões similares de comportamento por muitos indivíduos. Em segundo lugar, sugere-se o reconhecimento do papel do governo e das políticas públicas como ferramenta. Em terceiro lugar, indica-se a busca de relações condicionais que possam ser implementadas para um grande número de indivíduos para apoiar a resolução das questões sociais levantadas. Como exemplo, é identificada a baixa escolaridade como efeito social acumulado da repetição de padrões comportamentais, especialmente de adolescentes de famílias de baixa renda, com idade para cursar o ensino médio. Depois disso, é investigada a principal estratégia criada pelo governo para combater esse problema, o Programa Bolsa Família. Nesse Programa, jovens de 16 e 17 anos de famílias beneficiárias recebem um benefício se tiverem uma frequência escolar mensal mínima de 75%. Ainda assim, o comportamento de alguns jovens não se mantém. Por fim, é localizada a relação condicional prevista na regulamentação da Aprendizagem Profissional como potencial para aumentar a frequência escolar desses jovens. Para testar essa possibilidade, realizou-se um experimento com dois objetivos principais. O primeiro foi testar os efeitos da construção de um arranjo em âmbito local com o entrelaçamento do comportamento dos atores competentes (VI) para promover oferta e demanda de vagas de aprendizagem profissional (VD’s). O segundo foi testar o efeito do estabelecimento da aprendizagem profissional (VI) sobre o comportamento de ir à escola (VD) em jovens de 16 e 17 anos beneficiários do Programa Bolsa Família com baixa frequência escolar. Foi utilizado um delineamento de linha de base múltipla entre contextos, com intervenção em seis municípios em três fases. Os resultados evidenciaram que: a) arranjos intersetoriais aumentaram a oferta e a demanda de vagas por aprendizagem e b) a contratação como aprendiz aumentou a frequência escolar, na maioria dos casos. Não foi possível implementar a aprendizagem em larga escala para o público alvo, mas a pesquisa contribui para o desenvolvimento de novas práticas entrelaçadas nos municípios na busca pela efetivação dos direitos dos adolescentes à educação e à profissionalização.
This work explores the contribution of Behavior Analysis in promoting large scale social change. First, we identify social issues, such as the accumulated social effects of similar patterns of behavior by many individuals. Second, we recognize the role of the government in using public policy as a tool to shape social behavior. Third, we investigate conditional relations that can be implemented for many individuals to resolve these social issues. As an example, low levels of schooling is identified as the accumulated social effect of the repetition of behavioral patterns, especially by adolescents from low-income families of the age to attend secondary school. We turn to the main strategy created by the government to combat this problem, the Bolsa Família program. In this program, 16 and 17-year-olds in beneficiary families receive benefits if they have a monthly school attendance of 75% at minimum. In some cases, it seems that there are difficulties in maintaining this behavior. Finally, we hypothesize that the conditional relation established in regulating the Apprenticeship Program may help increase school attendance. To test this hypothesis, we run an experiment with two main objectives. First, we tested the effect of interlocking behavioral contingencies of the competent actors at the local level (IV) in increasing the supply and demand of apprenticeship positions (DV's). Second, we tested the effect of establishing an apprenticeship contract (IV) on the behavior of going to school (DV) in 16 and 17-year-olds beneficiaries of the Bolsa Família Program with low school attendance. A multiple baseline design across settings was carried out with the intervention in six municipalities in three phases. The results show that a) intersectoral arrangements increased the supply and demand of apprenticeship positions, and b) the apprenticeship increased school attendance on average. Although it was not possible to implement the Apprenticeship Program on a large scale for the target population, this research contributes to the development of new interlocked patterns in municipalities that seek to promote adolescents’ rights to education and employment.

الإتاحة: http://repositorio.unb.br/handle/10482/32800Test

المؤلفون: Ramos, Eliana Marisa, Carecchio, Miryam, Lemos, Roberta, Ferreira, Joana, Legati, Andrea, Sears, Renee Louise, Hsu, Sandy Chan, Panteghini, Celeste, Magistrelli, Luca, Salsano, Ettore, Esposito, Silvia, Taroni, Franco, Richard, Anne-Claire, Tranchant, Christine, Anheim, Mathieu, Ayrignac, Xavier, Goizet, Cyril, Vidailhet, Marie, Maltete, David, Wallon, David, Frebourg, Thierry, Pimentel, Lylyan, Geschwind, Daniel H, Vanakker, Olivier, Galasko, Douglas, Fogel, Brent L, Innes, A Micheil, Ross, Alison, Dobyns, William B, Alcantara, Diana, O'Driscoll, Mark, Hannequin, Didier, Campion, Dominique, French PFBC study group, Oliveira, João R, Garavaglia, Barbara, Coppola, Giovanni, Nicolas, Gaël

المصدر: European journal of human genetics : EJHG. 26(10)

مصطلحات موضوعية: French PFBC study group, Humans, Brain Diseases, Calcinosis, Receptor, Platelet-Derived Growth Factor beta, Proto-Oncogene Proteins c-sis, Receptors, G-Protein-Coupled, Receptors, Virus, Pedigree, Heterozygote, Phenotype, Mutation, Adolescent, Adult, Aged, Aged, 80 and over, Middle Aged, Child, Female, Male, Sodium-Phosphate Cotransporter Proteins, Type III, Genetic Variation, Young Adult, Cognitive Dysfunction, Receptor, Platelet-Derived Growth Factor beta, Receptors, G-Protein-Coupled, Virus, and over, Sodium-Phosphate Cotransporter Proteins, Type III, Genetics, Genetics & Heredity, Clinical Sciences

الوصف: Primary familial brain calcification (PFBC) is a rare cerebral microvascular calcifying disorder with a wide spectrum of motor, cognitive, and neuropsychiatric symptoms. It is typically inherited as an autosomal-dominant trait with four causative genes identified so far: SLC20A2, PDGFRB, PDGFB, and XPR1. Our study aimed at screening the coding regions of these genes in a series of 177 unrelated probands that fulfilled the diagnostic criteria for primary brain calcification regardless of their family history. Sequence variants were classified as pathogenic, likely pathogenic, or of uncertain significance (VUS), based on the ACMG-AMP recommendations. We identified 45 probands (25.4%) carrying either pathogenic or likely pathogenic variants (n = 34, 19.2%) or VUS (n = 11, 6.2%). SLC20A2 provided the highest contribution (16.9%), followed by XPR1 and PDGFB (3.4% each), and PDGFRB (1.7%). A total of 81.5% of carriers were symptomatic and the most recurrent symptoms were parkinsonism, cognitive impairment, and psychiatric disturbances (52.3%, 40.9%, and 38.6% of symptomatic individuals, respectively), with a wide range of age at onset (from childhood to 81 years). While the pathogenic and likely pathogenic variants identified in this study can be used for genetic counseling, the VUS will require additional evidence, such as recurrence in unrelated patients, in order to be classified as pathogenic.

وصف الملف: application/pdf

الوصول الحر: https://escholarship.org/uc/item/3567x16wTest

المؤلفون: Downey, Haylee, Freitas-Lemos, Roberta, Curran, Kelsey M., Serrano, Elena L., Davis, George C., Stein, Jeffrey S.

مصطلحات موضوعية: Delay discounting, probability discounting, scarcity, income shock, Stress, food security

الوصف: Prior laboratory studies suggest that scarcity increases delay discounting (devaluation of delayed outcomes) and disturbs other decision-making processes. Recent evidence on the effect of COVID-19 on delay discounting is mixed. In addition, no study has examined the effect of COVID-19-related scarcity on probability discounting (devaluation of probabilistic outcomes). The present study examined cross-sectional associations between COVID-19-related scarcity, delay discounting, and probability discounting. During April 2020, 1012 participants with low income were recruited on Amazon Mechanical Turk (MTurk) and completed measures of delay and probability discounting of money and food (grocery gift card), COVID-19-related financial impacts, stress, and food security. Regression analyses indicate that compared to those with no COVID-19 related financial impacts, those with severe COVID-19 related financial impacts had greater delay discounting of money and greater delay discounting of food. In addition, greater food insecurity in the past month was associated with greater delay discounting of food but not money. COVID-19 related financial impact was not associated with probability discounting of money or probability discounting of food. Combined with laboratory experiments, the present study provides additional support for the idea that scarcity or income shock may increase delay discounting, particularly during the onset of COVID-19. ; Submitted version ; Source info: JBEE-D-22-00698

وصف الملف: application/pdf

العلاقة: http://hdl.handle.net/10919/113975Test; Davis, George [0000-0001-5250-7514]; Stein, Jeffrey [0000-0001-5251-3447]

الإتاحة: http://hdl.handle.net/10919/113975Test

المؤلفون: Santana, Paulo Campanha, dos Santos Lemos, Roberta, Tietz, Ana Carolina

المصدر: Nomos: Revista do Programa de Pós-Graduação em Direito da UFC; v. 43 n. 1 (2023): jan/jun 2023; 17-28 ; 1807-3840

الوصف: O Instituto Nacional de Seguridade Social (INSS) possui uma grande demanda dos seus usuários. Há casos em que o administrado espera um considerável período de tempo para ter seu pedido/requerimento analisado. Portanto, o objetivo da presente é analisar o uso da Inteligência Artificial e do Chatbot, considerando a neurociência, na efetividade do atendimento virtual dos usuários. Pesquisas identificaram em maior e menor grau a efetividade do uso do Chatbot em instituições de seguridade social. Em percentual de respostas corretas, na Argentina, chegou a 93%, e, no Brasil, 57%. Nas demandas apresentadas de forma on-line perante instituições previdenciárias, no Panamá, foram 42%, e, no Uruguai, chegou a 95%. Diante desse cenário, questiona-se: em que medida a Inteligência Artificial e o Chatbot, considerando a neurociência, podem contribuir para efetividade do atendimento virtual? Para tanto, a metodologia utilizada é a hipotético-dedutiva, com abordagem qualitativa e quantitativa. Como resultado, identificou-se experiências do uso do Chatbot, a inteligência e a neurociência, com resultados positivos, inclusive, para tratamento contra depressão. O uso da Inteligência Artificial e do Chatbot inovam e tornam mais efetiva a prestação do serviço público previdenciário, pois está disponível 24 horas por dia, nos 7 dias da semana. Com isso, amplia-se a interação entre o administrado e o INSS. O uso da neurociência e a inteligência artificial nessa comunicação permite identificar reações, por meio da análise do discurso, que contribui significativamente para o maior grau de satisfação do usuário, bem como a própria solução das demandas apresentadas, gerando um atendimento digno, conforme previsão constitucional.

وصف الملف: application/pdf

العلاقة: http://www.periodicos.ufc.br/nomos/article/view/83401/249751Test; http://www.periodicos.ufc.br/nomos/article/view/83401Test

الإتاحة: http://www.periodicos.ufc.br/nomos/article/view/83401Test

المؤلفون: Yeh, Yu-Hua, Tegge, Allison N., Freitas-Lemos, Roberta, Myerson, Joel, Green, Leonard, Bickel, Warren K.

المساهمون: Tu, Wen-Jun, National Institute on Aging of the National Institutes of Health, Fralin Biomedical Research Institute at Virginia Tech Carilion

المصدر: PLOS ONE ; volume 18, issue 10, page e0292258 ; ISSN 1932-6203

الوصف: The Monetary Choice Questionnaire (MCQ) is a widely used behavioral task that measures the rate of delay discounting (i.e., k ), the degree to which a delayed reward loses its present value as a function of the time to its receipt. Both 21- and 27-item MCQs have been extensively validated and proven valuable in research. Different methods have been developed to streamline MCQ scoring. However, existing scoring methods have yet to tackle the issue of missing responses or provide clear guidance on imputing such data. Due to this lack of knowledge, the present study developed and compared three imputation approaches that leverage the MCQ’s structure and prioritize ease of implementation. Additionally, their performance was compared with mode imputation. A Monte Carlo simulation was conducted to evaluate the performance of these approaches in handling various missing responses in each observation across two datasets from prior studies that employed the 21- and 27-item MCQs. One of the three approaches consistently outperformed mode imputation across all performance measures. This approach involves imputing missing values using congruent non-missing responses to the items corresponding to the same k value or introducing random responses when congruent answers are unavailable. This investigation unveils a straightforward method for imputing missing data in the MCQ while ensuring unbiased estimates. Along with the investigation, an R tool was developed for researchers to implement this strategy while streamlining the MCQ scoring process.

الإتاحة: https://doi.org/10.1371/journal.pone.0292258Test

المؤلفون: Freitas-Lemos, Roberta, Tegge, Allison N., Tomlinson, Devin C., Yeh, Yu-Hua, Stein, Jeffrey S., Michael Cummings, K., Fong, Geoffrey T., Shields, Peter G., Hatsukami, Dorothy K., Bickel, Warren K.

المساهمون: National Cancer Institute

المصدر: Drug and Alcohol Dependence ; volume 253, page 111015 ; ISSN 0376-8716

الإتاحة: https://doi.org/10.1016/j.drugalcdep.2023.111015Test
https://api.elsevier.com/content/article/PII:S037687162301253X?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S037687162301253X?httpAccept=text/plainTest

المؤلفون: Freitas-Lemos, Roberta, Tomlinson, Devin C., Yeh, Yu-Hua, Dwyer, Candice L., Dai, Hongying Daisy, Leventhal, Adam, Tegge, Allison N., Bickel, Warren K.

المصدر: Preventive Medicine Reports ; volume 35, page 102280 ; ISSN 2211-3355

مصطلحات موضوعية: Public Health, Environmental and Occupational Health, Epidemiology

الإتاحة: https://doi.org/10.1016/j.pmedr.2023.102280Test
https://api.elsevier.com/content/article/PII:S2211335523001717?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S2211335523001717?httpAccept=text/plainTest

المؤلفون: Bickel, Warren K., Tomlinson, Devin C., Craft, William H., Ma, Manxiu, Dwyer, Candice L., Yeh, Yu-Hua, Tegge, Allison N., Freitas-Lemos, Roberta, Athamneh, Liqa N.

المصدر: Addiction Neuroscience ; volume 6, page 100068 ; ISSN 2772-3925

الإتاحة: https://doi.org/10.1016/j.addicn.2023.100068Test
https://api.elsevier.com/content/article/PII:S2772392523000081?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S2772392523000081?httpAccept=text/plainTest