المؤلفون: Choi, Byeongmin, Lee, YongHyun, Kyung, Yeunwoong, Kim, Eunchan

المصدر: Intelligent Automation & Soft Computing, vol. 36, no.1, pp. 71-82, 2023

مصطلحات موضوعية: Computer Science - Computation and Language, Computer Science - Artificial Intelligence, 68T07 (Secondary), 68T30, 68T50 (Primary), I.2.2, I.2.7

الوصف: Recently, pre-trained language representation models such as bidirectional encoder representations from transformers (BERT) have been performing well in commonsense question answering (CSQA). However, there is a problem that the models do not directly use explicit information of knowledge sources existing outside. To augment this, additional methods such as knowledge-aware graph network (KagNet) and multi-hop graph relation network (MHGRN) have been proposed. In this study, we propose to use the latest pre-trained language model a lite bidirectional encoder representations from transformers (ALBERT) with knowledge graph information extraction technique. We also propose to applying the novel method, schema graph expansion to recent language models. Then, we analyze the effect of applying knowledge graph-based knowledge extraction techniques to recent pre-trained language models and confirm that schema graph expansion is effective in some extent. Furthermore, we show that our proposed model can achieve better performance than existing KagNet and MHGRN models in CommonsenseQA dataset.
Comment: 12 pages, 9 figures

الوصول الحر: http://arxiv.org/abs/2211.07065Test

المؤلفون: Lee, Seonju, Lee, Seon Ah, Shinn, Jongyoon, Lee, Yonghyun

المصدر: International Journal of Nanomedicine ; volume Volume 19, page 4893-4906 ; ISSN 1178-2013

الإتاحة: https://doi.org/10.2147/ijn.s460468Test
https://www.dovepress.com/getfile.php?fileID=99428Test

المؤلفون: Lee, Yonghyun, Shinn, Jongyoon, Xu, Cheng, Dobson, Hannah E., Neamati, Nouri, Moon, James J.

المساهمون: U.S. Department of Health & Human Services | NIH | National Institute of Dental and Craniofacial Research, U.S. Department of Health & Human Services | NIH | National Institute of Diabetes and Digestive and Kidney Diseases, U.S. Department of Health & Human Services | NIH | National Institute of Neurological Disorders and Stroke, U.S. Department of Health & Human Services | NIH | National Cancer Institute, National Research Foundation of Korea (NRF) funded by the Ministry of Education

المصدر: Nature Communications ; volume 14, issue 1 ; ISSN 2041-1723

مصطلحات موضوعية: General Physics and Astronomy, General Biochemistry, Genetics and Molecular Biology, General Chemistry, Multidisciplinary

الوصف: Despite significant advances in immune checkpoint blockade (ICB), immunosuppression mediated by tumor-associated myeloid cells (TAMCs) poses a major barrier to cancer immunotherapy. In addition, while immunogenic cell death (ICD) provides a viable approach to inducing anti-tumor immune response, it remains unknown how to effectively trigger ICD while addressing immunosuppressive TAMCs. Here, we show that SC144, a gp130 inhibitor that blocks the IL-6/gp130/STAT3 pathway, induces ICD of tumor cells and polarizes macrophages to M1-phenotype in vitro. However, as SC144 also induces killing of CD8 + T-cells, we sought to deliver SC144 selectively to tumor cells and TAMCs. Toward this goal, we have developed hyaluronic acid-bilirubin nanoparticles (HABN) that accumulate in CD44 hi tumor cells and TAMCs. Systemic administration of SC144 loaded in HABN (SC144@HABN) induces apoptosis and ICD of tumor cells, increases the ratio of M1-like to M2-like macrophages, and decreases the frequency of myeloid-derived suppressor cells and CD4 + regulatory T-cells, while promoting anti-tumor CD8 + T-cells. Moreover, SC144@HABN combined with anti-PD-L1 ICB efficiently eliminates MC38 tumors and ICB-resistant 4T1 tumors. Overall, our work demonstrates a therapeutic strategy based on coordinated ICD induction and TAMC modulation and highlights the potential of combination chemoimmunotherapy.

الإتاحة: https://doi.org/10.1038/s41467-023-40270-5Test
https://www.nature.com/articles/s41467-023-40270-5.pdfTest
https://www.nature.com/articles/s41467-023-40270-5Test

المؤلفون: Shinn, Jongyoon, Park, Seojeong, Lee, Seonju, Park, Nayoon, Kim, Seojeong, Hwang, Seohui, Moon, James J., Kwon, Youngjoo, Lee, Yonghyun

المساهمون: Korea Health Industry Development Institute, Ministry of Education, National Research Foundation of Korea

المصدر: ACS Nano ; volume 18, issue 6, page 4704-4716 ; ISSN 1936-0851 1936-086X

الإتاحة: https://doi.org/10.1021/acsnano.3c06107Test

المؤلفون: Kim, Jinseong, Shim, Man Kyu, Moon, Yujeong, Kim, Jeongrae, Cho, Hanhee, Yun, Wan Su, Shim, Nayeon, Seong, Joon-Kyung, Lee, Yonghyun, Lim, Dong-Kwon, Kim, Kwangmeyung

المصدر: Journal of Nanobiotechnology; 3/13/2024, Vol. 22 Issue 1, p1-19, 19p

مصطلحات موضوعية: POLYMERSOMES, LIPOSOMES, IMMUNE checkpoint proteins, IMMUNOLOGIC memory, CANCER cells, IMMUNOTHERAPY, CELL death

مستخلص: Background: Immunogenic cell death (ICD) is a crucial approach to turn immunosuppressive tumor microenvironment (ITM) into immune-responsive milieu and improve the response rate of immune checkpoint blockade (ICB) therapy. However, cancer cells show resistance to ICD-inducing chemotherapeutic drugs, and non-specific toxicity of those drugs against immune cells reduce the immunotherapy efficiency. Methods: Herein, we propose cancer cell-specific and pro-apoptotic liposomes (Aposomes) encapsulating second mitochondria-derived activator of caspases mimetic peptide (SMAC-P)-doxorubicin (DOX) conjugated prodrug to potentiate combinational ICB therapy with ICD. The SMAC-P (AVPIAQ) with cathepsin B-cleavable peptide (FRRG) was directly conjugated to DOX, and the resulting SMAC-P-FRRG-DOX prodrug was encapsulated into PEGylated liposomes. Results: The SMAC-P-FRRG-DOX encapsulated PEGylated liposomes (Aposomes) form a stable nanostructure with an average diameter of 109.1 ± 5.14 nm and promote the apoptotic cell death mainly in cathepsin B-overexpressed cancer cells. Therefore, Aposomes induce a potent ICD in targeted cancer cells in synergy of SMAC-P with DOX in cultured cells. In colon tumor models, Aposomes efficiently accumulate in targeted tumor tissues via enhanced permeability and retention (EPR) effect and release the encapsulated prodrug of SMAC-P-FRRG-DOX, which is subsequently cleaved to SMAC-P and DOX in cancer cells. Importantly, the synergistic activity of inhibitors of apoptosis proteins (IAPs)-inhibitory SMAC-P sensitizing the effects of DOX induces a potent ICD in the cancer cells to promote dendritic cell (DC) maturation and stimulate T cell proliferation and activation, turning ITM into immune-responsive milieu. Conclusions: Eventually, the combination of Aposomes with anti-PD-L1 antibody results in a high rate of complete tumor regression (CR: 80%) and also prevent the tumor recurrence by immunological memory established during treatments. [ABSTRACT FROM AUTHOR]

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المؤلفون: Potortì, Francesco, Park, Sangjoon, Crivello, Antonino, Palumbo, Filippo, GIROLAMI, MICHELE, Barsocchi, Paolo, Lee, Soyeon, Torres-Sospedra, Joaquín, Jimenez Ruiz, Antonio Ramon, Perez-Navarro, Antoni, Mendoza-Silva, Germán Martín, Seco, Fernando, ortiz, miguel, PERUL, Johan, Renaudin, Valerie, Kang, Hyunwoong, Park, Soyoung, Lee, Jae Hong, Park, Chan Gook, Ha, Jisu, Han, JaeSeung, Park, Changjun, Kim, Keunhye, Lee, Yonghyun, Gye, Seunghun, lee, keumryeol, Kim, Eunjee, Choi, Jeongsik, choi, Yang-Seok, Talwar, Shilpa, Cho, Seong Yun, Ben-Moshe, Boaz, Scherbakov, Alex, Antsfeld, Leonid, Sansano-Sansano, Emilio, Chidlovskii, Boris, Kronenwett, Nikolai, Prophet, Silvia, Landay, Yael, Marbel, Revital, Zheng, Lingxiang, Peng, Ao, Lin, Zhichao, Wu, Bang, Ma, Chengqi, Poslad, Stefan, Selviah, David, Wu, Wei, Ma, Zixiang, Zhang, Wenchao, Wei, Dongyan, Yuan, Hong, Jiang, Jun-Bang, Huang, Shao-Yung, Liu, Jing-Wen, Su, Kuan-Wu, Leu, Jenq-Shiou, Nishiguchi, Kazuki, BOUSSELHAM, Walid, Uchiyama, Hideaki, Thomas, Diego, Shimada, Atsushi, Taniguchi, Rin-ichiro, Cortés Puschel, Vicente, Lungenstrass, Tomás, Ashraf, Imran, Lee, Chanseok, Ali, Muhammad Usman, Im, Yeongjun, Kim, Gunzung, Eom, Jeongsook, Hur, Soojung, Park, Yongwan, Opiela, Miroslav, Moreira, Adriano, Nicolau, Maria João, Pendão, Cristiano, Silva, Ivo, Meneses, Filipe, Costa, António, Trogh, Jens, Plets, David, Chien, Ying-Ren, Chang, Tzu-Yu, Fang, Shih-Hau, Tsao, Yu

مصطلحات موضوعية: indoor localisation, indoor navigation, competition, benchmarking, smartphone-based positioning, foot-mounted pedestrian dead reckoning, Wi-Fi fingerprinting, magnetic field, camera-based positioning, inertial-based positioning, sensor fusion, Kalman filter, particle filter, stakeholders, atmospheric measurements, particle measurements, real-time systems, wireless fidelity, sensor systems

الوصف: IPIN 2019 Competition, sixth in a series of IPIN competitions, was held at the CNR Research Area of Pisa (IT), integrated into the program of the IPIN 2019 Conference. It included two on-site real-time Tracks and three off-site Tracks. The four Tracks presented in this paper were set in the same environment, made of two buildings close together for a total usable area of 1000 m 2 outdoors and and 6000 m 2 indoors over three floors, with a total path length exceeding 500 m. IPIN competitions, based on the EvAAL framework, have aimed at comparing the accuracy performance of personal positioning systems in fair and realistic conditions: past editions of the competition were carried in big conference settings, university campuses and a shopping mall. Positioning accuracy is computed while the person carrying the system under test walks at normal walking speed, uses lifts and goes up and down stairs or briefly stops at given points. Results presented here are a showcase of state-of-the-art systems tested side by side in real-world settings as part of the on-site real-time competition Tracks. Results for off-site Tracks allow a detailed and reproducible comparison of the most recent positioning and tracking algorithms in the same environment as the on-site Tracks.

وصف الملف: application/pdf

العلاقة: Development of human enhancement fire helmet and fire suppression support system; Basic Science Research Program; ICT Research and Development Program of MSIP/IITP (Development of Precise Positioning Technology for the Enhancement of Pedestrian Position/Spatial Cognition and Sports Competition Analysis); MICROCEBUS; REPNIN PLUS; TECHNOFUSION(III)CM; Development of wireless communication tracking-based location information system in disaster scene for fire-fighters and person who requested rescue; Strategic Priority Research Program; IEEE Access, Vol. 8 (2020); F. Potortì et al., "The IPIN 2019 Indoor Localisation Competition—Description and Results," in IEEE Access, vol. 8, pp. 206674-206718, 2020, doi:10.1109/ACCESS.2020.3037221.; http://hdl.handle.net/10234/200929Test

الإتاحة: https://doi.org/10.1109/ACCESS.2020.3037221Test
http://hdl.handle.net/10234/200929Test

المؤلفون: Potorti, Francesco, Park, Sangjoon, Crivello, Antonino, Palumbo, Filippo, Girolami, Michele, Barsocchi, Paolo, Lee, Soyeon, Torres-Sospedra, Joaquin, Ruiz, Antonio Ramon Jimenez, Perez-Navarro, Antoni, Mendoza-Silva, German Martin, Seco, Fernando, Ortiz, Miguel, Perul, Johan, Renaudin, Valerie, Kang, Hyunwoong, Park, Soyoung, Lee, Jae Hong, Park, Chan Gook, Ha, Jisu, Han, Jaeseung, Park, Changjun, Kim, Keunhye, Lee, Yonghyun, Gye, Seunghun, Lee, Keumryeol, Kim, Eunjee, Choi, Jeong-Sik, Choi, Yang-Seok, Talwar, Shilpa, Cho, Seong Yun, Ben-Moshe, Boaz, Scherbakov, Alex, Antsfeld, Leonid, Sansano-Sansano, Emilio, Chidlovskii, Boris, Kronenwett, Nikolai, Prophet, Silvia, Landay, Yael, Marbel, Revital, Zheng, Lingxiang, Peng, Ao, Lin, Zhichao, Wu, Bang, Ma, Chengqi, Poslad, Stefan, Selviah, David R., Wu, Wei, Ma, Zixiang, Zhang, Wenchao, Wei, Dongyan, Yuan, Hong, Jiang, Jun-Bang, Huang, Shao-Yung, Liu, Jing-Wen, Su, Kuan-Wu, Leu, Jenq-Shiou, Nishiguchi, Kazuki, Bousselham, Walid, Uchiyama, Hideaki, Thomas, Diego, Shimada, Atsushi, Taniguchi, Rin-Ichiro, Puschel, Vicente Cortes, Poulsen, Tomas Lungenstrass, Ashraf, Imran, Lee, Chanseok, Ali, Muhammad Usman, Im, Yeongjun, Kim, Gunzung, Eom, Jeongsook, Hur, Soojung, Park, Yongwan, Opiela, Miroslav, Moreira, Adriano, Nicolau, Maria Joao, Pendao, Cristiano, Silva, Ivo, Meneses, Filipe, Costa, Antonio, Trogh, Jens, Plets, David, Chien, Ying-Ren, Chang, Tzu-Yu, Fang, Shih-Hau, Tsao, Yu

المصدر: IEEE access, 8, 206674–206718 ; ISSN: 2169-3536

مصطلحات موضوعية: ddc:620, Engineering & allied operations, info:eu-repo/classification/ddc/620

الوصف: PIN 2019 Competition, sixth in a series of IPIN competitions, was held at the CNR Research Area of Pisa (IT), integrated into the program of the IPIN 2019 Conference. It included two on-site real-time Tracks and three off-site Tracks. The four Tracks presented in this paper were set in the same environment, made of two buildings close together for a total usable area of 1000 m 2 outdoors and and 6000 m 2 indoors over three floors, with a total path length exceeding 500 m. IPIN competitions, based on the EvAAL framework, have aimed at comparing the accuracy performance of personal positioning systems in fair and realistic conditions: past editions of the competition were carried in big conference settings, university campuses and a shopping mall. Positioning accuracy is computed while the person carrying the system under test walks at normal walking speed, uses lifts and goes up and down stairs or briefly stops at given points. Results presented here are a showcase of state-of-the-art systems tested side by side in real-world settings as part of the on-site real-time competition Tracks. Results for off-site Tracks allow a detailed and reproducible comparison of the most recent positioning and tracking algorithms in the same environment as the on-site Tracks.

وصف الملف: application/pdf

العلاقة: info:eu-repo/semantics/altIdentifier/wos/000594446900001; info:eu-repo/semantics/altIdentifier/issn/2169-3536; https://publikationen.bibliothek.kit.edu/1000130123Test; https://publikationen.bibliothek.kit.edu/1000130123/104023450Test; https://doi.org/10.5445/IR/1000130123Test

الإتاحة: https://doi.org/10.5445/IR/1000130123Test
https://doi.org/10.1109/ACCESS.2020.3037221Test
https://publikationen.bibliothek.kit.edu/1000130123Test
https://publikationen.bibliothek.kit.edu/1000130123/104023450Test

المؤلفون: Lee, Yonghyun, Kamada, Nobuhiko, Moon, James J.

المساهمون: National Institutes of Health, Ministry of Education, National Research Foundation of Korea

المصدر: Advanced Drug Delivery Reviews ; volume 179, page 114021 ; ISSN 0169-409X

الإتاحة: https://doi.org/10.1016/j.addr.2021.114021Test
https://api.elsevier.com/content/article/PII:S0169409X21004142?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S0169409X21004142?httpAccept=text/plainTest

المؤلفون: Potorti, Francesco, Park, Sangjoon, Crivello, Antonino, Palumbo, Filippo, Girolami, Michele, Barsocchi, Paolo, Lee, Soyeon, Torres-Sospedra, Joaquín, Ruiz, Antonio Ramon Jimenez, Perez-Navarro, Antoni, Mendoza-Silva, German Martin, Seco, Fernando, Ortiz, Miguel, Perul, Johan, Renaudin, Valerie, Kang, Hyunwoong, Park, Soyoung, Lee, Jae Hong, Park, Chan Gook, Ha, Jisu, Han, Jaeseung, Park, Changjun, Kim, Keunhye, Lee, Yonghyun, Gye, Seunghun, Lee, Keumryeol, Kim, Eunjee, Choi, Jeong Sik, Choi, Yang Seok, Talwar, Shilpa, Cho, Seong Yun, Ben-Moshe, Boaz, Scherbakov, Alex, Antsfeld, Leonid, Sansano-Sansano, Emilio, Chidlovskii, Boris, Kronenwett, Nikolai, Prophet, Silvia, Landay, Yael, Marbel, Revital, Zheng, Lingxiang, Peng, Ao, Lin, Zhichao, Wu, Bang, Ma, Chengqi, Poslad, Stefan, Selviah, David R., Wu, Wei, Ma, Zixiang, Zhang, Wenchao, Wei, Dongyan, Yuan, Hong, Jiang, Jun-Bang, Huang, Shao-Yung, Liu, Jing-Wen, Su, Kuan-Wu, Nishiguchi, Kazuki, Bousselham, Walid, Uchiyama, Hideaki, Thomas, Diego, Shimada, Atsushi, Taniguchi, Rin-Ichiro, Cortes Puschel, Vicente, Lungenstrass Poulsen, Tomas, Ashraf, Imran, Lee, Chanseok, Ali, Muhammad Usman, Im, Yeongjun, Kim, Gunzung, Eom, Jeongsook, Hur, Soojung, Park, Yongwan, Opiela, Miroslav, Moreira, Adriano, Nicolau, Maria João, Pendão, Cristiano Gonçalves, Silva, Ivo Miguel Menezes, Meneses, Filipe, Costa, António, Trogh, Jens, Plets, David, Chien, Ying-Ren, Chang, Tzu-Yu, Fang, Shih-Hau, Tsao, Yu

مصطلحات موضوعية: benchmarking, camera-based positioning, competition, foot-mounted pedestrian dead reckoning, Indoor localisation, indoor navigation, inertial-based positioning, Kalman filter, magnetic field, particle filter, sensor fusion, smartphone-based positioning, Wi-Fi fingerprinting, Sensors, Wireless fidelity, Sensor systems, Real-time systems, Particle measurements, Atmospheric measurements, Stakeholders, Engenharia e Tecnologia::Engenharia Eletrotécnica, Eletrónica e Informática, Science & Technology

الوصف: IPIN 2019 Competition, sixth in a series of IPIN competitions, was held at the CNR Research Area of Pisa (IT), integrated into the program of the IPIN 2019 Conference. It included two on-site real-time Tracks and three off-site Tracks. The four Tracks presented in this paper were set in the same environment, made of two buildings close together for a total usable area of 1000 m2 outdoors and and 6000 m2 indoors over three floors, with a total path length exceeding 500 m. IPIN competitions, based on the EvAAL framework, have aimed at comparing the accuracy performance of personal positioning systems in fair and realistic conditions: past editions of the competition were carried in big conference settings, university campuses and a shopping mall. Positioning accuracy is computed while the person carrying the system under test walks at normal walking speed, uses lifts and goes up and down stairs or briefly stops at given points. Results presented here are a showcase of state-of-the-art systems tested side by side in real-world settings as part of the on-site real-time competition Tracks. Results for off-site Tracks allow a detailed and reproducible comparison of the most recent positioning and tracking algorithms in the same environment as the on-site Tracks. ; The authors would like to thank Siemens, the Electronic and Telecommunications Research Institute (ETRI), the Korean Institute of Communications and Information Sciences (KICS), Ganko Food, J-Power Systems, and the other sponsors who provided prizes for the winners of the competition (see http://ipin-conference.org/2019/awards.htmlTest for a complete list).

وصف الملف: application/pdf

العلاقة: https://ieeexplore.ieee.org/document/9253514Test; F. Potortì et al., "The IPIN 2019 Indoor Localisation Competition—Description and Results," in IEEE Access, vol. 8, pp. 206674-206718, 2020, doi:10.1109/ACCESS.2020.3037221; http://hdl.handle.net/1822/70552Test

الإتاحة: https://doi.org/10.1109/ACCESS.2020.3037221Test
http://hdl.handle.net/1822/70552Test

المؤلفون: Lee, Dong Yun, Kang, Sukmo, Lee, Yonghyun, Kim, Jin Yong, Yoo, Dohyun, Jung, Wonsik, Lee, Soyoung, Jeong, Yong Yeon, Lee, Kwangyeol, Jon, Sangyong

المصدر: Theranostics ; volume 10, issue 5, page 1997-2007 ; ISSN 1838-7640

الإتاحة: https://doi.org/10.7150/thno.39662Test
http://www.thno.org/v10p1997.htmTest