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1دورية أكاديمية
المؤلفون: Taleie, Haniyeh, Hajianfar, Ghasem, Sabouri, Maziar, Parsaee, Mozhgan, Houshmand, Golnaz, Bitarafan-Rajabi, Ahmad, Zaidi, Habib, Shiri Lord, Isaac
المصدر: ISSN: 0897-1889 ; Journal of digital imaging, vol. 36, no. 6 (2023) p. 2494-2506.
مصطلحات موضوعية: info:eu-repo/classification/ddc/616.8, info:eu-repo/classification/ddc/616.0757, Echocardiography / methods, Humans, Iron Overload / complications, Iron Overload / diagnostic imaging, Magnetic Resonance Imaging / methods, Myocardium, Stroke Volume, Thalassemia / complications, Thalassemia / diagnostic imaging, Ventricular Dysfunction, Left / complications, Left / etiology, Ventricular Function, Left, Beta-Thalassemia / complications, Beta-Thalassemia / diagnostic imaging
الوصف: Heart failure caused by iron deposits in the myocardium is the primary cause of mortality in beta-thalassemia major patients. Cardiac magnetic resonance imaging (CMRI) T2* is the primary screening technique used to detect myocardial iron overload, but inherently bears some limitations. In this study, we aimed to differentiate beta-thalassemia major patients with myocardial iron overload from those without myocardial iron overload (detected by T2*CMRI) based on radiomic features extracted from echocardiography images and machine learning (ML) in patients with normal left ventricular ejection fraction (LVEF > 55%) in echocardiography. Out of 91 cases, 44 patients with thalassemia major with normal LVEF (> 55%) and T2* ≤ 20 ms and 47 people with LVEF > 55% and T2* > 20 ms as the control group were included in the study. Radiomic features were extracted for each end-systolic (ES) and end-diastolic (ED) image. Then, three feature selection (FS) methods and six different classifiers were used. The models were evaluated using various metrics, including the area under the ROC curve (AUC), accuracy (ACC), sensitivity (SEN), and specificity (SPE). Maximum relevance-minimum redundancy-eXtreme gradient boosting (MRMR-XGB) (AUC = 0.73, ACC = 0.73, SPE = 0.73, SEN = 0.73), ANOVA-MLP (AUC = 0.69, ACC = 0.69, SPE = 0.56, SEN = 0.83), and recursive feature elimination-K-nearest neighbors (RFE-KNN) (AUC = 0.65, ACC = 0.65, SPE = 0.64, SEN = 0.65) were the best models in ED, ES, and ED&ES datasets. Using radiomic features extracted from echocardiographic images and ML, it is feasible to predict cardiac problems caused by iron overload.
العلاقة: info:eu-repo/semantics/altIdentifier/pmid/37735309; https://archive-ouverte.unige.ch/unige:172427Test; unige:172427
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2دورية أكاديمية
المؤلفون: Lopes, Luis R, Losi, Maria-Angela, Sheikh, Nabeel, Laroche, Cécile, Charron, Philippe, Gimeno, Juan, Kaski, Juan P, Maggioni, Aldo P, Tavazzi, Luigi, Arbustini, Eloisa, Brito, Dulce, Celutkiene, Jelena, Hagege, Albert, Linhart, Ales, Mogensen, Jens, Garcia-Pinilla, José Manuel, Ripoll-Vera, Tomas, Seggewiss, Hubert, Villacorta, Eduardo, Caforio, Alida, Elliott, Perry M
المصدر: Lopes , L R , Losi , M-A , Sheikh , N , Laroche , C , Charron , P , Gimeno , J , Kaski , J P , Maggioni , A P , Tavazzi , L , Arbustini , E , Brito , D , Celutkiene , J , Hagege , A , Linhart , A , Mogensen , J , Garcia-Pinilla , J M , Ripoll-Vera , T , Seggewiss , H , Villacorta , E , Caforio , A , Elliott , P M & Cardiomyopathy Registry Investigators Group 2023 , ' Association between common ....
مصطلحات موضوعية: Cardiomyopathies/complications, Cardiomyopathy, Hypertrophic/complications, Cardiovascular Diseases/epidemiology, Female, Heart Disease Risk Factors, Humans, Hypertension/complications, Obesity/complications, Risk Factors, Ventricular Dysfunction, Left/complications, Hypertension, Obesity, Genotype, Cardiovascular risk factors, Hypertrophic cardiomyopathy, Diabetes
الوصف: Aims The interaction between common cardiovascular risk factors (CVRF) and hypertrophic cardiomyopathy (HCM) is poorly studied. We sought to explore the relation between CVRF and the clinical characteristics of patients with HCM enrolled in the EURObservational Research Programme (EORP) Cardiomyopathy registry Methods and results: 1739 patients with HCM were studied. The relation between hypertension (HT), diabetes (DM), body mass index (BMI), and clinical traits was analysed. Analyses were stratified according to the presence or absence of a pathogenic variant in a sarcomere gene. The prevalence of HT, DM, and obesity (Ob) was 37, 10, and 21%, respectively. HT, DM, and Ob were associated with older age (P<0.001), less family history of HCM (HT and DM P<0.001), higher New York Heart Association (NYHA) class (P<0.001), atrial fibrillation (HT and DM P<0.001; Ob p = 0.03) and LV (left ventricular) diastolic dysfunction (HT and Ob P<0.001; DM P = 0.003). Stroke was more frequent in HT (P<0.001) and mutation-positive patients with DM (P = 0.02). HT and Ob were associated with higher provocable LV outflow tract gradients (HT P<0.001, Ob P = 0.036). LV hypertrophy was more severe in Ob (P = 0.018). HT and Ob were independently associated with NYHA class (OR 1.419, P = 0.017 and OR 1.584, P = 0.004, respectively). Other associations, including a higher proportion of females in HT and of systolic dysfunction in HT and Ob, were observed only in mutation-positive patients. Conclusion Common CVRF are associated with a more severe HCM phenotype, suggesting a proactive management of CVRF should be promoted. An interaction between genotype and CVRF was observed for some traits.
وصف الملف: application/pdf
العلاقة: https://portal.findresearcher.sdu.dk/da/publications/1cf50274-f7f7-49ac-9602-f521b0ba9ce0Test
الإتاحة: https://doi.org/10.1093/ehjqcco/qcac006Test
https://portal.findresearcher.sdu.dk/da/publications/1cf50274-f7f7-49ac-9602-f521b0ba9ce0Test
https://findresearcher.sdu.dk/ws/files/215968872/qcac006.pdfTest -
3دورية أكاديمية
المؤلفون: Li, Cheng-Yang, Shi, Yun-Qi
المصدر: Arquivos Brasileiros de Cardiologia. April 2019 112(4)
مصطلحات موضوعية: Cardiomyopathy, Hypertrophic/prevention and control, Myocardial, Percutaneous Transluminal Septal Myocardial Ablation (PTSMA), Ventricular Dysfunction Left/complications
الوصف: Background: The analysis of risk factors for predicting related complications has not been reported to date. Objective: This study aims to investigate the risk factors of related complications of percutaneous transluminal septal myocardial ablation (PTSMA) for hypertrophic obstructive cardiomyopathy (HOCM) retrospectively. Method: Clinical data, and one-year follow-up results of patients with HOCM, who underwent PTSMA between January 2000 and July 2013 in the Department of Cardiology, Liaoning Province People’s Hospital, Liaoning Province, China, were retrospectively analyzed to determine risk factors for operative complications with multiple logistic regression analysis. All p values are two-sided, with values of p < 0.05 being considered statistically significant. Results: Among 319 patients with HOCM, PTSMA was performed in 224 patients (120 males and 104 females, mean age was 48.20 ± 14.34 years old). The incidence of PTSMA procedure-related complications was 36.23% (66/224), which included three cardiac deaths, two cardiac shocks, one ST-segment elevated myocardial infarction, two ventricular fibrillations, 20 third-degree atrioventricular (AV) blocks (four patients were implanted with a permanent pacemaker (PPM)), 32 complete right bundle branch blocks, two complete left bundle branch blocks, and four puncture-related complications. After multivariate logistic regression analysis, it was found that age, gender, coronary artery diseases, diabetes, heart rate, cardiac function on admission, the number of septal ablations, and the volume of alcohol were not independent risk factors correlated to the whole complications, except for hypertension (OR: 4.856; 95% CI: 1.732-13.609). Early experience appears to be associated with the occurrence of complications. Conclusion: Hypertension was an independent risk factor for PTSMA procedure-related complications. It might be much safer and more efficient if PTSMA procedures are restricted to experienced centers, according to the analysis results for the learning curve.
وصف الملف: text/html
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المؤلفون: Butt, Jawad H., Kondo, Toru, Jhund, Pardeep S., Comin-Colet, Josep, de Boer, Rudolf A., Desai, Akshai S., Hernandez, Adrian F., Inzucchi, Silvio E., Janssens, Stefan P., Kosiborod, Mikhail N., Lam, Carolyn S. P., Langkilde, Anna Maria, Lindholm, Daniel, Martinez, Felipe, Petersson, Magnus, Shah, Sanjiv J., Thierer, Jorge, Vaduganathan, Muthiah, Verma, Subodh, Wilderang, Ulrica, Claggett, Brian C., Solomon, Scott D., McMurray, John J. V.
المصدر: Journal of the American College of Cardiology. 80(18):1705-1717
مصطلحات موضوعية: *Atrial Fibrillation/complications, *Heart Failure, *Ventricular Dysfunction, Left/complications, atrial fibrillation, clinical trial, heart failure, Humans, outcomes, Stroke Volume, Ventricular Function, Left
الوصف: BACKGROUND: Atrial fibrillation (AF) is common in heart failure (HF), is associated with worse outcomes compared with sinus rhythm, and may modify the effects of therapy. OBJECTIVES: This study examined the effects of dapagliflozin according to the presence or not of AF in the DELIVER (Dapagliflozin Evaluation to Improve the LIVEs of Patients With PReserved Ejection Fraction Heart Failure) trial. METHODS: A total of 6,263 patients with HF with New York Heart Association functional class II-IV, left ventricular ejection fraction $>$40%, evidence of structural heart disease, and elevated N-terminal pro-B-type natriuretic peptide levels were randomized to dapagliflozin or placebo. Clinical outcomes and the effect of dapagliflozin, according to AF status, were examined. The primary outcome was a composite of cardiovascular death or worsening HF. RESULTS: Of the 6,261 patients with data on baseline AF, 43.3% had no AF, 18.0% had paroxysmal AF, and 38.7% had persistent/permanent AF. The risk of the primary endpoint was higher in patients with AF, especially paroxysmal AF, driven by a higher rate of HF hospitalization: no AF, HF hospitalization rate per 100 person-years (4.5 [95% CI: 4.0-5.1]), paroxysmal AF (7.5 [95% CI: 6.4-8.7]), and persistent/permanent AF (6.4 [95% CI: 5.7-7.1]) (P $<$ 0.001). The benefit of dapagliflozin on the primary outcome was consistent across AF types: no AF, HR: 0.89 (95% CI: 0.74-1.08); paroxysmal AF, HR: 0.75 (95% CI: 0.58-0.97); persistent/permanent AF, HR: 0.79 (95% CI: 0.66-0.95) (Pinteraction = 0.49). Consistent effects were observed for HF hospitalization, cardiovascular death, all-cause mortality, and improvement in the KCCQ- TSS. CONCLUSIONS: In DELIVER, the beneficial effects of dapagliflozin compared with placebo on clinical events and symptoms were consistent, irrespective of type of AF at baseline. (Dapagliflozin Evaluation to Improve the LIVEs of Patients With PReserved Ejection Fraction Heart Failure. [DELIVER]; NCT03619213).
وصف الملف: print
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المؤلفون: McDowell, Kirsty, Welsh, Paul, Docherty, Kieran F., Morrow, David A., Jhund, Pardeep S., de Boer, Rudolf A., O’Meara, Eileen, Inzucchi, Silvio E., Kober, Lars, Kosiborod, Mikhail N., Martinez, Felipe A., Ponikowski, Piotr, Hammarstedt, Ann, Langkilde, Anna Maria, Sjostrand, Mikaela, Lindholm, Daniel, Solomon, Scott D., Sattar, Naveed, Sabatine, Marc S., McMurray, John J. V.
المصدر: European journal of heart failure. 24(6):1066-1076
مصطلحات موضوعية: *Heart Failure/complications, *Ventricular Dysfunction, Left/complications, Aged, Benzhydryl Compounds, Diabetes, Female, Glucosides/pharmacology, Heart failure, Humans, Male, Middle Aged, Mortality, Sodium-glucose cotransporter 2, Stroke Volume, Uric acid, Uric Acid
الوصف: AIMS: Blood uric acid (UA) levels are frequently elevated in patients with heart failure and reduced ejection fraction (HFrEF), may lead to gout and are associated with worse outcomes. Reduction in UA is desirable in HFrEF and sodium-glucose cotransporter 2 inhibitors may have this effect. We aimed to examine the association between UA and outcomes, the effect of dapagliflozin according to baseline UA level, and the effect of dapagliflozin on UA in patients with HFrEF in the DAPA-HF trial. METHODS AND RESULTS: The association between UA and the primary composite outcome of cardiovascular death or worsening heart failure, its components, and all-cause mortality was examined using Cox regression analyses among 3119 patients using tertiles of UA, after adjustment for other prognostic variables. Change in UA from baseline over 12 months was also evaluated. Patients in tertile 3 (UA $>$/=6.8 mg/dl) versus tertile 1 ($<$5.4 mg/dl) were younger (66.3 +/- 10.8 vs. 68 +/- 10.2 years), more often male (83.1% vs. 71.5%), had lower estimated glomerular filtration rate (58.2 +/- 17.4 vs. 70.6 +/- 18.7 ml/min/1.73 m(2) ), and more often treated with diuretics. Higher UA was associated with a greater risk of the primary outcome (adjusted hazard ratio tertile 3 vs. tertile 1: 1.32, 95% confidence interval [CI] 1.06-1.66; p = 0.01). The risk of heart failure hospitalization and cardiovascular death increased by 7% and 6%, respectively per 1 mg/dl unit increase of UA (p = 0.04 and p = 0.07). Spline analysis revealed a linear increase in risk above a cut-off UA value of 7.09 mg/dl. Compared with placebo, dapagliflozin reduced UA by 0.84 mg/dl (95% CI -0.93 to -0.74) over 12 months (p $<$ 0.001). Dapagliflozin improved outcomes, irrespective of baseline UA concentration. CONCLUSION: Uric acid remains an independent predictor of worse outcomes in a well-treated contemporary HFrEF population. Compared with placebo, dapagliflozin reduced UA and improved outcomes irrespective of UA concentration.
وصف الملف: print
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6دورية أكاديمية
المؤلفون: Scheen, André, Paquot, Nicolas
المصدر: Revue Médicale de Liège, 75 (4), 233-239 (2020)
مصطلحات موضوعية: Diabetes Mellitus, Type 2/complications/drug therapy, Humans, Hypoglycemic Agents/therapeutic use, Kidney, Kidney Diseases/complications, Stroke Volume, Ventricular Dysfunction, Left/complications, Ventricular Function, Left, Cardiovascular disease, Chronic kidney disease, Guidelines, Heart failure, Type 2 diabetes, Antidiabetic medications, Human health sciences, Cardiovascular & respiratory systems, Pharmacy, pharmacology & toxicology, Endocrinology, metabolism & nutrition, Sciences de la santé humaine, Systèmes cardiovasculaire & respiratoire, Pharmacie, pharmacologie & toxicologie, Endocrinologie, métabolisme & nutrition
الوصف: peer reviewed ; The strategy for the management of type 2 diabetes (T2D) has been updated late 2019-2020 by a group of experts of the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD). The indications of two pharmacological classes that have demonstrated a cardiovascular and renal protection, i.e. sodium-glucose cotransporter type 2 inhibitors (SGLT2i) and glucagon-like peptide-1 receptor agonists (GLP-1AR), are now extended because of the favourable results of recent clinical trials. In patients with T2D at high cardiovascular risk (even without previous event, but with indicators of atherosclerotic disease), the addition of these antidiabetic agents to metformin background therapy is now recommended independently of the glycated haemo notglobin (HbA1c) level. For SGLT2i, the prescription may be extended to patients with an estimated glomerular filtration rate down to 30 (instead of 60) ml/min/1.73 m(2), in particular in patients with progressive renal disease and albuminuria and in patients at risk of heart failure, especially if left ventricular ejection fraction is reduced. However, these new proposals could not be applied stricto sensu because of strict reimbursement criteria based upon HbA1c currently applied in our country.
العلاقة: urn:issn:0370-629X; urn:issn:2566-1566; https://orbi.uliege.be/handle/2268/246848Test; info:hdl:2268/246848; https://orbi.uliege.be/bitstream/2268/246848/1/202004_07.pdfTest; info:pmid:32267111
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7دورية أكاديمية
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8دورية أكاديمية
المؤلفون: Michelsen, Marie M., Pena, Adam, Mygind, Naja D., Bech, Jan, Gustafsson, Ida, Kastrup, Jens, Hansen, Henrik S., Høst, Nis, Hansen, Peter R., Prescott, Eva
المصدر: Michelsen , M M , Pena , A , Mygind , N D , Bech , J , Gustafsson , I , Kastrup , J , Hansen , H S , Høst , N , Hansen , P R & Prescott , E 2018 , ' Coronary microvascular dysfunction and myocardial contractile reserve in women with angina and no obstructive coronary artery disease ' , Echocardiography , vol. 35 , no. 2 , pp. 196-203 . https://doi.org/10.1111/echo.13767Test
مصطلحات موضوعية: Age Factors, Aged, Angina Pectoris/complications, Blood Flow Velocity, Cohort Studies, Coronary Circulation, Coronary Vessels/diagnostic imaging, Echocardiography/methods, Female, Humans, Microcirculation, Middle Aged, Myocardial Contraction, Prospective Studies, Ventricular Dysfunction, Left/complications
الوصف: BACKGROUND: Coronary microvascular dysfunction (CMD) is a potential cause of myocardial ischemia and may affect myocardial function at rest and during stress. We investigated whether CMD was associated with left ventricular diastolic and systolic function at rest and during pharmacologically induced hyperemic stress. METHODS: In a prospective cohort study, we included 963 women with angina, left ventricular ejection fraction (LVEF) >45%, and an invasive coronary angiogram without significant stenosis (<50%). Parameters of left ventricular diastolic function, LVEF, speckle tracking-derived global longitudinal strain (GLS), and coronary flow velocity reserve (CFVR) were assessed by transthoracic echocardiography at rest and during dipyridamole stress. The GLS and LVEF reserves were defined as the absolute increases in GLS and LVEF during stress. RESULTS: Coronary flow velocity reserve (CFVR) was measured in 919 women of whom 26% had CMD (defined as CFVR < 2). Coronary microvascular dysfunction (CMD) was associated with higher age and a higher resting heart rate. Women with CMD had a reduced GLS reserve (P = .005), while we found no association between CFVR and LVEF at rest, GLS at rest, or the LVEF reserve, respectively. Global longitudinal strain (GLS) reserve remained associated with CFVR (P = .002) in a multivariable regression analysis adjusted for age, hemodynamic variables, and GLS at rest. In age-adjusted analysis, women with low CFVR had no signs of left ventricular diastolic dysfunction measured by echocardiography at rest. CONCLUSION: The GLS reserve was significantly lower in women with CMD. The mechanisms underlying the association between CMD and GLS reserve warrant further study.
وصف الملف: application/pdf
العلاقة: https://portal.findresearcher.sdu.dk/da/publications/8bb78685-614f-4480-8870-14bd08222fbeTest
الإتاحة: https://doi.org/10.1111/echo.13767Test
https://portal.findresearcher.sdu.dk/da/publications/8bb78685-614f-4480-8870-14bd08222fbeTest
https://findresearcher.sdu.dk/ws/files/157118668/1912_CMDvsstrain_artikel.pdfTest -
9تقرير
المؤلفون: Bochard-Villanueva, Bruno, Estornell-Erill, Jordi
المصدر: Arquivos Brasileiros de Cardiologia. September 2015 105(3)
مصطلحات موضوعية: Ventricular Dysfunction, Left / complications, Heart Failure, Heart Valve Diseases, Endocarditis, Bacterial, Echocardiography, Transesophageal, Tomography, X-Ray Computed
وصف الملف: text/html
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10دورية أكاديمية
المساهمون: College of Medicine, Dept. of Internal Medicine, Oyvind S. Andersen, Otto A. Smiseth, Hisham Dokainish, Muaz M. Abudiab, Robert C. Schutt, Arnav Kumar, Kimi Sato, Serge Harb, Einar Gude, Espen W. Remme, Arne K. Andreassen, Jong-Won Ha, Jiaqiong Xu, Allan L. Klein, Sherif F. Nagueh, Ha, Jong Won
مصطلحات موضوعية: Aged, Cardiac Catheterization/methods, Dimensional Measurement Accuracy, Echocardiography, Doppler/methods, Feasibility Studies, Female, Heart Failure*/diagnosis, Heart Failure*/etiology, Heart Failure*/physiopathology, Humans, Male, Middle Aged, Reproducibility of Results, Ventricular Dysfunction, Left*/complications, Left*/diagnosis, Left*/physiopathology, Ventricular Pressure, Doppler, catheterization, diastole, heart failure, net reclassification improvement
الوصف: BACKGROUND: The diagnosis of heart failure may be challenging because symptoms are rather nonspecific. Elevated left ventricular (LV) filling pressure may be used to confirm the diagnosis, but cardiac catheterization is often not practical. Echocardiographic indexes are therefore used as markers of filling pressure. OBJECTIVES: This study investigated the feasibility and accuracy of comprehensive echocardiography in identifying patients with elevated LV filling pressure. METHODS: We conducted a multicenter study of 450 patients with a wide spectrum of cardiac diseases referred for cardiac catheterization. Left atrial volume index, in combination with flow velocities and tissue Doppler velocities, was used to estimate LV filling pressure. Invasively measured pressure was used as the gold standard. RESULTS: Mean left ventricular ejection fraction (LVEF) was 47%, with 209 patients having an LVEF <50%. Invasive measurements showed elevated LV filling pressure in 58% of patients. Clinical assessment had an accuracy of 72% in identifying patients with elevated filling pressure, whereas echocardiography had an accuracy of 87% (p < 0.001 vs. clinical assessment). The combination of clinical and echocardiographic assessment was incremental, with a net reclassification improvement of 1.5 versus clinical assessment (p < 0.001). CONCLUSIONS: Echocardiographic assessment of LV filling pressure is feasible and accurate. When combined with clinical data, it leads to a more accurate diagnosis, regardless of LVEF. ; open
العلاقة: JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY; J01770; OAK-2017-06053; https://ir.ymlib.yonsei.ac.kr/handle/22282913/161167Test; T201704229; JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, Vol.69(15) : 1937-1948, 2017
الإتاحة: https://doi.org/10.1016/j.jacc.2017.01.058Test
https://ir.ymlib.yonsei.ac.kr/handle/22282913/161167Test
النص الكامل